Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1504 products of "Autophagy"
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Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Formula:C20H23N3O2SPurity:99.33%Color and Shape:SolidMolecular weight:369.48Ethyl 3,4-dihydroxybenzoate
CAS:Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.Formula:C9H10O4Purity:99.88%Color and Shape:White Crystal Or PowderMolecular weight:182.17GSK621
CAS:GSK621 is a specific and potent AMPK activator.Formula:C26H20ClN3O5Purity:97.02% - 97.05%Color and Shape:SolidMolecular weight:489.91Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormula:C21H15ClF4N4O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:482.82Ref: TM-T1792
5mg34.00€10mg49.00€25mg75.00€50mg90.00€100mg137.00€200mg175.00€500mg294.00€1mL*10mM (DMSO)54.00€Enalaprilat Dihydrate
CAS:Enalaprilat Dihydrate (MK-422 Dihydrate) （IC50=1.94 nM） is a potent angiotensin-converting enzyme (ACE) inhibitor.Formula:C18H24N2O5·2H2OPurity:99.46% - 99.78%Color and Shape:SolidMolecular weight:348.43BDO
CAS:3BDO is a new mTOR activator. 3BDO inhibits autophagy.Formula:C18H17NO5Purity:97.76%Color and Shape:SolidMolecular weight:327.33Ref: TM-T14033
1mg34.00€2mg44.00€5mg64.00€10mg92.00€25mg195.00€50mg313.00€100mg467.00€1mL*10mM (DMSO)71.00€XCT790
CAS:XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).Formula:C23H13F9N4O3SPurity:99% - 99.61%Color and Shape:SolidMolecular weight:596.42Crizotinib hydrochloride
CAS:Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Formula:C21H23Cl3FN5OPurity:98.73% - 98.87%Color and Shape:SolidMolecular weight:486.8Ref: TM-T8399
5mg34.00€10mg50.00€25mg78.00€50mg94.00€100mg131.00€200mg162.00€500mg215.00€1mL*10mM (DMSO)56.00€Salirasib
CAS:Salirasib: Competitive PPMTase inhibitor, blocks Ras methylation, potential cancer treatment, Ki=2.6 μM.Formula:C22H30O2SPurity:99.45%Color and Shape:SolidMolecular weight:358.54Ref: TM-T6163
5mg34.00€10mg50.00€25mg90.00€50mg150.00€100mg210.00€200mg344.00€500mg567.00€1mL*10mM (DMSO)56.00€TA-02
CAS:TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.Formula:C20H13F2N3Purity:99.35% - 99.79%Color and Shape:SolidMolecular weight:333.33Ref: TM-T4646
5mg37.00€10mg55.00€25mg99.00€50mg152.00€100mg230.00€500mgTo inquire1mL*10mM (DMSO)40.00€LY294002
CAS:LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).Formula:C19H17NO3Purity:98% - 99.96%Color and Shape:Pale Yellow SolidMolecular weight:307.34Mirdametinib
CAS:Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.Formula:C16H14F3IN2O4Purity:99.11% - 99.63%Color and Shape:White PowderMolecular weight:482.19Ref: TM-T6189
1g898.00€5mg51.00€10mg74.00€25mg127.00€50mg175.00€100mg273.00€200mg406.00€500mg662.00€1mL*10mM (DMSO)55.00€Mavorixafor trihydrochloride
CAS:Mavorixafor trihydrochloride blocks CXCR4 (IC50: 13 nM) and suppresses T-tropic HIV-1 replication (IC50: 1-9 nM). It's orally active.Formula:C21H30Cl3N5Purity:98.00%Color and Shape:SolidMolecular weight:458.86Pseudolaric Acid B
CAS:Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.Formula:C23H28O8Purity:98.91% - 99.84%Color and Shape:SolidMolecular weight:432.46Regorafenib monohydrate
CAS:Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murineFormula:C21H17ClF4N4O4Purity:99.69%Color and Shape:SolidMolecular weight:500.83Ref: TM-T1792L
5mg34.00€10mg46.00€25mg65.00€50mg94.00€100mg133.00€200mg197.00€500mg329.00€1mL*10mM (DMSO)55.00€Oleanolic Acid
CAS:Oleanolic Acid (Caryophyllin) is a natural compound with anti-tumor activities, which are widely distributed in plants.Formula:C30H48O3Purity:97.04% - 98.51%Color and Shape:SolidMolecular weight:456.70KB-R7943 mesylate
CAS:KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM.Formula:C17H21N3O6S2Purity:99.88% - ≥95%Color and Shape:SolidMolecular weight:427.5GW 4064
CAS:GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).Formula:C28H22Cl3NO4Purity:98% - 99.94%Color and Shape:SolidMolecular weight:542.84Ref: TM-T2233
5mg52.00€10mg79.00€25mg132.00€50mg222.00€100mg403.00€200mg605.00€500mg954.00€1mL*10mM (DMSO)59.00€AZ304
CAS:AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).Formula:C27H25N5O2Purity:99.82%Color and Shape:SolidMolecular weight:451.52Neflamapimod
CAS:Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.Formula:C19H9Cl2F2N3OSPurity:97.88% - 99.75%Color and Shape:SolidMolecular weight:436.26JZL195
CAS:JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.Formula:C24H23N3O5Purity:99.81%Color and Shape:SolidMolecular weight:433.46Genipin
CAS:Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.Formula:C11H14O5Purity:99.09% - 99.21%Color and Shape:SolidMolecular weight:226.23Obeticholic Acid
CAS:Obeticholic Acid (6-ECDCA, INT-747) is a high-affinity, semisynthetic, bile acid-derived FXR agonist.Cost-effective and quality-assured.Formula:C26H44O4Purity:99.88% - 99.97%Color and Shape:SolidMolecular weight:420.63Ref: TM-T1789
5mg46.00€10mg50.00€25mg78.00€50mg94.00€100mg155.00€200mg259.00€500mg477.00€1mL*10mM (DMSO)50.00€ZSTK474
CAS:PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potentialFormula:C19H21F2N7O2Purity:98.29% - 99.95%Color and Shape:White PowderMolecular weight:417.41Torin 2
CAS:Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Formula:C24H15F3N4OPurity:98.31% - 99.32%Color and Shape:SolidMolecular weight:432.4Turofexorate Isopropyl
CAS:Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
Formula:C25H24F2N2O3Purity:98.55% - 99.73%Color and Shape:SolidMolecular weight:438.47AS1842856
CAS:AS1842856 is a Foxo1 inhibitor that blocks the transcriptional activity of Foxo1. AS1842856 has autophagy inhibitory activity. Cost-effective and quality-assured.Formula:C18H22FN3O3Purity:99.36% - >99.99%Color and Shape:SolidMolecular weight:347.38BC1618
CAS:BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling.Formula:C24H24F3NO2Purity:99.95%Color and Shape:SolidMolecular weight:415.45AZD 6482
CAS:AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.Formula:C22H24N4O4Purity:99.87% - 99.95%Color and Shape:SolidMolecular weight:408.45sbp-7455
CAS:SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.Formula:C16H17F3N4O2Purity:97.90% - 99.842%Color and Shape:SolidMolecular weight:354.33Typhaneoside
CAS:Typhaneoside (Aervitrin) is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction.Formula:C34H42O20Purity:98.92% - 99.95%Color and Shape:SolidMolecular weight:770.69SNX2112
CAS:SNX2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM.Formula:C23H27F3N4O3Purity:98.75% - 99.46%Color and Shape:SolidMolecular weight:464.48Ref: TM-T6305
1mg35.00€5mg75.00€10mg114.00€25mg205.00€50mg316.00€100mg452.00€200mg627.00€1mL*10mM (DMSO)77.00€Nordihydroguaiaretic acid
CAS:Nordihydroguaiaretic acid (NDGA) is a natural lipoxygenase (5-LOX) inhibitor. Nordihydroguaiaretic acid has antioxidant effect. Cost-effective and quality-assured.Formula:C18H22O4Purity:97.82% - 99.91%Color and Shape:SolidMolecular weight:302.36PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Formula:C19H16N4O3Purity:97.79% - 99.3%Color and Shape:SolidMolecular weight:348.36Gemcitabine hydrochloride
CAS:Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis.Formula:C9H11F2N3O4·HClPurity:99.28% - 99.98%Color and Shape:White Crystalline Granular OdorlessMolecular weight:299.66Dioscin
CAS:Dioscin (Collettiside III) is a saponin with antitumor activities.Formula:C45H72O16Purity:99.85% - 99.87%Color and Shape:SolidMolecular weight:869.04Ref: TM-T6473
5mg34.00€10mg42.00€25mg58.00€50mg81.00€100mg105.00€200mg152.00€500mg245.00€1mL*10mM (DMSO)52.00€Tezacaftor
CAS:Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.Formula:C26H27F3N2O6Purity:98.84% - >99.99%Color and Shape:SolidMolecular weight:520.5Ref: TM-T2263
1mg38.00€2mg50.00€5mg78.00€10mg116.00€25mg200.00€50mg324.00€100mg477.00€1mL*10mM (DMSO)94.00€Rasagiline Mesylate
CAS:Rasagiline Mesylate (AGN1135) is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.Formula:C13H17NO3SPurity:99.33%Color and Shape:White PowderMolecular weight:267.34AS-605240
CAS:AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).Formula:C12H7N3O2SPurity:97% - 99.91%Color and Shape:SolidMolecular weight:257.27Elubrixin HCl
CAS:Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist.Formula:C17H18Cl3FN4O4SColor and Shape:SolidMolecular weight:499.77BX795
CAS:BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.Formula:C23H26IN7O2SPurity:98% - 99.57%Color and Shape:SolidMolecular weight:591.47Ref: TM-T1830
5mg56.00€10mg92.00€25mg198.00€50mg324.00€100mg487.00€200mg702.00€500mg1,063.00€1mL*10mM (DMSO)84.00€Deoxypodophyllotoxin
CAS:Deoxypodophyllotoxin is cytotoxic, antineoplastic, anti-tumor, anti-angiogenic, antiviral, and anti-inflammatory.Formula:C22H22O7Purity:99.65% - 99.84%Color and Shape:SolidMolecular weight:398.41Piperlongumine
CAS:Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.Formula:C17H19NO5Purity:97.03% - 99.90%Color and Shape:SolidMolecular weight:317.34GLPG1837
CAS:GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.Formula:C16H20N4O3SPurity:99.64% - 99.91%Color and Shape:SolidMolecular weight:348.42SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Formula:C20H22F3N5OPurity:99.3% - >99.99%Color and Shape:SolidMolecular weight:405.42Oxyresveratrol
CAS:1.Formula:C14H12O4Purity:98.09% - 99.69%Color and Shape:Yellow SolidMolecular weight:244.24LC3-mHTT-IN-AN1
CAS:LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B.Formula:C15H9Br2NO3Purity:97.26%Color and Shape:SolidMolecular weight:411.04MG-132
CAS:MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!Formula:C26H41N3O5Purity:95% - 99.99%Color and Shape:White To Off-White PowderMolecular weight:475.62Ref: TM-T2154
10mg46.00€25mg84.00€50mg137.00€100mg205.00€200mg356.00€500mg447.00€1mL*10mM (DMSO)44.00€3-Bromopyruvic acid
CAS:3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition.
Formula:C3H3BrO3Purity:95% - 99.644%Color and Shape:White To Pale Yellow Crystalline PowderMolecular weight:166.96Cucurbitacin E
CAS:Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Formula:C32H44O8Purity:98.88% - 99.87%Color and Shape:SolidMolecular weight:556.69Ref: TM-T5S1467
1mg56.00€5mg109.00€10mg168.00€25mg284.00€50mg423.00€100mg610.00€1mL*10mM (DMSO)133.00€
