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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 994 products of "Proteases/Proteasome"

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  • GLS-1-IN-1


    GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.
    Formula:C26H25FN4OS
    Color and Shape:Solid
    Molecular weight:460.57

    Ref: TM-T62905

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • BAY-7598

    CAS:
    BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).
    Formula:C28H31N3O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:505.56

    Ref: TM-T10474

    25mg
    3,348.00€
    50mg
    4,213.00€
    100mg
    5,580.00€
  • GW311616 hydrochloride

    CAS:
    GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
    Formula:C19H32ClN3O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:433.99

    Ref: TM-T11525L

    1mg
    273.00€
    5mg
    818.00€
    10mg
    1,359.00€
  • Odiparcil

    CAS:
    Odiparcil is an orally active beta-d-thioxyloside analog.
    Formula:C15H16O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:324.35

    Ref: TM-T16377

    2mg
    161.00€
    25mg
    690.00€
    50mg
    897.00€
    100mg
    1,386.00€
  • AMG-222 tosylate

    CAS:
    AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.
    Formula:C39H47N9O6S
    Color and Shape:Solid
    Molecular weight:769.91

    Ref: TM-T71354

    25mg
    3,866.00€
    50mg
    5,111.00€
    100mg
    7,220.00€
  • BI-1942

    CAS:
    BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.
    Formula:C24H26N4O4
    Color and Shape:Solid
    Molecular weight:434.488

    Ref: TM-T205535

    10mg
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    50mg
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  • Valopicitabine dihydrochloride

    CAS:
    Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.
    Formula:C15H25ClN4O6
    Color and Shape:Solid
    Molecular weight:392.84

    Ref: TM-T29094

    25mg
    1,170.00€
    50mg
    1,521.00€
    100mg
    2,385.00€
  • Antiplatelet agent 3

    CAS:
    Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.
    Formula:C38H32N2O5
    Color and Shape:Solid
    Molecular weight:596.671

    Ref: TM-T206363

    10mg
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    50mg
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  • Plodicitinib

    CAS:
    Plodicitinib is an inhibitor of Janus tyrosine kinase 3/TEC family kinase, exhibiting anti-inflammatory properties.
    Formula:C19H22FN7O2
    Color and Shape:Solid
    Molecular weight:399.422

    Ref: TM-T206157

    10mg
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    50mg
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  • Dup-714

    CAS:
    Dup-714 is a thrombin inhibitor.
    Formula:C21H33BN6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:460.33

    Ref: TM-T27220

    25mg
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    50mg
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    100mg
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  • Zetomipzomib

    CAS:
    KZR-616: Immunoproteasome inhibitor targeting LMP7 (IC50: 39/57 nM) & LMP2 (IC50: 131/179 nM), potential in autoimmune disease research.
    Formula:C30H42N4O8
    Color and Shape:Solid
    Molecular weight:586.68

    Ref: TM-T37419

    25mg
    7,605.00€
    50mg
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    100mg
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  • Deleobuvir

    CAS:
    Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.
    Formula:C34H33BrN6O3
    Color and Shape:Solid
    Molecular weight:653.57

    Ref: TM-T31369

    1mg
    5,878.00€
  • GW311616

    CAS:
    GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
    Formula:C19H31N3O4S
    Color and Shape:Solid
    Molecular weight:397.53

    Ref: TM-T11525

    25mg
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    50mg
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    100mg
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  • TCL1

    CAS:
    TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.
    Formula:C19H14BrClN4O2S
    Color and Shape:Solid
    Molecular weight:477.762

    Ref: TM-T206909

    10mg
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    50mg
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  • Beclabuvir

    CAS:
    Beclabuvir blocks HCV NS5B polymerase at thumb site 1, effective on genotypes 1, 3, 4, 5 with IC50 <28 nM.
    Formula:C36H45N5O5S
    Purity:99.87% - 99.93%
    Color and Shape:Solid
    Molecular weight:659.84

    Ref: TM-T10493

    1mg
    128.00€
  • Tyrosinase-IN-37

    CAS:
    Tyrosinase-IN-37 (Compound 3c) is a potent inhibitor of tyrosinase, with an IC50 value of 1.02 μM, which is 14 times more effective than kojic acid (IC50 of 14.74 μM). This compound effectively prevents the browning of Rosa roxburghii and can also inhibit browning not caused by tyrosinase.
    Formula:C12H12N6S
    Color and Shape:Solid
    Molecular weight:272.33

    Ref: TM-T200626

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • BMT-052

    CAS:
    BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).
    Formula:C30H17D9F4N6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:635.61

    Ref: TM-T26871

    25mg
    2,718.00€
    50mg
    3,582.00€
    100mg
    4,950.00€
  • SSR-182289A (Free)

    CAS:
    SSR-182289A (Free) is a thrombin inhibitor.
    Formula:C30H33F2N5O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:597.68

    Ref: TM-T28857

    25mg
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    50mg
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    100mg
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  • Belactin A

    CAS:
    Belactin A acts as an inhibitor of vasohibin-1 [VASH-1] with an IC50 of 0.18 µg/ml.
    Formula:C17H21ClN2O4
    Color and Shape:Solid
    Molecular weight:352.81

    Ref: TM-T207748

    10mg
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    50mg
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  • RDN2150

    CAS:
    RDN2150 (Compound 25), a ZAP-70 inhibitor with an IC50 of 14.6 nM, covalently binds to the C346 residue of ZAP-70, suppressing the expression of CD25 and CD69
    Formula:C28H29ClN8O4
    Color and Shape:Solid
    Molecular weight:577.03

    Ref: TM-T81308

    1mg
    260.00€
    5mg
    580.00€
    10mg
    888.00€
    25mg
    1,783.00€
    50mg
    2,943.00€
    100mg
    3,979.00€
  • Immunoproteasome activator 1

    CAS:
    Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.
    Formula:C24H23N3O3
    Color and Shape:Solid
    Molecular weight:401.46

    Ref: TM-T200985

    25mg
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    50mg
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    100mg
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  • JBIR-22

    CAS:
    JBIR-22 is a natural inhibitor for protein−protein interaction of the homodimer of proteasome assembly factor 3.
    Formula:C23H33NO6
    Color and Shape:Solid
    Molecular weight:419.51

    Ref: TM-T71203

    25mg
    2,448.00€
    50mg
    3,222.00€
    100mg
    4,410.00€
  • AEP-IN-1


    APE-IN-1, a potent AEP inhibitor (IC50: 89 nM), aids Alzheimer's diagnosis and drug research.
    Formula:C18H27N3O3
    Color and Shape:Solid
    Molecular weight:333.43

    Ref: TM-T61004

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • Duazomycin sodium

    CAS:
    Duazomycin (Duazomycin A) sodium acts as a glutamine antagonist. It significantly enhances the efficacy of 6-Mercaptopurine (6-MP) in treating experimental autoimmune encephalomyelitis (EAE) without increasing toxicity.
    Formula:C8H10N3NaO4
    Color and Shape:Solid
    Molecular weight:235.17

    Ref: TM-T211286

    10mg
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    50mg
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  • Monosodium 2-sulfoterephthalate

    CAS:

    Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.

    Formula:C8H5NaO7S
    Color and Shape:Solid
    Molecular weight:268.176

    Ref: TM-T204212

    10mg
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    50mg
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  • HsClpP activator-1

    CAS:
    HsClpP activator-1 (compound 24) is a potent activator of HsClpP, with an EC50 of 0.22 μM. It effectively inhibits cancer cell growth, exhibiting IC50 values ranging from 0.1 to 1 μM.
    Formula:C23H20F5N3O2
    Color and Shape:Solid
    Molecular weight:465.42

    Ref: TM-T210884

    10mg
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    50mg
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  • Gemigliptin tartrate hydrate

    CAS:
    Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.
    Formula:C22H27F8N5O9
    Color and Shape:Solid
    Molecular weight:657.47

    Ref: TM-T212102

    10mg
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    50mg
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  • RXP03

    CAS:
    RXP03 is an MMPs inhibitor with K_i values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14 [1].
    Formula:C39H43N4O6P
    Color and Shape:Solid
    Molecular weight:694.76

    Ref: TM-T87349

    10mg
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    50mg
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  • Napsagatran hydrate

    CAS:
    Napsagatran hydrate is a novel and specific inhibitor of thrombin.
    Formula:C26H36N6O7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:576.66

    Ref: TM-T16273

    25mg
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    50mg
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    100mg
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  • ZINC09518833

    CAS:
    ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).
    Formula:C24H25N3O5
    Color and Shape:Solid
    Molecular weight:435.47

    Ref: TM-T200622

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • IDX184

    CAS:
    IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3
    Formula:C25H35N6O9PS
    Purity:97.15%
    Color and Shape:Solid
    Molecular weight:626.62

    Ref: TM-T27586

    1mg
    172.00€
    5mg
    432.00€
    10mg
    618.00€
    25mg
    973.00€
    50mg
    1,333.00€
  • Vaniprevir

    CAS:
    Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.
    Formula:C38H55N5O9S
    Purity:97.41%
    Color and Shape:Solid
    Molecular weight:757.94

    Ref: TM-T8675

    1mg
    792.00€
    5mg
    1,611.00€
    10mg
    2,178.00€
    25mg
    3,240.00€
    50mg
    4,365.00€
  • MIV-247

    CAS:
    MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.
    Formula:C17H24F3N3O4
    Purity:99.27%
    Color and Shape:Solid
    Molecular weight:391.39

    Ref: TM-T12051

    1mg
    1,234.00€
    2mg
    1,665.00€
    5mg
    2,475.00€
    10mg
    3,312.00€
    25mg
    4,941.00€
    50mg
    6,688.00€
  • JTK-109

    CAS:
    JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.
    Formula:C37H33ClFN3O4
    Purity:98.48% - 99.68%
    Color and Shape:Solid
    Molecular weight:638.13

    Ref: TM-T27696

    1mg
    296.00€
    5mg
    718.00€
    10mg
    982.00€
    25mg
    1,485.00€
    50mg
    2,008.00€
    100mg
    2,637.00€
    1mL*10mM (DMSO)
    1,108.00€
  • PD 151746

    CAS:
    PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.
    Formula:C11H8FNO2S
    Purity:98.63% - ≥95%
    Color and Shape:Solid
    Molecular weight:237.25

    Ref: TM-T2493

    5mg
    39.00€
    10mg
    62.00€
    25mg
    111.00€
    50mg
    172.00€
    1mL*10mM (DMSO)
    46.00€
  • Sebetralstat

    CAS:

    Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.

    Formula:C26H26FN5O4
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:491.51

    Ref: TM-T39350

    1mg
    35.00€
    5mg
    74.00€
    10mg
    105.00€
    25mg
    187.00€
    50mg
    279.00€
    100mg
    414.00€
  • ABT-072 potassium trihydrate

    CAS:
    ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).
    Formula:C24H32KN3O8S
    Color and Shape:Solid
    Molecular weight:561.69

    Ref: TM-T38510

    ne
    Discontinued
    Discontinued product
  • IPN60090 dihydrochloride

    CAS:
    IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.
    Formula:C24H29Cl2F3N8O3
    Color and Shape:Solid
    Molecular weight:605.44

    Ref: TM-T39544

    ne
    Discontinued
    Discontinued product
  • MMP13-IN-2

    CAS:
    MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.
    Formula:C24H19FN6O4S
    Color and Shape:Solid
    Molecular weight:506.51

    Ref: TM-T41079

    ne
    Discontinued
    Discontinued product
  • ALLM

    CAS:
    ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].
    Formula:C19H35N3O4S
    Purity:98%
    Color and Shape:White Powder
    Molecular weight:401.56

    Ref: TM-T14187

    50mg
    Discontinued
    100mg
    Discontinued
    Discontinued product
  • Oxindole

    CAS:

    Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.

    Formula:C8H7NO
    Purity:99.34%
    Color and Shape:Off-White Crystalline Powder
    Molecular weight:133.15

    Ref: TM-FR16741

    1g
    Discontinued
    5g
    Discontinued
    10g
    Discontinued
    Discontinued product
  • Butabindide oxalate

    CAS:
    CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor
    Formula:C19H27N3O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:393.43

    Ref: TM-T22619

    50mg
    Discontinued
    100mg
    Discontinued
    Discontinued product
  • Davelizomib

    CAS:

    Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].

    Formula:C21H26BF2N3O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:481.25

    Ref: TM-T79842

    ne
    Discontinued
    5mg
    Discontinued
    50mg
    Discontinued
    Discontinued product