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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 992 products of "Proteases/Proteasome"

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  • TP0597850

    CAS:
    TP0597850, a selective MMP2 inhibitor with an IC50 value of 0.22 nM, demonstrates a prolonged dissociation half-life from MMP2 (t1/2 = 265 minutes) [1].
    Formula:C41H57N9O13S
    Color and Shape:Solid
    Molecular weight:916.01

    Ref: TM-T74714

    5mg
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    50mg
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  • HCVP-IN-1

    CAS:
    HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.
    Formula:C30H34FN5O3
    Color and Shape:Solid
    Molecular weight:531.632

    Ref: TM-T41002

    5mg
    873.00€
  • CRA-2059 hydrochloride


    CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].
    Color and Shape:Solid

    Ref: TM-T38051

    5mg
    315.00€
    10mg
    492.00€
    25mg
    960.00€
  • 6,6′-Dihydroxythiobinupharidine

    CAS:
    6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold
    Formula:C30H42N2O4S
    Color and Shape:Solid
    Molecular weight:526.73

    Ref: TM-T79978

    5mg
    To inquire
    50mg
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  • Histatin 5

    CAS:
    Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.
    Formula:C133H195N51O33
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3036.29

    Ref: TM-TP1741

    1mg
    163.00€
    5mg
    562.00€
    10mg
    892.00€
  • SFTI-1

    CAS:
    SFTI-1, a cyclic peptide trypsin inhibitor comprising 14 amino acid residues, is a potent Bowman-Birk inhibitor.
    Formula:C67H104N18O18S2
    Color and Shape:Solid
    Molecular weight:1513.78

    Ref: TM-TP2622

    10mg
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    50mg
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  • Ac-Phe-Gly-pNA

    CAS:
    Ac-Phe-Gly-pNA is the chymotrypsin specific substrate [1] .
    Formula:C19H20N4O5
    Color and Shape:Solid
    Molecular weight:384.39

    Ref: TM-T74692

    5mg
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    50mg
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  • TAPI1 acetate


    TAPI1 acetate (TNF-α processing inhibitor-1) is a TACE (ADAM17) inhibitor that inhibits shedding of TNF-α cytokine receptors; MMP inhibitor .
    Formula:C28H41N5O7
    Purity:98.82% - 99.94%
    Color and Shape:Solid
    Molecular weight:559.65

    Ref: TM-T6009L

    1mg
    560.00€
    5mg
    1,198.00€
    10mg
    1,611.00€
    25mg
    2,385.00€
    50mg
    3,222.00€
  • Ellipyrone A


    Ellipyrone A: γ-pyrone macrocycle, inhibits DPP-4 (IC50=0.35mM), α-glucosidase (IC50=0.74mM), α-amylase (IC50=0.59mM).
    Formula:C25H34O8
    Color and Shape:Solid
    Molecular weight:462.53

    Ref: TM-T75492

    5mg
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    50mg
    To inquire
  • Peptide 74

    CAS:
    Peptide 74 is a synthetic peptide. It also inhibits the activated form of this enzyme.
    Formula:C62H107N23O20S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1558.79

    Ref: TM-TP2335

    100mg
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    500mg
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  • Sofosbuvir impurity A

    CAS:
    Sofosbuvir impurity A is an diastereoisomer of Sofosbuvir. Sofosbuvir is anHCV RNA replication inhibitor ,with potent anti-hepatitis C virus activity.
    Formula:C22H29FN3O9P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:529.45

    Ref: TM-T12956

    25mg
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    50mg
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    100mg
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  • VD2173

    CAS:
    VD2173: a macrocyclic peptide that inhibits HGF serine proteases, matriptase, and hepsin, potentially for lung cancer research.
    Formula:C31H45N9O6S
    Color and Shape:Solid
    Molecular weight:671.81

    Ref: TM-T74390

    5mg
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    50mg
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  • Linagliptin Methyldimer

    CAS:
    Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.
    Formula:C50H56N16O4
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:945.08

    Ref: TM-T67852

    1mg
    115.00€
    2mg
    166.00€
    5mg
    274.00€
    10mg
    406.00€
    25mg
    663.00€
    50mg
    919.00€
    100mg
    1,216.00€
  • 15,16-Dihydrotanshindiol C


    15,16-Dihydrotanshindiol C is a useful organic compound for research related to life sciences and the catalog number is T123985.
    Formula:C18H18O5
    Color and Shape:Solid
    Molecular weight:314.337

    Ref: TM-T123985

    1mg
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    5mg
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  • Ac-PAL-AMC

    CAS:
    Ac-PAL-AMC is a β1i/LMP2-specific substrate that fluoresces when cleaved; useful for measuring immunoproteasome activity.
    Formula:C26H34N4O6
    Color and Shape:Solid
    Molecular weight:498.57

    Ref: TM-T37421

    1mg
    241.00€
    5mg
    945.00€
    10mg
    1,665.00€
  • Leptosin D

    CAS:
    Leptosin D, a thiodiketopiperazine alkaloid derived from mushrooms, effectively inhibits tyrosinase activity, demonstrating an inhibition concentration (IC50)
    Formula:C25H24N4O3S2
    Color and Shape:Solid
    Molecular weight:492.61

    Ref: TM-T75472

    5mg
    To inquire
    50mg
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  • PSI-7409

    CAS:

    PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).

    Formula:C10H16FN2O14P3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:500.16

    Ref: TM-T12572

    25mg
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    50mg
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    100mg
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  • N-CBZ-Phe-Arg-AMC TFA


    N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.
    Formula:C35H37F3N6O8
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:726.7

    Ref: TM-T76010

    1mg
    52.00€
    5mg
    109.00€
    10mg
    160.00€
    25mg
    314.00€
    50mg
    498.00€
  • MK-6169

    CAS:
    MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.
    Formula:C54H62FN9O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1016.2

    Ref: TM-T24476

    25mg
    1,369.00€
  • Enzyme-IN-1

    CAS:
    Enzyme-IN-1(compound 1)为基于肽的N端亲核试剂(Ntn)水解酶抑制剂,特别针对20S蛋白酶体的糜胰蛋白酶样活性(CT-L)进行抑制,可能展现出抗炎特性。
    Formula:C36H50N4O7
    Color and Shape:Solid
    Molecular weight:650.8

    Ref: TM-T74878

    5mg
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    50mg
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  • DPP8/9-IN-1


    DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.
    Color and Shape:Odour Solid

    Ref: TM-T206718

    10mg
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    50mg
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  • (-)-Taxifolin

    CAS:
    (-)-Taxifolin, less active enantiomer with anti-tyrosinase, collagenase inhibition (IC50 = 193.3 μM), antifibrotic, antioxidant properties.
    Formula:C15H12O7
    Color and Shape:Solid
    Molecular weight:304.25

    Ref: TM-T38497

    25mg
    1,369.00€
  • Grazoprevir potassium salt

    CAS:

    Grazoprevir, a drug for hepatitis C, is a second-gen NS3/4a protease inhibitor.

    Formula:C38H49KN6O9S
    Color and Shape:Solid
    Molecular weight:805

    Ref: TM-T19948

    50mg
    To inquire
    100mg
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  • CRA-2059 TFA


    CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].
    Color and Shape:Solid

    Ref: TM-T38052

    5mg
    1,295.00€
  • Sofosbuvir impurity J

    CAS:
    Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
    Formula:C22H30FN4O8P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:528.47

    Ref: TM-T12965

    25mg
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    50mg
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    100mg
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  • HIV-1 TAT (48-60) Acetate


    Lilotomab (HH1) is a murine anti-CD37 antibody that can be used to synthesize anti-CD37 antibody-radionuclide couplings.
    Formula:C72H135N35O18
    Purity:99.93%
    Color and Shape:Soild
    Molecular weight:1779.07

    Ref: TM-T75964L

    1mg
    74.00€
    5mg
    150.00€
    10mg
    214.00€
    25mg
    364.00€
    50mg
    536.00€
  • L-Methionine-DL-sulfoximine

    CAS:
    MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.
    Formula:C5H12N2O3S
    Purity:99.56% - ≥98%
    Color and Shape:White Crystalline Powder
    Molecular weight:180.23

    Ref: TM-T41299

    50mg
    39.00€
    100mg
    52.00€
  • MMP-9-IN-6

    CAS:
    MMP-9-IN-6: MMP-9 inhibitor, IC50 of 50 µM, anti-ulcer, potential anti-tumor, for tissue repair studies.
    Formula:C25H19NO2
    Purity:98.96%
    Color and Shape:Soild
    Molecular weight:365.42

    Ref: TM-T77617

    1mg
    70.00€
    5mg
    138.00€
    10mg
    195.00€
    25mg
    309.00€
    50mg
    408.00€
    100mg
    562.00€
    200mg
    743.00€
  • Proteasome-IN-7


    Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.
    Formula:C48H56N6O10S
    Color and Shape:Solid
    Molecular weight:909.06

    Ref: TM-T205355

    10mg
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    50mg
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  • Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2

    CAS:
    Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic probe for MMP-1 and MMP-9 detection, releasing fluorescent Nma upon cleavage (Ex/Em: 340/440 nm).
    Formula:C49H68N14O12S
    Color and Shape:Solid
    Molecular weight:1077.22

    Ref: TM-T36360

    1mg
    384.00€
  • PF 00356231

    CAS:

    PF 00356231 is a selectivity inhibitor MMP-12 and can be used in studies about the treatment of emphysema and chronic obstructive pulmonary disease (COPD).

    Formula:C25H20N2O3S
    Purity:99.35%
    Color and Shape:Solid
    Molecular weight:428.5

    Ref: TM-T60071

    1mg
    185.00€
    5mg
    415.00€
    10mg
    622.00€
    25mg
    1,119.00€
    50mg
    1,679.00€
    100mg
    2,520.00€
    200mg
    3,780.00€
  • Calpain Inhibitor-1

    CAS:
    Calpain Inhibitor-1, a potent Calpain 1 blocker, has IC50 of 100 nM and Ki of 2.89 μM.
    Formula:C19H17FN6O5S
    Color and Shape:Solid
    Molecular weight:460.44

    Ref: TM-T38931

    5mg
    3,780.00€
  • APC-6860

    CAS:
    APC-6860, a serine protease inhibitor, targets multiple enzymes; most potent against human urokinase (Ki: 0.1 µM). Used in cancer research.
    Formula:C9H7IN2S
    Color and Shape:Solid
    Molecular weight:302.13

    Ref: TM-T39029

    5mg
    873.00€
  • N-CBZ-Phe-Arg-AMC

    CAS:
    Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.
    Formula:C33H36N6O6
    Purity:98%
    Color and Shape:White To Off-White Powder
    Molecular weight:612.68

    Ref: TM-TP1013

    100mg
    To inquire
    500mg
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  • PROTAC CG167


    PROTAC CG167 is a potent and selective PROTAC degrader of CypA. It degrades CypA in a dose-dependent manner in Jurkat cells, with a DC50 of 123 nM. Additionally, PROTAC CG167 exhibits antiviral activity by inhibiting HIV-1 and HCV. (Pink: CypA Ligand; Black: Linker; Blue: E3LigaseLigand)
    Formula:C65H79N13O11S
    Color and Shape:Solid
    Molecular weight:1250.47

    Ref: TM-T205234

    10mg
    To inquire
    50mg
    To inquire
  • Dansyl-Glu-Gly-Arg-Chloromethylketone

    CAS:
    Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically impedes serine/threonine proteases and has been shown to inhibit activated
    Formula:C26H36ClN7O7S
    Color and Shape:Solid
    Molecular weight:626.12

    Ref: TM-T80094

    5mg
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    50mg
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  • Ala-Phe-Pro-pNA TFA


    Ala-Phe-Pro-pNA TFA serves as a chromogenic substrate for tripeptidyl peptidase and can be utilized to assess the enzyme's activity.
    Color and Shape:Odour Solid

    Ref: TM-TXB-00595

    10mg
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    50mg
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  • Cathepsin C-IN-6


    Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastase
    Formula:C24H35N5O4·xC2HF3O2
    Color and Shape:Solid

    Ref: TM-T79496

    5mg
    To inquire
    50mg
    To inquire
  • BPHA

    CAS:
    BPHA is a selective oral inhibitor of MMP-2/9/14 (IC50: 12/16/17 nM), not affecting MMP-1/3/7, with anti-angiogenic and anti-tumor properties.
    Formula:C21H20N2O4S
    Purity:99.44%
    Color and Shape:Solid
    Molecular weight:396.46

    Ref: TM-T36712

    1mg
    167.00€
    5mg
    442.00€
    10mg
    620.00€
    25mg
    954.00€
    50mg
    1,305.00€
    100mg
    1,738.00€
    200mg
    2,322.00€
    1mL*10mM (DMSO)
    442.00€
  • Plasma kallikrein-IN-1

    CAS:
    Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.
    Formula:C23H25F2N7O
    Color and Shape:Solid
    Molecular weight:453.498

    Ref: TM-T40312

    5mg
    873.00€
  • Obtusifolin-2-O-glucoside

    CAS:
    Obtusifolin-2-O-glucoside (compound 7), a tyrosinase inhibitor with an IC50 value of 9.2 μM, can be isolated from cassia seed [1].
    Formula:C22H22O10
    Color and Shape:Solid
    Molecular weight:446.4

    Ref: TM-T75572

    5mg
    To inquire
    50mg
    To inquire
  • JC-10

    CAS:
    JC-10 is a potent inhibitor of metalloproteinases and is often used as a probe.
    Formula:C25H29Cl2IN4
    Purity:95%
    Color and Shape:Solid
    Molecular weight:583.34

    Ref: TM-TD0056

    1mg
    118.00€
  • LXE408 fumarate


    LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.

    Formula:C27H22FN7O6
    Purity:99.89%
    Color and Shape:Soild
    Molecular weight:559.51

    Ref: TM-T39214L

    1mg
    315.00€
    2mg
    472.00€
    5mg
    595.00€
    10mg
    947.00€
    25mg
    1,396.00€
    50mg
    1,890.00€
    100mg
    2,547.00€
  • NIM811

    CAS:
    NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.
    Formula:C62H111N11O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1202.635

    Ref: TM-T12226

    5mg
    To inquire
  • Nitidanin


    Nitidanin is a useful organic compound for research related to life sciences and the catalog number is T125599.
    Formula:C21H24O8
    Color and Shape:Solid
    Molecular weight:404.415

    Ref: TM-T125599

    1mg
    To inquire
    5mg
    To inquire
  • Aristololactam IIIa

    CAS:
    Aristololactam IIIa inhibits superoxide and elastase generation; IC50: 0.12 μg/mL and 0.20 μg/mL.
    Formula:C16H9NO4
    Color and Shape:Solid
    Molecular weight:279.25

    Ref: TM-T75619

    5mg
    To inquire
    50mg
    To inquire
  • Talabostat isomer mesylate


    Talabostat isomer mesylate, a PT100/Val-boroPro variant, is a potent oral DPP-IV inhibitor (Ki: 0.18 nM).
    Formula:C10H23BN2O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:310.18

    Ref: TM-T13069

    25mg
    To inquire
    50mg
    To inquire
    100mg
    To inquire
  • BAY 1217224

    CAS:

    BAY 1217224 is a neutral, non-prodrug Thrombin inhibitor with good oral pharmacokinetics.

    Formula:C24H27ClFN3O5
    Color and Shape:Solid
    Molecular weight:491.94

    Ref: TM-T39124

    25mg
    7,590.00€
  • Monodes(N-carboxymethyl)valine Daclatasvir

    CAS:
    Monodes(N-carboxymethyl)valine Daclatasvir, or Daclatasvir Impurity A, degrades Daclatasvir, a strong HCV NS5A inhibitor.
    Formula:C33H39N7O3
    Color and Shape:Solid
    Molecular weight:581.71

    Ref: TM-T37915

    5mg
    299.00€
    10mg
    507.00€
  • RXP470

    CAS:
    RXP470 is a potent and selective MMP-12 inhibitor (Ki 0.24 nM).
    Formula:C35H35BrClN4O10P
    Color and Shape:Solid
    Molecular weight:818

    Ref: TM-T28633

    5mg
    4,626.00€