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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 1045 products of "Proteases/Proteasome"

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  • KB-R7785

    CAS:
    <p>KB-R7785 is a novel ADAM12/MMP inhibitor improving heart function and insulin sensitivity by blocking HB-EGF and TNF-alpha.</p>
    Formula:C18H27N3O4
    Color and Shape:Solid
    Molecular weight:349.42
  • Cipemastat

    CAS:
    <p>Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM).</p>
    Formula:C22H36N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:436.55
  • Azt-pmap

    CAS:
    <p>AZT-PMPA, an aryl phosphate derivative of AZT and a nucleoside analogue, demonstrates anti-HIV activity[1].</p>
    Formula:C20H25N6O8P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:508.42
  • XL-784 free base

    CAS:
    <p>XL-784 free base selectively inhibits MMPs with IC50: MMP-1 (1.9µM), MMP-2 (0.81nM), MMP-3 (120nM), MMP-8 (10.8nM), MMP-9 (18nM), MMP-13 (0.56nM).</p>
    Formula:C21H22ClF2N3O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:549.93
  • MDL 27324

    CAS:
    <p>MDL 27324 is an inhibitor of human neutrophil elastase.</p>
    Formula:C29H38F3N5O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:641.7
  • AA74-1

    CAS:
    <p>AA74-1 is a potent, selective APEH inhibitor that significantly enhances T-cell proliferation by inhibiting APEH activity [1].</p>
    Formula:C16H28N4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:308.42
  • Ro 32-7315

    CAS:
    <p>Ro 32-7315 is a selective inhibitor of ADAM17.</p>
    Formula:C22H35N3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:453.6
  • MK-3281

    CAS:
    <p>MK-3281: Oral, potent HCV NS5B inhibitor with promising properties and efficacy in replication trials, suitable for clinical use.</p>
    Formula:C29H37N3O3
    Color and Shape:Solid
    Molecular weight:475.62
  • MDL 101146

    CAS:
    <p>MDL 101146 is an orally active neutrophil elastase inhibitor.</p>
    Formula:C29H37F5N4O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:632.62
  • JW 480

    CAS:
    <p>JW480 is a potent and selective inhibitor of KIAA1363, a serine hydrolase enzyme.</p>
    Formula:C22H23NO2
    Purity:99.72%
    Color and Shape:Solid
    Molecular weight:333.42
  • MMP-7-IN-2

    CAS:
    <p>MMP-7-IN-2 acts as a selective and potent MMP7 inhibitor and can be used to study inflammatory responses and vascular-related diseases.</p>
    Formula:C28H40ClF3N6O9S
    Purity:97.82%
    Color and Shape:Solid
    Molecular weight:729.17
  • Proteasome β2c/i-IN-1

    CAS:
    <p>Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].</p>
    Formula:C32H48N4O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:600.75
  • ND-378

    CAS:
    <p>ND-378 is a potent and selective inhibitor of MMP-2 with no inhibition on MMP-9 and MMP-14.</p>
    Formula:C18H19NO4S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:377.48
  • AZD-7295

    CAS:
    <p>AZD-7295 (A-689) is an NS5A inhibitor that may be used to treat HCV infection.</p>
    Formula:C32H35F3N4O5S
    Color and Shape:Solid
    Molecular weight:644.7
  • PTC725

    CAS:
    <p>PTC725 is a selective HCV 1b replicons inhibitor. It has been shown to target the nonstructural protein 4B.</p>
    Formula:C23H18F4N6O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:518.49
  • EP1013

    CAS:
    <p>EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.</p>
    Formula:C18H23FN2O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:382.38
  • HIV-1 protease-IN-12

    CAS:
    <p>HIV-1 protease-IN-12 (compound 35b) serves as a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 0.51 nM, and demonstrates efficacy against drug-</p>
    Formula:C25H35N3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:489.63
  • GSK-2485852

    CAS:
    <p>GSK-2485852, a NS5B inhibitor, is used potentially for treatment of HCV infection.</p>
    Formula:C27H25BF2N2O6S
    Color and Shape:Solid
    Molecular weight:554.37
  • MMP13-IN-3

    CAS:
    <p>MMP13-IN-3 is an oral, selective MMP-13 inhibitor with IC50 of 1 nM, &gt;1000x selective, for osteoarthritis treatment.</p>
    Formula:C24H22N4O5
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:446.46
  • TP0556351

    CAS:
    <p>TP0556351: potent MMP2 inhibitor with 0.2 nM IC50, reduces collagen in pulmonary fibrosis mice.</p>
    Formula:C50H70N10O16
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1067.15
  • Apratastat

    CAS:
    <p>Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs)</p>
    Formula:C17H22N2O6S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:414.5
  • MDL-101146, (R)-

    CAS:
    <p>MDL-101146, (R)- is an effective orally active inhibitor of human neutrophil elastase.</p>
    Formula:C29H37F5N4O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:632.62
  • LU-002i

    CAS:
    <p>LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].</p>
    Formula:C35H52N4O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:640.81
  • Phe-Pro-Ala-pNA

    CAS:
    <p>Phe-Pro-Ala-pNA is a chromogenic substrate utilized for assessing tripeptidyl peptidase activity.</p>
    Formula:C23H27N5O5
    Color and Shape:Solid
    Molecular weight:453.49
  • Flovagatran sodium

    CAS:
    <p>Flovagatran sodium, a thrombin inhibitor, is used potentially for the treatment of thrombosis.</p>
    Formula:C27H36BN3NaO7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:548.4
  • Z-FG-NHO-BzOME

    CAS:
    <p>Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S,</p>
    Formula:C27H27N3O7
    Color and Shape:Solid
    Molecular weight:505.52
  • HIV-1 protease-IN-7

    CAS:
    <p>HIV-1 protease-IN-7 (compound 16) is an orally active inhibitor of HIV-1 protease, exhibiting an IC50 of 3.52 nM and an EC50 of 37 nM [1].</p>
    Formula:C68H104N10O12S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1285.68
  • BAY-320

    CAS:
    <p>BAY-320 is a Bub1 inhibitor. With an IC50 of 680 nM for human Bub1 in the presence of 2 mM ATP.</p>
    Formula:C26H26F2N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:492.52
  • Cyclotheonellazole A

    CAS:
    <p>Cyclotheonellazole A inhibits elastase (IC50=0.034nM) &amp; chymotrypsin (IC50=0.62nM), a natural macrocyclic peptide.</p>
    Formula:C44H54N9NaO14S2
    Color and Shape:Solid
    Molecular weight:1020.07
  • JTK-853

    CAS:
    <p>JTK-853: novel non-nucleoside HCV polymerase inhibitor with strong antiviral activity (EC50: 0.38 μM genotype 1a, 0.035 μM 1b).</p>
    Formula:C28H23F7N6O4S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:704.64
  • Z-PDLDA-NHOH

    CAS:
    <p>Z-PDLDA-NHOH is a potent, specific vertebrate collagenase inhibitor [1].</p>
    Formula:C22H32N4O6
    Color and Shape:Solid
    Molecular weight:448.51
  • HIV-1 protease-IN-9

    CAS:
    <p>HIV-1 protease-IN-9 (compound 5b), a potent HIV-1 protease inhibitor, exhibits strong antiviral efficacy with a dissociation constant (K_i) of 0.028 nM and a</p>
    Formula:C37H41N7O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:679.83
  • DCLK1-IN-2

    CAS:
    <p>DCLK1-IN-2 (Compound I-5) is a potent inhibitor of DCLK1, exhibiting an IC50 of 171.3 nM, and demonstrates significant antiproliferative effects on SW1990 cell</p>
    Formula:C26H32N8O3S
    Color and Shape:Solid
    Molecular weight:536.65
  • Berotralstat HCl

    CAS:
    <p>Berotralstat HCl is a selective plasma kallikrein inhibitor, reducing pain and swelling in HAE by blocking bradykinin release.</p>
    Formula:C30H28Cl2F4N6O
    Color and Shape:Solid
    Molecular weight:635.4886
  • Z-DEVD-CMK

    CAS:
    <p>Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].</p>
    Formula:C27H35ClN4O12
    Color and Shape:Solid
    Molecular weight:643.04
  • I-XW-053

    CAS:
    <p>I-XW-053 is an inhibitor of capsid targeted HIV-1 replication using the hybrid structure based method to block the interface between CA N-terminal domains (NTD-</p>
    Formula:C22H16N2O2
    Purity:99.05%
    Color and Shape:Solid
    Molecular weight:340.37
  • O-Benzoylhydroxylamine

    CAS:
    <p>O-Benzoyl hydroxylamine exhibits properties as a dipeptidyl peptidase-IV (DPP-IV) inhibitor and demonstrates antidiabetic effects[1].</p>
    Formula:C7H7NO2
    Color and Shape:Solid
    Molecular weight:137.14
  • Kallikrein-IN-2

    CAS:
    <p>Kallikrein-IN-2 (compound 1) is an inhibitor of the kinin-releasing enzyme Kallikrein.</p>
    Formula:C28H25F3N4O4
    Color and Shape:Solid
    Molecular weight:538.52
  • Neurodegenerative Disorder-Targeting Compound 1

    CAS:
    <p>Neurodegenerative Disorder-Targeting Compound 1 is an inhibitor of calpain [1].</p>
    Formula:C28H28N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:484.55
  • NCI-B16

    CAS:
    <p>NCI-B16 is a small-molecule RNA binder that inhibits HCV (hepatitis C virus) replication [1].</p>
    Formula:C27H26N8O4
    Color and Shape:Solid
    Molecular weight:526.55
  • KCC009

    CAS:
    <p>KCC009 is a potent and selective Transglutaminase 2 Inhibitor.</p>
    Formula:C21H22BrN3O5
    Color and Shape:Solid
    Molecular weight:476.32
  • SQ 32056

    CAS:
    <p>SQ 32056 is a cathepsin E inhibitor.</p>
    Formula:C37H56N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:636.86
  • BMS-189664 HCl

    CAS:
    <p>BMS-189664 HCl is a selective and orally active thrombin active site inhibitor.</p>
    Formula:C22H35ClN6O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:515.07
  • Ecallantide

    CAS:
    <p>Ecallantide (DX-88) is a recombinant inhibitor specifically targeting plasma kallikrein, which serves to impede the synthesis of bradykinin.</p>
    Formula:C305H448N88O91S8
    Color and Shape:Solid
    Molecular weight:7059.88
  • Proteasome-IN-4


    <p>Proteasome-IN-4, a potent non-covalent inhibitor (IC50=8.39nM), halts cancer cell growth, useful for oncology studies.</p>
    Formula:C44H58N6O5
    Color and Shape:Solid
    Molecular weight:750.97
  • MMP-145

    CAS:
    <p>MMP-145 is used as a protease inhibitor.</p>
    Formula:C20H20N2O7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:432.45
  • HIV-1 protease-IN-8

    CAS:
    <p>HIV-1 protease-IN-8 (compound 34b) is a potent inhibitor of the HIV-1 protease enzyme, exhibiting an IC50 of 0.32 nM.</p>
    Formula:C25H35N3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:489.63
  • Human enteropeptidase-IN-1

    CAS:
    <p>Enteropeptidase-IN-1: orally active, potent inhibitor, low systemic exposure, for anti-obesity research.</p>
    Formula:C20H18N4O7
    Color and Shape:Solid
    Molecular weight:426.38
  • MeOSuc-AAPV-CMK

    CAS:
    <p>MeOSuc-AAPV-CMK (Elastase Inhibitor III) serves as an inhibitor of elastase, as well as cathepsin G and proteinase 3, and impedes leukocyte elastase-mediated</p>
    Formula:C22H35ClN4O7
    Color and Shape:Solid
    Molecular weight:502.99
  • NK3201

    CAS:
    <p>NK3201, a specific chymase inhibitor, suppresses bleomycin-induced pulmonary fibrosis in hamsters.</p>
    Formula:C31H29N5O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:567.59