Neuroscience
Neuroscience inhibitors are compounds designed to modulate the activity of specific proteins, enzymes, or receptors within the nervous system. These inhibitors are crucial for studying the molecular mechanisms underlying neural function, synaptic transmission, and neurodegenerative diseases. By targeting neurotransmitter receptors, ion channels, and signaling pathways, neuroscience inhibitors aid in the exploration of brain function and the development of therapeutic strategies for neurological disorders such as Alzheimer's, Parkinson's, and epilepsy. At CymitQuimica, we offer a comprehensive range of high-quality neuroscience inhibitors to support your research in neurobiology, neuropharmacology, and cognitive sciences.
Subcategories of "Neuroscience"
- 5-HT Receptor(1,020 products)
- ACK(1 products)
- AChR(619 products)
- ATP Citrate Lyase(17 products)
- Adrenergic Receptor(3,022 products)
- BACE(36 products)
- Beta Amyloid(222 products)
- CaMK(72 products)
- Cyclooxygenase (COX) Inhibitors(599 products)
- Dopamine Receptor(442 products)
- GABA Receptor(365 products)
- Gamma-secretase(62 products)
- GluR(262 products)
- GlyT(26 products)
- Histamine Receptor(385 products)
- LRRK2(42 products)
- Melatonin Receptor(26 products)
- NMDAR(13 products)
- OX Receptor(41 products)
- Opioid Receptor(322 products)
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Found 5557 products of "Neuroscience"
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Pardoprunox
CAS:Pardoprunox (SLV-308) is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties.Formula:C12H15N3O2Purity:98%Color and Shape:SolidMolecular weight:233.27Catestatin
CAS:Non-competitive inhibitor of nicotinic receptors; blocks cationic signalling and catecholamine release; stimulates histamine release. IC50 ~200-250nM.Formula:C107H173N37O26SPurity:98%Color and Shape:SolidMolecular weight:2425.84Aftin-5
CAS:Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.Formula:C19H26N6OColor and Shape:SolidMolecular weight:354.45Nicardipine pyridine metabolite II
CAS:Nicardipine pyridine metabolite II is a biaoctive chemical.Formula:C26H27N3O6Color and Shape:SolidMolecular weight:477.516-hydroxy Buspirone
CAS:6-Hydroxy Buspirone, an active metabolite of the anxiolytic compound buspirone, is produced via the cytochrome P450 (CYP) isoform CYP3A4.Formula:C21H31N5O3Molecular weight:401.50Aprofene
CAS:Aprofene blocks acetylcholine receptors, used for peptic ulcers, endarteritis, cholecystitis, and colitis.Formula:C21H27NO2Color and Shape:SolidMolecular weight:325.44Aβ1-42 aggregation inhibitor 1
CAS:Aβ1-42 aggregation inhibitor 1 effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), demonstrating IC50 values of 2.64 μM and 1.29Formula:C29H32N4SColor and Shape:SolidMolecular weight:468.66Dianicline dihydrochloride
CAS:Dianicline dihydrochloride is a partial agonist of α4β2 nicotinic acetylcholine receptor. It increases cessation rates in a dose-dependent manner.Formula:C13H16N2OPurity:98%Color and Shape:SolidMolecular weight:216.28VU0029767
CAS:<p>VU0029767 is an allosteric enhancer of the M1 muscarinic receptor, capable of modulating the receptor's activity. This compound enhances M1 receptor activity by increasing agonist affinity. However, VU0029767 demonstrates distinct characteristics from other compounds, particularly under varying experimental conditions such as its interaction with mutated M1 receptors and its effects on downstream signaling pathways.</p>Formula:C21H21N3O3Color and Shape:SolidMolecular weight:363.41Ketanserinol
CAS:<p>Ketanserinol is a metabolite of the antihypertensive drug ketanserin, which blocks 5-HT2 receptors to treat protamine-induced pulmonary hypertension.</p>Formula:C22H24FN3O3Color and Shape:SolidMolecular weight:397.445-Methyltryptamine hydrochloride
CAS:5-Methyltryptamine hydrochloride is a high-affinity 5-HT1C receptor ligand and a partial agonist of 5-HT. 5-Methyltryptamine hydrochloride protects mice subjected to burn, tourniquet and endotoxin shock.Formula:C11H15ClN2Purity:99.45%Color and Shape:SolidMolecular weight:210.703Phenglutarimide hydrochloride
CAS:Phenglutarimide hydrochloride is an anticholinergic. It is used as an antiparkinsonian agent.Formula:C17H25ClN2O2Color and Shape:SolidMolecular weight:324.857-Acetoxy-1-methylquinolinium iodide
CAS:7-Acetoxy-1-methylquinolinium iodide (AMQI) is a cholinesterase substrate for inhibitor detection with 320 nm Ex and 410 nm Em.Formula:C12H12INO2Color and Shape:SolidMolecular weight:329.13VU0477886
CAS:VU0477886: Potent mGlu4 PAM, effective in preclinical Parkinson's model HIC.Formula:C20H13ClN4O3Purity:98%Color and Shape:SolidMolecular weight:392.806S-Nalfurafine
CAS:Controlled Product<p>Applications 6S-Nalfurafine is a stereoisomer of Nalfurafine (N255600), a on-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test. Nalfurafine is a new therapeutic agent for the treatment of uremic pruritus in hemodialysis patients.<br>References Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004); Mori, T., et al.: Life Sci., 75, 2433 (2004); Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006); Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010)<br></p>Formula:C28H32N2O5Color and Shape:NeatMolecular weight:476.562-(4-Chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride
CAS:Controlled ProductFormula:C13H17Cl2NOColor and Shape:NeatMolecular weight:274.192Z-Nalfurafine
CAS:Controlled Product<p>Applications 2Z-Nalfurafine is a geometric isomer of Nalfurafine (N255600), a on-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rats on the CPP (Conditioned Place Preference) test. Nalfurafine is a new therapeutic agent for the treatment of uremic pruritus in hemodialysis patients.<br>References Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004); Mori, T., et al.: Life Sci., 75, 2433 (2004); Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006); Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010)<br></p>Formula:C28H32N2O5Color and Shape:NeatMolecular weight:476.562-(3-Chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride
CAS:Controlled ProductFormula:C13H17Cl2NOColor and Shape:NeatMolecular weight:274.19Nalfurafine N-Oxide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Nalfurafine N-Oxide, is an impurity of Nalfurafine (N255600), which is a κ-opioid receptor agonist marketed as a treatment for uremic pruritus in hemodialysis patients.<br>References Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004), Mori, T., et al.: Life Sci., 75, 2433 (2004), Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006), Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010),<br></p>Formula:C28H32N2O6Color and Shape:NeatMolecular weight:492.56Paroxetine hydrochloride hemihydrate
CAS:<p>Paroxetine hydrochloride hemihydrate (Paxil) is an effective and selective serotonin reuptake inhibitor (SSRI).</p>Formula:C38H44Cl2F2N2O7Purity:99.949%Color and Shape:SolidMolecular weight:749.67LY 344864
CAS:LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.Formula:C21H22FN3OPurity:98%Color and Shape:SolidMolecular weight:351.42Dolasetron Mesylate
CAS:Dolasetron Mesylate (MDL-73147EF) is an antagonist of the 5-HT3 receptor and can be used in research on the treatment of vomiting and nausea followingFormula:C20H24N2O6SPurity:99.05%Color and Shape:White PowderMolecular weight:420.48Alosetron ((Z)-2-butenedioate)
CAS:Alosetron (GR 68755) (Z)-2-butenedioate is a Serotonin 5HT3-receptor antagonist that is used in the treatment of irritable bowel syndrome.Formula:C21H22N4O5Purity:98%Color and Shape:SolidMolecular weight:410.42(+)-Nipecotic acid
CAS:(+)-Nipecotic acid ((+)-β-Homoproline) is a specific inhibitor of GABA transport and uptake, capable of activating GABAA receptors.Formula:C6H11NO2Purity:99.38%Color and Shape:SolidMolecular weight:129.16ZK93423
CAS:ZK93423: potent benzodiazepine agonist, IC50=1nM, non-selective, Ki=4.1-6nM for α1-α5 GABAA subunits.Formula:C23H22N2O4Color and Shape:SolidMolecular weight:390.43PF-03463275 2HCl
CAS:PF-03463275 is an orally available, CNS-penetrant inhibitor of SLC6A9, a GlyT1 glycine transporter.Formula:C19H24Cl3FN4OPurity:98%Color and Shape:SolidMolecular weight:449.78CP 135807
CAS:CP 135807 is a 5-HT1D receptor agonist.Formula:C19H21N5O2Purity:98%Color and Shape:SolidMolecular weight:351.4Tilapertin
CAS:Tilapertin is an oral glycine transporter type-1 inhibitor.Formula:C20H21F3N2O2Purity:98%Color and Shape:SolidMolecular weight:378.39Lesopitron dihydrochloride
CAS:Lesopitron dihydrochloride with IC50 of 125 nM in rat hippocampal membranes, is a full and selective 5-HT1A receptor agonist.Formula:C15H23Cl3N6Purity:98%Color and Shape:SolidMolecular weight:393.74AFDX384
CAS:AFDX384 is potent M2/M4 selective antagonist.Formula:C28H42N6O5SColor and Shape:SolidMolecular weight:574.74VU6010572
CAS:VU6010572: potent, selective mGlu3 modulator, IC50 245 nM, high CNS penetration.Formula:C20H18FNO3Color and Shape:SolidMolecular weight:339.36VU6001966
CAS:VU6001966: potent, selective mGlu2 inhibitor (IC50=78 nM), negative modulator, with good CNS penetration.Formula:C17H15FN4O2Purity:98%Color and Shape:SolidMolecular weight:326.33Aβ Fibrillization modulator 1
CAS:Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.Formula:C17H12N4O3SSeColor and Shape:SolidMolecular weight:431.33Bisindolylmaleimide VII
CAS:Bisindolylmaleimide VII is a selective inhibitor of protein kinase C.Formula:C27H27N5O2Color and Shape:SolidMolecular weight:453.54DPNB-ABT594
DPNB-ABT594, a nitrobenzyl-caged ABT594, selectively activates α4β2 over α7 nAChRs; used to study Ca²⁺ signaling in MHb.Formula:C31H46ClN3O11Color and Shape:SolidMolecular weight:672.16AChE-IN-12
CAS:AChE-IN-12 inhibited rat/eel AChE, crossed BBB, prevented Aβ1-42 aggregation, and has potential for Alzheimer's research.Formula:C33H41NO7Color and Shape:SolidMolecular weight:563.68Sulfoxaflor
CAS:Sulfoxaflor (GF 2032) is an agonist of nAChR1 and nAChR2 subtypes and a systemic insecticide. Cost-effective and quality-assured.Formula:C10H10F3N3OSPurity:99.56%Color and Shape:SolidMolecular weight:277.27AC-42
CAS:<p>AC-42 is an allosteric agonist of M1 muscarinic receptor.</p>Formula:C20H31NOColor and Shape:SolidMolecular weight:301.47BMS-911172
CAS:BMS-911172 is an adaptor associated kinase 1 (AAK1 kinase) inhibitor with an IC 50 of 35 nM.Formula:C16H19F2N3O3Color and Shape:SolidMolecular weight:339.34CGS 12066B dimaleate
CAS:5-HT1B full agonistFormula:C25H25F3N4O8Purity:98%Color and Shape:SolidMolecular weight:566.48RX 801077
CAS:RX 801077 is a selective I2R agonist, Ki of 70.1 nM, with anti-inflammatory and neuroprotective properties for TBI research.Formula:C11H10N2OColor and Shape:SolidMolecular weight:186.21CP 93129 dihydrochloride
CAS:5-HT1B agonist, potent and highly selectiveFormula:C12H14ClN3OPurity:98%Color and Shape:SolidMolecular weight:251.71Parapenzolate bromide
CAS:Parapenzolate bromide is an orally active mAChR antagonist. parapenzolate bromide is an anticholinergic and antitussive agent.Formula:C21H26BrNO3Color and Shape:SolidMolecular weight:420.347S 14506 hydrochloride
CAS:S 14506 hydrochloride is a 5-HT1A receptor full agonist.Formula:C24H27ClFN3O2Purity:99.92%Color and Shape:SolidMolecular weight:443.94Prucalopride hydrochloride
CAS:Prucalopride hydrochloride is a selective agonist of the 5-HT4.Formula:C18H27Cl2N3O3Purity:98%Color and Shape:SolidMolecular weight:404.33ZM 169369
CAS:ICI 169369, a 5-HT2/5-HT1C antagonist, can evoke endothelium-dependent relaxation in rabbit aorta.Formula:C19H20N2SColor and Shape:SolidMolecular weight:308.44Nitroflurbiprofen
CAS:<p>Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive</p>Formula:C19H20FNO5Purity:99.88%Color and Shape:SolidMolecular weight:361.36Zatosetron maleate
CAS:Zatosetron maleate（LY 277359 maleate） is a potent and selective serotonin 5HT3 receptor antagonist for the study of acute migraine.Formula:C23H29ClN2O6Purity:98.07%Color and Shape:SolidMolecular weight:464.94(Rac)-VU 6008667
CAS:(Rac)-VU 6008667 is a selective M5 NAM with IC50 of 1.8 μM, high CNS penetration.Formula:C24H17ClF2N2O2Purity:99.82%Color and Shape:SolidMolecular weight:438.85VU0409106
CAS:VU0409106 is a potent, mGlu5-selective inhibitor.Formula:C15H11FN4O2SPurity:98%Color and Shape:SolidMolecular weight:330.34
