Proteases/Proteasome
Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.
Subcategories of "Proteases/Proteasome"
- Acetyl-CoA Carboxylase(41 products)
- Cysteine Protease(117 products)
- DPP-4(26 products)
- Glutaminase(44 products)
- HIV Protease(477 products)
- PAI-1(27 products)
- Protease Inhibitors(49 products)
- Protease-activated Receptor(55 products)
- Proteasome(84 products)
- Serine Protease(55 products)
- p97(15 products)
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Found 899 products for "Proteases/Proteasome".
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Talabostat isomer mesylate
Talabostat isomer mesylate, a PT100/Val-boroPro variant, is a potent oral DPP-IV inhibitor (Ki: 0.18 nM).Formula:C10H23BN2O6SPurity:98%Color and Shape:SolidMolecular weight:310.18Hepcidin-1 (mouse)
CAS:Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion.Formula:C111H169N31O35S8Color and Shape:SolidMolecular weight:2754.24DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Color and Shape:Odour SolidCollagen Type II Fragment
CAS:Collagen Type II Fragment is a peptide with anti-inflammatory properties that effectively inhibits collagen-induced arthritis (CIA) in mice. It is useful for research focused on inflammation and immunity [1].Formula:C106H174N32O37Color and Shape:SolidMolecular weight:2488.71Ac-DEMEEC-OH
CAS:Ac-DEMEEC-OH is a competitive inhibitor of the HCV NS3 protease with a Ki of 0.6 µM.Formula:C29H44N6O16S2Color and Shape:SolidMolecular weight:796.82Nostosin G
Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).Formula:C25H33N5O6Color and Shape:SolidMolecular weight:499.56Cathepsin Inhibitor 4
Cathepsin Inhibitor 4 (Compound 45) is a selective inhibitor of Cathepsin S, with a Ki value of 0.04 nM.
Formula:C24H35N3O5Molecular weight:445.25767Talopeptin
CAS:Talopeptin is a specific thermolysin inhibitor.Formula:C23H34N3O10PPurity:98%Color and Shape:SolidMolecular weight:543.50Ellipyrone A
Ellipyrone A: γ-pyrone macrocycle, inhibits DPP-4 (IC50=0.35mM), α-glucosidase (IC50=0.74mM), α-amylase (IC50=0.59mM).Formula:C25H34O8Color and Shape:SolidMolecular weight:462.53Leptosin D
CAS:Leptosin D, a thiodiketopiperazine alkaloid derived from mushrooms, effectively inhibits tyrosinase activity, demonstrating an inhibition concentration (IC50)Formula:C25H24N4O3S2Color and Shape:SolidMolecular weight:492.61α 1(I) Collagen (614-639), human
CAS:This is a peptide inhibitor of collagen fibrillar matrix assembly.Formula:C134H189N37O39Purity:98%Color and Shape:SolidMolecular weight:2942.16Plasma kallikrein-IN-1
CAS:Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.Formula:C23H25F2N7OColor and Shape:SolidMolecular weight:453.498Histatin 5
CAS:Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.Formula:C133H195N51O33Purity:98%Color and Shape:SolidMolecular weight:3036.29VD2173
CAS:VD2173: a macrocyclic peptide that inhibits HGF serine proteases, matriptase, and hepsin, potentially for lung cancer research.Formula:C31H45N9O6SColor and Shape:SolidMolecular weight:671.81Tyrosinase-IN-43
Tyrosinase-IN-43 (Compound 12j) is a competitive tyrosinase inhibitor with an IC50 value of 10.49 μM for tyrosinase. It exhibits significant antioxidant activity and can be used in the study and treatment of pigmentation-related conditions such as melasma, freckles, age spots, and post-inflammatory hyperpigmentation.CRA-2059 hydrochloride
CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].Color and Shape:SolidAc-Phe-Gly-pNA
CAS:Ac-Phe-Gly-pNA is the chymotrypsin specific substrate [1] .Formula:C19H20N4O5Color and Shape:SolidMolecular weight:384.39DPP-4-IN-14
DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.Formula:C33H27N7O3Color and Shape:SolidMolecular weight:569.613NIM811
CAS:NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.Formula:C62H111N11O12Purity:98%Color and Shape:SolidMolecular weight:1202.635Lonodelestat TFA
Lonodelestat TFA, an oral peptide, selectively inhibits hNE, potentially aiding in CF research.Formula:C73H112F3N15O21Color and Shape:SolidMolecular weight:1592.75EP 171
CAS:EP 171 is a potent agonist of TP-receptors.Formula:C23H29FO5Color and Shape:SolidMolecular weight:404.47MK-6169
CAS:MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.Formula:C54H62FN9O8SPurity:98%Color and Shape:SolidMolecular weight:1016.2Tyrosinase-IN-32
Tyrosinase-IN-32 (compound 11), a hydroxamate-based alkaloid extracted from black pepper (Piper nigrum L.), functions as an inhibitor of mushroom tyrosinase. In addition to its inhibitory properties, it exhibits antioxidant activity.Formula:C15H19NO3Color and Shape:SolidMolecular weight:261.32FFAGLDD
"FFAGLDD: MMP9 peptide for controlled DOX delivery inside cells."Formula:C37H49N7O12Purity:98%Color and Shape:SolidMolecular weight:783.82Enzyme-IN-1
CAS:Enzyme-IN-1（compound 1）为基于肽的N端亲核试剂（Ntn）水解酶抑制剂，特别针对20S蛋白酶体的糜胰蛋白酶样活性（CT-L）进行抑制，可能展现出抗炎特性。Formula:C36H50N4O7Color and Shape:SolidMolecular weight:650.8Elastatinal
CAS:Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.Formula:C21H36N8O7Color and Shape:SolidMolecular weight:512.56Acetyl-Calpastatin(184-210)(human) TFA
Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.Formula:C144H231F3N36O46SColor and Shape:SolidMolecular weight:3291.65L-Methionine-DL-sulfoximine
CAS:MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.Formula:C5H12N2O3SPurity:99.56% - ≥98%Color and Shape:White SolidMolecular weight:180.23C3TD879
CAS:C3TD879 is an active molecule that can be used in life science related research. The CAS number of C3TD879 is 2850259-33-3.Formula:C22H28N4OMolecular weight:364.48Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Formula:C48H56N6O10SColor and Shape:SolidMolecular weight:909.06Adamtsostatin 4
CAS:Adamtsostatin 4, an anti-angiogenic peptide, is utilized in research related to angiogenesis inhibition [1].Formula:C80H121N27O27S2Molecular weight:1957.11GSK2818713
CAS:GSK2818713 is a novel Hepatitis C NS5A replication complex inhibitor.Formula:C46H56N8O8Color and Shape:SolidMolecular weight:849.002C-telopeptide
CAS:C-telopeptide from type I collagen is released during bone resorption; it correlates with bone mineral density.Formula:C34H56N14O13Purity:98%Color and Shape:SolidMolecular weight:868.9Talabostat
CAS:Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.Formula:C9H19BN2O3Color and Shape:SolidMolecular weight:214.07L 659286
CAS:L 659286 is one kind of cephalosporin derivative.Formula:C17H21N5O7S2Color and Shape:SolidMolecular weight:471.51AP-C2
CAS:AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.Formula:C18H16N4SPurity:99.99%Color and Shape:SolidMolecular weight:320.41Acetyl-Calpastatin(184-210)(human)
CAS:Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.Formula:C142H230N36O44SPurity:98%Color and Shape:SolidMolecular weight:3177.65TMC647055 Choline salt
TMC647055 choline salt is a selective and cell-permeating inhibitor of HCV NS5B (IC50: 34 nM).Formula:C37H53N5O8SPurity:98%Color and Shape:SolidMolecular weight:727.91Cathepsin C-IN-6
Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastaseFormula:C24H35N5O4·xC2HF3O2Color and Shape:SolidTAPI1 acetate
TAPI1 acetate (TNF-α processing inhibitor-1) is a TACE (ADAM17) inhibitor that inhibits shedding of TNF-α cytokine receptors; MMP inhibitor .Formula:C28H41N5O7Purity:98.82% - 99.94%Color and Shape:White SolidMolecular weight:559.65Linagliptin Methyldimer
CAS:Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.Formula:C50H56N16O4Purity:99.91%Color and Shape:SolidMolecular weight:945.08N-CBZ-Phe-Arg-AMC TFA
N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.Formula:C35H37F3N6O8Purity:99.88%Color and Shape:White SolidMolecular weight:726.7APC-6860
CAS:APC-6860, a serine protease inhibitor, targets multiple enzymes; most potent against human urokinase (Ki: 0.1 µM). Used in cancer research.Formula:C9H7IN2SColor and Shape:SolidMolecular weight:302.13Dihydrofuran-3(2H)-one
CAS:Dihydrofuran-3(2H)-one, with CAS No. 22929-52-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Dihydrofuran-3(2H)-one provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C4H6O2Purity:99.92%Molecular weight:86.09Carboxypeptidase C
CAS:Carboxypeptidase C removes COOH-terminal amino acids and others in peptides for biochemical studies.Color and Shape:SolidMMP-9/MMP-13 Inhibitor I
CAS:MMP-9/MMP-13 Inhibitor I is a dual inhibitor of MMP-9 and MMP-13 with IC50 of both 0.9 nM.Formula:C25H25N3O6SColor and Shape:SolidMolecular weight:495.55TNO211 TFA
TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) TFA is a fluorescent substrate incorporating a MMP-cleavable Gly-Leu bond and an EDANS/Dabcyl pair functioning as a fluorophore/quencher combination. This compound specifically detects matrix metalloproteinase (MMP) activity with excitation and emission wavelengths at 340/485 nm.Color and Shape:Odour SolidMonodes(N-carboxymethyl)valine Daclatasvir
CAS:Monodes(N-carboxymethyl)valine Daclatasvir, or Daclatasvir Impurity A, degrades Daclatasvir, a strong HCV NS5A inhibitor.Formula:C33H39N7O3Color and Shape:SolidMolecular weight:581.71Cathepsin D/E Substrate, Fluorogenic
CathepsinD/E Substrate, Fluorogenic, is an 11-amino acid peptide specifically designed as a substrate for cathepsins D and E, demonstrating selectivity by not acting as a substrate for cathepsins B, H, or L.Formula:C83H119N21O18Color and Shape:SolidMolecular weight:1697.9042Dutogliptin
CAS:Dutogliptin (PHX-1149 free base) is an oral, effective and selective dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.Formula:C10H20BN3O3Purity:98%Color and Shape:SolidMolecular weight:241.10
