
Proteases/Proteasome
Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.
Subcategories of "Proteases/Proteasome"
- Acetyl-CoA Carboxylase(34 products)
- Cysteine Protease(96 products)
- DPP-4(20 products)
- Glutaminase(40 products)
- HIV Protease(447 products)
- PAI-1(25 products)
- Protease Inhibitors(50 products)
- Protease-activated Receptor(54 products)
- Proteasome(94 products)
- Serine Protease(50 products)
- p97(14 products)
Show 3 more subcategories
Found 1045 products of "Proteases/Proteasome"
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AL-611
CAS:<p>AL-611 is an HCV NS5B polymerase inhibitor ( EC 50 = 5 nM).</p>Formula:C25H33F2N6O8PColor and Shape:SolidMolecular weight:614.544Radalbuvir
CAS:<p>Radalbuvir (GS-9669) is an investigational antiviral agent for the treatment of hepatitis C virus (HCV) infection as an NS5B inhibitor.</p>Formula:C30H41NO6SColor and Shape:SolidMolecular weight:543.71Rivulariapeptolides 1155
<p>Rivulariapeptolides 1155 inhibits chymotrypsin (41.84 nM), elastase (4.94 nM), and proteinase K (56.54 nM).</p>Formula:C59H81N9O15Color and Shape:SolidMolecular weight:1156.33Recombinant Proteinase K
<p>Recombinant Proteinase K: serine protease, cleaves carboxy-terminus peptides, digests proteins, purifies nucleic acids.</p>Color and Shape:SolidGSK2336805
CAS:<p>GSK-2336805, an HCV NS5A inhibitor, is effective against genotypes 1, 4, 5, and some of 6.</p>Formula:C42H52N8O8Color and Shape:SolidMolecular weight:796.91Leptosphaerodione
CAS:<p>Leptosphaerodione from Remotididymella sp.: a potent UPS inhibitor with 3.2 μM IC50 in HeLa cells; anti-tumor.</p>Formula:C21H22O5Color and Shape:SolidMolecular weight:354.4Histargin
CAS:<p>Histargin is an enzyme inhibitor separated from Streptomyces roseoviridis.</p>Formula:C14H25N7O4Color and Shape:SolidMolecular weight:355.39Proteasome-IN-7
<p>Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.</p>Formula:C48H56N6O10SColor and Shape:SolidMolecular weight:909.06Peptide 74
CAS:<p>Peptide 74 is a synthetic peptide. It also inhibits the activated form of this enzyme.</p>Formula:C62H107N23O20S2Purity:98%Color and Shape:SolidMolecular weight:1558.79α 1 Antichymotrypsin, Human Plasma
CAS:<p>Alpha 1 Antichymotrypsin, Human Plasma is an inhibitor of serine proteases. This compound is present in amyloid lesions associated with Alzheimer's disease and can be utilized in Alzheimer's research.</p>Color and Shape:SolidAPC-6860
CAS:<p>APC-6860, a serine protease inhibitor, targets multiple enzymes; most potent against human urokinase (Ki: 0.1 µM). Used in cancer research.</p>Formula:C9H7IN2SColor and Shape:SolidMolecular weight:302.13PSI-7409
CAS:<p>PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).</p>Formula:C10H16FN2O14P3Purity:98%Color and Shape:SolidMolecular weight:500.16AMG-222
CAS:<p>AMG-222 (ALS-2-0426, ALS-20426) is a DPP-4 inhibitor and may be used in the treatment of type 2 diabetes.</p>Formula:C32H39N9O3Color and Shape:SolidMolecular weight:597.71Ac-VDQQD-pNA
CAS:<p>Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).</p>Formula:C31H43N9O14Color and Shape:SolidMolecular weight:765.73Sitagliptin fenilalanil hydrochloride
CAS:<p>Sitagliptin phenylalanine hydrochloride, a dipeptidyl peptidase-4 (DPP-4) inhibitor [1], is a chemical compound utilized in medical applications.</p>Formula:C25H25ClF6N6O2Color and Shape:SolidMolecular weight:590.95PS 915
CAS:<p>PS 915 is a substrate for colorimetric assay. It was used for plasma antithrombin.</p>Formula:C27H36ClN7O6Purity:98%Color and Shape:SolidMolecular weight:590.08Fotagliptin benzoate
CAS:<p>Fotagliptin benzoate, a DPP-4 inhibitor (IC50=2.27 nM), is safe in rats/dogs, useful for Type 2 diabetes research.</p>Formula:C24H25FN6O3Color and Shape:SolidMolecular weight:464.49HCV-IN-41
CAS:<p>HCV-IN-41: potent HCV inhibitor; EC50 - 0.006762 nM (1b), 5.183 nM (2a), 1.365 nM (3a), 142.2 nM (4a); hinders RNA replication.</p>Formula:C48H56N6O8Color and Shape:SolidMolecular weight:844.99Befovacimab
CAS:<p>Befovacimab, a human IgG2 antibody, targets TFPI for hemophilia A/B research.</p>Color and Shape:LiquidBerotralstat
CAS:<p>Berotralstat (BCX7353) is an oral, low-toxicity, specific kallikrein inhibitor for hereditary angioedema research, blocking bradykinin release.</p>Formula:C30H26F4N6OColor and Shape:SolidMolecular weight:562.56Tyrosinase-IN-34
<p>Tyrosinase-IN-34 (compound 5a), a human tyrosinase inhibitor (IC 50: 3.5 μM), shows promise in regulating melanogenesis and pigmentation.</p>Formula:C19H14BrClN4OColor and Shape:SolidMolecular weight:429.7Histatin 5 (TFA)(115966-68-2,free)
<p>Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM</p>Formula:C135H196F3N51O35Purity:98%Color and Shape:SolidMolecular weight:3150.32NVP-DPP728 dihydrochloride
CAS:<p>NVP-DPP728 dihydrochloride is a potent, selective DPP-IV inhibitor with a Ki of 11 nM, useful in diabetes research.</p>Formula:C15H20Cl2N6OColor and Shape:SolidMolecular weight:371.27Stevia Powder
<p>Stevia Powder, a natural sweetener, possesses antioxidant properties. It regulates antifibrotic pathways in cirrhotic rats, demonstrated by a reduction in hepatic stellate cells and decreased expression of matrix metalloproteinases MMP2 and MMP13. Furthermore, it increases the antifibrotic molecule Smad7, which helps prevent the elevation of serum necrosis and bile retention markers, thereby inhibiting the progression of liver fibrosis.</p>Color and Shape:Odour SolidCP-346086 dihydrate
CAS:<p>CP-346086 dihydrate is a strong oral MTP inhibitor with 2.0 nM IC50, reducing cholesterol and triglycerides in vivo.</p>Formula:C26H26F3N5O3Color and Shape:SolidMolecular weight:513.521Ecallantide TFA
<p>Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention of</p>Color and Shape:Odour SolidPseudostellarin G
CAS:<p>Pseudostellarin G, a naturally occurring cyclo-octapeptide, exhibits inhibitory activity against tyrosinase and suppresses melanin production.</p>Formula:C42H56N8O9Color and Shape:SolidMolecular weight:816.94MK-6169
CAS:<p>MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.</p>Formula:C54H62FN9O8SPurity:98%Color and Shape:SolidMolecular weight:1016.2KKI-5
CAS:<p>KKI 5: Serine protease inhibitor, blocks kallikrein & plasmin, potential for cancer therapy & angioedema treatment.</p>Formula:C35H55N11O9Purity:98%Color and Shape:SolidMolecular weight:773.88Dutogliptin
CAS:<p>Dutogliptin (PHX-1149 free base) is an oral, effective and selective dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.</p>Formula:C10H20BN3O3Purity:98%Color and Shape:SolidMolecular weight:241.10CL 82198 hydrochloride
CAS:<p>CL 82198 hydrochloride selectively inhibits MMP-13, not MMP-1/9/TACE, and blocks HP75 invasion and neurotoxicity in zebrafish.</p>Formula:C17H23ClN2O3Color and Shape:SolidMolecular weight:338.83Acetyl-Calpastatin(184-210)(human)
CAS:<p>Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.</p>Formula:C142H230N36O44SPurity:98%Color and Shape:SolidMolecular weight:3177.65Anticancer agent 114
<p>Anticancer agent 114: oral dipeptide boronic acid, proteasome inhibitor, IC 50 = 2.2 nM, halts RPMI-8226 cell growth, for multiple myeloma research.</p>Formula:C28H33BF6N2O7Color and Shape:SolidMolecular weight:634.37AP-C2
CAS:<p>AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.</p>Formula:C18H16N4SPurity:99.87%Color and Shape:SoildMolecular weight:320.41C-telopeptide
CAS:<p>C-telopeptide from type I collagen is released during bone resorption; it correlates with bone mineral density.</p>Formula:C34H56N14O13Purity:98%Color and Shape:SolidMolecular weight:868.9Tyrosinase-IN-32
<p>Tyrosinase-IN-32 (compound 11), a hydroxamate-based alkaloid extracted from black pepper (Piper nigrum L.), functions as an inhibitor of mushroom tyrosinase. In addition to its inhibitory properties, it exhibits antioxidant activity.</p>Formula:C15H19NO3Color and Shape:SolidMolecular weight:261.32EP 171
CAS:<p>EP 171 is a potent agonist of TP-receptors.</p>Formula:C23H29FO5Color and Shape:SolidMolecular weight:404.47Elastatinal
CAS:<p>Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.</p>Formula:C21H36N8O7Color and Shape:Yellowish SolidMolecular weight:512.56Ac-DEMEEC-OH
CAS:<p>Ac-DEMEEC-OH is a competitive inhibitor of the HCV NS3 protease with a Ki of 0.6 µM.</p>Formula:C29H44N6O16S2Color and Shape:SolidMolecular weight:796.82HIV-1 TAT (48-60) Acetate
<p>Lilotomab (HH1) is a murine anti-CD37 antibody that can be used to synthesize anti-CD37 antibody-radionuclide couplings.</p>Formula:C72H135N35O18Purity:99.93%Color and Shape:SoildMolecular weight:1779.07STK33-IN-1
CAS:<p>STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC 50 of 7 nM.</p>Formula:C24H27N7O2Color and Shape:SolidMolecular weight:445.527GSK2818713
CAS:<p>GSK2818713 is a novel Hepatitis C NS5A replication complex inhibitor.</p>Formula:C46H56N8O8Color and Shape:SolidMolecular weight:849.002FiVe1
CAS:<p>FiVe1 is a vimentin-binding compound that disrupts mitosis in cancer cells, causing cell death, with an IC50 of 234 nM in FOXC2-HMLER.</p>Formula:C18H16Cl2N4Purity:99.67%Color and Shape:SolidMolecular weight:359.25BMS-767778
CAS:<p>BMS-767778, a DPP-4 inhibitor, is used potentially for the treatment of type 2 diabetes.</p>Formula:C19H20Cl2N4O2Color and Shape:SolidMolecular weight:407.29Linagliptin Methyldimer
CAS:<p>Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.</p>Formula:C50H56N16O4Purity:97.23%Color and Shape:SolidMolecular weight:945.08RXP470
CAS:<p>RXP470 is a potent and selective MMP-12 inhibitor (Ki 0.24 nM).</p>Formula:C35H35BrClN4O10PColor and Shape:SolidMolecular weight:818Plasma kallikrein-IN-1
CAS:<p>Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.</p>Formula:C23H25F2N7OColor and Shape:SolidMolecular weight:453.498Paritaprevir dihydrate
CAS:<p>Paritaprevir dihydrate: potent oral HCV NS3/4A inhibitor (EC50: 0.21-1 nM), SARS-CoV-3CL blocker (IC50: 1.31 μM), metabolized by CYP3A, boosted by Ritonavir.</p>Formula:C40H47N7O9SColor and Shape:SolidMolecular weight:801.91CTTHWGFTLC, CYCLIC
CAS:<p>CTT Gelatinase Inhibitor peptide blocks MMP-2/9, hindering cancer by stopping tumor growth.</p>Formula:C52H71N13O14S2Purity:98%Color and Shape:SolidMolecular weight:1166.33midesteine
CAS:<p>Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.</p>Formula:C12H13NO3S3Purity:99.52% - 99.98%Color and Shape:SolidMolecular weight:315.43

