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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 1094 products of "Proteases/Proteasome"

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  • UK 356618

    CAS:
    <p>UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).</p>
    Formula:C34H43N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:557.72
  • GW311616

    CAS:
    GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
    Formula:C19H31N3O4S
    Color and Shape:Solid
    Molecular weight:397.53
  • SMCypI C31


    SMCypIC31, a non-peptide cyclophilin inhibitor, blocks PPIase at 0.1 μM IC50 and fights various HCV genotypes (EC50: 1.20-7.76 μM).
    Formula:C27H30N4O2S
    Color and Shape:Solid
    Molecular weight:474.62
  • TCL1

    CAS:
    TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.
    Formula:C19H14BrClN4O2S
    Color and Shape:Solid
    Molecular weight:477.762
  • BAY-7598

    CAS:
    <p>BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).</p>
    Formula:C28H31N3O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:505.56
  • Cathepsin C-IN-4


    Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).
    Formula:C21H14ClF3N4S
    Color and Shape:Solid
    Molecular weight:446.88
  • Freselestat

    CAS:
    Freselestat (ONO-6818) inhibits neutrophil elastase, reduces interleukin 8, C5B-9, and inflammation in cardiopulmonary bypass.
    Formula:C23H28N6O4
    Color and Shape:Solid
    Molecular weight:452.51
  • MeO-Suc-Ala-Ala-Pro-Ala-CMK

    CAS:
    MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).
    Formula:C20H31ClN4O7
    Color and Shape:Solid
    Molecular weight:474.936
  • GW311616 hydrochloride

    CAS:
    GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
    Formula:C19H32ClN3O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:433.99
  • SD-7300

    CAS:
    <p>SD-7300 (SC-81490) functions as an orally active inhibitor targeting MMP-2, MMP-9, and MMP-13, exhibiting potent inhibition with K_i values of 0.03, 0.01, and 0.03 nM, respectively. By inhibiting these metalloproteinases, SD-7300 effectively reduces extracellular matrix degradation by tumor cells, thereby curbing their invasion and metastasis. Additionally, this compound acts as a dose-dependent inhibitor of mouse corneal angiogenesis and prevents interleukin-1-induced degradation of bovine cartilage. SD-7300 is applicable in the study of breast cancer.</p>
    Formula:C21H30F3N3O7S
    Color and Shape:Solid
    Molecular weight:525.54
  • Marizomib

    CAS:
    Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.
    Formula:C15H20ClNO4
    Purity:98.03% - 99.41%
    Color and Shape:Solid
    Molecular weight:313.78
  • Tyrosinase-IN-33

    CAS:
    <p>Tyrosinase-IN-33 (compound 5), a pyridine-based compound, acts as an effective inhibitor of diphenolase activity in mushroom tyrosinase. It significantly reduces enzyme activity with an IC50 of 9.0 μM.</p>
    Formula:C19H17NS2
    Color and Shape:Solid
    Molecular weight:323.48
  • RDN2150

    CAS:
    RDN2150 (Compound 25), a ZAP-70 inhibitor with an IC50 of 14.6 nM, covalently binds to the C346 residue of ZAP-70, suppressing the expression of CD25 and CD69
    Formula:C28H29ClN8O4
    Color and Shape:Solid
    Molecular weight:577.03
  • Ciluprevir

    CAS:
    Ciluprevir is a selective HCV NS3 protease inhibitor, effective against non-genotype-1 HCV; less potent for genotypes 2/3.
    Formula:C40H50N6O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:774.93
  • Piceid 6″-O-azelaic acid ester


    Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.
    Formula:C24H36O10
    Color and Shape:Solid
    Molecular weight:484.54
  • GSK-2878175

    CAS:
    GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.
    Formula:C27H23BClFN2O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:568.81
  • Tyrosinase-IN-35

    CAS:
    Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.
    Formula:C17H15N5OS
    Color and Shape:Solid
    Molecular weight:337.40
  • Kallikrein-IN-1

    CAS:
    Kallikrein-IN-1 (Formula A) is an inhibitor of the kinin-releasing enzyme Kallikrein.
    Formula:C28H26FN5O4
    Color and Shape:Solid
    Molecular weight:515.54
  • JBIR-22

    CAS:
    JBIR-22 is a natural inhibitor for protein−protein interaction of the homodimer of proteasome assembly factor 3.
    Formula:C23H33NO6
    Color and Shape:Solid
    Molecular weight:419.51
  • Cathepsin K inhibitor 2

    CAS:
    Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.
    Formula:C30H33F4N5O3
    Color and Shape:Solid
    Molecular weight:587.61
  • M826


    M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in
    Formula:C28H45N7O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:575.7
  • RJF02215

    CAS:
    RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.
    Formula:C17H12ClN3OS3
    Color and Shape:Solid
    Molecular weight:405.95
  • (2S,4R)-Teneligliptin

    CAS:
    (2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.
    Formula:C22H30N6OS
    Color and Shape:Solid
    Molecular weight:426.578
  • AMG-222 tosylate

    CAS:
    <p>AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.</p>
    Formula:C39H47N9O6S
    Color and Shape:Solid
    Molecular weight:769.91
  • AEP-IN-1


    APE-IN-1, a potent AEP inhibitor (IC50: 89 nM), aids Alzheimer's diagnosis and drug research.
    Formula:C18H27N3O3
    Color and Shape:Solid
    Molecular weight:333.43
  • TMPRSS6-IN-1 TFA


    <p>TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.</p>
    Formula:C35H41F3N8O6S2
    Color and Shape:Solid
    Molecular weight:790.875
  • BI-1915

    CAS:
    <p>BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.</p>
    Formula:C21H37N5O3
    Color and Shape:Solid
    Molecular weight:407.55
  • Valopicitabine

    CAS:
    <p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>
    Formula:C15H24N4O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:356.37
  • Plasma kallikrein-IN-2


    Plasma kallikrein-IN-2: PKal inhibitor, IC50=0.1 nM. Used in angioedema, diabetic eye disease research.
    Formula:C28H24ClF3N8O3
    Color and Shape:Solid
    Molecular weight:612.99
  • JTK-109

    CAS:
    JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.
    Formula:C37H33ClFN3O4
    Purity:98.48% - 99.68%
    Color and Shape:Solid
    Molecular weight:638.13
  • IDX184

    CAS:
    IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3
    Formula:C25H35N6O9PS
    Purity:97.15%
    Color and Shape:Solid
    Molecular weight:626.62
  • MIV-247

    CAS:
    MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.
    Formula:C17H24F3N3O4
    Purity:99.27%
    Color and Shape:Solid
    Molecular weight:391.39
  • Vaniprevir

    CAS:
    Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.
    Formula:C38H55N5O9S
    Purity:97.41%
    Color and Shape:Solid
    Molecular weight:757.94
  • PD 151746

    CAS:
    <p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>
    Formula:C11H8FNO2S
    Purity:98.63% - ≥95%
    Color and Shape:Solid
    Molecular weight:237.25
  • Sebetralstat

    CAS:
    <p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>
    Formula:C26H26FN5O4
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:491.51
  • 3-Deazaadenosine

    CAS:
    3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.
    Formula:C11H14N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:266.25

    Ref: TM-T10111L

    5mg
    Discontinued
    Discontinued product
  • MMP13-IN-2

    CAS:
    MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.
    Formula:C24H19FN6O4S
    Color and Shape:Solid
    Molecular weight:506.51

    Ref: TM-T41079

    ne
    Discontinued
    Discontinued product
  • IPN60090 dihydrochloride

    CAS:
    IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.
    Formula:C24H29Cl2F3N8O3
    Color and Shape:Solid
    Molecular weight:605.44

    Ref: TM-T39544

    ne
    Discontinued
    Discontinued product
  • ALLM

    CAS:
    ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].
    Formula:C19H35N3O4S
    Purity:98%
    Color and Shape:White Powder
    Molecular weight:401.56

    Ref: TM-T14187

    50mg
    Discontinued
    100mg
    Discontinued
    Discontinued product
  • ABT-072 potassium trihydrate

    CAS:
    ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).
    Formula:C24H32KN3O8S
    Color and Shape:Solid
    Molecular weight:561.69

    Ref: TM-T38510

    ne
    Discontinued
    Discontinued product
  • Oxindole

    CAS:
    <p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>
    Formula:C8H7NO
    Purity:99.34%
    Color and Shape:Off-White Crystalline Powder
    Molecular weight:133.15

    Ref: TM-FR16741

    1g
    Discontinued
    5g
    Discontinued
    10g
    Discontinued
    Discontinued product
  • Butabindide oxalate

    CAS:
    <p>CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor</p>
    Formula:C19H27N3O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:393.43

    Ref: TM-T22619

    50mg
    Discontinued
    100mg
    Discontinued
    Discontinued product
  • Davelizomib

    CAS:
    <p>Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].</p>
    Formula:C21H26BF2N3O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:481.25

    Ref: TM-T79842

    ne
    Discontinued
    5mg
    Discontinued
    50mg
    Discontinued
    Discontinued product