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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 987 products of "Proteases/Proteasome"

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  • AEP-IN-1


    APE-IN-1, a potent AEP inhibitor (IC50: 89 nM), aids Alzheimer's diagnosis and drug research.
    Formula:C18H27N3O3
    Color and Shape:Solid
    Molecular weight:333.43

    Ref: TM-T61004

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • Faldaprevir

    CAS:
    Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotype.
    Formula:C40H49BrN6O9S
    Purity:99.04% - 99.19%
    Color and Shape:Solid
    Molecular weight:869.82

    Ref: TM-T19685

    1mg
    250.00€
    5mg
    610.00€
    10mg
    853.00€
    25mg
    1,243.00€
  • CM-352

    CAS:
    CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.
    Formula:C24H29N3O6S
    Purity:97.24%
    Color and Shape:Solid
    Molecular weight:487.57

    Ref: TM-T70470

    1mg
    374.00€
    5mg
    793.00€
    10mg
    973.00€
    25mg
    1,279.00€
  • Feniralstat

    CAS:
    Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.
    Formula:C26H25F2N5O4
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:509.51

    Ref: TM-T63507

    1mg
    178.00€
    5mg
    467.00€
    10mg
    668.00€
    25mg
    1,369.00€
    50mg
    1,783.00€
    1mL*10mM (DMSO)
    532.00€
  • BI-1942

    CAS:
    BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.
    Formula:C24H26N4O4
    Color and Shape:Solid
    Molecular weight:434.488

    Ref: TM-T205535

    10mg
    To inquire
    50mg
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  • TCL1

    CAS:
    TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.
    Formula:C19H14BrClN4O2S
    Color and Shape:Solid
    Molecular weight:477.762

    Ref: TM-T206909

    10mg
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    50mg
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  • Cyclophilin inhibitor 1

    CAS:
    Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.
    Formula:C31H39N5O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:593.67

    Ref: TM-T10919

    25mg
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    50mg
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    100mg
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  • ABT-072

    CAS:
    ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.
    Formula:C24H27N3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:469.55

    Ref: TM-T14086

    25mg
    1,691.00€
    50mg
    2,205.00€
    100mg
    3,345.00€
  • Cathepsin C-IN-5

    CAS:

    Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.

    Formula:C21H17ClN6OS
    Color and Shape:Solid
    Molecular weight:436.92

    Ref: TM-T62494

    25mg
    812.00€
    50mg
    1,054.00€
    100mg
    1,529.00€
  • Pyridoxatin

    CAS:
    Pyridoxatin: fungal metabolite; blocks TBARS production, prevents AAPH-induced hemolysis, and acts against C. albicans.
    Formula:C15H21NO3
    Color and Shape:Solid
    Molecular weight:263.33

    Ref: TM-T70891

    1mg
    298.00€
    500µg
    178.00€
  • Beclabuvir

    CAS:
    Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.
    Formula:C36H45N5O5S
    Purity:99.87% - 99.93%
    Color and Shape:Solid
    Molecular weight:659.84

    Ref: TM-T10493

    1mg
    128.00€
  • CatD-IN-1

    CAS:
    CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.
    Formula:C18H18Cl2N4O5
    Color and Shape:Solid
    Molecular weight:441.265

    Ref: TM-T205617

    10mg
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    50mg
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  • HCV-IN-7

    CAS:
    HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.
    Formula:C40H48N8O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:768.92

    Ref: TM-T11548

    25mg
    2,313.00€
    50mg
    3,042.00€
    100mg
    4,140.00€
  • Idraparinux Na

    CAS:
    Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa Inhibitor
    Formula:C38H55Na9O49S7
    Color and Shape:Solid
    Molecular weight:1727.14

    Ref: TM-T70536

    25mg
    6,094.00€
    50mg
    8,082.00€
    100mg
    11,700.00€
  • Freselestat quarterhydrate


    ONO-6818 quarterhydrate: oral neutrophil elastase inhibitor, Ki 12.2 nM; >100x less effective on other proteases; strong anti-inflammatory.
    Formula:C23H30N6O5
    Color and Shape:Solid
    Molecular weight:457.03

    Ref: TM-T62846

    25mg
    1,026.00€
    50mg
    1,341.00€
    100mg
    2,052.00€
  • Faldaprevir sodium

    CAS:
    Faldaprevir sodium: HCV treatment, inhibits NS3/NS4A protease, P-glycoprotein, CYP3A4, UGT1A1.
    Formula:C40H48BrN6NaO9S
    Color and Shape:Solid
    Molecular weight:891.81

    Ref: TM-T71215

    25mg
    2,718.00€
    50mg
    3,582.00€
    100mg
    4,950.00€
  • Anti-infective agent 10

    CAS:
    Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.
    Formula:C26H25N3O7S
    Color and Shape:Solid
    Molecular weight:523.56

    Ref: TM-T207374

    10mg
    To inquire
    50mg
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  • DPP-4-IN-15

    CAS:
    DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.
    Formula:C17H14F3N3O2S
    Color and Shape:Solid
    Molecular weight:381.372

    Ref: TM-T205036

    10mg
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    50mg
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  • Tyrosinase-IN-29

    CAS:
    Tyrosinase-IN-29 (compound 5c) is an effective inhibitor of abTYR tyrosinase, demonstrating an IC50 value of 6.11 μM. It is suitable for further research into the inhibition of excessive skin pigmentation.
    Formula:C10H9NO2
    Color and Shape:Solid
    Molecular weight:175.18

    Ref: TM-T88534

    10mg
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    50mg
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  • SBI-581


    SBI-581: oral, potent TAO3 inhibitor, IC50=42nM, alters TKS5α at RAB11+ vesicles, blocks invadopodia, good mouse pharmacokinetics, anti-tumor.
    Formula:C24H21N3O2
    Color and Shape:Solid
    Molecular weight:383.44

    Ref: TM-T61663

    25mg
    1,305.00€
    50mg
    2,088.00€
    100mg
    3,357.00€
  • Zetomipzomib

    CAS:
    KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.
    Formula:C30H42N4O8
    Color and Shape:Solid
    Molecular weight:586.68

    Ref: TM-T37419

    25mg
    7,605.00€
    50mg
    To inquire
    100mg
    To inquire
  • Tyrosinase-IN-20

    CAS:
    Tyrosinase-IN-20 (compound 6a) acts as a potent Tyrosinase inhibitor, demonstrating an IC 50 value of 28.50 μM [1].
    Formula:C17H18N2O2S
    Color and Shape:Solid
    Molecular weight:314.4

    Ref: TM-T87588

    10mg
    To inquire
    50mg
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  • Deleobuvir

    CAS:
    Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.
    Formula:C34H33BrN6O3
    Color and Shape:Solid
    Molecular weight:653.57

    Ref: TM-T31369

    1mg
    5,878.00€
  • GW311616

    CAS:
    GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
    Formula:C19H31N3O4S
    Color and Shape:Solid
    Molecular weight:397.53

    Ref: TM-T11525

    25mg
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    50mg
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    100mg
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  • RJF02215

    CAS:
    RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.
    Formula:C17H12ClN3OS3
    Color and Shape:Solid
    Molecular weight:405.95

    Ref: TM-T89894

    10mg
    To inquire
    50mg
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  • Valopicitabine

    CAS:
    Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic
    Formula:C15H24N4O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:356.37

    Ref: TM-T13281

    25mg
    2,547.00€
    50mg
    3,861.00€
    100mg
    4,599.00€
  • Tyrosinase-IN-35

    CAS:
    Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.
    Formula:C17H15N5OS
    Color and Shape:Solid
    Molecular weight:337.40

    Ref: TM-T200078

    25mg
    1,444.00€
    50mg
    1,882.00€
    100mg
    2,375.00€
  • Tyrosinase-IN-33

    CAS:
    Tyrosinase-IN-33 (compound 5), a pyridine-based compound, acts as an effective inhibitor of diphenolase activity in mushroom tyrosinase. It significantly reduces enzyme activity with an IC50 of 9.0 μM.
    Formula:C19H17NS2
    Color and Shape:Solid
    Molecular weight:323.48

    Ref: TM-T200002

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • JBJ-08-178-01

    CAS:
    JBJ-08-178-01, a mutant-selective tyrosine kinase inhibitor, targets (HER2) human epidermal growth factor receptor 2 and exhibits antitumoral activity. This compound not only diminishes HER2's kinase activity and protein levels through the induction of proteasomal degradation of the receptor but also shows promise in non-small-cell lung cancer research.
    Formula:C31H30N8O3
    Color and Shape:Solid
    Molecular weight:562.62

    Ref: TM-T200308

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • CE-2072

    CAS:
    CE-2072 is a synthetic host serine proteases inhibitor.
    Formula:C33H41N5O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:603.71

    Ref: TM-T25218

    25mg
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    50mg
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    100mg
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  • Ciluprevir

    CAS:
    Ciluprevir is a selective HCV NS3 protease inhibitor, effective against non-genotype-1 HCV; less potent for genotypes 2/3.
    Formula:C40H50N6O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:774.93

    Ref: TM-T19627

    25mg
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    50mg
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    100mg
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  • Piceid 6″-O-azelaic acid ester


    Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.
    Formula:C24H36O10
    Color and Shape:Solid
    Molecular weight:484.54

    Ref: TM-T63219

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • GSK-2878175

    CAS:
    GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.
    Formula:C27H23BClFN2O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:568.81

    Ref: TM-T27470

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • Gemigliptin tartrate hydrate

    CAS:
    Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.
    Formula:C22H27F8N5O9
    Color and Shape:Solid
    Molecular weight:657.47

    Ref: TM-T212102

    10mg
    To inquire
    50mg
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  • UK-370106

    CAS:
    UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-
    Formula:C35H44N2O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:572.73

    Ref: TM-T13249

    10mg
    1,009.00€
  • MeO-Suc-Ala-Ala-Pro-Ala-CMK

    CAS:
    MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).
    Formula:C20H31ClN4O7
    Color and Shape:Solid
    Molecular weight:474.936

    Ref: TM-T206832

    10mg
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    50mg
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  • Kallikrein-IN-1

    CAS:
    Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.
    Formula:C28H26FN5O4
    Color and Shape:Solid
    Molecular weight:515.54

    Ref: TM-T63579

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • RXP03

    CAS:
    RXP03 is an MMPs inhibitor with K_i values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14 [1].
    Formula:C39H43N4O6P
    Color and Shape:Solid
    Molecular weight:694.76

    Ref: TM-T87349

    10mg
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    50mg
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  • PNU-248686A

    CAS:
    PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).
    Formula:C22H18ClNaO5S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:484.95

    Ref: TM-T12511

    25mg
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    50mg
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    100mg
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  • Monosodium 2-sulfoterephthalate

    CAS:

    Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.

    Formula:C8H5NaO7S
    Color and Shape:Solid
    Molecular weight:268.176

    Ref: TM-T204212

    10mg
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    50mg
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  • Cathepsin K inhibitor 2

    CAS:
    Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.
    Formula:C30H33F4N5O3
    Color and Shape:Solid
    Molecular weight:587.61

    Ref: TM-T64159

    25mg
    1,927.00€
    50mg
    2,507.00€
    100mg
    3,168.00€
  • (2S,4R)-Teneligliptin

    CAS:
    (2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.
    Formula:C22H30N6OS
    Color and Shape:Solid
    Molecular weight:426.578

    Ref: TM-T206299

    10mg
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    50mg
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  • JBIR-22

    CAS:
    JBIR-22 is a natural inhibitor for protein−protein interaction of the homodimer of proteasome assembly factor 3.
    Formula:C23H33NO6
    Color and Shape:Solid
    Molecular weight:419.51

    Ref: TM-T71203

    25mg
    2,448.00€
    50mg
    3,222.00€
    100mg
    4,410.00€
  • Freselestat

    CAS:
    Freselestat (ONO-6818) inhibits neutrophil elastase, reduces interleukin 8, C5B-9, and inflammation in cardiopulmonary bypass.
    Formula:C23H28N6O4
    Color and Shape:Solid
    Molecular weight:452.51

    Ref: TM-T31877

    10mg
    396.00€
  • TMPRSS6-IN-1 TFA


    TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.
    Formula:C35H41F3N8O6S2
    Color and Shape:Solid
    Molecular weight:790.875

    Ref: TM-T204739

    10mg
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    50mg
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  • Narlaprevir

    CAS:
    Narlaprevir (SCH 900518) is an HCV NS3 inhibitor with anti-HCV activity, inhibiting SARS-CoV-2, and useful in virus infection research.
    Formula:C36H61N5O7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:707.96

    Ref: TM-T16274

    2mg
    225.00€
  • BI-1915

    CAS:

    BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.

    Formula:C21H37N5O3
    Color and Shape:Solid
    Molecular weight:407.55

    Ref: TM-T206466

    10mg
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    50mg
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  • Plasma kallikrein-IN-2


    Plasma kallikrein-IN-2: PKal inhibitor, IC50=0.1 nM. Used in angioedema, diabetic eye disease research.
    Formula:C28H24ClF3N8O3
    Color and Shape:Solid
    Molecular weight:612.99

    Ref: TM-T72337

    25mg
    2,718.00€
    50mg
    3,582.00€
    100mg
    4,950.00€
  • RDN2150

    CAS:
    RDN2150 (Compound 25), a ZAP-70 inhibitor with an IC50 of 14.6 nM, covalently binds to the C346 residue of ZAP-70, suppressing the expression of CD25 and CD69
    Formula:C28H29ClN8O4
    Color and Shape:Solid
    Molecular weight:577.03

    Ref: TM-T81308

    1mg
    260.00€
    5mg
    580.00€
    10mg
    888.00€
    25mg
    1,783.00€
    50mg
    2,943.00€
    100mg
    3,979.00€
  • Valopicitabine dihydrochloride

    CAS:
    Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.
    Formula:C15H25ClN4O6
    Color and Shape:Solid
    Molecular weight:392.84

    Ref: TM-T29094

    25mg
    1,170.00€
    50mg
    1,521.00€
    100mg
    2,385.00€