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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 1045 products of "Proteases/Proteasome"

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  • BR351

    CAS:
    <p>BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13).</p>
    Formula:C20H25FN2O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:424.49
  • BMS-986094

    CAS:
    <p>INX 08189 is an RNA-directed RNA polymerase (NS5B) inhibitor.</p>
    Formula:C30H39N6O9P
    Color and Shape:Solid
    Molecular weight:658.64
  • (S)-BI-1001

    CAS:
    <p>(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).</p>
    Formula:C19H15BrClNO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:420.68
  • JPM-OEt

    CAS:
    <p>JPM-OEt: broad-spectrum, covalent cysteine cathepsin inhibitor with antitumor effects.</p>
    Formula:C20H28N2O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:392.45
  • LB-30057

    CAS:
    <p>LB-30057 is used as an oral thrombin inhibitor.</p>
    Formula:C26H31N5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:493.62
  • Grazoprevir sodium salt

    CAS:
    <p>Grazoprevir sodium salt is a selective Hepatitis C virus NS3/4a protease inhibitor with broad activity across genotypes and resistant variants.</p>
    Formula:C38H50N6NaO9S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:789.9
  • Anticancer agent 82

    CAS:
    <p>Anticancer agent 82, a FiVe1 derivative, selectively targets VIM in cancer cells to disrupt mitosis, with improved oral bioavailability.</p>
    Formula:C19H18Cl2N4O
    Color and Shape:Solid
    Molecular weight:389.28
  • U 27391

    CAS:
    <p>U 27391 is a metalloproteinase inhibitor. It acts by inhibits the action of human recombinant interleukin-1beta and glycosaminoglycan synthesis.</p>
    Formula:C23H36N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:448.56
  • Tyrosinase-IN-4

    CAS:
    <p>Tyrosinase-IN-4, a potent inhibitor, has uses in skin-whitening, food preservation, cosmetics, agriculture, and medicine.</p>
    Formula:C15H9ClO3
    Color and Shape:Solid
    Molecular weight:272.68
  • Gemigliptin Tartrate(911637-19-9 free base)

    CAS:
    <p>Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4).</p>
    Formula:C22H25F8N5O8
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:639.45
  • Cysteine protease inhibitor-2

    CAS:
    <p>Cysteine protease inhibitor from US20070032499A1; halts DCT116 at 6.5μM, PC3 at 4.4μM.</p>
    Formula:C13H5N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:247.21
  • ZD8321

    CAS:
    <p>ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).</p>
    Formula:C18H28F3N3O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:423.43
  • Proteasome-IN-1

    CAS:
    <p>Proteasome-IN-1 is an inhibitor of proteasome.</p>
    Formula:C42H35N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:657.76
  • Tanomastat

    CAS:
    <p>Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor.</p>
    Formula:C23H19ClO3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:410.91
  • MDL-101146, (S)-

    CAS:
    <p>MDL-101146, (S)- is an effective orally active inhibitor of human neutrophil elastase.</p>
    Formula:C29H37F5N4O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:632.62
  • IMB-26

    CAS:
    <p>IMB-26 is an HCV inhibitor (EC50: 2.1 μM) and has shown potent anti-HCV effects.</p>
    Formula:C20H23BrN2O6
    Color and Shape:Solid
    Molecular weight:467.31
  • Tyrosinase-IN-6

    CAS:
    <p>Tyrosinase-IN-6 (4B) is a potent tyrosinase inhibitor (IC50=3.80 μM) with good antioxidant activity.</p>
    Formula:C24H31N3O2
    Color and Shape:Solid
    Molecular weight:393.52
  • ZD-0892

    CAS:
    <p>ZD-0892: potent, selective neutrophil elastase inhibitor; Ki 6.7 nM (human), 200 nM (porcine).</p>
    Formula:C24H32F3N3O5
    Purity:95% - 99.53%
    Color and Shape:Solid
    Molecular weight:499.52
  • SLK/STK10-IN-1

    CAS:
    <p>SLK/STK10-IN-1 is a selective and potent inhibitor of SLK and STK10 with potential antitumor activity.</p>
    Formula:C17H13ClN2O3
    Purity:99.34%
    Color and Shape:Solid
    Molecular weight:328.75
  • Prodipine hydrochloride

    CAS:
    <p>Prodipine hydrochloride for purified and plasma Dipeptidyl peptidase IV (DPP IV) from the rabbit (IC50 of 4.5 μM and 30 μM, respectively).</p>
    Formula:C20H26ClN
    Purity:98%
    Color and Shape:Solid
    Molecular weight:315.88
  • DTS

    CAS:
    <p>DTS is a selective and isoform-specific RSK1 kinase inhibitor. It also has broad cancer therapeutic potential.</p>
    Formula:C14H14S3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:278.46
  • TAPI-1

    CAS:
    <p>TAPI1 (TAPI) , an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors.</p>
    Formula:C26H37N5O5
    Purity:≥95%
    Color and Shape:Solid
    Molecular weight:499.6
  • ZYZ-488

    CAS:
    <p>ZYZ-488 is an Apoptosis protease activating factor-1 (Apaf-1) inhibitor, which suppresses the activation of procaspase-9 and procaspase-3.</p>
    Formula:C20H29N3O11
    Purity:99.04%
    Color and Shape:Solid
    Molecular weight:487.46
  • Desethyl KBT-3022

    CAS:
    <p>Desethyl KBT-3022 is an active metabolite of the antiplatelet compound KBT-3022.</p>
    Formula:C23H20N2O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:420.48
  • ND-322 HCl

    CAS:
    <p>ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion.</p>
    Formula:C15H16ClNO3S2
    Purity:99.49%
    Color and Shape:Solid
    Molecular weight:357.88
  • Cyclophilin inhibitor 3

    CAS:
    <p>Cyclophilin inhibitor 3 (compound 7c), a potent inhibitor of cyclophilin A (CypA), exhibited potent anti-HCV effects with an EC50 value of 4.2 μM.</p>
    Formula:C34H38N4O6
    Color and Shape:Solid
    Molecular weight:598.69
  • STOCK2S-26016

    CAS:
    <p>WNK-IN-B, a cell-permeable diaminoacridine, selectively inhibits WNK signaling in mpkDCT/MOVAS by targeting SPAK/OSR1 CCT domain.</p>
    Formula:C20H19N3O2
    Color and Shape:Solid
    Molecular weight:333.38
  • MMP13-IN-4

    CAS:
    <p>MMP13-IN-4 (compound 13) is a potent, selective MMP-13 inhibitor with an IC50 of 14.6 μM, implicated in the pathology of osteoarthritis (OA) [1].</p>
    Formula:C21H17BrN4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:485.29
  • Efegatran sulfate

    CAS:
    <p>Efegatran sulfate (LY294468 sulfate) is a potent thrombin inhibitor used in the treatment of thrombotic disorders.</p>
    Formula:C21H34N6O7S
    Purity:≥98% - ≥98%
    Color and Shape:Solid
    Molecular weight:514.6
  • Desirudin

    CAS:
    <p>Desirudin (CGP 39393) inhibits thrombin, prevents thrombosis, and is used in thrombocytopenia research.</p>
    Color and Shape:Solid
  • Z-LLF-CHO

    CAS:
    <p>Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM.</p>
    Formula:C29H39N3O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:509.64
  • SJA6017

    CAS:
    <p>SJA6017: inhibits calpain-1/2, cathepsins B/L; prevents apoptosis, protects spinal cord, boosts function. IC50s: 7.5-78 nM.</p>
    Formula:C17H25FN2O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:372.45
  • AA9 TG2 inhibitor

    CAS:
    <p>AA9 is a novel transglutaminase (TG2) inhibitor.</p>
    Formula:C32H36N4O5
    Color and Shape:Solid
    Molecular weight:556.65
  • GS-9256

    CAS:
    <p>GS-9256 is a selective inhibitor of the HCV NS3 protease, exhibiting favorable pharmacokinetic properties and antiviral activity [1].</p>
    Formula:C46H56ClF2N6O8PS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:957.46
  • Cysteine Protease inhibitor

    CAS:
    <p>Cysteine protease inhibitors are inhibitors of cysteine proteases. Target: Cysteine Protease</p>
    Formula:C18H14N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:302.33
  • SQ 32602

    CAS:
    <p>SQ 32602 is a cathepsin E inhibitor.</p>
    Formula:C32H52N3O7P
    Color and Shape:Solid
    Molecular weight:621.74
  • Tyrosinase-IN-8


    <p>Tyrosinase-IN-8, a potent inhibitor of tyrosinase, demonstrates an inhibitory concentration (IC 50) value of 1.6 µM and exhibits low cytotoxicity while</p>
    Formula:C16H12O4
    Color and Shape:Solid
    Molecular weight:268.26
  • Alicapistat

    CAS:
    <p>Alicapistat (ABT-957) is a human calpains 1 and 2 inhibitor. It can potentially be used to treat Alzheimer's disease (AD).</p>
    Formula:C25H27N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:433.5
  • VEL-0230

    CAS:
    <p>VEL-0230 (NC-2300) is a cathespin K inhibitor boosting bone growth and reducing loss, targeting bone diseases and developed by Velcura Therapeutics.</p>
    Formula:C14H24NNaO5
    Color and Shape:Solid
    Molecular weight:309.33
  • JNJ-10329670

    CAS:
    <p>JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.</p>
    Formula:C30H34ClF3N6O3S
    Color and Shape:Solid
    Molecular weight:651.14
  • BMS-488043

    CAS:
    <p>BMS-488043 is a novel and unique oral small molecule HIV fusion inhibitor that inhibits the attachment of Human Immunodeficiency Virus type 1 (HIV-1) to CD4(+)</p>
    Formula:C22H22N4O5
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:422.43
  • BAY-43-9695

    CAS:
    <p>BAY-43-9695 is a non-nucleoside compound with anti-human cytomegalovirus (HCMV) activity. It is the major metabolite of BAY-38-4766.</p>
    Formula:C22H25N3O4S
    Purity:99.50% - 99.65%
    Color and Shape:Solid
    Molecular weight:427.52
  • BMS-929075

    CAS:
    <p>BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic</p>
    Formula:C31H24F2N4O3
    Purity:98.44% - 99.94%
    Color and Shape:Solid
    Molecular weight:538.54
  • NP-313

    CAS:
    <p>NP-313 (NSC-4264) is a potent antithrombotic that blocks platelet aggregation via thromboxane A2 synthesis inhibition and targets SOCC-mediated Ca2+ efflux.</p>
    Formula:C12H8ClNO3
    Purity:98.97%
    Color and Shape:Solid
    Molecular weight:249.65
  • TY-51469

    CAS:
    <p>TY-51469 is an inhibitor of chymase (IC50s for simian and human chymases: 0.4 and 7.0 nM, respectively).</p>
    Formula:C20H15FN2O6S4
    Purity:99.65%
    Color and Shape:Solid
    Molecular weight:526.6
  • CZL55

    CAS:
    <p>CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS).</p>
    Formula:C20H22N2O6
    Purity:98.19%
    Color and Shape:Solid
    Molecular weight:386.4
  • (2RS)-FPMPA

    CAS:
    <p>(2RS)-FPMPA(FPMPA) has antiviral activity with an IC50 value of 1.85 μM measured in human MT12 cells infected with SHIV (DH4R).</p>
    Formula:C9H13FN5O4P
    Purity:99.9% - >99.99%
    Color and Shape:Solid
    Molecular weight:305.2
  • GSK-364735

    CAS:
    <p>GSK-364735 is an HIV-1 IN inhibitor.</p>
    Formula:C19H18FN3O4
    Purity:97.73%
    Color and Shape:Solid
    Molecular weight:371.36
  • TG2-IN-3h

    CAS:
    <p>TG2-IN-3h is a highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (tg2) inhibitor</p>
    Formula:C21H26N4O4S
    Purity:99.34% - 99.76%
    Color and Shape:Solid
    Molecular weight:430.52
  • UPGL00004

    CAS:
    <p>UPGL00004: potent GAC inhibitor, IC50=29 nM, Kd=27 nM, suppresses triple-negative breast cancer cell growth.</p>
    Formula:C25H26N8O2S2
    Purity:97.93%
    Color and Shape:Solid
    Molecular weight:534.66