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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 1045 products of "Proteases/Proteasome"

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  • AL-611

    CAS:
    <p>AL-611 is an HCV NS5B polymerase inhibitor ( EC 50 = 5 nM).</p>
    Formula:C25H33F2N6O8P
    Color and Shape:Solid
    Molecular weight:614.544
  • Radalbuvir

    CAS:
    <p>Radalbuvir (GS-9669) is an investigational antiviral agent for the treatment of hepatitis C virus (HCV) infection as an NS5B inhibitor.</p>
    Formula:C30H41NO6S
    Color and Shape:Solid
    Molecular weight:543.71
  • Rivulariapeptolides 1155


    <p>Rivulariapeptolides 1155 inhibits chymotrypsin (41.84 nM), elastase (4.94 nM), and proteinase K (56.54 nM).</p>
    Formula:C59H81N9O15
    Color and Shape:Solid
    Molecular weight:1156.33
  • Recombinant Proteinase K


    <p>Recombinant Proteinase K: serine protease, cleaves carboxy-terminus peptides, digests proteins, purifies nucleic acids.</p>
    Color and Shape:Solid
  • GSK2336805

    CAS:
    <p>GSK-2336805, an HCV NS5A inhibitor, is effective against genotypes 1, 4, 5, and some of 6.</p>
    Formula:C42H52N8O8
    Color and Shape:Solid
    Molecular weight:796.91
  • Leptosphaerodione

    CAS:
    <p>Leptosphaerodione from Remotididymella sp.: a potent UPS inhibitor with 3.2 μM IC50 in HeLa cells; anti-tumor.</p>
    Formula:C21H22O5
    Color and Shape:Solid
    Molecular weight:354.4
  • Histargin

    CAS:
    <p>Histargin is an enzyme inhibitor separated from Streptomyces roseoviridis.</p>
    Formula:C14H25N7O4
    Color and Shape:Solid
    Molecular weight:355.39
  • Proteasome-IN-7


    <p>Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.</p>
    Formula:C48H56N6O10S
    Color and Shape:Solid
    Molecular weight:909.06
  • Peptide 74

    CAS:
    <p>Peptide 74 is a synthetic peptide. It also inhibits the activated form of this enzyme.</p>
    Formula:C62H107N23O20S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1558.79
  • α 1 Antichymotrypsin, Human Plasma

    CAS:
    <p>Alpha 1 Antichymotrypsin, Human Plasma is an inhibitor of serine proteases. This compound is present in amyloid lesions associated with Alzheimer's disease and can be utilized in Alzheimer's research.</p>
    Color and Shape:Solid
  • APC-6860

    CAS:
    <p>APC-6860, a serine protease inhibitor, targets multiple enzymes; most potent against human urokinase (Ki: 0.1 µM). Used in cancer research.</p>
    Formula:C9H7IN2S
    Color and Shape:Solid
    Molecular weight:302.13
  • PSI-7409

    CAS:
    <p>PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).</p>
    Formula:C10H16FN2O14P3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:500.16
  • AMG-222

    CAS:
    <p>AMG-222 (ALS-2-0426, ALS-20426) is a DPP-4 inhibitor and may be used in the treatment of type 2 diabetes.</p>
    Formula:C32H39N9O3
    Color and Shape:Solid
    Molecular weight:597.71
  • Ac-VDQQD-pNA

    CAS:
    <p>Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).</p>
    Formula:C31H43N9O14
    Color and Shape:Solid
    Molecular weight:765.73
  • Sitagliptin fenilalanil hydrochloride

    CAS:
    <p>Sitagliptin phenylalanine hydrochloride, a dipeptidyl peptidase-4 (DPP-4) inhibitor [1], is a chemical compound utilized in medical applications.</p>
    Formula:C25H25ClF6N6O2
    Color and Shape:Solid
    Molecular weight:590.95
  • PS 915

    CAS:
    <p>PS 915 is a substrate for colorimetric assay. It was used for plasma antithrombin.</p>
    Formula:C27H36ClN7O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:590.08
  • Fotagliptin benzoate

    CAS:
    <p>Fotagliptin benzoate, a DPP-4 inhibitor (IC50=2.27 nM), is safe in rats/dogs, useful for Type 2 diabetes research.</p>
    Formula:C24H25FN6O3
    Color and Shape:Solid
    Molecular weight:464.49
  • HCV-IN-41

    CAS:
    <p>HCV-IN-41: potent HCV inhibitor; EC50 - 0.006762 nM (1b), 5.183 nM (2a), 1.365 nM (3a), 142.2 nM (4a); hinders RNA replication.</p>
    Formula:C48H56N6O8
    Color and Shape:Solid
    Molecular weight:844.99
  • Befovacimab

    CAS:
    <p>Befovacimab, a human IgG2 antibody, targets TFPI for hemophilia A/B research.</p>
    Color and Shape:Liquid
  • Berotralstat

    CAS:
    <p>Berotralstat (BCX7353) is an oral, low-toxicity, specific kallikrein inhibitor for hereditary angioedema research, blocking bradykinin release.</p>
    Formula:C30H26F4N6O
    Color and Shape:Solid
    Molecular weight:562.56
  • Tyrosinase-IN-34


    <p>Tyrosinase-IN-34 (compound 5a), a human tyrosinase inhibitor (IC 50: 3.5 μM), shows promise in regulating melanogenesis and pigmentation.</p>
    Formula:C19H14BrClN4O
    Color and Shape:Solid
    Molecular weight:429.7
  • Histatin 5 (TFA)(115966-68-2,free)


    <p>Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM</p>
    Formula:C135H196F3N51O35
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3150.32
  • NVP-DPP728 dihydrochloride

    CAS:
    <p>NVP-DPP728 dihydrochloride is a potent, selective DPP-IV inhibitor with a Ki of 11 nM, useful in diabetes research.</p>
    Formula:C15H20Cl2N6O
    Color and Shape:Solid
    Molecular weight:371.27
  • Stevia Powder


    <p>Stevia Powder, a natural sweetener, possesses antioxidant properties. It regulates antifibrotic pathways in cirrhotic rats, demonstrated by a reduction in hepatic stellate cells and decreased expression of matrix metalloproteinases MMP2 and MMP13. Furthermore, it increases the antifibrotic molecule Smad7, which helps prevent the elevation of serum necrosis and bile retention markers, thereby inhibiting the progression of liver fibrosis.</p>
    Color and Shape:Odour Solid
  • CP-346086 dihydrate

    CAS:
    <p>CP-346086 dihydrate is a strong oral MTP inhibitor with 2.0 nM IC50, reducing cholesterol and triglycerides in vivo.</p>
    Formula:C26H26F3N5O3
    Color and Shape:Solid
    Molecular weight:513.521
  • Ecallantide TFA


    <p>Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention of</p>
    Color and Shape:Odour Solid
  • Pseudostellarin G

    CAS:
    <p>Pseudostellarin G, a naturally occurring cyclo-octapeptide, exhibits inhibitory activity against tyrosinase and suppresses melanin production.</p>
    Formula:C42H56N8O9
    Color and Shape:Solid
    Molecular weight:816.94
  • MK-6169

    CAS:
    <p>MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.</p>
    Formula:C54H62FN9O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1016.2
  • KKI-5

    CAS:
    <p>KKI 5: Serine protease inhibitor, blocks kallikrein &amp; plasmin, potential for cancer therapy &amp; angioedema treatment.</p>
    Formula:C35H55N11O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:773.88
  • Dutogliptin

    CAS:
    <p>Dutogliptin (PHX-1149 free base) is an oral, effective and selective dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.</p>
    Formula:C10H20BN3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:241.10
  • CL 82198 hydrochloride

    CAS:
    <p>CL 82198 hydrochloride selectively inhibits MMP-13, not MMP-1/9/TACE, and blocks HP75 invasion and neurotoxicity in zebrafish.</p>
    Formula:C17H23ClN2O3
    Color and Shape:Solid
    Molecular weight:338.83
  • Acetyl-Calpastatin(184-210)(human)

    CAS:
    <p>Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion &amp; Aβ42/Aβ40 ratio.</p>
    Formula:C142H230N36O44S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3177.65
  • Anticancer agent 114


    <p>Anticancer agent 114: oral dipeptide boronic acid, proteasome inhibitor, IC 50 = 2.2 nM, halts RPMI-8226 cell growth, for multiple myeloma research.</p>
    Formula:C28H33BF6N2O7
    Color and Shape:Solid
    Molecular weight:634.37
  • AP-C2

    CAS:
    <p>AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.</p>
    Formula:C18H16N4S
    Purity:99.87%
    Color and Shape:Soild
    Molecular weight:320.41
  • C-telopeptide

    CAS:
    <p>C-telopeptide from type I collagen is released during bone resorption; it correlates with bone mineral density.</p>
    Formula:C34H56N14O13
    Purity:98%
    Color and Shape:Solid
    Molecular weight:868.9
  • Tyrosinase-IN-32


    <p>Tyrosinase-IN-32 (compound 11), a hydroxamate-based alkaloid extracted from black pepper (Piper nigrum L.), functions as an inhibitor of mushroom tyrosinase. In addition to its inhibitory properties, it exhibits antioxidant activity.</p>
    Formula:C15H19NO3
    Color and Shape:Solid
    Molecular weight:261.32
  • EP 171

    CAS:
    <p>EP 171 is a potent agonist of TP-receptors.</p>
    Formula:C23H29FO5
    Color and Shape:Solid
    Molecular weight:404.47
  • Elastatinal

    CAS:
    <p>Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.</p>
    Formula:C21H36N8O7
    Color and Shape:Yellowish Solid
    Molecular weight:512.56
  • Ac-DEMEEC-OH

    CAS:
    <p>Ac-DEMEEC-OH is a competitive inhibitor of the HCV NS3 protease with a Ki of 0.6 µM.</p>
    Formula:C29H44N6O16S2
    Color and Shape:Solid
    Molecular weight:796.82
  • HIV-1 TAT (48-60) Acetate


    <p>Lilotomab (HH1) is a murine anti-CD37 antibody that can be used to synthesize anti-CD37 antibody-radionuclide couplings.</p>
    Formula:C72H135N35O18
    Purity:99.93%
    Color and Shape:Soild
    Molecular weight:1779.07
  • STK33-IN-1

    CAS:
    <p>STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC 50 of 7 nM.</p>
    Formula:C24H27N7O2
    Color and Shape:Solid
    Molecular weight:445.527
  • GSK2818713

    CAS:
    <p>GSK2818713 is a novel Hepatitis C NS5A replication complex inhibitor.</p>
    Formula:C46H56N8O8
    Color and Shape:Solid
    Molecular weight:849.002
  • FiVe1

    CAS:
    <p>FiVe1 is a vimentin-binding compound that disrupts mitosis in cancer cells, causing cell death, with an IC50 of 234 nM in FOXC2-HMLER.</p>
    Formula:C18H16Cl2N4
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:359.25
  • BMS-767778

    CAS:
    <p>BMS-767778, a DPP-4 inhibitor, is used potentially for the treatment of type 2 diabetes.</p>
    Formula:C19H20Cl2N4O2
    Color and Shape:Solid
    Molecular weight:407.29
  • Linagliptin Methyldimer

    CAS:
    <p>Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.</p>
    Formula:C50H56N16O4
    Purity:97.23%
    Color and Shape:Solid
    Molecular weight:945.08
  • RXP470

    CAS:
    <p>RXP470 is a potent and selective MMP-12 inhibitor (Ki 0.24 nM).</p>
    Formula:C35H35BrClN4O10P
    Color and Shape:Solid
    Molecular weight:818
  • Plasma kallikrein-IN-1

    CAS:
    <p>Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.</p>
    Formula:C23H25F2N7O
    Color and Shape:Solid
    Molecular weight:453.498
  • Paritaprevir dihydrate

    CAS:
    <p>Paritaprevir dihydrate: potent oral HCV NS3/4A inhibitor (EC50: 0.21-1 nM), SARS-CoV-3CL blocker (IC50: 1.31 μM), metabolized by CYP3A, boosted by Ritonavir.</p>
    Formula:C40H47N7O9S
    Color and Shape:Solid
    Molecular weight:801.91
  • CTTHWGFTLC, CYCLIC

    CAS:
    <p>CTT Gelatinase Inhibitor peptide blocks MMP-2/9, hindering cancer by stopping tumor growth.</p>
    Formula:C52H71N13O14S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1166.33
  • midesteine

    CAS:
    <p>Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.</p>
    Formula:C12H13NO3S3
    Purity:99.52% - 99.98%
    Color and Shape:Solid
    Molecular weight:315.43