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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 984 products of "Proteases/Proteasome"

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  • Kallikrein-IN-1

    CAS:
    Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.
    Formula:C28H26FN5O4
    Color and Shape:Solid
    Molecular weight:515.54

    Ref: TM-T63579

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • UK 356618

    CAS:
    UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).
    Formula:C34H43N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:557.72

    Ref: TM-T17201

    5mg
    386.00€
    10mg
    673.00€
    25mg
    1,369.00€
  • CM-352

    CAS:
    CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.
    Formula:C24H29N3O6S
    Purity:97.24%
    Color and Shape:Solid
    Molecular weight:487.57

    Ref: TM-T70470

    1mg
    374.00€
    5mg
    793.00€
    10mg
    973.00€
    25mg
    1,279.00€
  • Cathepsin K inhibitor 2

    CAS:
    Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.
    Formula:C30H33F4N5O3
    Color and Shape:Solid
    Molecular weight:587.61

    Ref: TM-T64159

    25mg
    1,927.00€
    50mg
    2,507.00€
    100mg
    3,168.00€
  • Beclabuvir

    CAS:
    Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.
    Formula:C36H45N5O5S
    Purity:99.87% - 99.93%
    Color and Shape:Solid
    Molecular weight:659.84

    Ref: TM-T10493

    1mg
    128.00€
  • (2S,4R)-Teneligliptin

    CAS:
    (2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.
    Formula:C22H30N6OS
    Color and Shape:Solid
    Molecular weight:426.578

    Ref: TM-T206299

    10mg
    To inquire
    50mg
    To inquire
  • ZINC09518833

    CAS:
    ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).
    Formula:C24H25N3O5
    Color and Shape:Solid
    Molecular weight:435.47

    Ref: TM-T200622

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • TMPRSS6-IN-1 TFA


    TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.
    Formula:C35H41F3N8O6S2
    Color and Shape:Solid
    Molecular weight:790.875

    Ref: TM-T204739

    10mg
    To inquire
    50mg
    To inquire
  • Marizomib

    CAS:
    Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.
    Formula:C15H20ClNO4
    Purity:98.03% - 99.41%
    Color and Shape:Solid
    Molecular weight:313.78

    Ref: TM-T16012

    1mg
    525.00€
    5mg
    1,121.00€
    100µg
    120.00€
    500µg
    321.00€
  • BI-1915

    CAS:

    BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.

    Formula:C21H37N5O3
    Color and Shape:Solid
    Molecular weight:407.55

    Ref: TM-T206466

    10mg
    To inquire
    50mg
    To inquire
  • Vaniprevir

    CAS:
    Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.
    Formula:C38H55N5O9S
    Purity:97.41%
    Color and Shape:Solid
    Molecular weight:757.94

    Ref: TM-T8675

    1mg
    792.00€
    5mg
    1,611.00€
    10mg
    2,178.00€
    25mg
    3,240.00€
    50mg
    4,365.00€
  • IDX184

    CAS:
    IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3
    Formula:C25H35N6O9PS
    Purity:97.15%
    Color and Shape:Solid
    Molecular weight:626.62

    Ref: TM-T27586

    1mg
    172.00€
    5mg
    432.00€
    10mg
    618.00€
    25mg
    973.00€
    50mg
    1,333.00€
  • JTK-109

    CAS:
    JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.
    Formula:C37H33ClFN3O4
    Purity:98.48% - 99.68%
    Color and Shape:Solid
    Molecular weight:638.13

    Ref: TM-T27696

    1mg
    296.00€
    5mg
    718.00€
    10mg
    982.00€
    25mg
    1,485.00€
    50mg
    2,008.00€
    100mg
    2,637.00€
    1mL*10mM (DMSO)
    1,108.00€
  • MIV-247

    CAS:
    MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.
    Formula:C17H24F3N3O4
    Purity:99.27%
    Color and Shape:Solid
    Molecular weight:391.39

    Ref: TM-T12051

    1mg
    1,234.00€
    2mg
    1,665.00€
    5mg
    2,475.00€
    10mg
    3,312.00€
    25mg
    4,941.00€
    50mg
    6,688.00€
  • PD 151746

    CAS:
    PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.
    Formula:C11H8FNO2S
    Purity:98.63% - ≥95%
    Color and Shape:Solid
    Molecular weight:237.25

    Ref: TM-T2493

    5mg
    39.00€
    10mg
    62.00€
    25mg
    111.00€
    50mg
    172.00€
    1mL*10mM (DMSO)
    46.00€
  • Sebetralstat

    CAS:

    Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.

    Formula:C26H26FN5O4
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:491.51

    Ref: TM-T39350

    1mg
    35.00€
    5mg
    74.00€
    10mg
    105.00€
    25mg
    187.00€
    50mg
    279.00€
    100mg
    414.00€
  • ABT-072 potassium trihydrate

    CAS:
    ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).
    Formula:C24H32KN3O8S
    Color and Shape:Solid
    Molecular weight:561.69

    Ref: TM-T38510

    ne
    Discontinued
    Discontinued product
  • MMP13-IN-2

    CAS:
    MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.
    Formula:C24H19FN6O4S
    Color and Shape:Solid
    Molecular weight:506.51

    Ref: TM-T41079

    ne
    Discontinued
    Discontinued product
  • IPN60090 dihydrochloride

    CAS:
    IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.
    Formula:C24H29Cl2F3N8O3
    Color and Shape:Solid
    Molecular weight:605.44

    Ref: TM-T39544

    ne
    Discontinued
    Discontinued product