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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 1045 products of "Proteases/Proteasome"

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  • HIV-1 protease-IN-14


    <p>HIV-1protease-IN-14 (compound 5ae) is an effective inhibitor of HIV-1protease, exhibiting Ki values of 0.28 nM and 56.9 nM against WTHIV-1PR and R41THIV-1PR, respectively. This compound also demonstrates low cytotoxicity.</p>
    Color and Shape:Odour Solid
  • LXE408 fumarate


    <p>LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.</p>
    Formula:C27H22FN7O6
    Purity:99.89%
    Color and Shape:Soild
    Molecular weight:559.51
  • Tyrosinase-IN-38


    <p>Tyrosinase-IN-38 (compound 6b) is a competitive inhibitor of tyrosinase, demonstrating an IC50 of 25.82 μM and exhibits antioxidant activity.</p>
    Color and Shape:Odour Solid
  • Nitidanin


    <p>Nitidanin is a useful organic compound for research related to life sciences and the catalog number is T125599.</p>
    Formula:C21H24O8
    Color and Shape:Solid
    Molecular weight:404.415
  • Nostosin G


    <p>Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).</p>
    Formula:C25H33N5O6
    Color and Shape:Solid
    Molecular weight:499.56
  • Benzamidine

    CAS:
    <p>Benzamidine is a reversible competitive inhibitor of trypsin with a Ki of 19 μM. It also exhibits inhibitory activity on an enzyme in homogenized porcine sperm acrosome, with a Ki of 4 μM.</p>
    Formula:C7H8N2
    Color and Shape:Solid
    Molecular weight:120.15
  • Phepropeptin C

    CAS:
    <p>Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.</p>
    Formula:C38H60N6O6
    Color and Shape:Solid
    Molecular weight:696.92
  • CRA-2059 TFA


    <p>CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].</p>
    Color and Shape:Solid
  • Lonodelestat TFA


    <p>Lonodelestat TFA, an oral peptide, selectively inhibits hNE, potentially aiding in CF research.</p>
    Formula:C73H112F3N15O21
    Color and Shape:Solid
    Molecular weight:1592.75
  • Sulodexide

    CAS:
    <p>Sulodexide is an orally administered combination of glycosaminoglycans, consisting of low molecular weight heparin (80%) and dermatan sulfate (20%). It demonstrates antithrombotic properties by interacting with antithrombin III (AT III) and heparin cofactor II (HC II), and by inhibiting thrombin formation. Additionally, sulodexide enhances profibrinolytic activity by releasing tissue plasminogen activator (tPA). It also offers endothelial protection, possesses anti-inflammatory effects, and alleviates chronic venous disease.</p>
    Color and Shape:Solid
  • Dazcapistat

    CAS:
    <p>Dazcapistat is a potent calpain inhibitor, with IC50s of &lt;3 μM for calpain 1, calpain 2 and calpain 9, respectively.</p>
    Formula:C21H18FN3O4
    Purity:99.11%
    Color and Shape:Solid
    Molecular weight:395.38
  • Leptosin D

    CAS:
    <p>Leptosin D, a thiodiketopiperazine alkaloid derived from mushrooms, effectively inhibits tyrosinase activity, demonstrating an inhibition concentration (IC50)</p>
    Formula:C25H24N4O3S2
    Color and Shape:Solid
    Molecular weight:492.61
  • ADAM8-IN-1

    CAS:
    <p>ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC 50 value of 73 nM.</p>
    Formula:C44H44Br4N6O12S2
    Color and Shape:Solid
    Molecular weight:1232.6
  • TWH106


    <p>TWH106 is an inhibitor of the cyclophilin (Cyp) enzyme, exhibiting strong affinity for CypA and CypB with dissociation constants (KD) of 53 nM and 139 nM, respectively. It effectively inhibits the replication of HIV and HCV, demonstrating antiviral activity.</p>
    Color and Shape:Odour Solid
  • Tyrosinase/elastase-IN-1


    <p>Tyrosinase/elastase-IN-1, a triterpenoid extracted from the leaves of Rubus fraxinifolius, exhibits inhibitory activities against both tyrosinase and elastase</p>
    Formula:C33H52O5
    Color and Shape:Solid
    Molecular weight:528.76
  • Talopeptin

    CAS:
    <p>Talopeptin is a specific thermolysin inhibitor.</p>
    Formula:C23H34N3O10P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:543.50
  • Z-FG-NHO-Bz

    CAS:
    <p>Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].</p>
    Formula:C26H25N3O6
    Color and Shape:Solid
    Molecular weight:475.49
  • Pirmitegravir

    CAS:
    <p>Pirmitegravir (STP0404) is a potent ALLINI, blocks LEDGF/p75 site, shows antiviral action against HIV.</p>
    Formula:C27H31ClN4O3
    Purity:99.79% - 99.79%
    Color and Shape:Solid
    Molecular weight:495.01
  • Metolazone

    CAS:
    <p>Metolazone (SR-720-22) is a quinazoline-sulfonamide derived diuretic that inhibits sodium chloride symporters.</p>
    Formula:C16H16ClN3O3S
    Purity:98.14% - 98.5%
    Color and Shape:Crystals From Ethanol Solid
    Molecular weight:365.83
  • Leptosphaerodione

    CAS:
    <p>Leptosphaerodione from Remotididymella sp.: a potent UPS inhibitor with 3.2 μM IC50 in HeLa cells; anti-tumor.</p>
    Formula:C21H22O5
    Color and Shape:Solid
    Molecular weight:354.4