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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 1045 products of "Proteases/Proteasome"

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  • (2R,3S)-Emricasan

    CAS:
    <p>(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.</p>
    Formula:C26H27F4N3O7
    Color and Shape:Solid
    Molecular weight:569.5
  • Beclabuvir

    CAS:
    <p>Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 &lt;28 nM.</p>
    Formula:C36H45N5O5S
    Purity:99.87% - 99.93%
    Color and Shape:Solid
    Molecular weight:659.84
  • Immunoproteasome activator 1

    CAS:
    <p>Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.</p>
    Formula:C24H23N3O3
    Color and Shape:Solid
    Molecular weight:401.46
  • UK-370106

    CAS:
    <p>UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-</p>
    Formula:C35H44N2O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:572.73
  • Isobutylamido thiazolyl resorcinol

    CAS:
    <p>Isobutylamido thiazolyl resorcinol is a tyrosinase (Tyrosinase) inhibitor that prevents pigment deposition induced by ultraviolet radiation.</p>
    Formula:C13H14N2O3S
    Color and Shape:Solid
    Molecular weight:278.33
  • LK-732

    CAS:
    <p>LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.</p>
    Formula:C25H29N5O3S
    Color and Shape:Solid
    Molecular weight:479.59
  • Boc3Arg


    <p>Boc 3 Arg is a tert-butyl carbamate-protected arginine compound. It serves as an efficient tag that induces degradation by directly targeting proteins to the 20S proteasome.</p>
    Formula:C21H39N5O7
    Color and Shape:Solid
    Molecular weight:473.56
  • 3-Aminobenzene-1,2-diol

    CAS:
    <p>3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.</p>
    Formula:C6H7NO2
    Color and Shape:Solid
    Molecular weight:125.13
  • TGase2-IN-1

    CAS:
    <p>TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 µM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 µM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.</p>
    Formula:C23H25N3O3
    Color and Shape:Solid
    Molecular weight:391.46
  • Tyrosinase-IN-39


    <p>Tyrosinase-IN-39 (compound 5r) is a competitive inhibitor of tyrosinase, with an IC50 of 6.4 μM, and is used in the study of skin diseases.</p>
    Formula:C23H19N5O4S2
    Color and Shape:Solid
    Molecular weight:493.56
  • SCO-792


    <p>SCO-792: potent, reversible oral enteropeptidase inhibitor, with slow in vitro dissociation and in vivo protein digestion blocking.</p>
    Formula:C22H22N4O8·xH2O
    Color and Shape:Solid
  • PNU-248686A

    CAS:
    <p>PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).</p>
    Formula:C22H18ClNaO5S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:484.95
  • CM-352

    CAS:
    <p>CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.</p>
    Formula:C24H29N3O6S
    Purity:99.36%
    Color and Shape:Solid
    Molecular weight:487.57
  • DPP-4-IN-15

    CAS:
    <p>DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.</p>
    Formula:C17H14F3N3O2S
    Color and Shape:Solid
    Molecular weight:381.372
  • UK 356618

    CAS:
    <p>UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).</p>
    Formula:C34H43N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:557.72
  • Verducatib

    CAS:
    <p>Verducatib is an inhibitor of cathepsins (cathepsin).</p>
    Formula:C31H35FN4O3
    Color and Shape:Solid
    Molecular weight:530.633
  • Anti-infective agent 10

    CAS:
    <p>Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.</p>
    Formula:C26H25N3O7S
    Color and Shape:Solid
    Molecular weight:523.56
  • HCV-IN-40

    CAS:
    <p>HCV-IN-39 is a potent oral drug inhibiting HCV, effective on GT1a (EC50: 0.259μM), GT1b (EC50: 0.434μM), GT1b CES1 (EC50: 0.069μM) replicons.</p>
    Formula:C21H26BrFN3O9P
    Color and Shape:Solid
    Molecular weight:594.32
  • RBx-0597

    CAS:
    <p>RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.</p>
    Formula:C19H20F2N4O2
    Color and Shape:Solid
    Molecular weight:374.384
  • GB111-NH2

    CAS:
    <p>GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].</p>
    Formula:C33H39N3O6
    Color and Shape:Solid
    Molecular weight:573.68