Proteases/Proteasome
Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.
Subcategories of "Proteases/Proteasome"
- Acetyl-CoA Carboxylase(38 products)
- Cysteine Protease(111 products)
- DPP-4(24 products)
- Glutaminase(44 products)
- HIV Protease(505 products)
- PAI-1(26 products)
- Protease Inhibitors(50 products)
- Protease-activated Receptor(54 products)
- Proteasome(89 products)
- Serine Protease(54 products)
- p97(15 products)
Show 3 more subcategories
Found 987 products of "Proteases/Proteasome"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
LY 806303
CAS:LY 806303 is a highly selective thrombin inhibitor.Formula:C16H14O5SPurity:98%Color and Shape:SolidMolecular weight:318.34Evogliptin HCl
CAS:Evogliptin (DA-1229), a DPP4 inhibitor, enhances insulin sensitivity and delays diabetes onset.Formula:C19H27ClF3N3O3Color and Shape:SolidMolecular weight:437.88PSI-7409 tetrasodium
CAS:PSI-7409 tetrasodium, a sofosbuvir metabolite, inhibits GT 1b, 2a, 3a, 4a NS5B polymerases with IC50s of 1.6, 2.8, 0.7, 2.6 μM.Formula:C10H16FN2Na4O14P3Purity:98%Color and Shape:SolidMolecular weight:592.117Thrombin Inhibitor 2
CAS:Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor. Thrombin Inhibitor 2 has antithrombotic activity.Formula:C19H16ClF3N6O2Purity:98%Color and Shape:SolidMolecular weight:452.82Alvelestat tosylate
CAS:Alvelestat can inhibit neutrophil elastase (NE), which acts an important role in NET formation.Formula:C32H30F3N5O7S2Purity:98%Color and Shape:SolidMolecular weight:717.73DPP-4-IN-2
CAS:DPP-4-IN-2, analog of Alogliptin with 79 nM IC50, is a research tool for diabetes.Formula:C18H18N6OColor and Shape:SolidMolecular weight:334.38Tyrosinase-IN-8
Tyrosinase-IN-8, a potent inhibitor of tyrosinase, demonstrates an inhibitory concentration (IC 50) value of 1.6 µM and exhibits low cytotoxicity whileFormula:C16H12O4Color and Shape:SolidMolecular weight:268.26SQ 32602
CAS:SQ 32602 is a cathepsin E inhibitor.Formula:C32H52N3O7PColor and Shape:SolidMolecular weight:621.74SJA6017
CAS:SJA6017: inhibits calpain-1/2, cathepsins B/L; prevents apoptosis, protects spinal cord, boosts function. IC50s: 7.5-78 nM.Formula:C17H25FN2O4SPurity:98%Color and Shape:SolidMolecular weight:372.45CP-471474
CAS:MMP inhibitor with IC50: MMP-2 (0.7 nM), MMP-13 (0.9 nM), MMP-9 (13 nM), MMP-3 (16 nM), MMP-1 (1170 nM); reduces heart dilation post-infarct.Formula:C16H17FN2O5SPurity:98%Color and Shape:SolidMolecular weight:368.38Sheng Gelieting
CAS:CGT-8012 inhibits DP-IV enzyme, aiding type II diabetes research, with an IC50 of 87 nM.Formula:C17H16F6N4OColor and Shape:SolidMolecular weight:406.33Tec-IN-21
CAS:Tec-IN-21 is an inhibitor of Tec kinase, it also blocks unconventional secretion of fibroblast growth factor 2 (FGF2).Formula:C16H15ClN4O2SPurity:98%Color and Shape:SolidMolecular weight:362.83Cysteine Protease inhibitor hydrochloride
CAS:Cysteine Protease inhibitor hydrochloride is a cysteine protease inhibitor.Formula:C18H15ClN4OPurity:98%Color and Shape:SolidMolecular weight:338.79JNJ-10329670
CAS:JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.Formula:C30H34ClF3N6O3SColor and Shape:SolidMolecular weight:651.14HCV-IN-33
CAS:HCV-IN-33 (Compound (S)-3i) is an inhibitor of HCV entry.Formula:C31H36ClN5Color and Shape:SolidMolecular weight:514.1Gü2602
CAS:Gü2602 inhibits the cathepsin K zymogen autocatalytic activation that is a potent, reversible inhibitor of cathepsin K (CatK) with a Ki of 0.013 nM for matureFormula:C16H22N4O3Color and Shape:SolidMolecular weight:318.37Tyrosinase-IN-3
CAS:Tyrosinase-IN-3 inhibits melanin production; potential for skin whitening and food preservation.Formula:C21H23NO5Color and Shape:SolidMolecular weight:369.41Anticancer agent 82
CAS:Anticancer agent 82, a FiVe1 derivative, selectively targets VIM in cancer cells to disrupt mitosis, with improved oral bioavailability.Formula:C19H18Cl2N4OColor and Shape:SolidMolecular weight:389.28Tyrosinase-IN-6
CAS:Tyrosinase-IN-6 (4B) is a potent tyrosinase inhibitor (IC50=3.80 μM) with good antioxidant activity.Formula:C24H31N3O2Color and Shape:SolidMolecular weight:393.52Alicapistat
CAS:Alicapistat (ABT-957) is a human calpains 1 and 2 inhibitor. It can potentially be used to treat Alzheimer's disease (AD).Formula:C25H27N3O4Purity:98%Color and Shape:SolidMolecular weight:433.5VEL-0230
CAS:VEL-0230 (NC-2300) is a cathespin K inhibitor boosting bone growth and reducing loss, targeting bone diseases and developed by Velcura Therapeutics.Formula:C14H24NNaO5Color and Shape:SolidMolecular weight:309.33PK44 phosphate
CAS:PK44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50: 15.8 nM).Formula:C17H19F5N7O5PColor and Shape:SolidMolecular weight:527.349BAY8040
CAS:BAY8040 is a potent selective human neutrophilic elastase inhibitor with excellent potency and selectivity with promising pharmacokinetic characteristics.Formula:C21H16F3N5O2Color and Shape:SolidMolecular weight:427.38AA10 TG2 inhibitor
CAS:AA10 is an irreversible inhibitor of transglutaminase 2 (TG2).Formula:C32H36N4O5Color and Shape:SolidMolecular weight:556.65DPP-4-IN-1
CAS:DPP-4-IN-1 inhibits DPP-4 with 49 nM IC50, ideal for diabetes study, akin to Alogliptin.Formula:C19H19ClN6Color and Shape:SolidMolecular weight:366.85CAY10704
CAS:CAY10704: Potent HCV inhibitor, EC50=17 nM, low cytotoxicity, good in mice, liver-targeted, not hepatotoxic, weak against dengue.Formula:C18H20Cl2N2Color and Shape:SolidMolecular weight:335.27ASPER-29
CAS:ASPER-29, an Asperphenamate analog, inhibits cathepsins L/S with IC50s of 6.03/5.02 μM, useful in cancer migration/invasion research.Formula:C31H29BrN2O5SColor and Shape:SolidMolecular weight:621.54Elasnin
CAS:Elasnin is a reversible inhibitor of elastase for human granulocyte and pancreatic enzymes with IC50 values of 1.3 and 30 µg/ml, respectively.Formula:C24H40O4Color and Shape:SolidMolecular weight:392.57Tyrosinase-IN-5
CAS:Tyrosinase-IN-5 (16c) inhibits tyrosinase with 0.02 μM IC50, reduces melanogenesis, and is low-toxicity.Formula:C18H13N3O6Color and Shape:SolidMolecular weight:367.31BRD-8899
CAS:BRD-8899 is a STK33 inhibitor, with an IC 50 of 11 nM [1].Formula:C17H22N4O3SColor and Shape:SolidMolecular weight:362.45HCV-IN-36
CAS:HCV-IN-36: oral HCV inhibitor, EC50 0.016 μM, CC50 8.78 μM, potent antiviral.Formula:C30H36ClN5Color and Shape:SolidMolecular weight:502.09GLS1 Inhibitor-3
CAS:GLS1 Inhibitor-3 (compound C147) is a potent inhibitor of GLS1 (IC50: 27.98 nM) and exhibits anti-proliferative effects.Formula:C30H32N10O2SColor and Shape:SolidMolecular weight:596.71MMP-2/9-IN-1
CAS:MMP-2/9-IN-1 (Compound 4a) is a potent dual inhibitor of MMP-2 (IC50: 56 nM) and MMP-9 (IC50: 38 nM). leading to DNA fragmentation.Formula:C14H16IN7SColor and Shape:SolidMolecular weight:441.29(R)-ND-336
CAS:(R)-ND-336: potent, selective MMP-9 inhibitor (K i = 19 nM); inhibits MMP-2 (127 nM), MMP-14 (119 nM); studied for diabetic foot ulcers.Formula:C16H18ClNO3S2Color and Shape:SolidMolecular weight:371.89L-873724
CAS:L-873724: Selective, reversible cathepsin K inhibitor; IC50s—cat K: 0.2 nM, cat S: 178 nM, cat L: 264 nM, cat B: 5239 nM; inhibits bone resorption.Formula:C23H26F3N3O3SPurity:98%Color and Shape:SolidMolecular weight:481.53JO146
CAS:JO146为针对沙眼衣原体高温需要蛋白A(CtHtrA)的蛋白酶抑制剂，其对CtHtrA和人中性粒细胞弹性蛋白酶(HNE)的IC50值分别为21.86 μM和1.15 μM，可应用于细菌感染的抑制。Formula:C31H44N3O7PColor and Shape:SolidMolecular weight:601.67Immunoproteasome inhibitor 1
CAS:Potent, reversible immunoproteasome inhibitor; Ki: β5c 1.18 μM, β1i 0.27 μM, β5i 1.91 μM; potential in treating cancer.Formula:C20H26N2O4Color and Shape:SolidMolecular weight:358.43CAA0225
CAS:CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.Formula:C28H29N3O5Color and Shape:SolidMolecular weight:487.55MDL 27399
CAS:MDL 27399 suppresses human neutrophil cathepsin G.Formula:C26H36N4O8Color and Shape:SolidMolecular weight:532.59AM 4299 B
CAS:AM 4299 B is a novel inhibitor of a thiol protease.Formula:C16H27N3O7Purity:98%Color and Shape:SolidMolecular weight:373.4Calpain Inhibitor XI
CAS:Calpain Inhibitor XI, a reversible covalent inhibitor of calpain-1, is utilized in the research of neurodegenerative disorders.Formula:C26H40N4O6Color and Shape:SolidMolecular weight:504.62HCV-IN-35
CAS:HCV-IN-35 is a potent inhibitor of HCV and shows potential for infectious disease research.Formula:C30H36ClN5Color and Shape:SolidMolecular weight:502.09Calpain-2-IN-1
CAS:Calpain-2-IN-1 is a selective calpain-2 inhibitor with Ki values of 181 nM for calpain-1 and 7.8 nM for calpain-2, applicable for neurodegenerative diseases a.Formula:C28H37N3O7Color and Shape:SolidMolecular weight:527.61Tyrosinase-IN-10
CAS:Tyrosinase-IN-10 serves as a partially competitive inhibitor of tyrosinase, demonstrating an inhibition concentration (IC50) value of 1.6 μM against the enzyme'Formula:C16H12O4Color and Shape:SolidMolecular weight:268.26TAPI-0
CAS:TAPI-0 is a matrix metalloprotease (MMP) and TACE inhibitor.Formula:C24H32N4O5Color and Shape:SolidMolecular weight:456.53NAAA-IN-2
CAS:NAAA-IN-2, a selective inhibitor with 50 nM IC50, targets NAAA, an enzyme hydrolyzing PEA/OEA, and may aid inflammation and pain studies.Formula:C11H13N3O2SColor and Shape:SolidMolecular weight:251.3MMP-1-IN-1
MMP-1-IN-1 is a highly potent MMP-1 inhibitor with an IC 50 of 0.034 μM .Formula:C14H17ClN2O3Color and Shape:SolidMolecular weight:296.75(3S,4S)-A2-32-01
(3S,4S)-A2-32-01, a less active (S,S)-enantiomer of A2-32-01. A2-32-01 is a potent caseinolytic protein proteases (ClpP) inhibitor .Formula:C19H27NO2Color and Shape:SolidMolecular weight:301.42Azo-Resveratrol
CAS:Azo-Resveratrol is an analog of Resveratrol used as a potent tyrosinase inhibitor.Formula:C12H10N2O3Color and Shape:SolidMolecular weight:230.22HCV-IN-34
CAS:HCV-IN-35, an oral HCV blocker, has an EC50 of 0.010 μM and a CC50 of 7.5 μM, indicating strong antiviral effects.Formula:C31H36ClN5Color and Shape:SolidMolecular weight:514.1
