Toxicology

<p>Applications Gadobutrol is a gadolinium-based MRI contrast agent (GBCA).<br>References Laurent, S., et al.: Contrast Media Mol. Imaging, 1, 128 (2006); Frenzel, T., et al.: Invest. Radiol., 43, 817 (2008)<br></p>

<p>Applications Pretilachlor is a chloroacetanalide herbicide. Pretilachlor is commonly used for weed control in wet seeded rice<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mohankumar, P.D. et al.: J. Trop. Agric., 34, 149 (34, 149 (1996); Ravisankar, N. et al.: Ind. J. Agron., 53, 57 (2008); Singh, S. et al.: Crop Prot., 27, 660 (2008);<br></p>

<p>Applications Steroid hormone with weak androgenic effects.<br>References Wartman, C., et al.: Aquatic Toxicol., 92, 131 (2009), Gohil, V., et al.: Nat., Biotechnol., 28, 249 (2010), Phapale, P., et al.: Clin. Pharmacol. Ther., 87, 426 (2010),<br></p>

<p>Applications Strobilurin fungicide; inhibits mitochondrial respiration by blocking electron transfer between cytochromes b and c1. Agricultural fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smalling, K., et al.: Environ. Toxicol. Chem., 29, 2593 (2010), Lu, X., et al.: Phytopathol., 100, 1162 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),<br></p>

<p>Applications Labelled Fenhexamid (F247650). Hydroxyanilide fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yamashita, M., et al.: J. Phys. Chem., 88, 4451 (1984), Kende, A., et al.: Microchem. J., 84, 63 (2006),<br></p>

<p>Applications A potent inhibitor of estrone sulfatase. Inhibits estrone sulfatase &gt;99% at 0.1uM in intact MCF-7 cells, IC50=65pM.<br>References Woo, L.W., et al.: J. Med. Chem., 41, 1068 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications 2-Chloro-5-[[4,5-dihydro-2-(nitroamino)-1H-imidazol-1-yl]methyl]-3-pyridinol is an analog of Imidacloprid (I274990) which is an active ingredient in certain neuro-active insecticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chauzat, M., et al.: Env. Entomol., 38, 514 (2009), Patial, A., et al.: Env. Ecol., 27, 320 (2009), Fernandez-Bayo, J., et al.: J. Agric., Food Chem., 57, 5435 (2009), Tomizawa, M., et al.: J. Med. Chem., 52, 3735 (2009), Chem. and Eng. News 90: 10 (2012)<br></p>

<p>Applications Capreomycin Sulfate is used in the treatment of MDR-tuberculosis in conjunction with other anti-tuberculosis drugs.<br>References Garcia-C. et al.: Antimicrob. Agents Chemother., 56, 2612 (2012); Reisfeld, B. et al.: Antimicrob. Agents Chemother., 56, 926 (2012);<br></p>

<p>Applications Used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.<br>References Gillet, Y., et al.: Lancet, 359, 753 (2002), Turos, E., et al.: Bioorg. Med. Chem. Lett., 2002, 12, 2229 (2002),<br></p>

<p>Applications Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed cells and cancer cells. Deguelin also exhibits potent tumor suppressive effects in xenograft tumor models for many human cancers.<br>References Chang, D.J.. et al.: J. Med. Chem., 55, 10863 (2012);<br></p>

<p>Stability Light Sensitive<br>Applications Methiocarb acts as a pesticide which is used in the protection of crops from insects and fungus. Also useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wong, J. et al.: J. Agri,. Food. Chem., 58, 5897 (2010); Ghini, S. et al.: Arch. Env. Cont. Toxicol., 47, 479 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications Monosultap is a type of insecticide that is used in agricultural use to regulate insect growth against Pieris rapae.<br>References Zhong, G.H., et al.: J. Appl. Ent., 125, 563 (2001);<br></p>

<p>Applications Systemic post-emergence herbicide for use in food crops and mesquite.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pik, A.J., J. Agric. Food Chem., 25, 1054 (1977), Bovey, R.W., et al.: Weed. Sci., 33, 349 (1985),<br></p>

<p>Stability Hygroscopic<br>Applications Thionazin is a highly toxic organophosphorus pesticide used to protect crops and gardens from microorganisms and pests (such as the glasshouse whitefly and wireworms).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Critchley, B.: Bull. Entomol. Res., 62, 327 (1972); French, N., et al.: Plant Pathol., 22, 99 (1973); Griffiths, D.: Entomol. Exp. Appl., 10, 171 (1967); Lloyd, G. &amp; Bell, G.: Analyst, 91, 808 (1966)<br></p>

<p>Applications Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis. Potent JAK2 inhibitor.<br>References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);<br></p>

<p>Applications Dihexadecyl(dimethyl)azanium bromide is an ionic olefin derivative used in the preparation of metal-containing ionic liquids for use in particle synthesis and materials with magnetic or thermochromic properties.<br>References Zabel, A.; et al.: Int. J. Mol. Sci., 17, 596/1 (2016).<br></p>

<p>Applications A metabolite of Amitraz (A633320).<br>References Knowles, C., et al.: J. Sci. Health, 16, 547 (1981), Zhu, N., et al.: J. Pestic., 33, 32 (1994), Du, X., et al.: Environ. Chem., 14, 258 (1995),<br></p>

<p>Applications Labelled analogue of Glycopyrrolate Bromide, a novel pharmaceutical compound based on PDE IV inhibitors. Glycopyrrolate Bromide is used in the treatment of respiratory complaints.<br>References Gomez, et al.: Br. J. Anaesth., 74, 549 (1995);<br></p>

<p>Applications Isotope labelled Acephate (A130850) acts as a contact and systemic insecticide in agriculture through pesticide formulations. Through perinatal exposure studies, it has been linked to hyperglycemia, changes in lipid metabolism and type 2 diabetes (1). Acephate exposed Drosophila melanogaster potentially display an L-ascorbic acid mediated defense (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Ribeiro, T., et al.: Toxicology, 372, 12-21 (2016); Rajak, P., et al.: J. Hazard. Mater., 321, 690-702 (2017)<br></p>

<p>Applications Fenoxaprop-P is an agro-product, used in pesticide formulations.<br>References Han, Y. et al. et al.: J. Sep. Sci., 40, 878 (2017);<br></p>

<p>Applications A metabolite of Amonafide.<br>References Felder, T.B., et al.: Drug Metab. Dispos., 15, 773 (1987), Frei, E., et al.: Cancer Res., 48, 6417 (1988), Liu, Y., et al.: Bioorg. Med. Chem., 14, 2935 (2006),<br></p>

<p>Applications Esfenvalerate is the most potent insecticidal isomer of Fenvalerate (F279450), a pyrethroid insecticide used to control insects from food crops, animal feed and cotton products.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nakayama, I. et al.: Adv. Pestic. Sci., Plenary Lect. Symp. Pap. Int. Congr. Pestic. Chem., 2, 174 (1979); Mikami, N. et al.: Pest. Sci., 16, 46 (1985); Palmquist, K.R. et al.: Environ. Toxicol. Chem., 27, 1721 (2008);<br></p>

<p>Stability Hygroscopic<br>Applications An alpha agonist, causing constriction of conjunctival blood vessels. Used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.<br>References Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 2881 (2005), Sandri, G., et al.: Eur. J. Pharm. Biopharm., 62, 59 (2006), Rosenthal, R., et al.: J. Ocular Pharmacol. Ther., 22, 440 (2007), Sabio, S., et al.: J. App. Oral Sci., 16, 280 (2008),<br></p>

<p>Applications Antiarrhythmic (class IA). Sodium channel blocker.<br>References Adelstein, et al.: J. Med. Chem., 16, 309 (1973), Czeisler, J.L., et al.: J. Pharm. Sci., 74, 750 (1985), Taylor, E.H., et al.: Ann. Clin. Lab. Sci., 16, 289 (1986),<br></p>

<p>Applications 26-Deoxymonensin A Sodium Salt is a metabolite of Monensin (M515600, Na salt); a polyether antibiotic and coccidiostat.<br>References Pospisil, S., et al.: Appl. Environ. Microb., 60, 1561 (1994); Ashworth, D.M., et al.: J. Antibiot., 42, 1088 (1989);<br></p>

<p>Stability Air Sensitive<br>Applications Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.<br>References Sitar, D.S., et al.: J. Pharmacol. Exp. Ther., 184, 432 (1973), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 8, 351 (1979), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984), Atterwill, C.K., et al.: Food Chem. Toxicol., 29, 355 (1991),<br></p>

<p>Applications Coproporphyrin III-15N4 Tetramethyl Ester is a methyl ester derivative of Coproporphyrin III-15N4. Coproporphyrin I and III Tetramethyl Ester are nutritional requirements for the development of N. brasiliensis egg to third stage larvae. Coproporphyrin I and III Tetramethyl Ester are tetrapyrrole compounds excreted by Rhodobacter sphaeroides.<br>References Lida, K. et al.: Chem. Pharm. Bull., 55, 1067 (2007); Bolla, R. et al.: Comp. Biochem. Physiol. Part B, 48, 147 (1974)<br></p>

<p>Applications: Has been used as antiseptic, anthelmintic and counter-irritant in alopecia.<br>Dangerous Goods Info: Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Diggle, S., et al.: Chem. Biol., 13, 701 (2006), Tashiro, Y., et al.: J. Bacteriol.,190, 3969 (2008),<br></p>

<p>Applications Flunitrazepam is used as an hypnotic. This is a controlled substance (depressant).<br>References Sternbach, L.H., et al.: J. Med. Chem., 6, 261 (1963), Eidelberg, E., et al.: Neurology, 5, 223 (1965), Caplan, Y., et al.: J. Anal. Toxicol., 25, 396 (2001), Wood, M., et al.: Forensic Sci. Int., 150, 227 (2005),<br></p>

<p>Applications Methyl-1-Testosterone is a derivative of dihydrotestosterone. Methyl-1-Testosterone is a designer anabolic steroid that is on the world anti-doping agency’s (WADA) prohibited list.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Parr, M.K. et al.: Endocrinology, 152, 4718 (2011); Liu, Y. et al.: Drug Test. Anal., 3, 54 (2011); Jeon, B.W. et al.: Anal. Bioanal. Chem., 401, 1353 (2011);<br></p>

<p>Stability Air sensitive, Material darkens in storage with no loss in purity<br>Applications Aniline is used in the manufacture of dyes, medicinals, resins, varnishes, perfumes, as a vulcanizing rubber or even as a solvent (1,2). Hazardous and noxious substance which affects the early life stages of marine animals (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Dyes and metabolites, Environmental Testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Barkov, A. et al.: Russ. Chem. Bull. 2012. Aug:61(8) pp1564-92. Zhang, X. et al.: Synthesis. 2013 45(10): 1357-13633. Cunha, I. et. al.: Environ. Sci. Pollut. Res. Int. 2017 Mar 10.<br></p>

<p>Applications An antitumor agent which also acts as a chemosterilant for male houseflies and other insects. Antineoplastic.<br>References Chang, S.C., et al.: Science, 144, 57 (1964), Ames, M.M., et al.: Cancer Res., 39, 5016 (1979), D’Incalci, M., et al.: Br. J. Cancer, 41, 630 (1980),<br></p>

<p>Applications A novel antiplatelet agent; it is a third-generation thienopyridine. Antiplatelet agent Prasugrel showed greater platelet inhibition and decreased incidence of ischemic events than Clopidogrel but may induce increased incidence of bleeding in patient with acute coronary syndrome<br>References Von Beckerath, N., et al.: Circulation, 112, 2946 (2005), Jernberg, T., et al.: Eur. Heart J., 27, 1166 (2006), Farid, N., et al.: Drug Metab. Dispos., 35, 1096 (2007), Farid, N., et al.: Clin. Pharmacol. Ther., 81, 735 (2007), Jakubowski, J., et al.: J. Cardiovasc. Pharmacol., 49, 167 (2007), Wiviott, S., et al.: N. Engl. J. Med., 357, 2001 (2007),<br></p>

<p>Applications An inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells.<br>References Park, J.M., et al.: J. Urol., 162, 1110 (1999), Watson, M., et al.: Brit. J. Pharmacol., 127, 590 (1999)<br></p>

<p>Applications Antipruritic. Antibacterial, antimicrobial agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Robinson, et al.: J. Pharm. Pharmacol., 18, 19 (1966), Abdel-Moety, E., et al.: Eur. J. Pharm. Sci., 5, 1 (1997), Basavaiah, K., et al.: Chem. Pharm. Bull., 47, 1351 (1999),<br></p>

<p>Applications Nebivolol is a cardioselective beta-1 receptor blocking agent.<br>References Montoya, A., et al.: Oncotarget, 8, 6446-6460 (2017);<br></p>

<p>Applications Suxibuzone is a prodrug of the non steroidal anti inflammatory drug phenylbutazone. It is a drug used for joint and muscular pain.<br>References Monreal, L., et al.: res. Vet. Sci., 76, 145 (2004); Mizushima, Y., et al.: Pharm., 25, 39 (1982); Yasuda, Y., et al.: J. Pharm. Sci., 71, 565 (1982)<br></p>

<p>Applications Thiram is an ectoparasiticide. Thiram is used in agriculture to prevent fungal diseases in seed and crops. Thiram has other applications ranging from use as a topical bactericide to animal repellent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sahni, M.L. et al.: Ind. Phytopathol., 20, 71 (1967); Vir, D.: Pesticide, 11, 39 (1977); Welch, J.F. et al.: Plant. Dis. Rep., 35, 57 (1952);<br></p>

<p>Applications Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitric oxide donor.<br>References Tanayama, S. et al.: Xenobiotica, 4, 175 (1974); Yamada, M. et al.: Chem. Pharmac. Bull., 35, 3390 (1987); Messin, R. et al.: Adv. Ther., 23, 107 (2006);<br></p>

<p>Applications Labelled analog of Nilotinib (AMN1O7), which might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>

<p>Applications Quinmerac-3,8-dicarboxylic Acid is a impurity of Quinmerac (Q696500(P)) which is a Auxin-type herbicide.<br>References Grossmann, K., et al.: J. Exp. Bot., 52, 1811 (2001),<br></p>

<p>Applications Olanzapine is a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic. Neuroprotective product.<br>References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)<br></p>

<p>Applications 2-[4-(2,4-Dichloro-5-hydroxyphenoxy)phenoxy]propanoic Acid Methyl Ester, is the metabolite of Diclofop-methyl, used as a herbicide.<br>References Tanaka, F. S., et al.: J. Agri. Food Chem., 38, 553 (1990);<br></p>

<p>Applications O,O-Dimethyl-d6 Dithiophosphate is the isotope labelled analog of O,O-Dimethyl Dithiophosphate (3, an dimethyl phosphorodithiolate derivatives used as insecticides.<br></p>

<p>Applications Labelled Tamsulosin. Specific α1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy.<br>References Kawabe, K., et al.: J. Urol., 144, 908 (1990), Abrams, P., et al.: Br. J. Urol., 76, 325 (1995), Michel, M.C., Expert Opin. Pharmacother., 5, 151 (2004),<br></p>

<p>Applications Terbufoxon Sulfoxide is a metabolite of Terbufoxon (T109075), a pesticide used in the protection of fruit and vegetable crops against insects. Acetylcholinesterase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rahman, Md. M. et al.: Food Chem., 133, 604 (2012); Stojan, J. et al.: Biochem., 5599 (2008); Polgar, L. et al.: J. Chrom. A., 1249, 83 (2012);<br></p>

<p>Applications S-Benzyl di-sec-Butylthiocarbamate is an herbicide used in fruits and vegetables.<br>References Wang, Z. et al.: Anal. Meth., 7, 6358 (2015);<br></p>

<p>Applications Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),<br></p>

<p>Applications 4,4'-Dichlorodiphenyltrichloroethane is a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyltrichloroethane functions by opening sodium ion channels in the insects’ neurons, causing them to fire spontaneously which in turn leads to death. 4,4'-Dichlorodiphenyltrichloroethane is banned for agricultural use in North America, it is still commonly used in some countries and particularly as a means of malaria control.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Balkew, M. et al.: Paras. Vect., 3, No pp. given (2010); Kikankie, C.K. et al.: Malaria J., 9, No pp. given. (2010); Battu, R.S. et al.: Sci. Total Environ., 78, 173 (1989);<br></p>

<p>Applications Bispyribac is used as a herbicide for the prevention and control of weeds.<br>References Alister, C., et al.: Crop Prot., 25, 202 (2006), Chandi, G., et al.: J. Food Eng., 79, 592 (2007), Wilkowska, A., et al.: Food Chem., 125, 803 (2011),<br></p>

<p>Applications Labelled Tiludronic Acid (T441250). A biphosphonate bone resorption inhibitor.<br>References Fraser, W.D., et al.: Postgrad. Med. J., 73, 496 (1997),<br></p>

<p>Applications Controlled substance (depressant). Anxiolytic.<br>References Schwartz, M.A., et al.: J. Pharm. Sci., 62, 1776 (1973), Chalmers, P., et al.: Anesthesia, 39, 370 (1984), Hassan, M.M., et al.: Anal. Profiles Drug Subs., 16, 1 (1987),<br></p>

<p>Applications PhIP (A617000) derivative. Carcinogen.<br></p>

<p>Applications The main metabolite of Entacapone and Tolcapone.<br>References Mannisto, P., et al.: Prog. Drug Res., 39, 291(1992), Nishi, H., et al.: J. Pharm. Biomed. Anal., 11, 1277 (1993), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),<br></p>

<p>Applications Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic.<br>References Assmann, I., et al.: Curr. Med. Res. Opin., 13, 325 (1995), Trausch, B., et al.: Biopharm. Drug Dispos., 16, 403 (1995),<br></p>

<p>Applications A metabolite of Daunorubicin. Used as an antineoplastic. Complexes with DNA. Inhibits DNA and RNA synthesis.<br>References Mizuno, N.S., et al.: Cancer Res., 35, 1542 (1975), Munger, C., et al.: Cancer Res., 48, 2404 (1988), Kobayashi, Y., et al.: J. Biol. Chem., 275, 17639 ( 2000), Burke, B., et al.: Cardiovasc. Toxicol., 2, 41 (2002),<br></p>

<p>Applications NS-398 is a selective Cox-2 inhibitor neuroprotective agent.<br></p>

<p>Applications Fluticasone Propionate-d5 is the labeled analogue of Fluticasone Propionate (F599500), a derivative of Flumethasone. An antiallergic; anti-asthmatic; anti-inflammatory.<br>References Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990); Mitchison, H.C., et al.: Gut, 32, 260 (1991); Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)<br></p>

<p>Applications Chloroxuron<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Daidzein-3',5',8-d3 is labelled Daidzein (D103500) which is an inactive analog of Genistein (Cat. #G350000). It blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity.<br>References Jones, P., et al.: J. Biol. Chem., 274, 32008 (1999), Hassan, M., et al.: Anticancer Res., 19, 5657 (1999), Salti, G., et al.: Eur. J . Cancer, 36, 796 (2000).<br></p>

<p>Applications 1,2,3-Benzotriazin-4(3H)-one is part of a group of compounds that exhibit antimicrobial activity. 1,2,3-Benzotriazin-4(3H)-one is also used as a reagent to synthesize 1,2,3-Benzotriazin-4-one-arylpiperazine derivatives, compounds that act as Serotonin (HCl: S274980) receptor ligands.<br>References Caliendo, G., et al.: Bioorg. Med. Chem., 8, 533 (2000); Kar, A., et al.: Pharmazie, 35, 466 (1980)<br></p>

<p>Applications Labelled Menthol. Used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.<br>References Ikaheimo, I., et al.: J. Antimicrob. Chemother., 46, 287 (2000), Gillet, Y., et al.: Lancet, 359, 753 (2002), Turos, E., et al.: Bioorg. Med. Chem. Lett., 2002, 12, 2229 (2002),<br></p>

<p>Applications cis-9-Hexadecenoylcarnitine Inner Salt is an L-carnitine metobolite which are often used to diagnose specific inherited metabolic diseases.<br>References Yang, S. et l.: J. Chrom. B., Anal. Tech. Biomed. Life Sci., 857, 251 (2007); Minkler, P. et al.: J. Chrom. B., Anal. Tech. Biomed. Life Sci. 1061, 128 (2017);<br></p>

<p>Applications Dichlorobenzenamine is used in the synthesis of effective inhibitors of plant δ1-pyrroline-4-carboxylate reductase. Also used in the preparation of anti-tumor agents based upon diaryl urea derivatives.<br>References Forlani, G. et al.: J. Agri. Food Chem., 61, 6792 (2013); Zhai, X. et al.: Molecules, 18, 2904 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Pirlimycin Hydrochloride (Mixture of Diastereomers) is a semi-synthetic lincosaminide antibiotic; structural analog of Clindamycin. Antibacterial.<br>References Ahonkhai, V.I., et al.: Antimicrob. Agents Chemother., 21, 902 (1982); Qadri, S.M.H., et al.: J. Antibiot., 36, 42 (1983); Birkenmeyer, R.D., et al.: J. Med. Chem., 27, 216 (1984);<br></p>

<p>Applications Fluoxetine (F597100) derivative.<br>References Cashman, J. et al.: Bioorgan Med. Chem. 17, 337 (2009)<br></p>

<p>Stability Hygroscopic<br>Applications N-(2-Ethyl-6-methylphenyl)-N-(2-sulfoacetyl)-L-alanine is a pesticide metabolite that is a pollutant found in in surface water and groundwater.<br>References Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013); Hand, L., et al.: Environ. Toxicol. Chem., 35, 1401 (2016);<br></p>

<p>Applications A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to benzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor. Controlled Substance.<br>References Mandrioli, R. et al.: Curr.Drug Metab., 8, 827 (2008); Nakazawa, Y. et al.: Psychopharmacol., 44, 165 (1975); Yakushiji, T. et al.: Br. J. Pharmacol., 98, 735 (1989);<br></p>

<p>Applications N-Acetylaminomethylphosphoric Acid is been found to show inhibitory properties towards ureases.<br>References Berlicki, L. et al.: Amino Acids, 42, 1937 (2012);<br></p>

<p>Applications 1-Naphthol-D7 β-D-Glucuronide Sodium Salt is the isotope labelled analog of 1-Naphthol β-D-Glucuronide Sodium Salt (N368000); a metabolite of 1-Naphthol.<br>References Redegeld, F., et al.: J. Pharmacol. Exp. Ther., 244, 263 (1988); Lohr, J., et al.: Pharmacol. Rev., 50, 107 (1998); Yokota, H., et al.: Biochem. J., 340, 405 (1999); Daidoji, T., et al.: Drug Metab. Dispos., 31, 993 (2003)<br></p>

<p>Applications Semi-synthetic cephalosporin antibiotic.<br>References Muggleton, et al.: Antimicrob. Agents Chemother., 253 (1968), Marrelli, L.P., et al.: Anal. Profiles Drug Subs., 4, 21 (1975),<br></p>

<p>Applications Labelled Bortezomib, which the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells.d6-3%d7-10%d8-86%<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005)<br></p>

<p>Stability Hygroscopic<br>Applications The antibiotics Fosmidomycin and FR900098 are members of a unique class of phosphonic acid natural products that inhibit the nonmevalonate pathway for isoprenoid biosynthesis. Both are potent antibacterial and antimalarial compounds.<br>References Altschul, S., et al.: J. Mol. Biol., 215, 403 (1990), Altschul, S., et al.: J. Mol. Biol., 215, 403 (1990), Noda, M., et al.: J. Biol. Chem., 279, 46143 (2004), Snow, R., et al.: Nature, 434, 214 (2005),<br></p>

<p>Applications Tebuthiuron is an nonselective broad spectrum herbicide used to control weeds, woody and herbaceous plants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abdel, G.M., et al.: Agr. Biol. J. North. Am., 3, 125 (2012); Pyvovarenko, T., et al.: Method. Molec. Biol., 754, 45 (2011);<br></p>

<p>Applications A labelled β1-Adrenergic blocker. Used as an antihypertensive.<br>References Van de Water, A., et al.: J. Cardiovasc. Pharmacol., 11, 552 (1988), De Cree, J., et al.: Angiology, 41, 95 (1990)<br></p>

<p>Applications Non-specific CNS stimulant; convulsant; narcotic antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),<br></p>

<p>Applications Labelled Tetrabenazine. Dopamine depleting agent. An antidyskinetic; antipsychotic.<br>References Schwartz, et al.: Biochem. Pharmacol., 15, 645 (1966), Janovic, J., et al.: Ann. Neurol., 11, 41 (1982), Janovic, J., et al.: Neurology, 38, 391 (1988),<br></p>

<p>Applications Brompheniramine (cas# 86-22-6) is a useful research chemical.<br></p>

<p>Applications Trimethyl Thiophosphate is one of the impurities of Diphos [3383-96-8]; Also, it is a reactant used in the synthesis of O,O-Dimethyl 5-[2,2,2-trichloro-1-(β,β,β-trichloro-α-hydroxyethylthio)ethyl]thiophosphate, which is used as an acaricides and fungicides.<br>References Perlova, T. G., et al.: Khimiya v Sel’skom Khozyaistve, 14, 24-25 (1976); Sohr, J., et al.: Ger. (East) (1976), DD 118884 A1 19760320<br></p>