
Proteases/Proteasome
Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.
Subcategories of "Proteases/Proteasome"
- Acetyl-CoA Carboxylase(36 products)
- Cysteine Protease(111 products)
- DPP-4(24 products)
- Glutaminase(44 products)
- HIV Protease(501 products)
- PAI-1(26 products)
- Protease Inhibitors(50 products)
- Protease-activated Receptor(54 products)
- Proteasome(89 products)
- Serine Protease(54 products)
- p97(15 products)
Show 3 more subcategories
Found 994 products of "Proteases/Proteasome"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Elastatinal
CAS:Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.Formula:C21H36N8O7Color and Shape:Yellowish SolidMolecular weight:512.56TP0597850
CAS:TP0597850, a selective MMP2 inhibitor with an IC50 value of 0.22 nM, demonstrates a prolonged dissociation half-life from MMP2 (t1/2 = 265 minutes) [1].Formula:C41H57N9O13SColor and Shape:SolidMolecular weight:916.01HCVP-IN-1
CAS:HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.Formula:C30H34FN5O3Color and Shape:SolidMolecular weight:531.632CRA-2059 hydrochloride
CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].Color and Shape:Solid6,6′-Dihydroxythiobinupharidine
CAS:6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-foldFormula:C30H42N2O4SColor and Shape:SolidMolecular weight:526.73Histatin 5
CAS:Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.Formula:C133H195N51O33Purity:98%Color and Shape:SolidMolecular weight:3036.29SFTI-1
CAS:SFTI-1, a cyclic peptide trypsin inhibitor comprising 14 amino acid residues, is a potent Bowman-Birk inhibitor.Formula:C67H104N18O18S2Color and Shape:SolidMolecular weight:1513.78Ac-Phe-Gly-pNA
CAS:Ac-Phe-Gly-pNA is the chymotrypsin specific substrate [1] .Formula:C19H20N4O5Color and Shape:SolidMolecular weight:384.3915,16-Dihydrotanshindiol C
15,16-Dihydrotanshindiol C is a useful organic compound for research related to life sciences and the catalog number is T123985.Formula:C18H18O5Color and Shape:SolidMolecular weight:314.337TAPI1 acetate
TAPI1 acetate (TNF-α processing inhibitor-1) is a TACE (ADAM17) inhibitor that inhibits shedding of TNF-α cytokine receptors; MMP inhibitor .Formula:C28H41N5O7Purity:98.82% - 99.94%Color and Shape:SolidMolecular weight:559.65Ellipyrone A
Ellipyrone A: γ-pyrone macrocycle, inhibits DPP-4 (IC50=0.35mM), α-glucosidase (IC50=0.74mM), α-amylase (IC50=0.59mM).Formula:C25H34O8Color and Shape:SolidMolecular weight:462.53Peptide 74
CAS:Peptide 74 is a synthetic peptide. It also inhibits the activated form of this enzyme.Formula:C62H107N23O20S2Purity:98%Color and Shape:SolidMolecular weight:1558.79Sofosbuvir impurity A
CAS:Sofosbuvir impurity A is an diastereoisomer of Sofosbuvir. Sofosbuvir is anHCV RNA replication inhibitor ,with potent anti-hepatitis C virus activity.Formula:C22H29FN3O9PPurity:98%Color and Shape:SolidMolecular weight:529.45VD2173
CAS:VD2173: a macrocyclic peptide that inhibits HGF serine proteases, matriptase, and hepsin, potentially for lung cancer research.Formula:C31H45N9O6SColor and Shape:SolidMolecular weight:671.81Ac-PAL-AMC
CAS:Ac-PAL-AMC is a β1i/LMP2-specific substrate that fluoresces when cleaved; useful for measuring immunoproteasome activity.Formula:C26H34N4O6Color and Shape:SolidMolecular weight:498.57Leptosin D
CAS:Leptosin D, a thiodiketopiperazine alkaloid derived from mushrooms, effectively inhibits tyrosinase activity, demonstrating an inhibition concentration (IC50)Formula:C25H24N4O3S2Color and Shape:SolidMolecular weight:492.61PSI-7409
CAS:PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).
Formula:C10H16FN2O14P3Purity:98%Color and Shape:SolidMolecular weight:500.16N-CBZ-Phe-Arg-AMC TFA
N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.Formula:C35H37F3N6O8Purity:99.88%Color and Shape:SolidMolecular weight:726.7MK-6169
CAS:MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.Formula:C54H62FN9O8SPurity:98%Color and Shape:SolidMolecular weight:1016.2Enzyme-IN-1
CAS:Enzyme-IN-1(compound 1)为基于肽的N端亲核试剂(Ntn)水解酶抑制剂,特别针对20S蛋白酶体的糜胰蛋白酶样活性(CT-L)进行抑制,可能展现出抗炎特性。Formula:C36H50N4O7Color and Shape:SolidMolecular weight:650.8DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Color and Shape:Odour Solid(-)-Taxifolin
CAS:(-)-Taxifolin, less active enantiomer with anti-tyrosinase, collagenase inhibition (IC50 = 193.3 μM), antifibrotic, antioxidant properties.Formula:C15H12O7Color and Shape:SolidMolecular weight:304.25Linagliptin Methyldimer
CAS:Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.Formula:C50H56N16O4Purity:99.91%Color and Shape:SolidMolecular weight:945.08CRA-2059 TFA
CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].Color and Shape:SolidSofosbuvir impurity J
CAS:Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.Formula:C22H30FN4O8PPurity:98%Color and Shape:SolidMolecular weight:528.47HIV-1 TAT (48-60) Acetate
Lilotomab (HH1) is a murine anti-CD37 antibody that can be used to synthesize anti-CD37 antibody-radionuclide couplings.Formula:C72H135N35O18Purity:99.93%Color and Shape:SoildMolecular weight:1779.07L-Methionine-DL-sulfoximine
CAS:MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.Formula:C5H12N2O3SPurity:99.56% - ≥98%Color and Shape:White Crystalline PowderMolecular weight:180.23MMP-9-IN-6
CAS:MMP-9-IN-6: MMP-9 inhibitor, IC50 of 50 µM, anti-ulcer, potential anti-tumor, for tissue repair studies.Formula:C25H19NO2Purity:98.96%Color and Shape:SoildMolecular weight:365.42Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Formula:C48H56N6O10SColor and Shape:SolidMolecular weight:909.06Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2
CAS:Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic probe for MMP-1 and MMP-9 detection, releasing fluorescent Nma upon cleavage (Ex/Em: 340/440 nm).Formula:C49H68N14O12SColor and Shape:SolidMolecular weight:1077.22PF 00356231
CAS:PF 00356231 is a selectivity inhibitor MMP-12 and can be used in studies about the treatment of emphysema and chronic obstructive pulmonary disease (COPD).
Formula:C25H20N2O3SPurity:99.35%Color and Shape:SolidMolecular weight:428.5Calpain Inhibitor-1
CAS:Calpain Inhibitor-1, a potent Calpain 1 blocker, has IC50 of 100 nM and Ki of 2.89 μM.Formula:C19H17FN6O5SColor and Shape:SolidMolecular weight:460.44Grazoprevir potassium salt
CAS:Grazoprevir, a drug for hepatitis C, is a second-gen NS3/4a protease inhibitor.
Formula:C38H49KN6O9SColor and Shape:SolidMolecular weight:805APC-6860
CAS:APC-6860, a serine protease inhibitor, targets multiple enzymes; most potent against human urokinase (Ki: 0.1 µM). Used in cancer research.Formula:C9H7IN2SColor and Shape:SolidMolecular weight:302.13PROTAC CG167
PROTAC CG167 is a potent and selective PROTAC degrader of CypA. It degrades CypA in a dose-dependent manner in Jurkat cells, with a DC50 of 123 nM. Additionally, PROTAC CG167 exhibits antiviral activity by inhibiting HIV-1 and HCV. (Pink: CypA Ligand; Black: Linker; Blue: E3LigaseLigand)Formula:C65H79N13O11SColor and Shape:SolidMolecular weight:1250.47N-CBZ-Phe-Arg-AMC
CAS:Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.Formula:C33H36N6O6Purity:98%Color and Shape:White To Off-White PowderMolecular weight:612.68Dansyl-Glu-Gly-Arg-Chloromethylketone
CAS:Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically impedes serine/threonine proteases and has been shown to inhibit activatedFormula:C26H36ClN7O7SColor and Shape:SolidMolecular weight:626.12Cathepsin C-IN-6
Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastaseFormula:C24H35N5O4·xC2HF3O2Color and Shape:SolidBPHA
CAS:BPHA is a selective oral inhibitor of MMP-2/9/14 (IC50: 12/16/17 nM), not affecting MMP-1/3/7, with anti-angiogenic and anti-tumor properties.Formula:C21H20N2O4SPurity:99.44%Color and Shape:SolidMolecular weight:396.46Ref: TM-T36712
1mg167.00€5mg442.00€10mg620.00€25mg954.00€50mg1,305.00€100mg1,738.00€200mg2,322.00€1mL*10mM (DMSO)442.00€Ala-Phe-Pro-pNA TFA
Ala-Phe-Pro-pNA TFA serves as a chromogenic substrate for tripeptidyl peptidase and can be utilized to assess the enzyme's activity.Color and Shape:Odour SolidPlasma kallikrein-IN-1
CAS:Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.Formula:C23H25F2N7OColor and Shape:SolidMolecular weight:453.498Obtusifolin-2-O-glucoside
CAS:Obtusifolin-2-O-glucoside (compound 7), a tyrosinase inhibitor with an IC50 value of 9.2 μM, can be isolated from cassia seed [1].Formula:C22H22O10Color and Shape:SolidMolecular weight:446.4LXE408 fumarate
LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.
Formula:C27H22FN7O6Purity:99.89%Color and Shape:SoildMolecular weight:559.51NIM811
CAS:NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.Formula:C62H111N11O12Purity:98%Color and Shape:SolidMolecular weight:1202.635JC-10
CAS:JC-10 is a potent inhibitor of metalloproteinases and is often used as a probe.Formula:C25H29Cl2IN4Purity:95%Color and Shape:SolidMolecular weight:583.34Aristololactam IIIa
CAS:Aristololactam IIIa inhibits superoxide and elastase generation; IC50: 0.12 μg/mL and 0.20 μg/mL.Formula:C16H9NO4Color and Shape:SolidMolecular weight:279.25Nitidanin
Nitidanin is a useful organic compound for research related to life sciences and the catalog number is T125599.Formula:C21H24O8Color and Shape:SolidMolecular weight:404.415BAY 1217224
CAS:BAY 1217224 is a neutral, non-prodrug Thrombin inhibitor with good oral pharmacokinetics.
Formula:C24H27ClFN3O5Color and Shape:SolidMolecular weight:491.94Monodes(N-carboxymethyl)valine Daclatasvir
CAS:Monodes(N-carboxymethyl)valine Daclatasvir, or Daclatasvir Impurity A, degrades Daclatasvir, a strong HCV NS5A inhibitor.Formula:C33H39N7O3Color and Shape:SolidMolecular weight:581.71Talabostat isomer mesylate
Talabostat isomer mesylate, a PT100/Val-boroPro variant, is a potent oral DPP-IV inhibitor (Ki: 0.18 nM).Formula:C10H23BN2O6SPurity:98%Color and Shape:SolidMolecular weight:310.18

