
Proteases/Proteasome
Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.
Subcategories of "Proteases/Proteasome"
- Acetyl-CoA Carboxylase(35 products)
- Cysteine Protease(110 products)
- DPP-4(20 products)
- Glutaminase(44 products)
- HIV Protease(498 products)
- PAI-1(25 products)
- Protease Inhibitors(50 products)
- Protease-activated Receptor(54 products)
- Proteasome(95 products)
- Serine Protease(56 products)
- p97(15 products)
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Found 1094 products of "Proteases/Proteasome"
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UK 356618
CAS:<p>UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).</p>Formula:C34H43N3O4Purity:98%Color and Shape:SolidMolecular weight:557.72GW311616
CAS:GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Formula:C19H31N3O4SColor and Shape:SolidMolecular weight:397.53SMCypI C31
SMCypIC31, a non-peptide cyclophilin inhibitor, blocks PPIase at 0.1 μM IC50 and fights various HCV genotypes (EC50: 1.20-7.76 μM).Formula:C27H30N4O2SColor and Shape:SolidMolecular weight:474.62TCL1
CAS:TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.Formula:C19H14BrClN4O2SColor and Shape:SolidMolecular weight:477.762BAY-7598
CAS:<p>BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).</p>Formula:C28H31N3O6Purity:98%Color and Shape:SolidMolecular weight:505.56Cathepsin C-IN-4
Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).Formula:C21H14ClF3N4SColor and Shape:SolidMolecular weight:446.88Freselestat
CAS:Freselestat (ONO-6818) inhibits neutrophil elastase, reduces interleukin 8, C5B-9, and inflammation in cardiopulmonary bypass.Formula:C23H28N6O4Color and Shape:SolidMolecular weight:452.51MeO-Suc-Ala-Ala-Pro-Ala-CMK
CAS:MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).Formula:C20H31ClN4O7Color and Shape:SolidMolecular weight:474.936GW311616 hydrochloride
CAS:GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).Formula:C19H32ClN3O4SPurity:98%Color and Shape:SolidMolecular weight:433.99SD-7300
CAS:<p>SD-7300 (SC-81490) functions as an orally active inhibitor targeting MMP-2, MMP-9, and MMP-13, exhibiting potent inhibition with K_i values of 0.03, 0.01, and 0.03 nM, respectively. By inhibiting these metalloproteinases, SD-7300 effectively reduces extracellular matrix degradation by tumor cells, thereby curbing their invasion and metastasis. Additionally, this compound acts as a dose-dependent inhibitor of mouse corneal angiogenesis and prevents interleukin-1-induced degradation of bovine cartilage. SD-7300 is applicable in the study of breast cancer.</p>Formula:C21H30F3N3O7SColor and Shape:SolidMolecular weight:525.54Marizomib
CAS:Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.Formula:C15H20ClNO4Purity:98.03% - 99.41%Color and Shape:SolidMolecular weight:313.78Tyrosinase-IN-33
CAS:<p>Tyrosinase-IN-33 (compound 5), a pyridine-based compound, acts as an effective inhibitor of diphenolase activity in mushroom tyrosinase. It significantly reduces enzyme activity with an IC50 of 9.0 μM.</p>Formula:C19H17NS2Color and Shape:SolidMolecular weight:323.48RDN2150
CAS:RDN2150 (Compound 25), a ZAP-70 inhibitor with an IC50 of 14.6 nM, covalently binds to the C346 residue of ZAP-70, suppressing the expression of CD25 and CD69Formula:C28H29ClN8O4Color and Shape:SolidMolecular weight:577.03Ciluprevir
CAS:Ciluprevir is a selective HCV NS3 protease inhibitor, effective against non-genotype-1 HCV; less potent for genotypes 2/3.Formula:C40H50N6O8SPurity:98%Color and Shape:SolidMolecular weight:774.93Piceid 6″-O-azelaic acid ester
Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.Formula:C24H36O10Color and Shape:SolidMolecular weight:484.54GSK-2878175
CAS:GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.Formula:C27H23BClFN2O6SPurity:98%Color and Shape:SolidMolecular weight:568.81Tyrosinase-IN-35
CAS:Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.Formula:C17H15N5OSColor and Shape:SolidMolecular weight:337.40Kallikrein-IN-1
CAS:Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.Formula:C28H26FN5O4Color and Shape:SolidMolecular weight:515.54JBIR-22
CAS:JBIR-22 is a natural inhibitor for protein−protein interaction of the homodimer of proteasome assembly factor 3.Formula:C23H33NO6Color and Shape:SolidMolecular weight:419.51Cathepsin K inhibitor 2
CAS:Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.Formula:C30H33F4N5O3Color and Shape:SolidMolecular weight:587.61M826
M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity inFormula:C28H45N7O6Purity:98%Color and Shape:SolidMolecular weight:575.7RJF02215
CAS:RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.Formula:C17H12ClN3OS3Color and Shape:SolidMolecular weight:405.95(2S,4R)-Teneligliptin
CAS:(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.Formula:C22H30N6OSColor and Shape:SolidMolecular weight:426.578AMG-222 tosylate
CAS:<p>AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.</p>Formula:C39H47N9O6SColor and Shape:SolidMolecular weight:769.91AEP-IN-1
APE-IN-1, a potent AEP inhibitor (IC50: 89 nM), aids Alzheimer's diagnosis and drug research.Formula:C18H27N3O3Color and Shape:SolidMolecular weight:333.43TMPRSS6-IN-1 TFA
<p>TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.</p>Formula:C35H41F3N8O6S2Color and Shape:SolidMolecular weight:790.875BI-1915
CAS:<p>BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.</p>Formula:C21H37N5O3Color and Shape:SolidMolecular weight:407.55Valopicitabine
CAS:<p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>Formula:C15H24N4O6Purity:98%Color and Shape:SolidMolecular weight:356.37Plasma kallikrein-IN-2
Plasma kallikrein-IN-2: PKal inhibitor, IC50=0.1 nM. Used in angioedema, diabetic eye disease research.Formula:C28H24ClF3N8O3Color and Shape:SolidMolecular weight:612.99JTK-109
CAS:JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.Formula:C37H33ClFN3O4Purity:98.48% - 99.68%Color and Shape:SolidMolecular weight:638.13IDX184
CAS:IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3Formula:C25H35N6O9PSPurity:97.15%Color and Shape:SolidMolecular weight:626.62MIV-247
CAS:MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.Formula:C17H24F3N3O4Purity:99.27%Color and Shape:SolidMolecular weight:391.39Vaniprevir
CAS:Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.Formula:C38H55N5O9SPurity:97.41%Color and Shape:SolidMolecular weight:757.94PD 151746
CAS:<p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>Formula:C11H8FNO2SPurity:98.63% - ≥95%Color and Shape:SolidMolecular weight:237.25Sebetralstat
CAS:<p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>Formula:C26H26FN5O4Purity:99.85%Color and Shape:SolidMolecular weight:491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS:Formula:C37H48N6O5S2Purity:≥98%Color and Shape:SolidMolecular weight:720.94423-Deazaadenosine
CAS:3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.Formula:C11H14N4O4Purity:98%Color and Shape:SolidMolecular weight:266.25MMP13-IN-2
CAS:MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.Formula:C24H19FN6O4SColor and Shape:SolidMolecular weight:506.51IPN60090 dihydrochloride
CAS:IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.Formula:C24H29Cl2F3N8O3Color and Shape:SolidMolecular weight:605.44ALLM
CAS:ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].Formula:C19H35N3O4SPurity:98%Color and Shape:White PowderMolecular weight:401.56ABT-072 potassium trihydrate
CAS:ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).Formula:C24H32KN3O8SColor and Shape:SolidMolecular weight:561.69Oxindole
CAS:<p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>Formula:C8H7NOPurity:99.34%Color and Shape:Off-White Crystalline PowderMolecular weight:133.15Butabindide oxalate
CAS:<p>CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor</p>Formula:C19H27N3O6Purity:98%Color and Shape:SolidMolecular weight:393.43Davelizomib
CAS:<p>Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].</p>Formula:C21H26BF2N3O7Purity:98%Color and Shape:SolidMolecular weight:481.25


