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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 898 products for "Proteases/Proteasome".

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  • Monodes(N-carboxymethyl)valine Daclatasvir

    CAS:
    Monodes(N-carboxymethyl)valine Daclatasvir, or Daclatasvir Impurity A, degrades Daclatasvir, a strong HCV NS5A inhibitor.
    Formula:C33H39N7O3
    Color and Shape:Solid
    Molecular weight:581.71

    Ref: TM-T37915

    5mg
    299.00€
    10mg
    507.00€
  • Calpain Inhibitor-1

    CAS:
    Calpain Inhibitor-1, a potent Calpain 1 blocker, has IC50 of 100 nM and Ki of 2.89 μM.
    Formula:C19H17FN6O5S
    Color and Shape:Solid
    Molecular weight:460.44

    Ref: TM-T38931

    5mg
    3,780.00€
  • D-DOPA

    CAS:
    D-DOPA, an L-DOPA enantiomer, alters rat dopamine neurons and can modulate Parkinson's symptoms.
    Formula:C9H11NO4
    Color and Shape:Solid
    Molecular weight:197.19

    Ref: TM-T37605

    50mg
    178.00€
    100mg
    349.00€
    250mg
    717.00€
    500mg
    1,161.00€
  • Linagliptin Methyldimer

    CAS:
    Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.
    Formula:C50H56N16O4
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:945.08

    Ref: TM-T67852

    1mg
    109.00€
    2mg
    158.00€
    5mg
    260.00€
    10mg
    385.00€
    25mg
    628.00€
    50mg
    872.00€
    100mg
    1,153.00€
  • Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2

    CAS:
    Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effect
    Formula:C47H64N14O10
    Color and Shape:Solid
    Molecular weight:985.1

    Ref: TM-T76347

    5mg
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    50mg
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  • Berotralstat

    CAS:
    Berotralstat (BCX7353) is an oral, low-toxicity, specific kallikrein inhibitor for hereditary angioedema research, blocking bradykinin release.
    Formula:C30H26F4N6O
    Color and Shape:Solid
    Molecular weight:562.56

    Ref: TM-T35869

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • EP 171

    CAS:
    EP 171 is a potent agonist of TP-receptors.
    Formula:C23H29FO5
    Color and Shape:Solid
    Molecular weight:404.47

    Ref: TM-T27273

    25mg
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    50mg
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    100mg
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  • Suc-AAP-Abu-pNA

    CAS:
    Suc-AAP-Abu-pNA is a specific substrate for pancreatic elastase (Km = 100 μM; Kcat/Km = 35,300 s-1 M-1 for rat pancreatic elastase; Km = 30 μM; Kcat/Km = 351,
    Formula:C25H34N6O9
    Color and Shape:Solid
    Molecular weight:562.57

    Ref: TM-T36351

    1mg
    132.00€
  • [Asp371]-Tyrosinase (369-377), human

    CAS:
    Tyrosinase (369-377,YMDGTMSQV) originates from tyrosinase and needs TAP and proteosome for cell presentation.
    Formula:C42H66N10O16S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1031.16

    Ref: TM-TP1623

    100mg
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    500mg
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  • Acetyl-Calpastatin(184-210)(human), Negative Control


    Acetyl-Calpastatin(184-210)(human), Negative Control is a control scrambled peptide corresponding to Acetyl-Calpastatin(184-210)(human). Acetyl-Calpastatin(184-210)(human) functions as a potent, selective, and reversible calpain inhibitor.
    Formula:C142H230N36O44S
    Color and Shape:Solid
    Molecular weight:3175.65874

    Ref: TM-TP3489

    10mg
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    50mg
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  • PF 00356231

    CAS:
    PF 00356231 is a selectivity inhibitor MMP-12 and can be used in studies about the treatment of emphysema and chronic obstructive pulmonary disease (COPD).
    Formula:C25H20N2O3S
    Purity:99.35%
    Color and Shape:Solid
    Molecular weight:428.5

    Ref: TM-T60071

    1mg
    175.00€
    5mg
    394.00€
    10mg
    590.00€
    25mg
    1,060.00€
    50mg
    1,591.00€
    100mg
    2,387.00€
    200mg
    3,580.00€
  • DPP8/9-IN-1


    DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.
    Color and Shape:Odour Solid

    Ref: TM-T206718

    10mg
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    50mg
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  • CDD-3290


    CDD-3290 serves as a functional therapeutic tool specifically designed to enable the precise detection and inhibition of the proteolytic activity of PSA which plays a pivotal role in the progression of prostate cancer during strictly monitored laboratory observation periods and molecular investigations to evaluate the pharmacological potential of targeted kallikrein inhibition in specialized preclinical research environments.
    Formula:C17H14N6O2
    Purity:99.13%
    Color and Shape:White Solid
    Molecular weight:334.33

    Ref: TM-T89314

    1mg
    172.00€
  • Lonodelestat TFA


    Lonodelestat TFA, an oral peptide, selectively inhibits hNE, potentially aiding in CF research.
    Formula:C73H112F3N15O21
    Color and Shape:Solid
    Molecular weight:1592.75

    Ref: TM-T76216

    5mg
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    50mg
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  • TWH106


    TWH106 is an inhibitor of the cyclophilin (Cyp) enzyme, exhibiting strong affinity for CypA and CypB with dissociation constants (KD) of 53 nM and 139 nM, respectively. It effectively inhibits the replication of HIV and HCV, demonstrating antiviral activity.
    Color and Shape:Odour Solid

    Ref: TM-T206100

    10mg
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    50mg
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  • Histatin 5

    CAS:
    Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.
    Formula:C133H195N51O33
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3036.29

    Ref: TM-TP1741

    1mg
    163.00€
    5mg
    562.00€
    10mg
    892.00€
  • BPHA

    CAS:
    BPHA is a selective oral inhibitor of MMP-2/9/14 (IC50: 12/16/17 nM), not affecting MMP-1/3/7, with anti-angiogenic and anti-tumor properties.
    Formula:C21H20N2O4S
    Purity:99.44%
    Color and Shape:Solid
    Molecular weight:396.46

    Ref: TM-T36712

    1mg
    167.00€
    5mg
    442.00€
    1mL*10mM (DMSO)
    442.00€
    10mg
    620.00€
    25mg
    954.00€
    50mg
    1,305.00€
    100mg
    1,738.00€
    200mg
    2,322.00€
  • BMS-767778

    CAS:
    BMS-767778, a DPP-4 inhibitor, is used potentially for the treatment of type 2 diabetes.
    Formula:C19H20Cl2N4O2
    Color and Shape:Solid
    Molecular weight:407.29

    Ref: TM-T26857

    25mg
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    50mg
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    100mg
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  • α 1 Antichymotrypsin, Human Plasma

    CAS:
    Alpha 1 Antichymotrypsin, Human Plasma is an inhibitor of serine proteases. This compound is present in amyloid lesions associated with Alzheimer's disease and can be utilized in Alzheimer's research.
    Color and Shape:Solid

    Ref: TM-TP3129

    10mg
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    50mg
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  • Z-FG-NHO-Bz

    CAS:
    Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].
    Formula:C26H25N3O6
    Color and Shape:Solid
    Molecular weight:475.49

    Ref: TM-T80740

    5mg
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    50mg
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  • Sitagliptin fenilalanil hydrochloride

    CAS:
    Sitagliptin phenylalanine hydrochloride, a dipeptidyl peptidase-4 (DPP-4) inhibitor [1], is a chemical compound utilized in medical applications.
    Formula:C25H25ClF6N6O2
    Color and Shape:Solid
    Molecular weight:590.95

    Ref: TM-T74592

    2mg
    85.00€
  • MeOSuc-AAPA-CMK


    MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase (HNE) [1].
    Formula:C20H31ClN4O8
    Color and Shape:Solid
    Molecular weight:490.94

    Ref: TM-T80553

    5mg
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    50mg
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  • Dutogliptin

    CAS:
    Dutogliptin (PHX-1149 free base) is an oral, effective and selective dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
    Formula:C10H20BN3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:241.10

    Ref: TM-T11128

    25mg
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    50mg
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    100mg
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  • Trivalent hydroxyarsinothricn


    Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.
    Formula:C4H10AsNO4
    Color and Shape:Solid
    Molecular weight:210.98258

    Ref: TM-T210094

    10mg
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    50mg
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  • LXE408 fumarate


    LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.
    Formula:C27H22FN7O6
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:559.51

    Ref: TM-T39214L

    1mg
    299.00€
    2mg
    447.00€
    5mg
    563.00€
    1mL*10mM (DMSO)
    830.00€
    10mg
    897.00€
    25mg
    1,324.00€
    50mg
    1,791.00€
    100mg
    2,412.00€
  • ADAM8-IN-1

    CAS:
    ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC 50 value of 73 nM.
    Formula:C44H44Br4N6O12S2
    Color and Shape:Solid
    Molecular weight:1232.6

    Ref: TM-T73998

    5mg
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    50mg
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  • Cathepsin L-IN-3

    CAS:
    Cathepsin L-IN-3, a tripeptide-sized inhibitor of cathepsin L, effectively targets this specific enzyme.
    Formula:C41H49N7O4S
    Color and Shape:Solid
    Molecular weight:735.94

    Ref: TM-TP2558

    10mg
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    50mg
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  • HCV-IN-4

    CAS:
    HCV-IN-4: Potent, oral HCV NS5A inhibitor; effective vs GT1a/b, GT2b, GT3a, Y93H, L31V; EC90s: 3 pM-0.02 nM.
    Formula:C52H58FN9O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:956.07

    Ref: TM-TP1468

    100mg
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    500mg
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  • MMP-3 Inhibitor

    CAS:
    MMP-3 Inhibitor is a peptide matrix metalloproteinase-3 (MMP-3) inhibitor with a Ki value of 95 nM.MMP-3 inhibitor has anticancer and antitumor activity.
    Formula:C27H46N10O9S
    Purity:98.87%
    Color and Shape:White Solid
    Molecular weight:686.78

    Ref: TM-T37048

    1mg
    77.00€
    5mg
    197.00€
    1mL*10mM (DMSO)
    210.00€
    10mg
    294.00€
    25mg
    497.00€
    50mg
    717.00€
    100mg
    982.00€
    500mg
    1,998.00€
  • Tyrosinase-IN-38


    Tyrosinase-IN-38 (compound 6b) is a competitive inhibitor of tyrosinase, demonstrating an IC50 of 25.82 μM and exhibits antioxidant activity.
    Color and Shape:Odour Solid

    Ref: TM-T200602

    10mg
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    50mg
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  • Pseudostellarin G

    CAS:
    Pseudostellarin G, a naturally occurring cyclo-octapeptide, exhibits inhibitory activity against tyrosinase and suppresses melanin production.
    Formula:C42H56N8O9
    Color and Shape:Solid
    Molecular weight:816.94

    Ref: TM-TP2861

    10mg
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    50mg
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  • Dansyl-Glu-Gly-Arg-Chloromethylketone

    CAS:
    Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically impedes serine/threonine proteases and has been shown to inhibit activated
    Formula:C26H36ClN7O7S
    Color and Shape:Solid
    Molecular weight:626.12

    Ref: TM-T80094

    5mg
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    50mg
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  • APC-6860

    CAS:
    APC-6860, a serine protease inhibitor, targets multiple enzymes; most potent against human urokinase (Ki: 0.1 µM). Used in cancer research.
    Formula:C9H7IN2S
    Color and Shape:Solid
    Molecular weight:302.13

    Ref: TM-T39029

    5mg
    873.00€
  • Iso-VQA-ACC acetate


    Iso-VQA-ACC acetate serves as a substrate for the constitutive proteasome.
    Color and Shape:Odour Solid

    Ref: TM-TP2884

    10mg
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    50mg
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  • (R)-BAY-85-8501


    (R)-BAY-85-8501 is the less active enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent Human Neutrophil Elastase (HNE)inhibitor(IC50 of 65 pM).
    Formula:C22H17F3N4O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:474.46

    Ref: TM-T12613

    25mg
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    50mg
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    100mg
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  • Grazoprevir potassium salt

    CAS:
    Grazoprevir, a drug for hepatitis C, is a second-gen NS3/4a protease inhibitor.
    Formula:C38H49KN6O9S
    Color and Shape:Solid
    Molecular weight:805

    Ref: TM-T19948

    50mg
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    100mg
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  • AMG-222

    CAS:
    AMG-222 (ALS-2-0426, ALS-20426) is a DPP-4 inhibitor and may be used in the treatment of type 2 diabetes.
    Formula:C32H39N9O3
    Color and Shape:Solid
    Molecular weight:597.71

    Ref: TM-T29970

    25mg
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    50mg
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    100mg
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  • 6,6′-Dihydroxythiobinupharidine

    CAS:
    6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold
    Formula:C30H42N2O4S
    Color and Shape:Solid
    Molecular weight:526.73

    Ref: TM-T79978

    5mg
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    50mg
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  • Ac-PAL-AMC

    CAS:
    Ac-PAL-AMC is a β1i/LMP2-specific substrate that fluoresces when cleaved; useful for measuring immunoproteasome activity.
    Formula:C26H34N4O6
    Color and Shape:Solid
    Molecular weight:498.57

    Ref: TM-T37421

    1mg
    241.00€
    5mg
    945.00€
    10mg
    1,665.00€
  • Talabostat

    CAS:
    Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.
    Formula:C9H19BN2O3
    Color and Shape:Solid
    Molecular weight:214.07

    Ref: TM-T37861

    5mg
    100.00€
    10mg
    148.00€
    50mg
    545.00€
  • Radalbuvir

    CAS:
    Radalbuvir (GS-9669) is an investigational antiviral agent for the treatment of hepatitis C virus (HCV) infection as an NS5B inhibitor.
    Formula:C30H41NO6S
    Color and Shape:Solid
    Molecular weight:543.71

    Ref: TM-T34254

    25mg
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    50mg
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    100mg
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  • PROTAC CG167


    PROTAC CG167 is a potent and selective PROTAC degrader of CypA. It degrades CypA in a dose-dependent manner in Jurkat cells, with a DC50 of 123 nM. Additionally, PROTAC CG167 exhibits antiviral activity by inhibiting HIV-1 and HCV. (Pink: CypA Ligand; Black: Linker; Blue: E3LigaseLigand)
    Formula:C65H79N13O11S
    Color and Shape:Solid
    Molecular weight:1250.47

    Ref: TM-T205234

    10mg
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    50mg
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  • Stevia Powder


    Stevia Powder, a natural sweetener, possesses antioxidant properties. It regulates antifibrotic pathways in cirrhotic rats, demonstrated by a reduction in hepatic stellate cells and decreased expression of matrix metalloproteinases MMP2 and MMP13. Furthermore, it increases the antifibrotic molecule Smad7, which helps prevent the elevation of serum necrosis and bile retention markers, thereby inhibiting the progression of liver fibrosis.
    Color and Shape:Odour Solid

    Ref: TM-TN8189

    10mg
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    50mg
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  • VD2173

    CAS:
    VD2173: a macrocyclic peptide that inhibits HGF serine proteases, matriptase, and hepsin, potentially for lung cancer research.
    Formula:C31H45N9O6S
    Color and Shape:Solid
    Molecular weight:671.81

    Ref: TM-T74390

    5mg
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    50mg
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  • Cathepsin K inhibitor 7


    Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.
    Color and Shape:Odour Solid

    Ref: TM-T89126

    10mg
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    50mg
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  • NIM811

    CAS:
    NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.
    Formula:C62H111N11O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1202.635

    Ref: TM-T12226

    5mg
    To inquire
  • Bortezomib analog


    Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.
    Color and Shape:Odour Solid

    Ref: TM-T200528

    10mg
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    50mg
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  • Cathepsin D and E FRET Substrate

    CAS:
    Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.
    Formula:C85H122N22O19
    Color and Shape:Solid
    Molecular weight:1756.046

    Ref: TM-T37504

    1mg
    743.00€
    5mg
    2,980.00€
  • Histatin 5 (TFA)(115966-68-2,free)


    Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM
    Formula:C135H196F3N51O35
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3150.32

    Ref: TM-TP1446

    1mg
    159.00€
    5mg
    532.00€
    10mg
    832.00€
    25mg
    1,489.00€
    50mg
    2,247.00€
  • NVP-DPP728 dihydrochloride

    CAS:
    NVP-DPP728 dihydrochloride is a potent, selective DPP-IV inhibitor with a Ki of 11 nM, useful in diabetes research.
    Formula:C15H20Cl2N6O
    Color and Shape:Solid
    Molecular weight:371.27

    Ref: TM-T39481

    25mg
    1,369.00€