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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 1045 products of "Proteases/Proteasome"

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  • SCO-792


    <p>SCO-792: potent, reversible oral enteropeptidase inhibitor, with slow in vitro dissociation and in vivo protein digestion blocking.</p>
    Formula:C22H22N4O8·xH2O
    Color and Shape:Solid
  • PNU-248686A

    CAS:
    <p>PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).</p>
    Formula:C22H18ClNaO5S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:484.95
  • CM-352

    CAS:
    <p>CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.</p>
    Formula:C24H29N3O6S
    Purity:99.36%
    Color and Shape:Solid
    Molecular weight:487.57
  • DPP-4-IN-15

    CAS:
    <p>DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.</p>
    Formula:C17H14F3N3O2S
    Color and Shape:Solid
    Molecular weight:381.372
  • UK 356618

    CAS:
    <p>UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).</p>
    Formula:C34H43N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:557.72
  • Verducatib

    CAS:
    <p>Verducatib is an inhibitor of cathepsins (cathepsin).</p>
    Formula:C31H35FN4O3
    Color and Shape:Solid
    Molecular weight:530.633
  • Anti-infective agent 10

    CAS:
    <p>Anti-infective agent 10 (Compound Example 30) is an ns5b polymerase inhibitor that functions as an anti-HCV agent.</p>
    Formula:C26H25N3O7S
    Color and Shape:Solid
    Molecular weight:523.56
  • HCV-IN-40

    CAS:
    <p>HCV-IN-39 is a potent oral drug inhibiting HCV, effective on GT1a (EC50: 0.259μM), GT1b (EC50: 0.434μM), GT1b CES1 (EC50: 0.069μM) replicons.</p>
    Formula:C21H26BrFN3O9P
    Color and Shape:Solid
    Molecular weight:594.32
  • RBx-0597

    CAS:
    <p>RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.</p>
    Formula:C19H20F2N4O2
    Color and Shape:Solid
    Molecular weight:374.384
  • GB111-NH2

    CAS:
    <p>GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].</p>
    Formula:C33H39N3O6
    Color and Shape:Solid
    Molecular weight:573.68
  • Marizomib

    CAS:
    <p>Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.</p>
    Formula:C15H20ClNO4
    Purity:98.03% - 99.41%
    Color and Shape:Solid
    Molecular weight:313.78
  • GSK5852


    <p>GSK5852, an HCV NS5B inhibitor, has IC50 of 50 nM; potently fights HCV with EC50 of 3.0 nM for GT1a and 1.7 nM for GT1b.</p>
    Formula:C27H27BF2N2O6S
    Color and Shape:Solid
    Molecular weight:556.39
  • Odiparcil

    CAS:
    <p>Odiparcil is an orally active beta-d-thioxyloside analog.</p>
    Formula:C15H16O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:324.35
  • BI-1942

    CAS:
    <p>BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.</p>
    Formula:C24H26N4O4
    Color and Shape:Solid
    Molecular weight:434.488
  • Freselestat quarterhydrate


    <p>ONO-6818 quarterhydrate: oral neutrophil elastase inhibitor, Ki 12.2 nM; &gt;100x less effective on other proteases; strong anti-inflammatory.</p>
    Formula:C23H30N6O5
    Color and Shape:Solid
    Molecular weight:457.03
  • Plodicitinib

    CAS:
    <p>Plodicitinib is an inhibitor of Janus tyrosine kinase 3/TEC family kinase, exhibiting anti-inflammatory properties.</p>
    Formula:C19H22FN7O2
    Color and Shape:Solid
    Molecular weight:399.422
  • CatD-IN-1

    CAS:
    <p>CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.</p>
    Formula:C18H18Cl2N4O5
    Color and Shape:Solid
    Molecular weight:441.265
  • Matriptase-IN-2 free base

    CAS:
    <p>Matriptase-IN-2 free base, a matriptase inhibitor with a K i of 5 nM, has potential applications in musculoskeletal system disorder research (WO2011023958A1; compound 432) [1].</p>
    Formula:C29H33Cl2N5O3S
    Color and Shape:Solid
    Molecular weight:602.58
  • GLS-1-IN-1


    <p>GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.</p>
    Formula:C26H25FN4OS
    Color and Shape:Solid
    Molecular weight:460.57
  • Valopicitabine

    CAS:
    <p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>
    Formula:C15H24N4O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:356.37
  • SSR-182289A (Free)

    CAS:
    <p>SSR-182289A (Free) is a thrombin inhibitor.</p>
    Formula:C30H33F2N5O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:597.68
  • BMT-052

    CAS:
    <p>BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).</p>
    Formula:C30H17D9F4N6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:635.61
  • Tilpisertib fosmecarbil

    CAS:
    <p>Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.</p>
    Formula:C35H36ClN8O7P
    Color and Shape:Solid
    Molecular weight:747.14
  • Monosodium 2-sulfoterephthalate

    CAS:
    <p>Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.</p>
    Formula:C8H5NaO7S
    Color and Shape:Solid
    Molecular weight:268.176
  • Idraparinux Na

    CAS:
    <p>Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa Inhibitor</p>
    Formula:C38H55Na9O49S7
    Color and Shape:Solid
    Molecular weight:1727.14
  • HCV-IN-7

    CAS:
    <p>HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.</p>
    Formula:C40H48N8O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:768.92
  • Tyrosinase-IN-37

    CAS:
    <p>Tyrosinase-IN-37 (Compound 3c) is a potent inhibitor of tyrosinase, with an IC50 value of 1.02 μM, which is 14 times more effective than kojic acid (IC50 of 14.74 μM). This compound effectively prevents the browning of Rosa roxburghii and can also inhibit browning not caused by tyrosinase.</p>
    Formula:C12H12N6S
    Color and Shape:Solid
    Molecular weight:272.33
  • BI 224436

    CAS:
    <p>BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.</p>
    Formula:C27H26N2O4
    Color and Shape:Solid
    Molecular weight:442.51
  • ZINC09518833

    CAS:
    <p>ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).</p>
    Formula:C24H25N3O5
    Color and Shape:Solid
    Molecular weight:435.47
  • Napsagatran hydrate

    CAS:
    <p>Napsagatran hydrate is a novel and specific inhibitor of thrombin.</p>
    Formula:C26H36N6O7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:576.66
  • Dup-714

    CAS:
    <p>Dup-714 is a thrombin inhibitor.</p>
    Formula:C21H33BN6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:460.33
  • Feniralstat

    CAS:
    <p>Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.</p>
    Formula:C26H25F2N5O4
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:509.51
  • M826


    <p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>
    Formula:C28H45N7O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:575.7
  • Cathepsin K inhibitor 2

    CAS:
    <p>Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.</p>
    Formula:C30H33F4N5O3
    Color and Shape:Solid
    Molecular weight:587.61
  • (2S,4R)-Teneligliptin

    CAS:
    <p>(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.</p>
    Formula:C22H30N6OS
    Color and Shape:Solid
    Molecular weight:426.578
  • Kallikrein-IN-1

    CAS:
    <p>Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.</p>
    Formula:C28H26FN5O4
    Color and Shape:Solid
    Molecular weight:515.54
  • TCL1

    CAS:
    <p>TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.</p>
    Formula:C19H14BrClN4O2S
    Color and Shape:Solid
    Molecular weight:477.762
  • Cathepsin C-IN-5

    CAS:
    <p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>
    Formula:C21H17ClN6OS
    Color and Shape:Solid
    Molecular weight:436.92
  • GSK-2878175

    CAS:
    <p>GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>
    Formula:C27H23BClFN2O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:568.81
  • Piceid 6″-O-azelaic acid ester


    <p>Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.</p>
    Formula:C24H36O10
    Color and Shape:Solid
    Molecular weight:484.54
  • ABT-072

    CAS:
    <p>ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.</p>
    Formula:C24H27N3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:469.55
  • Cyclophilin inhibitor 1

    CAS:
    <p>Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.</p>
    Formula:C31H39N5O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:593.67
  • Ciluprevir

    CAS:
    <p>Ciluprevir is a selective HCV NS3 protease inhibitor, effective against non-genotype-1 HCV; less potent for genotypes 2/3.</p>
    Formula:C40H50N6O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:774.93
  • MK-8876

    CAS:
    <p>MK-8876 is an Inhibitor of HCV NS5B Site D.</p>
    Formula:C32H24F2N4O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:614.62
  • GW311616

    CAS:
    <p>GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).</p>
    Formula:C19H31N3O4S
    Color and Shape:Solid
    Molecular weight:397.53
  • MeO-Suc-Ala-Ala-Pro-Ala-CMK

    CAS:
    <p>MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).</p>
    Formula:C20H31ClN4O7
    Color and Shape:Solid
    Molecular weight:474.936
  • RIPK1-IN-26

    CAS:
    <p>RIPK1-IN-26 is a potent inhibitor of Receptor-Interacting Serine/Threonine Kinase 1 (RIPK1), exhibiting anti-necrotic properties in cells. This compound demonstrates good metabolic stability and binding specificity in mice. RIPK1-IN-26 holds potential for development as a PET imaging probe and in the research of neurodegenerative diseases.</p>
    Formula:C15H20FNO2
    Color and Shape:Solid
    Molecular weight:265.32
  • Freselestat

    CAS:
    <p>Freselestat (ONO-6818) inhibits neutrophil elastase, reduces interleukin 8, C5B-9, and inflammation in cardiopulmonary bypass.</p>
    Formula:C23H28N6O4
    Color and Shape:Solid
    Molecular weight:452.51
  • TMPRSS6-IN-1 TFA


    <p>TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.</p>
    Formula:C35H41F3N8O6S2
    Color and Shape:Solid
    Molecular weight:790.875
  • JBJ-08-178-01

    CAS:
    <p>JBJ-08-178-01, a mutant-selective tyrosine kinase inhibitor, targets (HER2) human epidermal growth factor receptor 2 and exhibits antitumoral activity. This compound not only diminishes HER2's kinase activity and protein levels through the induction of proteasomal degradation of the receptor but also shows promise in non-small-cell lung cancer research.</p>
    Formula:C31H30N8O3
    Color and Shape:Solid
    Molecular weight:562.62