
Proteases/Proteasome
Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.
Subcategories of "Proteases/Proteasome"
- Acetyl-CoA Carboxylase(41 products)
- Cysteine Protease(117 products)
- DPP-4(26 products)
- Glutaminase(44 products)
- HIV Protease(476 products)
- PAI-1(27 products)
- Protease Inhibitors(49 products)
- Protease-activated Receptor(55 products)
- Proteasome(84 products)
- Serine Protease(55 products)
- p97(15 products)
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Found 898 products for "Proteases/Proteasome".
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Monodes(N-carboxymethyl)valine Daclatasvir
CAS:Monodes(N-carboxymethyl)valine Daclatasvir, or Daclatasvir Impurity A, degrades Daclatasvir, a strong HCV NS5A inhibitor.Formula:C33H39N7O3Color and Shape:SolidMolecular weight:581.71Calpain Inhibitor-1
CAS:Calpain Inhibitor-1, a potent Calpain 1 blocker, has IC50 of 100 nM and Ki of 2.89 μM.Formula:C19H17FN6O5SColor and Shape:SolidMolecular weight:460.44D-DOPA
CAS:D-DOPA, an L-DOPA enantiomer, alters rat dopamine neurons and can modulate Parkinson's symptoms.Formula:C9H11NO4Color and Shape:SolidMolecular weight:197.19Linagliptin Methyldimer
CAS:Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.Formula:C50H56N16O4Purity:99.91%Color and Shape:SolidMolecular weight:945.08Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
CAS:Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effectFormula:C47H64N14O10Color and Shape:SolidMolecular weight:985.1Berotralstat
CAS:Berotralstat (BCX7353) is an oral, low-toxicity, specific kallikrein inhibitor for hereditary angioedema research, blocking bradykinin release.Formula:C30H26F4N6OColor and Shape:SolidMolecular weight:562.56EP 171
CAS:EP 171 is a potent agonist of TP-receptors.Formula:C23H29FO5Color and Shape:SolidMolecular weight:404.47Suc-AAP-Abu-pNA
CAS:Suc-AAP-Abu-pNA is a specific substrate for pancreatic elastase (Km = 100 μM; Kcat/Km = 35,300 s-1 M-1 for rat pancreatic elastase; Km = 30 μM; Kcat/Km = 351,Formula:C25H34N6O9Color and Shape:SolidMolecular weight:562.57[Asp371]-Tyrosinase (369-377), human
CAS:Tyrosinase (369-377,YMDGTMSQV) originates from tyrosinase and needs TAP and proteosome for cell presentation.Formula:C42H66N10O16S2Purity:98%Color and Shape:SolidMolecular weight:1031.16Acetyl-Calpastatin(184-210)(human), Negative Control
Acetyl-Calpastatin(184-210)(human), Negative Control is a control scrambled peptide corresponding to Acetyl-Calpastatin(184-210)(human). Acetyl-Calpastatin(184-210)(human) functions as a potent, selective, and reversible calpain inhibitor.Formula:C142H230N36O44SColor and Shape:SolidMolecular weight:3175.65874PF 00356231
CAS:PF 00356231 is a selectivity inhibitor MMP-12 and can be used in studies about the treatment of emphysema and chronic obstructive pulmonary disease (COPD).Formula:C25H20N2O3SPurity:99.35%Color and Shape:SolidMolecular weight:428.5DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Color and Shape:Odour SolidCDD-3290
CDD-3290 serves as a functional therapeutic tool specifically designed to enable the precise detection and inhibition of the proteolytic activity of PSA which plays a pivotal role in the progression of prostate cancer during strictly monitored laboratory observation periods and molecular investigations to evaluate the pharmacological potential of targeted kallikrein inhibition in specialized preclinical research environments.Formula:C17H14N6O2Purity:99.13%Color and Shape:White SolidMolecular weight:334.33Lonodelestat TFA
Lonodelestat TFA, an oral peptide, selectively inhibits hNE, potentially aiding in CF research.Formula:C73H112F3N15O21Color and Shape:SolidMolecular weight:1592.75TWH106
TWH106 is an inhibitor of the cyclophilin (Cyp) enzyme, exhibiting strong affinity for CypA and CypB with dissociation constants (KD) of 53 nM and 139 nM, respectively. It effectively inhibits the replication of HIV and HCV, demonstrating antiviral activity.Color and Shape:Odour SolidHistatin 5
CAS:Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.Formula:C133H195N51O33Purity:98%Color and Shape:SolidMolecular weight:3036.29BPHA
CAS:BPHA is a selective oral inhibitor of MMP-2/9/14 (IC50: 12/16/17 nM), not affecting MMP-1/3/7, with anti-angiogenic and anti-tumor properties.Formula:C21H20N2O4SPurity:99.44%Color and Shape:SolidMolecular weight:396.46Ref: TM-T36712
1mg167.00€5mg442.00€1mL*10mM (DMSO)442.00€10mg620.00€25mg954.00€50mg1,305.00€100mg1,738.00€200mg2,322.00€BMS-767778
CAS:BMS-767778, a DPP-4 inhibitor, is used potentially for the treatment of type 2 diabetes.Formula:C19H20Cl2N4O2Color and Shape:SolidMolecular weight:407.29α 1 Antichymotrypsin, Human Plasma
CAS:Alpha 1 Antichymotrypsin, Human Plasma is an inhibitor of serine proteases. This compound is present in amyloid lesions associated with Alzheimer's disease and can be utilized in Alzheimer's research.Color and Shape:SolidZ-FG-NHO-Bz
CAS:Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].Formula:C26H25N3O6Color and Shape:SolidMolecular weight:475.49Sitagliptin fenilalanil hydrochloride
CAS:Sitagliptin phenylalanine hydrochloride, a dipeptidyl peptidase-4 (DPP-4) inhibitor [1], is a chemical compound utilized in medical applications.Formula:C25H25ClF6N6O2Color and Shape:SolidMolecular weight:590.95MeOSuc-AAPA-CMK
MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase (HNE) [1].Formula:C20H31ClN4O8Color and Shape:SolidMolecular weight:490.94Dutogliptin
CAS:Dutogliptin (PHX-1149 free base) is an oral, effective and selective dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.Formula:C10H20BN3O3Purity:98%Color and Shape:SolidMolecular weight:241.10Trivalent hydroxyarsinothricn
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.Formula:C4H10AsNO4Color and Shape:SolidMolecular weight:210.98258LXE408 fumarate
LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.Formula:C27H22FN7O6Purity:99.89%Color and Shape:SolidMolecular weight:559.51Ref: TM-T39214L
1mg299.00€2mg447.00€5mg563.00€1mL*10mM (DMSO)830.00€10mg897.00€25mg1,324.00€50mg1,791.00€100mg2,412.00€ADAM8-IN-1
CAS:ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC 50 value of 73 nM.Formula:C44H44Br4N6O12S2Color and Shape:SolidMolecular weight:1232.6Cathepsin L-IN-3
CAS:Cathepsin L-IN-3, a tripeptide-sized inhibitor of cathepsin L, effectively targets this specific enzyme.Formula:C41H49N7O4SColor and Shape:SolidMolecular weight:735.94HCV-IN-4
CAS:HCV-IN-4: Potent, oral HCV NS5A inhibitor; effective vs GT1a/b, GT2b, GT3a, Y93H, L31V; EC90s: 3 pM-0.02 nM.Formula:C52H58FN9O8Purity:98%Color and Shape:SolidMolecular weight:956.07MMP-3 Inhibitor
CAS:MMP-3 Inhibitor is a peptide matrix metalloproteinase-3 (MMP-3) inhibitor with a Ki value of 95 nM.MMP-3 inhibitor has anticancer and antitumor activity.Formula:C27H46N10O9SPurity:98.87%Color and Shape:White SolidMolecular weight:686.78Ref: TM-T37048
1mg77.00€5mg197.00€1mL*10mM (DMSO)210.00€10mg294.00€25mg497.00€50mg717.00€100mg982.00€500mg1,998.00€Tyrosinase-IN-38
Tyrosinase-IN-38 (compound 6b) is a competitive inhibitor of tyrosinase, demonstrating an IC50 of 25.82 μM and exhibits antioxidant activity.Color and Shape:Odour SolidPseudostellarin G
CAS:Pseudostellarin G, a naturally occurring cyclo-octapeptide, exhibits inhibitory activity against tyrosinase and suppresses melanin production.Formula:C42H56N8O9Color and Shape:SolidMolecular weight:816.94Dansyl-Glu-Gly-Arg-Chloromethylketone
CAS:Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically impedes serine/threonine proteases and has been shown to inhibit activatedFormula:C26H36ClN7O7SColor and Shape:SolidMolecular weight:626.12APC-6860
CAS:APC-6860, a serine protease inhibitor, targets multiple enzymes; most potent against human urokinase (Ki: 0.1 µM). Used in cancer research.Formula:C9H7IN2SColor and Shape:SolidMolecular weight:302.13Iso-VQA-ACC acetate
Iso-VQA-ACC acetate serves as a substrate for the constitutive proteasome.Color and Shape:Odour Solid(R)-BAY-85-8501
(R)-BAY-85-8501 is the less active enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent Human Neutrophil Elastase (HNE)inhibitor(IC50 of 65 pM).Formula:C22H17F3N4O3SPurity:98%Color and Shape:SolidMolecular weight:474.46Grazoprevir potassium salt
CAS:Grazoprevir, a drug for hepatitis C, is a second-gen NS3/4a protease inhibitor.Formula:C38H49KN6O9SColor and Shape:SolidMolecular weight:805AMG-222
CAS:AMG-222 (ALS-2-0426, ALS-20426) is a DPP-4 inhibitor and may be used in the treatment of type 2 diabetes.Formula:C32H39N9O3Color and Shape:SolidMolecular weight:597.716,6′-Dihydroxythiobinupharidine
CAS:6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-foldFormula:C30H42N2O4SColor and Shape:SolidMolecular weight:526.73Ac-PAL-AMC
CAS:Ac-PAL-AMC is a β1i/LMP2-specific substrate that fluoresces when cleaved; useful for measuring immunoproteasome activity.Formula:C26H34N4O6Color and Shape:SolidMolecular weight:498.57Talabostat
CAS:Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.Formula:C9H19BN2O3Color and Shape:SolidMolecular weight:214.07Radalbuvir
CAS:Radalbuvir (GS-9669) is an investigational antiviral agent for the treatment of hepatitis C virus (HCV) infection as an NS5B inhibitor.Formula:C30H41NO6SColor and Shape:SolidMolecular weight:543.71PROTAC CG167
PROTAC CG167 is a potent and selective PROTAC degrader of CypA. It degrades CypA in a dose-dependent manner in Jurkat cells, with a DC50 of 123 nM. Additionally, PROTAC CG167 exhibits antiviral activity by inhibiting HIV-1 and HCV. (Pink: CypA Ligand; Black: Linker; Blue: E3LigaseLigand)Formula:C65H79N13O11SColor and Shape:SolidMolecular weight:1250.47Stevia Powder
Stevia Powder, a natural sweetener, possesses antioxidant properties. It regulates antifibrotic pathways in cirrhotic rats, demonstrated by a reduction in hepatic stellate cells and decreased expression of matrix metalloproteinases MMP2 and MMP13. Furthermore, it increases the antifibrotic molecule Smad7, which helps prevent the elevation of serum necrosis and bile retention markers, thereby inhibiting the progression of liver fibrosis.Color and Shape:Odour SolidVD2173
CAS:VD2173: a macrocyclic peptide that inhibits HGF serine proteases, matriptase, and hepsin, potentially for lung cancer research.Formula:C31H45N9O6SColor and Shape:SolidMolecular weight:671.81Cathepsin K inhibitor 7
Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.Color and Shape:Odour SolidNIM811
CAS:NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin.Formula:C62H111N11O12Purity:98%Color and Shape:SolidMolecular weight:1202.635Bortezomib analog
Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.Color and Shape:Odour SolidCathepsin D and E FRET Substrate
CAS:Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.Formula:C85H122N22O19Color and Shape:SolidMolecular weight:1756.046Histatin 5 (TFA)(115966-68-2,free)
Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μMFormula:C135H196F3N51O35Purity:98%Color and Shape:SolidMolecular weight:3150.32NVP-DPP728 dihydrochloride
CAS:NVP-DPP728 dihydrochloride is a potent, selective DPP-IV inhibitor with a Ki of 11 nM, useful in diabetes research.Formula:C15H20Cl2N6OColor and Shape:SolidMolecular weight:371.27

