Autophagy

Indophagolin: autophagy inhibitor, IC50 140 nM; blocks P2X4, P2X1, P2X3 receptors, IC50s 2.71, 2.40, 3.49 μM.

Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.

BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.

CCT007093 is an effective PPM1D (WIP1) inhibitor (IC50: 8.4 μM).

<p>Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).</p>

Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane.

Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.

Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).

Pyriproxyfen (S-31183) is an insecticide that acts as a biomimetic of juvenile hormone.

Enzastaurin (LY317615) (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.

UNC0638 inhibits G9a and GLP lysine methyltransferases with IC50 <15 nM and 19 nM, respectively, showing high selectivity.

CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.

<p>3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition.</p>

Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.

AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values ​​of 0.69nM and 10nM.Cost-effective and quality-assured.

Dioscin (Collettiside III) is a saponin with antitumor activities.

740 Y-P (740YPDGFR) is a PI3K activator with cell permeability,binds GST fusion proteins containing the N-and C-terminal SH2 domains of p85. Low-Cost!

mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer with antiviral and antitumor activity for the study of non-small cell lung cancer.

Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.

Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.

Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug.

H-89 is a PKA inhibitor, a candidate cardioprotectant, induces spatial learning impairment in rats, and can be used to study myocardial infarction.

Ezetimibe ketone (EZM-K) exhibits antioxidant activity and alleviates H2O2-induced NRK-52E cell apoptosis by upregulating Nrf2 and HO-1 levels.

Chenodeoxycholic Acid sodium salt (CDCA sodium salt) is a bile acid in humans that activates the nuclear receptor FXR, rescues axonal degeneration of induced pluripotent stem cell-derived neurons in patients with spastic paraplegia type 5 and cerebral xanthomatosis, and can be used to study pancreatic necrosis.

Ketanserin tartrate (KJK-945 tartrate) is a 5-HT2A receptor and α1-adrenergic receptor antagonist for the study of systemic sclerosis.

SB 203580 hydrochloride (Adezmapimod hydrochloride) is a p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy.

Fluvastatin (XU-62320) is an HMG-CoA reductase inhibitor used to lower plasma cholesterol levels and prevent cardiovascular disease.

ML 145 is a selective antagonist of GPR35/CXCR8 (IC50/EC50 of 20.1 nM)

Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets.

Tigecycline-d9 is a deuterated compound of Tigecycline. Tigecycline has a CAS number of 220620-09-7. Tigecycline is a broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex.

Gefitinib-d6 is a deuterated compound of Gefitinib. Gefitinib has a CAS number of 184475-35-2. Gefitinib is an EGFR tyrosine kinase inhibitor and can inhibit Tyr1173, Tyr992, Tyr1173 and Tyr992 (IC50s: 37/37/26/57 nM).

Rosuvastatin-d6 Sodium Salt is a deuterated compound of Rosuvastatin Sodium Salt. Rosuvastatin Sodium Salt has a CAS number of 1007871-86-4.

Lovastatin-d3 is a deuterated compound of Lovastatin. Lovastatin has a CAS number of 75330-75-5. Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.

Reserpine-d9 is a deuterated compound of Reserpine. Reserpine has a CAS number of 50-55-5. Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.

Irinotecan-d10 Hydrochloride is a deuterated compound of Irinotecan Hydrochloride. Irinotecan Hydrochloride has a CAS number of 100286-90-6. Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.

DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.

<p>BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .</p>

<p>VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.</p>

Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).

<p>Alisol A: induces autophagy, anti-cancer, inhibits HepG2, MDA-MB-231, MCF-7 cells.</p>

MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.

Brivanib Alaninate (BMS-582664) is an alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic effect.

Orally active atorvastatin inhibits HMG-CoA reductase, lowers lipids, hinders SV-SMC cell growth, and can up thrombotic risk with clopidogrel.

Metyrapone Tartrate: a test inhibitor for diagnosing Cushing's; blocks steroid 11-beta-hydroxylase.

Euchrysine 3RX is an agent of bioactive chemicals.

<p>Chloroquine: treats malaria, amebiasis, rheumatoid arthritis, lupus; works by inhibiting parasites in red blood cells.</p>

Rac-Efavirenz is a non stereospecific structure of Efavirenz.

Apatinib-d8 is a deuterated compound of Apatinib. Apatinib has a CAS number of 811803-05-1. Apatinib is an orally bioavailable and specific VEGFR2 inhibitor (IC50: 1 nM). In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.

Lamotrigine-d3 is a deuterated compound of Lamotrigine. Lamotrigine has a CAS number of 84057-84-1. Lamotrigine is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity.

<p>YT-8-8 is a ligand for the p62-ZZ domain and can activate p62-dependent selective autophagy. This compound is also applicable in AUTOTAC design.</p>