Tyrosine Kinase/Adaptors
Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.
Subcategories of "Tyrosine Kinase/Adaptors"
- ALK(112 products)
- CSF-1R(42 products)
- EGFR(572 products)
- Ephrin Receptor(23 products)
- FLT(92 products)
- Fibroblast Growth Factor Receptor (FGFR)(169 products)
- HER(5 products)
- Hck(3 products)
- IGF-1R(88 products)
- PDGFR(126 products)
- PYK2(7 products)
- Src(79 products)
- TAM Receptor(32 products)
- Tie-2(20 products)
- Trk receptor(59 products)
- Tyrosine Kinases(26 products)
- VEGFR(268 products)
- c-Fms(108 products)
- c-Kit(101 products)
- c-Met/HGFR(128 products)
- c-RET(51 products)
Show 13 more subcategories
Found 1370 products of "Tyrosine Kinase/Adaptors"
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7-Hydroxy-4H-chromen-4-one
CAS:<p>7-Hydroxy-4H-chromen-4-one (7-hydroxy-4-benzopyrone) is a Src kinase inhibitor (IC50 of <300 μM).</p>Formula:C9H6O3Purity:97.65%Color and Shape:SolidMolecular weight:162.14AG 555
CAS:<p>AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.</p>Formula:C19H18N2O3Purity:98.02% - 99.94%Color and Shape:SolidMolecular weight:322.36TAS6417
CAS:<p>Zipalertinib (TAS6417, CLN-081) is a novel, highly potent, orally active covalent EGFR tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>Formula:C23H20N6OPurity:99.71%Color and Shape:SolidMolecular weight:396.44Tetramethylcurcumin
CAS:<p>Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also</p>Formula:C25H28O6Purity:97.69% - 99.94%Color and Shape:SolidMolecular weight:424.49EOC317
CAS:<p>EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).</p>Formula:C27H26F5N7O3Purity:98.00% - 99.26%Color and Shape:SolidMolecular weight:591.53BTK IN-1
CAS:<p>BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).</p>Formula:C19H21ClN6OPurity:97.38%Color and Shape:SolidMolecular weight:384.86Tyrphostin A1
CAS:<p>Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .</p>Formula:C11H8N2OPurity:98.32%Color and Shape:SolidMolecular weight:184.19Pyridostatin TFA
CAS:<p>Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-</p>Formula:C37H35F9N8O11Purity:97.09% - 99.84%Color and Shape:SolidMolecular weight:938.71Tirbanibulin
CAS:<p>Tirbanibulin (KX2-391) is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of a variety of cancers.</p>Formula:C26H29N3O3Purity:99.43% - 99.67%Color and Shape:SolidMolecular weight:431.53RO495
CAS:<p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>Formula:C17H14Cl2N6OPurity:97.94%Color and Shape:SolidMolecular weight:389.24UNC2250
CAS:<p>UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM).</p>Formula:C24H36N6O2Purity:98.57% - 99.87%Color and Shape:SolidMolecular weight:440.58ZD-4190
CAS:<p>ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.</p>Formula:C19H16BrFN6O2Purity:99.12%Color and Shape:SolidMolecular weight:459.27PI3K-IN-1
CAS:<p>PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.</p>Formula:C31H29N5O6SPurity:97.03% - 98%Color and Shape:SolidMolecular weight:599.66Uniconazole
CAS:<p>Uniconazole is a plant growth regulator that inhibit cytochrome P450 707As (Ki=68 nM).</p>Formula:C15H18ClN3OPurity:99.94%Color and Shape:White-Light Brown CrystallineMolecular weight:291.78XL228
CAS:<p>XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).</p>Formula:C22H31N9OPurity:99.07%Color and Shape:SolidMolecular weight:437.54ID-8
CAS:<p>ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.</p>Formula:C16H14N2O4Purity:99.32%Color and Shape:SolidMolecular weight:298.29SCR-1481B1
CAS:<p>SCR-1481B1 (c-Met inhibitor 2) has activity against cancers dependent on Met activation and also has activity against cancers as a VEGFR inhibitor</p>Formula:C32H40ClF2N6O13PPurity:98.07%Color and Shape:SolidMolecular weight:821.12WZ4002
CAS:<p>WZ4002 is a mutant-selective EGFR inhibitor for EGFR(L858R) and EGFR(T790M) with IC50 of 2 nM/8 nM.</p>Formula:C25H27ClN6O3Purity:97.51%Color and Shape:SolidMolecular weight:494.97GW786034B
CAS:<p>Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.</p>Formula:C21H23N7O2S·HClPurity:99.87%Color and Shape:SolidMolecular weight:473.98Epitinib
CAS:<p>Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).</p>Formula:C24H26N6O2Color and Shape:SolidMolecular weight:430.5CHMFL-BMX-078
CAS:<p>CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.</p>Formula:C33H35N7O6Purity:>99.99%Color and Shape:SolidMolecular weight:625.67BMS-911543
CAS:<p>BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.</p>Formula:C23H28N8OPurity:97.69% - 99.98%Color and Shape:SolidMolecular weight:432.52AZ7550
CAS:<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formula:C27H31N7O2Purity:97.07% - 99.75%Color and Shape:SolidMolecular weight:485.58CP-724714
CAS:<p>CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2</p>Formula:C27H27N5O3Purity:97.1% - 98.82%Color and Shape:SolidMolecular weight:469.54Pralsetinib
CAS:<p>Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T</p>Formula:C27H32FN9O2Purity:97.88% - 99.8%Color and Shape:SolidMolecular weight:533.6LDN-214117
CAS:<p>LDN-214117 is a potent and selective ALK2 inhibitor.</p>Formula:C25H29N3O3Purity:98% - 99.82%Color and Shape:SolidMolecular weight:419.52RG14620
CAS:<p>RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.</p>Formula:C14H8Cl2N2Purity:99.82% - 99.87%Color and Shape:SolidMolecular weight:275.13PP121
CAS:<p>PP-121 inhibits PDGFR, Hck, mTOR, VEGFR2, Src, Abl, and DNA-PK with IC50 values ranging from 2 to 60 nM.</p>Formula:C17H17N7Purity:98.45% - 99.67%Color and Shape:SolidMolecular weight:319.36Dovitinib lactate
CAS:<p>Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).</p>Formula:C24H27FN6O4Purity:99.54% - 99.77%Color and Shape:SolidMolecular weight:482.51LDN193189
CAS:<p>LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.</p>Formula:C25H22N6Purity:98% - 99.86%Color and Shape:SolidMolecular weight:406.48AAL-993
CAS:<p>AAL-993: VEGFR inhibitor; IC50: 130 nM (1), 23 nM (2), 18 nM (3); weak on other tyrosine kinases; antiangiogenic & antitumor.</p>Formula:C20H16F3N3OPurity:99.65%Color and Shape:SolidMolecular weight:371.36Protein kinase inhibitors 1
CAS:<p>Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.</p>Formula:C18H17N5O3SPurity:98%Color and Shape:SolidMolecular weight:383.42AZ304
CAS:<p>AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).</p>Formula:C27H25N5O2Purity:99.82%Color and Shape:SolidMolecular weight:451.52FGFR2-IN-3
CAS:<p>FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].</p>Formula:C28H24FN7O2Purity:99.63%Color and Shape:SoildMolecular weight:509.53Gefitinib hydrochloride
CAS:<p>Obtustatin triacetate is an integrin derived from the venom of Vipera lebetina obtusa and is an α1β1 integrin and in vivo angiogenesis inhibitor.</p>Formula:C22H25Cl2FN4O3Purity:99.8%Color and Shape:SolidMolecular weight:483.36PDGFR Tyrosine Kinase Inhibitor III
CAS:<p>PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that</p>Formula:C27H27N5O4Purity:99.50%Color and Shape:SoildMolecular weight:485.53Indirubin Derivative E804
CAS:<p>Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.</p>Formula:C20H19N3O4Purity:98.54%Color and Shape:SolidMolecular weight:365.38Tivozanib hydrochloride hydrate
CAS:<p>Tivozanib hydrochloride hydrate (AV-951 hydrochloride hydrate) is a VEGFR tyrosine kinase inhibitor that inhibits VEGFR-1, VEGFR-2, VEGFR-3 .</p>Formula:C22H22Cl2N4O6Purity:98.66%Color and Shape:SolidMolecular weight:509.34Toceranib
CAS:<p>Toceranib phosphate, orally active, inhibits RTK, PDGFR, VEGFR, Kit; Kis 5 nM PDGFRβ, 6 nM KDR; has antitumor effects.</p>Formula:C22H25FN4O2Purity:97.14%Color and Shape:SolidMolecular weight:396.46Anumigilimab
CAS:<p>Anumigilimab (CSL-324) is a fully human therapeutic anti-G-CSFR antibody with potential anti-tumor activity for the study of inflammation.</p>Purity:95.75% (SEC-HPLC) - 98.43% (SEC-HPLC)Color and Shape:LiquidMolecular weight:143.86 kDaH-8 hydrochloride
CAS:<p>H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.</p>Formula:C12H17Cl2N3O2SPurity:99.93%Color and Shape:White To Off-White Crystalline SolidMolecular weight:338.25Cavutilide
CAS:<p>Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.</p>Formula:C22H26FN3O3Purity:99.82% - 99.85%Color and Shape:SolidMolecular weight:399.458Naquotinib mesylate
CAS:<p>Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFR</p>Formula:C31H46N8O6SPurity:98%Color and Shape:SolidMolecular weight:658.81BMS-690514
CAS:<p>BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.</p>Formula:C19H24N6O2Purity:99.08%Color and Shape:SolidMolecular weight:368.43Brivanib (alaninate)
CAS:<p>Brivanib Alaninate (BMS-582664) is an alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic effect.</p>Formula:C22H24FN5O4Purity:99.46% - 99.66%Color and Shape:SolidMolecular weight:441.46NVP-BSK805
CAS:NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.Formula:C27H28F2N6OPurity:98%Color and Shape:SolidMolecular weight:490.55(Rac)-SAR131675
CAS:<p>(Rac)-SAR131675 is an effective and specific VEGFR-3 inhibitor, which inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells.</p>Formula:C18H22N4O4Purity:98.34% - 99.1%Color and Shape:SolidMolecular weight:358.39Almonertinib hydrochloride
CAS:<p>Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.</p>Formula:C30H36ClN7O2Purity:98.01% - 98.12%Color and Shape:SolidMolecular weight:562.1Canertinib dihydrochloride
CAS:<p>Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and</p>Formula:C24H27Cl3FN5O3Purity:99.13% - >99.99%Color and Shape:SolidMolecular weight:558.86Frunevetmab
CAS:<p>Frunevetmab (NV-02) is a feline-adapted monoclonal antibody targeting NGF (nerve growth factor), with a Kd value of 20 pM. Feline osteoarthritis (OA).</p>Purity:95% - 95%Color and Shape:LiquidFiclatuzumab
CAS:<p>Ficlatuzumab is a humanized anti-HGF mAb that inhibits c-Met signaling for squamous cell carcinoma treatment.</p>Purity:95%Color and Shape:LiquidFigitumumab
CAS:<p>Figitumumab is a potent anti-IGF1R mAb (IC50=1.8 nM) showing promise in advanced lung squamous cell carcinoma.</p>Purity:95%Color and Shape:LiquidFasinumab
CAS:<p>Fasinumab (anti-NGF mAb) is in Phase III trials for acute sciatica & knee OA. It significantly improves pain & function vs. placebo.</p>Purity:95%Color and Shape:LiquidBriquilimab
CAS:<p>Briquilimab is a humanized antibody that inhibits the SCF-KIT interaction, inducing mast cell apoptosis for research into inflammatory diseases.</p>Purity:95% - 95%Color and Shape:LiquidPonezumab
CAS:<p>Ponezumab (PF-04360365), a humanized IgG2 antibody, lowers Aβ in the CNS & boosts mice memory. Used in Alzheimer's research.</p>Color and Shape:LiquidAnbenitamab
CAS:<p>Anbenitamab (KN-026) is a bispecific HER2 antibody for metastatic breast cancer research, blocking HER2 pathways and mediating ADCC.</p>Color and Shape:LiquidCabiralizumab
CAS:<p>Cabiralizumab is an anti-CSF1R monoclonal antibody that enhances T cell infiltration, inhibits osteoclasts, and is used in RA and immune-oncology research.</p>Purity:95% - 95%Color and Shape:LiquidFutuximab
CAS:<p>Futuximab, a chimeric monoclonal antibody, targets distinct epitopes on the epidermal growth factor receptor (EGFR), exhibiting antineoplastic activity [1].</p>Purity:95% - 95%Color and Shape:LiquidImgatuzumab
CAS:<p>Imgatuzumab (RG 7160) is a humanized anti-EGFR monoclonal antibody and immunomodulator for cancer research.</p>Color and Shape:LiquidMolecular weight:145.0 (kDa)Barzolvolimab
CAS:<p>Barzolvolimab (CDX 0159), a humanized IgG1 monoclonal antibody, blocks KIT activation and treats chronic urticaria.</p>Color and Shape:LiquidZanidatamab
CAS:<p>Zanidatamab (ZW25) is a bispecific, humanized monoclonal antibody that targets two distinct epitopes (ECD2 and ECD4) of the HER2 receptor, exhibiting anti-tumor</p>Color and Shape:LiquidIzalontamab
CAS:<p>Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers.</p>Purity:95%+ - 95%+Color and Shape:Liquid6-Bn-cAMP
CAS:<p>6-Bn-cAMP is a selective activator of cAMP-dependent protein kinase (PKA) that does not activate Epac. Compared to cAMP, 6-Bn-cAMP enhances hydrolytic stability against PDE, esterases, and amidases, and significantly increases membrane permeability.</p>Formula:C17H18N5O6PColor and Shape:SolidMolecular weight:419.33Namilumab
CAS:<p>Namilumab (AMG203) is a humanised IgG1 monoclonal antibody that neutralises GM-CSF. rheumatoid arthritis and active axial spondyloarthritis.</p>Purity:95%Color and Shape:LiquidZalutumumab
CAS:<p>Zalutumumab is a high-affinity fully human monoclonal antibody ,the extracellular domain of the EGFR squamous cell carcinoma of the head and neck (SCCHN).</p>Purity:95%Color and Shape:LiquidFulranumab
CAS:<p>Fulranumab (AMG-403) is a humanised monoclonal antibody targeting NGF, analgesic effects, and can be used for the study of chronic pain.</p>Purity:95%Color and Shape:LiquidElgemtumab
CAS:<p>Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation antitumour.</p>Purity:95%Color and Shape:LiquidTanezumab
CAS:<p>Tanezumab (RN-624) is a humanised monoclonal antibody targeting NGF，pain conditions, including osteoarthritis, knee arthritis, and neuropathic pain.</p>Purity:95%Color and Shape:LiquidAnti-IGFBP2 Antibody (M14)
<p>Anti-IGFBP2 Antibody (M14) is a human monoclonal antibody inhibitor that binds with high affinity to IGFBP2 and prevents its interaction with IGF1. Additionally, Anti-IGFBP2 Antibody (M14) can inhibit the recruitment of human endothelial cells, thereby obstructing tumor progression in human metastatic cancers.</p>Color and Shape:Odour LiquidDusigitumab
CAS:<p>Dusigitumab (MEDI573) is a fully humanised monoclonal antibody targeting IGF1/IGF2, inhibiting IGF1/IGF2-induced IGF-1R phosphorylation.</p>Purity:95% - 95%Color and Shape:LiquidAnti-Mouse CD117 Antibody
<p>Anti-Mouse CD117 Antibody, a rat-derived IgG2b isotype, acts as an inhibitor specific to the mouse CD117 antigen.</p>Purity:98%Color and Shape:Odour SolidBecotatug
CAS:<p>Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib and Osimertinib, functioning as a synthetic antibody-drug conjugate</p>Purity:95% - 95%Color and Shape:LiquidAnti-Mouse GM-CSF Antibody (MP1-22E9)
<p>Anti-Mouse GM-CSF Antibody is a rat-derived IgG2a isotype inhibitor that targets mouse granulocyte-macrophage colony-stimulating factor (GM-CSF).</p>Purity:98%Color and Shape:Odour LiquidDepatuxizumab
CAS:<p>Depatuxizumab is a humanised monoclonal antibody targeting EGFR with blood-brain barrier (BBB) permeability, inhibit tumor growth,GBM,SCCHN.</p>Purity:95%Color and Shape:LiquidDavutamig
CAS:<p>Davutamig (REGN-5093) is a humanized IgG4-kappa, anti-MET monoclonal antibody that binds to two distinct, nonoverlapping epitopes on the MET receptor.</p>Purity:98%Color and Shape:LiquidVeligrotug
CAS:<p>Veligrotug is an IV anti-IGF-1R antibody for thyroid eye disease, reducing diplopia and orbital inflammation, supporting autoimmune ophthalmopathy research.</p>Purity:95% - 95%Color and Shape:LiquidSerclutamab
CAS:<p>Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).</p>Purity:98%Color and Shape:LiquidDovitinib Dilactic Acid
CAS:<p>Dovitinib dilactic acid: multitarget RTK inhibitor for FLT3/c-Kit (IC50=1-2 nM), FGFR1/3, VEGFR1-4 (IC50=8-13 nM), less effective on InsR, EGFR. Phase 4.</p>Formula:C21H21FN6O·2C3H6O3Purity:98%Color and Shape:SolidMolecular weight:572.59CSF1R-IN-19
CAS:<p>CSF1R-IN-19 is a robust inhibitor of CSF1R that influences the exchange of inflammatory factors between TAMs and glioma cells. It holds potential for cancer research [1].</p>Formula:C20H27N7OColor and Shape:SolidMolecular weight:381.47ZM323881 hydrochloride
CAS:<p>ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.</p>Formula:C22H19ClFN3O2Purity:99.43%Color and Shape:SolidMolecular weight:411.86Icotinib
CAS:<p>Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.</p>Formula:C22H21N3O4Purity:99.76% - 99.94%Color and Shape:SolidMolecular weight:391.42lavendustin A
CAS:<p>lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.</p>Formula:C21H19NO6Purity:98%Color and Shape:Off-White SolidMolecular weight:381.388-MA-cAMP
CAS:<p>8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.</p>Formula:C11H15N6O6PColor and Shape:SolidMolecular weight:358.258-Chloro-cAMP sodium
CAS:<p>8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.</p>Formula:C10H10ClN5NaO6PColor and Shape:SolidMolecular weight:385.63S961
CAS:<p>S961: High-affinity IR antagonist; IC50: HIR-A 0.048 nM, HIR-B 0.027 nM, HIGF-IR 630 nM.</p>Formula:C211H297N55O71S2Purity:98%Color and Shape:SolidMolecular weight:4804.13IGF-1R modulator 1
CAS:<p>IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.</p>Formula:C22H17N3O4Color and Shape:SolidMolecular weight:387.39TAK-285
CAS:<p>TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.</p>Formula:C26H25ClF3N5O3Purity:99.73%Color and Shape:SolidMolecular weight:547.96BMS-754807
CAS:<p>BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.</p>Formula:C23H24FN9OPurity:99.69% - 99.94%Color and Shape:SolidMolecular weight:461.49GW843682X
CAS:<p>GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).</p>Formula:C22H18F3N3O4SPurity:99.92%Color and Shape:SolidMolecular weight:477.46CP-547632
CAS:<p>CP-547632 is an oral ATP-competitive inhibitor of VEGFR-2/FGF kinase with IC50s of 11/9 nM, highly selective, has antitumor activity.</p>Formula:C20H24BrF2N5O3SPurity:99.39%Color and Shape:SolidMolecular weight:532.4Icotinib Hydrochloride
CAS:<p>Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.</p>Formula:C22H22ClN3O4Purity:99.89%Color and Shape:SolidMolecular weight:427.88AMG-458
CAS:<p>AMG-458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.</p>Formula:C30H29N5O5Purity:99.91% - 99.98%Color and Shape:SolidMolecular weight:539.58PDGFRα kinase inhibitor 1
CAS:<p>PDGFRα kinase inhibitor 1 is a type II PDGFRα kinase inhibitor that inhibits both PDGFRα and PDGFRβ.</p>Formula:C34H34N8O2Purity:99.78%Color and Shape:SolidMolecular weight:586.69TrkA-IN-1
CAS:<p>TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.</p>Formula:C25H20N4OPurity:98%Color and Shape:SolidMolecular weight:392.45EGFR/C797S-IN-1
CAS:<p>EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.</p>Formula:C28H30N4O3Color and Shape:SolidMolecular weight:470.56EGFR-IN-25
CAS:<p>EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.</p>Formula:C34H43N9O2Color and Shape:SolidMolecular weight:609.76BKI-1369
CAS:<p>BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).</p>Formula:C23H27N7OColor and Shape:SolidMolecular weight:417.51JBJ-09-063 hydrochloride
<p>JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.</p>Formula:C31H30ClFN4O3SColor and Shape:SolidMolecular weight:593.11Tavilermide
CAS:<p>Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.</p>Formula:C24H32N6O11Purity:98.98%Color and Shape:SolidMolecular weight:580.54DUN73423
CAS:<p>DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.</p>Formula:C19H16N6OPurity:98.09%Color and Shape:SolidMolecular weight:344.37
