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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 986 products of "Proteases/Proteasome"

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  • EP 171

    CAS:
    EP 171 is a potent agonist of TP-receptors.
    Formula:C23H29FO5
    Color and Shape:Solid
    Molecular weight:404.47

    Ref: TM-T27273

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  • Enzyme-IN-1

    CAS:
    Enzyme-IN-1(compound 1)为基于肽的N端亲核试剂(Ntn)水解酶抑制剂,特别针对20S蛋白酶体的糜胰蛋白酶样活性(CT-L)进行抑制,可能展现出抗炎特性。
    Formula:C36H50N4O7
    Color and Shape:Solid
    Molecular weight:650.8

    Ref: TM-T74878

    5mg
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    50mg
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  • Iso-VQA-ACC acetate


    Iso-VQA-ACC acetate serves as a substrate for the constitutive proteasome.
    Color and Shape:Odour Solid

    Ref: TM-TP2884

    10mg
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    50mg
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  • (-)-Taxifolin

    CAS:
    (-)-Taxifolin, less active enantiomer with anti-tyrosinase, collagenase inhibition (IC50 = 193.3 μM), antifibrotic, antioxidant properties.
    Formula:C15H12O7
    Color and Shape:Solid
    Molecular weight:304.25

    Ref: TM-T38497

    25mg
    1,369.00€
  • TP0597850

    CAS:
    TP0597850, a selective MMP2 inhibitor with an IC50 value of 0.22 nM, demonstrates a prolonged dissociation half-life from MMP2 (t1/2 = 265 minutes) [1].
    Formula:C41H57N9O13S
    Color and Shape:Solid
    Molecular weight:916.01

    Ref: TM-T74714

    5mg
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    50mg
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  • KKI-5

    CAS:

    KKI 5: Serine protease inhibitor, blocks kallikrein & plasmin, potential for cancer therapy & angioedema treatment.

    Formula:C35H55N11O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:773.88

    Ref: TM-TP1792

    1mg
    64.00€
    5mg
    172.00€
    10mg
    299.00€
  • AR-H067637

    CAS:
    AR-H067637 is a fast-acting, reversible thrombin inhibitor with K(i) 2-4 nM; it also reduces clot-bound thrombin and platelet activation/aggregation.
    Formula:C21H21ClF2N4O4
    Color and Shape:Solid
    Molecular weight:466.87

    Ref: TM-T26657

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  • AL-611

    CAS:

    AL-611 is an HCV NS5B polymerase inhibitor ( EC 50 = 5 nM).

    Formula:C25H33F2N6O8P
    Color and Shape:Solid
    Molecular weight:614.544

    Ref: TM-T39082

    5mg
    922.00€
  • Obtusifolin-2-O-glucoside

    CAS:
    Obtusifolin-2-O-glucoside (compound 7), a tyrosinase inhibitor with an IC50 value of 9.2 μM, can be isolated from cassia seed [1].
    Formula:C22H22O10
    Color and Shape:Solid
    Molecular weight:446.4

    Ref: TM-T75572

    5mg
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    50mg
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  • Cyanopeptolin 954

    CAS:
    Cyanopeptolin 954 is a chlorine-containing Microcystis aeruginosa NIVA Cya 43 chymotrypsin Inhibitor.
    Formula:C46H63ClN8O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:955.5

    Ref: TM-T25280

    5mg
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  • TP0628103

    CAS:
    TP0628103 (compound 18) acts as a selective MMP-7 inhibitor, exhibiting a potent IC 50 value of 0.17 nM, which is crucial in the contexts of cancer and fibrosis [1].
    Formula:C51H67ClF3N11O11S
    Color and Shape:Solid
    Molecular weight:1134.66

    Ref: TM-T87556

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  • 6-Acetylnimbandiol

    CAS:
    6-Acetylnimbandiol, a non-toxic agent, inhibits tyrosinase (IC50=69.85 μM), melanin, and MITF; useful in melanoma studies.
    Formula:C28H34O8
    Color and Shape:Solid
    Molecular weight:498.56

    Ref: TM-T75506

    5mg
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    50mg
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  • Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human)

    CAS:
    Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) is a peptide utilized as a fluorescence resonance energy transfer (FRET) based substrate for
    Formula:C69H103N23O24
    Color and Shape:Solid
    Molecular weight:1638.7

    Ref: TM-T81838

    5mg
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    50mg
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  • Rivulariapeptolides 1185


    Rivulariapeptolides 1185 inhibits serine proteases; IC50: chymotrypsin 13.17 nM, elastase 23.59 nM, proteinase K 55.26 nM.
    Formula:C61H87N9O15
    Color and Shape:Solid
    Molecular weight:1186.39

    Ref: TM-T75649

    5mg
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  • Carboxypeptidase C

    CAS:
    Carboxypeptidase C removes COOH-terminal amino acids and others in peptides for biochemical studies.
    Color and Shape:Solid

    Ref: TM-T76168

    5mg
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    50mg
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  • BMS-767778

    CAS:
    BMS-767778, a DPP-4 inhibitor, is used potentially for the treatment of type 2 diabetes.
    Formula:C19H20Cl2N4O2
    Color and Shape:Solid
    Molecular weight:407.29

    Ref: TM-T26857

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  • Bortezomib analog


    Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.
    Color and Shape:Odour Solid

    Ref: TM-T200528

    10mg
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  • HCVP-IN-1

    CAS:
    HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.
    Formula:C30H34FN5O3
    Color and Shape:Solid
    Molecular weight:531.632

    Ref: TM-T41002

    5mg
    873.00€
  • Benzamidine

    CAS:
    Benzamidine is a reversible competitive inhibitor of trypsin with a Ki of 19 μM. It also exhibits inhibitory activity on an enzyme in homogenized porcine sperm acrosome, with a Ki of 4 μM.
    Formula:C7H8N2
    Color and Shape:Solid
    Molecular weight:120.15

    Ref: TM-T203133

    10mg
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  • Acetyl-Calpastatin(184-210)(human) TFA


    Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.
    Formula:C144H231F3N36O46S
    Color and Shape:Solid
    Molecular weight:3291.65

    Ref: TM-T75794

    5mg
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    50mg
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  • Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2

    CAS:
    Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effect
    Formula:C47H64N14O10
    Color and Shape:Solid
    Molecular weight:985.1

    Ref: TM-T76347

    5mg
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    50mg
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  • Fluostatin A sodium

    CAS:
    Fluostatin A, a fluorenone compound initially isolated from Streptomyces, demonstrates selective inhibition towards dipeptidyl peptidase 3 (DPP-3) compared to
    Formula:C18H9O5·Na
    Color and Shape:Solid
    Molecular weight:328.25

    Ref: TM-T83863

    1mg
    1,089.00€
  • TAPI1 acetate


    TAPI1 acetate (TNF-α processing inhibitor-1) is a TACE (ADAM17) inhibitor that inhibits shedding of TNF-α cytokine receptors; MMP inhibitor .
    Formula:C28H41N5O7
    Purity:98.82% - 99.94%
    Color and Shape:Solid
    Molecular weight:559.65

    Ref: TM-T6009L

    1mg
    560.00€
    5mg
    1,198.00€
    10mg
    1,611.00€
    25mg
    2,385.00€
    50mg
    3,222.00€
  • Fotagliptin benzoate

    CAS:
    Fotagliptin benzoate, a DPP-4 inhibitor (IC50=2.27 nM), is safe in rats/dogs, useful for Type 2 diabetes research.
    Formula:C24H25FN6O3
    Color and Shape:Solid
    Molecular weight:464.49

    Ref: TM-T73875

    5mg
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    50mg
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  • Sofosbuvir impurity H


    Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir.
    Formula:C29H33FN3O10P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:633.56

    Ref: TM-T12963

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  • DPP8/9-IN-1


    DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.
    Color and Shape:Odour Solid

    Ref: TM-T206718

    10mg
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  • Ellipyrone B


    Ellipyrone B, a γ-pyrone-based macrocyclic polyketide with antihyperglycemic properties, demonstrates inhibitory activity against dipeptidyl peptidase-4 (IC 50
    Formula:C25H38O7
    Color and Shape:Solid
    Molecular weight:450.57

    Ref: TM-T75493

    5mg
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    50mg
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  • HCV-IN-4

    CAS:
    HCV-IN-4: Potent, oral HCV NS5A inhibitor; effective vs GT1a/b, GT2b, GT3a, Y93H, L31V; EC90s: 3 pM-0.02 nM.
    Formula:C52H58FN9O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:956.07

    Ref: TM-TP1468

    100mg
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  • MMP-3 Inhibitor

    CAS:
    MMP-3 Inhibitor is a peptide matrix metalloproteinase-3 (MMP-3) inhibitor with a Ki value of 95 nM.MMP-3 inhibitor has anticancer and antitumor activity.
    Formula:C27H46N10O9S
    Purity:98.87%
    Color and Shape:Solid
    Molecular weight:686.78

    Ref: TM-T37048

    1mg
    77.00€
    5mg
    197.00€
    10mg
    294.00€
    25mg
    497.00€
    50mg
    717.00€
    100mg
    982.00€
    500mg
    1,998.00€
    1mL*10mM (DMSO)
    210.00€
  • PSI-353661

    CAS:
    PSI-353661 (GS-558093), inhibits HCV's NS5B polymerase; EC90: 8nM (wild-type), 11nM (S282T); active in human hepatocytes.
    Formula:C24H32FN6O8P
    Color and Shape:Solid
    Molecular weight:582.52

    Ref: TM-T74301

    5mg
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    50mg
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  • Sofosbuvir impurity A

    CAS:
    Sofosbuvir impurity A is an diastereoisomer of Sofosbuvir. Sofosbuvir is anHCV RNA replication inhibitor ,with potent anti-hepatitis C virus activity.
    Formula:C22H29FN3O9P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:529.45

    Ref: TM-T12956

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  • TWH106


    TWH106 is an inhibitor of the cyclophilin (Cyp) enzyme, exhibiting strong affinity for CypA and CypB with dissociation constants (KD) of 53 nM and 139 nM, respectively. It effectively inhibits the replication of HIV and HCV, demonstrating antiviral activity.
    Color and Shape:Odour Solid

    Ref: TM-T206100

    10mg
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  • Plasma kallikrein-IN-1

    CAS:
    Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.
    Formula:C23H25F2N7O
    Color and Shape:Solid
    Molecular weight:453.498

    Ref: TM-T40312

    5mg
    873.00€
  • HCV-IN-7 hydrochloride

    CAS:
    HCV-IN-7 hydrochloride: Oral, potent HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.
    Formula:C40H50Cl2N8O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:841.85

    Ref: TM-T11548L

    25mg
    1,369.00€
  • Ichorcumab

    CAS:

    Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.

    Color and Shape:Liquid

    Ref: TM-T9901A-779

    1mg
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  • STK33-IN-1

    CAS:
    STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC 50 of 7 nM.
    Formula:C24H27N7O2
    Color and Shape:Solid
    Molecular weight:445.527

    Ref: TM-T38835

    5mg
    873.00€
  • 15,16-Dihydrotanshindiol C


    15,16-Dihydrotanshindiol C is a useful organic compound for research related to life sciences and the catalog number is T123985.
    Formula:C18H18O5
    Color and Shape:Solid
    Molecular weight:314.337

    Ref: TM-T123985

    1mg
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  • Grazoprevir potassium salt

    CAS:

    Grazoprevir, a drug for hepatitis C, is a second-gen NS3/4a protease inhibitor.

    Formula:C38H49KN6O9S
    Color and Shape:Solid
    Molecular weight:805

    Ref: TM-T19948

    50mg
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  • Sitagliptin fenilalanil hydrochloride

    CAS:
    Sitagliptin phenylalanine hydrochloride, a dipeptidyl peptidase-4 (DPP-4) inhibitor [1], is a chemical compound utilized in medical applications.
    Formula:C25H25ClF6N6O2
    Color and Shape:Solid
    Molecular weight:590.95

    Ref: TM-T74592

    2mg
    85.00€
  • Dansyl-Glu-Gly-Arg-Chloromethylketone

    CAS:
    Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically impedes serine/threonine proteases and has been shown to inhibit activated
    Formula:C26H36ClN7O7S
    Color and Shape:Solid
    Molecular weight:626.12

    Ref: TM-T80094

    5mg
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    50mg
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  • Ac-PAL-AMC

    CAS:
    Ac-PAL-AMC is a β1i/LMP2-specific substrate that fluoresces when cleaved; useful for measuring immunoproteasome activity.
    Formula:C26H34N4O6
    Color and Shape:Solid
    Molecular weight:498.57

    Ref: TM-T37421

    1mg
    241.00€
    5mg
    945.00€
    10mg
    1,665.00€
  • Talabostat

    CAS:
    Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.
    Formula:C9H19BN2O3
    Color and Shape:Solid
    Molecular weight:214.07

    Ref: TM-T37861

    5mg
    100.00€
    10mg
    148.00€
    50mg
    545.00€
  • Stevia Powder


    Stevia Powder, a natural sweetener, possesses antioxidant properties. It regulates antifibrotic pathways in cirrhotic rats, demonstrated by a reduction in hepatic stellate cells and decreased expression of matrix metalloproteinases MMP2 and MMP13. Furthermore, it increases the antifibrotic molecule Smad7, which helps prevent the elevation of serum necrosis and bile retention markers, thereby inhibiting the progression of liver fibrosis.
    Color and Shape:Odour Solid

    Ref: TM-TN8189

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  • PROTAC CG167


    PROTAC CG167 is a potent and selective PROTAC degrader of CypA. It degrades CypA in a dose-dependent manner in Jurkat cells, with a DC50 of 123 nM. Additionally, PROTAC CG167 exhibits antiviral activity by inhibiting HIV-1 and HCV. (Pink: CypA Ligand; Black: Linker; Blue: E3LigaseLigand)
    Formula:C65H79N13O11S
    Color and Shape:Solid
    Molecular weight:1250.47

    Ref: TM-T205234

    10mg
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  • Z-FG-NHO-Bz

    CAS:
    Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].
    Formula:C26H25N3O6
    Color and Shape:Solid
    Molecular weight:475.49

    Ref: TM-T80740

    5mg
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    50mg
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  • 5-epi-Arvestonate A

    CAS:

    5-epi-Arvestonate A, a sesquiterpenoid from Seriphidium transiliense, stimulates melanogenesis and suppresses IFN-γ-chemokine in HaCaT cells.

    Formula:C16H26O5
    Color and Shape:Solid
    Molecular weight:298.37

    Ref: TM-T75535

    5mg
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    50mg
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  • VD2173

    CAS:
    VD2173: a macrocyclic peptide that inhibits HGF serine proteases, matriptase, and hepsin, potentially for lung cancer research.
    Formula:C31H45N9O6S
    Color and Shape:Solid
    Molecular weight:671.81

    Ref: TM-T74390

    5mg
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    50mg
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  • α 1 Antichymotrypsin, Human Plasma

    CAS:
    Alpha 1 Antichymotrypsin, Human Plasma is an inhibitor of serine proteases. This compound is present in amyloid lesions associated with Alzheimer's disease and can be utilized in Alzheimer's research.
    Color and Shape:Solid

    Ref: TM-TP3129

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  • NIM811

    CAS:
    NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.
    Formula:C62H111N11O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1202.635

    Ref: TM-T12226

    5mg
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  • Anticancer agent 114


    Anticancer agent 114: oral dipeptide boronic acid, proteasome inhibitor, IC 50 = 2.2 nM, halts RPMI-8226 cell growth, for multiple myeloma research.
    Formula:C28H33BF6N2O7
    Color and Shape:Solid
    Molecular weight:634.37

    Ref: TM-T74839

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