Biochemicals and Reagents

<p>RG 102240 (RG) is a small molecule that inhibits GTPase-activating protein, which is a molecular switch that controls the activity of many proteins. RG binds to the target protein's ATP-binding site and prevents it from functioning. RG has been shown to inhibit the growth of cancer cells in culture and to downregulate the expression of genes involved in tumorigenesis. It has also been shown to have anti-inflammatory properties. In addition, it has been shown to act as an insulin-like growth factor receptor agonist, which may be useful for treating prostate cancer cells with multidrug resistance, and as an inhibitor of atp-dependent transport, which may be useful for treating cardiac disease.</p>

<p>2B-(SP) is a monoclonal antibody that inhibits the phosphorylation of proteins by inhibiting the activity of protein phosphatase. This, in turn, prevents activation of tyrosine kinases and blocks dopamine-induced locomotor activity. 2B-(SP) also blocks cholinergic signaling in h9c2 cells, which may be due to its ability to inhibit the enzyme acetylcholinesterase. 2B-(SP) has been shown to inhibit cardiac hypertrophy in vivo, as well as cardiac fibrosis and cardiomyopathy in rats.</p>

<p>Arphamenine B is a potent, selective, and reversible inhibitor of the protein tyrosine phosphatase 1B (PTP1B). Arphamenine B binds to PTP1B with high affinity and specificity. It is a useful tool for studying protein-protein interactions and protein function. Arphamenine B can also be used as an activator or ligand for receptors, especially G-protein coupled receptors. This peptide has been shown to inhibit ion channels such as calcium channels, potassium channels, and sodium channels.</p>

<p>MonoFITC INSL4 is a peptide that is used as a research tool. It is an activator of the Insulin-like Growth Factor Receptor 4 (IGF-1R) and can be used to study the protein interactions of the receptor. MonoFITC INSL4 has shown to inhibit the binding of insulin and IGF-1, which are ligands for the receptor. This peptide has also been shown to activate phosphatidylinositol 3-kinase, which is a cellular signalling pathway involved in many cellular processes such as proliferation and apoptosis.</p>

<p>III-31-C is a complex chemical compound, which is synthetically derived, with specific molecular architecture designed to facilitate targeted interactions at a biochemical level. It predominantly originates from a series of controlled laboratory reactions involving precursor chemicals that are meticulously purified to ensure high efficacy and consistency.</p>

<p>(S)-ML753286 is a chiral small molecule antagonist, which is a synthetic compound with potential applications in biochemical research. It primarily originates from the study of receptor-ligand interactions and is known for its particular efficacy in modulating specific signaling pathways.</p>

<p>ZSET1446 is a zirconium oxide particle that contains dopamine. It is used for the treatment of neurodegenerative disorders, such as Parkinson's disease and schizophrenia. ZSET1446 has been shown to enhance the response of acetylcholine in mouse strains with a mutation in the α7 nicotinic acetylcholine receptor. This potentiation of cholinergic responses may be due to its ability to bind to dopamine receptors on the cell surface or its ability to act as an agonist at these receptors. ZSET1446 has also been shown to have psychotic effects, which may be due to its ability to bind to dopamine receptors on neurons. Chronic oral administration of this drug has been shown to result in potentiation of α7 nicotinic acetylcholine receptors and can lead to increased risk for psychosis.</p>

<p>MX69 is a compound that inhibits the BCL-2 protein. It was developed as an anti-cancer drug, but has also been found to have an inhibitory effect on PD-L1 and pd-l1. MX69 has shown to reduce the mitochondrial membrane potential of cancer cells, causing cell apoptosis. It also reduces pro-apoptotic proteins, such as Bax and Bak, which are involved in programmed cell death. This drug is low potency and does not kill healthy cells in culture. MX69 has been shown to be effective against chemotherapy resistance and can stabilize the protein Bcl2 in cancer cells with high levels of this protein.</p>

<p>PYBG is a protein-based analog that has been developed as an anticancer agent. It works by inhibiting specific kinases that play a role in cancer cell growth and survival. PYBG has shown potent activity against various types of cancer cells, including those from human origin. In Chinese medicinal practices, PYBG has been used to treat urinary tract infections and other ailments. This protein-based inhibitor has also been found to induce apoptosis in cancer cells, leading to the death of these cells and preventing the progression of tumors. PYBG is a promising new therapy for cancer treatment due to its ability to disrupt the cell cycle and inhibit tumor growth.</p>

<p>(R)-CR8 is an analog of the natural amino acid L-cysteine. In vivo, (R)-CR8 is converted to cysteine, which functions as a precursor for other important biological molecules, such as glutathione, taurine and S-adenosylmethionine. (R)-CR8 has been shown to protect neurons from apoptotic cell death induced by chronic exposure to high levels of glutamate or oxygen deprivation. It also has neuroprotective properties in vivo in an animal model of Parkinson's disease. The pharmacokinetic properties of (R)-CR8 have been studied in vivo and in vitro human cells, and it has been shown to be well tolerated when administered orally at doses up to 1 g/kg body weight.</p>

<p>CMPD101 is a dopamine receptor agonist that has been shown to have antimicrobial effects. It has a pyrazole ring that binds to the cation channel, which causes an increase in the permeability of the membrane to potassium ions and leads to cardiac arrest. CMPD101 is also able to bind to other receptors such as oxytocin, CB2, and d2 dopamine receptors. This compound has been shown in vivo treatment for metabolic disorders and autoimmune diseases as well as having pharmacokinetic properties.</p>

<p>MM 47755 is a natural compound that has demonstrated inhibitory activity against the enolate of glycopeptide antibiotics. It is an enantiopure molecule, which means it is composed of a single type of chiral center. MM 47755 is an inhibitor of bacterial enzymes that are involved in the synthesis and degradation of glycopeptide antibiotics. MM 47755 binds to these enzymes (enolases) in a manner similar to those of the natural substrate, slowing down their metabolic activity and leading to inhibition.</p>

<p>BRL 15572 is a 5-HT7 receptor agonist that is used to treat migraine, chronic pain, and other conditions. It has been shown to be effective in animal models of analgesia and as an antinociceptive agent. BRL 15572 binds to the 5-HT2A receptor and inhibits the release of gamma-aminobutyric acid (GABA) from the tegmental area in rats, which may be responsible for its antimigraine properties. The drug also reduces the production of serotonin in the brain by blocking 5-HT1 receptors. BRL 15572 has been shown to be effective against HIV infection, although it does not bind to HIV itself. The drug has a high affinity for 5-HT7 receptors and blocks the influx of calcium ions into cells, leading to reduced production of nitric oxide in neurons. This effect can be seen using optical imaging techniques when measuring changes in calcium concentrations within cells following exposure to BRL 15572.</p>

<p>Inhibitor of adenylate kinase</p>

<p>Quinaprilat hydrate is a prodrug of quinapril that inhibits the activity of angiotensin-converting enzyme (ACE). Quinaprilat hydrate has been shown to be effective in reducing blood pressure and improving symptoms of congestive heart failure. The oral prodrug is converted to the active form, quinapril, by esterases in the bowel. This process can be inhibited by drugs such as cimetidine, which blocks the activity of esterases. Quinaprilat hydrate has been found to have antioxidative properties, which may reduce myocardial infarct size and improve cardiac function in vitro. The drug also reduces levels of a protein called PSCK9 that can lead to high cholesterol and heart disease.</p>

<p>PVHD121 is a potent anticancer agent that belongs to the group of spindle poisons. It is a molecular probe that binds to microtubules and inhibits their assembly. This results in the loss of cell shape, nuclear fragmentation, and cell death. PVHD121 has been shown to be more potent than colchicine at high concentrations in the treatment of cancer cells. It also inhibits the proliferation of HCT116 cells and induces chromosome segregation in human lung cancer cells.</p>

<p>Monoclonal antibody for treatment of eosinophilic asthma</p>

<p>Leptin is a protein hormone that is produced by fat cells. Leptin regulates appetite and energy use, and it has been shown to be involved in the regulation of body weight. Leptin binds to receptors on the surface of cells, which activates signaling pathways inside the cell. This receptor can be activated by other ligands such as ghrelin, adiponectin, and insulin. Leptin also inhibits ion channels in neurons, resulting in an increase in potassium conductance.</p>

<p>BMS-779788 is a drug for the treatment of dyslipidemia and other conditions. It has been shown to inhibit the constitutive androstane receptor, which is involved in inflammation and oxidative stress. BMS-779788 also inhibits the synthesis of fatty acids, leading to an increase in the production of high-density lipoprotein cholesterol. This agent has also been shown to be effective against statins-resistant patients with hypercholesterolemia. BMS-779788 is currently being investigated as a potential therapeutic agent for cardiovascular disorders such as atherosclerosis, myocardial infarction, and stroke.</p>

<p>Estrogen receptor agonist; macrolide</p>

<p>Duocarmycin DM is an anticancer drug that selectively targets cancer cells and induces apoptosis. It works by binding to the minor groove of DNA and forming a covalent bond with adenine, which leads to DNA damage and ultimately cell death. Duocarmycin DM has been shown to be effective against a variety of human cancer cell lines, including those resistant to other chemotherapeutic agents. This drug also inhibits kinases involved in tumor growth and angiogenesis, making it a promising candidate for cancer therapy. Duocarmycin DM has been studied as an analog to artesunate and chloroquine in Chinese patients with cancer. Inhibitors of this drug have been identified in urine samples from patients receiving treatment, indicating its potential as a therapeutic agent for the treatment of cancer.</p>

<p>Src Inhibitor 1 (SI1) is a molecule that inhibits the activity of src, which is a tyrosine kinase. It has been shown to inhibit the growth of cancer cells and reduce the mitochondrial membrane potential in cardiac cells. Src inhibitor 1 also inhibits protein synthesis and reduces inflammation in mice by blocking epidermal growth factor receptor signaling. SI1 binds to ATP and blocks its binding to DNA, thereby inhibiting DNA synthesis. This inhibition can be reversed by adding dNTPs or dextran sulfate. SI1 has also been shown to have antioxidant effects by inducing mitochondrial superoxide dismutase activity.</p>

<p>A 1120 is a growth factor that has been shown to accelerate the production of lipofuscin, a pigment present in eye cells. A 1120 is also known to react with boron nitride and produce an analytical method for the detection of hydrogen. A 1120 has been found to have eye-protective effects, which may be due to its ability to inhibit the accumulation of lipofuscin and prevent oxidative damage in photoreceptor cells. In addition, A 1120 can prevent degeneration of retinal ganglion cells in animal models and can improve visual function in patients with macular degeneration.</p>

<p>Interferon-beta 1a is a cytokine that is used to treat multiple sclerosis and other diseases. It is the product of human recombinant DNA technology and has been shown to be an effective treatment for MS. Interferon-beta 1a inhibits the growth of neuroblastoma cells by inducing apoptosis, or programmed cell death. The drug also down-regulates the expression of proinflammatory cytokines in sh-sy5y neuroblastoma cells. Interferon-beta 1a has been shown to inhibit the proliferation of CHO (Chinese Hamster Ovarian) cells in vitro and may have therapeutic potential for the treatment of breast cancer, colorectal cancer, and ovarian cancer.</p>

<p>Dimetacrine is a drug used to treat patients with clinical conditions, such as infectious diseases, which are characterized by high levels of hydrochloric acid in the body. Dimetacrine prevents the accumulation of hydrochloric acid by binding to the enzyme that controls its production. Dimetacrine has been shown to be beneficial in clinical studies for patients with chronic schizophrenia and autoimmune disease. Clinical response rates were significantly higher than those seen in placebo-treated patients. The mechanism of action is not fully understood, but it appears that dimetacrine inhibits the formation of hydroxyl radicals and reduces inflammation in patients with autoimmune diseases.</p>

<p>PS77 is a processable antimicrobial agent that inhibits the growth of bacteria by binding to their ribosomes. It has been shown to have an effect on thrombocytopenia in rats, which may be due to its inhibition of the production of gene products. PS77 binds to the ribosome and prevents protein synthesis, thereby inhibiting bacterial growth. This drug also has been shown to increase the production of retinoic acid, which may be due to its ability to inhibit fructan metabolism. PS77 has been shown to bind polydentate ligands and can potentially serve as a new target for antibiotic development.</p>

<p>Please enquire for more information about Desmethylene paroxetine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Idarubicinol is an analog of the anticancer drug idarubicin and is known for its potent apoptotic effects on cancer cells. It works by inhibiting protein kinases, which are enzymes that play a crucial role in cancer cell growth and division. Idarubicinol has been shown to be effective against a wide range of human cancers, including Chinese hamster ovary (CHO) tumors. This medicinal compound has been identified in urine samples from patients undergoing chemotherapy with idarubicin, indicating that it may play a role in the treatment of cancer. As an inhibitor of kinases, Idarubicinol has potential as a therapeutic agent for the treatment of various types of cancer.</p>

<p>Inhibitor of glutaminyl cyclase QPCT</p>

<p>PTC-209 HBr is a raman, interferometry, gravitational, and experimentally measured constant. It is the newtonian scheme of the systematic atomic constant. PTC-209 HBr was calculated by using the quantum theory of atoms to determine the constant of gravity. The quantum theory of atoms is a systematic scheme that uses quantum mechanics to describe properties and behavior of atoms.</p>

<p>Inhibitor of aldose reductase</p>

<p>Diazepinomicin is an amide antibiotic that binds to the benzodiazepine receptor, which is a ligand-gated ion channel. Diazepinomicin has been shown to be an effective agent in the treatment of solid tumours and cervical cancer. It is a reactive molecule that interacts with hydroxyl groups on proteins, leading to cell death. Diazepinomicin inhibits farnesyl diphosphate (FPP) synthesis, which is required for the production of many cellular components such as proteins and cholesterol. The inhibition of FPP synthesis causes a decrease in mitochondrial membrane potential, leading to cell death.</p>

<p>Ovalicin is a peptide that has been used in research as an activator. It is a potent and specific inhibitor of voltage-gated ion channels, such as nicotinic acetylcholine receptors. Ovalicin also interacts with other proteins, including receptor and ligand interactions, which have led to its use as a research tool for investigating protein interactions. Ovalicin can be used in pharmacology to study the effects of drugs on cells by measuring the change in ion channel activity.</p>

<p>Please enquire for more information about Mitotane-13C6 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Serotonin (5-HT2C) receptor agonist</p>

<p>TH1760 is a microdialysis probe that is used to measure the concentration of cortisol in human body fluids. The probe consists of a semipermeable membrane and an electrochemical cell. It is used for the diagnosis of psychotic disorder, liver disease, and cancer. The probe has been shown to accurately measure cortisol levels in humans with symptoms of depression and anxiety. TH1760 has also been shown to be a valid biomarker for bladder cancer.</p>

<p>Alniditan is a diagnostic agent that is used for the detection of 5-HT1A receptors in vivo. It has been shown to be an absorption enhancer and is able to cross the blood-brain barrier. Alniditan binds to the 5-HT1A receptor, which is a neurotransmitter receptor that regulates mood, appetite, and sleep. Alniditan has been shown to inhibit the production of messenger RNA (mRNA) in rat hippocampal formation cells, as well as its binding with human serum proteins. This drug also has a high affinity for fatty acid receptors and exhibits agonist activity at these sites.</p>

<p>Rac1 is a member of the Rho family of small GTPases that regulates many cellular processes, such as cell movement, apoptosis, and transcription. Rac1 has been shown to regulate the activity of ion channels and ligand-gated ion channels. This protein also plays a role in signal transduction by activating phospholipase C and regulating the activity of other proteins such as tyrosine kinases. Rac1 is activated by peptides containing arginine-glycine-aspartate (RGD) motifs and is inhibited by antibodies against this protein. Rac1 has been shown to activate the transcription factor CREB, which is important for synaptic plasticity. Rac1 is expressed in high levels in neurons, cardiac muscle cells, macrophages, and some epithelial cells. This protein has been used to study cell biology and pharmacology because it can be easily purified from human sources using Gst tagged recombinant human Rac1 (GST-Rac</p>

<p>Please enquire for more information about 1-[2-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-ethylurea including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Bisphenol A-d6 β-D-glucuronide is a metabolite of bisphenol A (BPA) that has been found to be detectable in human serum. In this study, the authors analyzed urine samples from women and found that BPA-d6 glucuronide was present in all samples, but not in the same concentrations. The concentrations ranged from 0.1 to 2.0 ng/mL, with higher concentrations being associated with women who had higher levels of BPA exposure. The authors also found that BPA-d6 glucuronide was detectable in human serum. This metabolite can be measured with an enzymatic reaction and a dilution method. It is recommended for future studies to determine whether or not BPA-d6 glucuronide is present in human urine samples from men as well as children and older adults.</p>

<p>Glyburide potassium is a drug that belongs to the class of sulfonylureas and is used as an oral hypoglycemic agent. It acts by stimulating pancreatic beta cells to release insulin. Glyburide potassium has been shown to increase intracellular Ca2+ levels, inhibit ATP-sensitive K+ channels, and stimulate enzyme activities in human erythrocytes. The drug also inhibits sodium carbonate-induced ionotropic gelation in aqueous solutions. Glyburide potassium has been shown to be a potent inhibitor of high-sensitivity C-reactive protein (hsCRP) activity in vitro. It also inhibits neuronal function in vitro through its effects on monoclonal antibodies.</p>

<p>Please enquire for more information about 17-Phenoxy trinor prostaglandin f2α including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-Epi-darunavir is a potent HIV protease inhibitor that blocks the cleavage of polyproteins that are necessary for the assembly and release of new viruses. It is an epimer of darunavir and has been shown to be more potent than its parent compound. 1-Epi-darunavir binds to the active site of HIV protease and prevents the formation of a complex between the enzyme and its substrate, leading to inhibition of HIV replication. This drug also inhibits ion channels, including calcium channels, potassium channels, sodium channels, and chloride channels. 1-Epi-darunavir has been shown to inhibit ligand binding to receptors in cell culture, such as peptides or antibodies.</p>

<p>Z-Leu-Leu-H aldehyde is a water soluble and non-toxic chemical compound that belongs to the class of heterocycles. It inhibits ion channels by binding to their receptor and also has a high affinity for ligand binding sites. Z-Leu-Leu-H aldehyde is used as a research tool in pharmacology, cell biology, and antibody production. It can be used to activate or inhibit the function of proteins in cells by acting as an agonist or antagonist, respectively. This chemical is also an inhibitor with high purity, which is suitable for use in protein crystallization experiments.</p>

<p>Palbociclib is a CDK4 inhibitor that is used to treat cancer. It inhibits the activity of Cdk4 and prevents cells from progressing through the cell cycle, leading to their death. Palbociclib has been shown to inhibit tumor growth in humans with breast cancer and other proliferative disorders. The drug binds directly to Cdk4, preventing it from phosphorylating its substrates. This inhibition leads to the accumulation of p27, which suppresses the activity of cyclin-dependent kinases (CDKs). Inhibition of CDKs prevents cells from entering mitosis and results in cell death by apoptosis.</p>

<p>Atovaquone is a medication used to treat chronic viral hepatitis and other conditions. It inhibits the synthesis of RNA by binding to the polymerase enzyme. This drug has been shown to be effective in treating patients with hepatitis and autoimmune diseases, such as lysis, cell lysis, and diagnosis. Atovaquone also has a role in the treatment of chronic HBV infection by inhibiting the production of viral DNA. Atovaquone is a prodrug that is converted into its active form, hydroxychloroquine (HCQ), by cytochrome P450 enzymes. HCQ is then converted into chloroquine (CQ) through further oxidation reactions. CQ can inhibit protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division.<br>ATPO has also been shown to have anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.</p>

<p>CZ415 is a novel, small molecule that inhibits the activity of collagen. CZ415 has been shown to inhibit the proliferation of cervical cancer cells and the growth of xenograft tumors in mice. It also inhibits tumor cell migration and invasion, as well as the formation of new blood vessels required for tumor growth. The underlying mechanism by which CZ415 inhibits tumor growth is through induction of autophagy, a process by which cells degrade their own proteins and organelles. In addition to its anti-cancer effects, CZ415 has been shown to reduce inflammation in lung fibroblasts in vitro and may be useful for treating autoimmune diseases or other conditions where inflammation is an issue.<br>CZ415 has not yet been tested on humans but initial studies indicate that it may be well tolerated with few side effects.</p>

<p>GNF-7 is a molecule that inhibits the bcr-abl kinase, which plays a key role in chronic myelogenous leukemia (CML) and some other cancers. GNF-7 binds to the ATP binding site of the bcr-abl kinase, inhibiting its activity. It also induces caspase-independent cell death by hydrogen bond interactions with amino acids in the ATP binding site. The study has shown that GNF-7 is effective on monocytes, myeloid leukemia cells, and inflammatory bowel disease cells. GNF-7 is a small molecule that can be synthesized by chemical methods and is thus cheaper than many other cancer drugs.</p>

<p>PF 04885614 is a potent and selective inhibitor of human potassium channels. The molecular mechanism of inhibition by PF 04885614 remains to be elucidated. In cell-based experiments, it was found that PF 04885614 binds to the extracellular domain of the hERG channel with high affinity and inhibits its function. This antibody is intended for use as a research tool in cell biology, peptides, pharmacology, ligand, activation, ion channels and life science.<br>PF 04885614 has been shown to react with mouse, rat and human erythrocytes as well as with bovine and porcine brain tissue.</p>

<p>AN3199 is a potent inducer of the dicarboxylic acid transporter DctP in E. coli. It induces the expression of dctP and thus increases the uptake of succinate from the environment. AN3199 is also able to modify growth rate and increase the transfer of DNA between cells. The mutant strain AN3199-2 has a modified profile that includes an increased growth rate and altered uptake, but not complementation or chromosomal modifications.</p>

<p>TAK-659 is a small molecule that has been shown to be highly selective for the epidermal growth factor receptor (EGFR). It inhibits the phosphorylation of EGFR and subsequent downstream signaling through protein kinases. TAK-659 may be used for the treatment of autoimmune diseases, including psoriasis, rheumatoid arthritis, and Crohn's disease. In addition, this drug has been shown to inhibit platelet aggregation and to stimulate hematopoietic cells in cancer patients. TAK-659 is also being investigated as a potential drug for the treatment of cancer due to its ability to inhibit cellular transformation.</p>

<p>GE-2270 A is a protein that has been shown to inhibit the cycle of Chinese hamster ovary cells. This inhibitor has also demonstrated anticancer activity against leukemia and other tumor cell lines. GE-2270 A is an analog of the kinase inhibitors, which are used in medicinal chemistry to target cancer cells. This protein has been found in human urine and has been shown to induce apoptosis in cancer cells. The potential use of GE-2270 A as a therapeutic agent for cancer treatment is currently being investigated.</p>

<p>MEK1 inhibitor</p>

<p>4-Bromoestrone is a synthetic estrogen that has been shown to be useful in the treatment of breast cancer. It has been used as an antineoplastic drug, which is a substance that slows the growth of abnormal cells. 4-Bromoestrone can be acetylated by a nitro group and then converted into 4-bromotamoxifen (4-BT), which is a potent anti-tumor agent. The structure of 4-bromoestrone resembles that of estrogens, but it lacks the C2 methyl group found on estradiol and other estrogens, which makes it more difficult for enzymes to convert it into other estrogens. 4-Bromoestrone binds with high affinity to estrogen receptors and can activate them without requiring any cofactors or cofactors. This means that the drug has no effect on tissues that do not contain these receptors.</p>

<p>Anti Motilin (Porcine) Serum is a potent inhibitor of motilin, a peptide hormone that stimulates the gastrointestinal tract. The anti motilin serum is useful for pharmacological research as well as in cell biology, where it can be used to inhibit motilin-induced contraction in cultured cells. Anti motilin also serves as an excellent research tool for studying the regulation of other receptors and ion channels. It has been shown to activate these receptors and ion channels.</p>

<p>Parsaclisib hydrochloride is a research tool that is used to study the activation of receptors. It has been shown to be a ligand for the Tumor Necrosis Factor Receptor (TNFR) and the receptor for Advanced Glycation End-Products (RAGE). Parsaclisib hydrochloride can also inhibit ion channels, such as calcium channels, potassium channels, and chloride channels. In addition, it has been shown to bind to antibodies and peptides. The binding of this drug affects these proteins' functions in cell biology and pharmacology.</p>

<p>Resminostat is a small molecule that inhibits the transcriptional co-activator, pd-l1. It has been shown to be very effective at reducing the growth of squamous cell carcinoma cells in vitro and in vivo. Resminostat also reduces liver fat content and steatosis by inhibiting fatty acid synthesis. Resminostat has been shown to induce apoptosis in cancer cells through inhibition of nuclear DNA replication, which leads to decreased production of proteins required for cell division. This drug has not been tested on humans but is being investigated as a potential treatment for hepatic steatosis, a condition characterized by excess fat accumulation in the liver.</p>

<p>Formoterol fumarate is a long-acting bronchodilator that is used to treat asthma and chronic cough. It works by relaxing the muscles in the airways, which makes breathing easier. Formoterol fumarate can be administered as a dry powder inhaler or as an oral inhalation solution. The most common side effects of this drug are headache, palpitations, and heart rate changes. Formoterol fumarate should not be taken by people with a history of heart disease or those who are at risk for it. Formoterol fumarate does not contain hydrogen fluoride (HF). Analysis of formoterol fumarate can be performed using chromatographic analysis, which involves separating the different components of a mixture based on their physical properties.</p>

<p>Stafia-1-dipivaloyloxymethyl ester is a research tool that may be used to study protein interactions. It can also be used in the development of new drugs for treating diseases such as Parkinson's, Alzheimer's, and schizophrenia. Stafia-1-dipivaloyloxymethyl ester is an activator of the G protein coupled receptors (GPCRs) and ion channels. Stafia-1-dipivaloyloxymethyl ester has been shown to be a specific ligand for the human GPCR receptor called the metabotropic glutamate receptor 2 (mGlu2). It binds to this receptor and activates it by increasing calcium ion influx. This process leads to the opening of ion channels, which causes an increase in neurotransmitter release from nerve cells.</p>

<p>Zatosetron is a peptide that acts as an activator of the 5-HT3 receptor. It has been shown to have the ability to inhibit ion channels and activate protein interactions. The binding of zatosetron to the 5-HT3 receptor leads to activation of phospholipase C, which in turn causes a release of calcium from intracellular stores. Zatosetron has also been shown to be an inhibitor of the ligand-gated ion channel, nicotinic acetylcholine receptor (nAChR). In addition, it binds with high affinity and selectivity to human serotonin receptors.<br>Zatosetron is used in research as a tool for studying cell biology, pharmacology, and protein interactions.</p>

<p>BPD-Ring B is a peptide that binds to the nicotinic acetylcholine receptors of the central nervous system. It is an antagonist with high specificity for the alpha7 subtype of these receptors. BPD-Ring B has been used as a research tool to study ion channels, receptor ligands, and protein interactions. It has also been used as a pharmacological probe to study ion channels in cell cultures and to investigate drug effects on neurotransmitter release.</p>

<p>Inhibitor of MAP4K4 kinases; cytoprotective</p>

<p>XE 991 dihydrochloride is a small molecule inhibitor, which is an experimental compound used primarily in neuroscience research. It is sourced synthetically and serves as a specific and selective blocker of the K_v7/M (KCNQ) potassium channels. The mode of action of XE 991 dihydrochloride involves binding to these channels, thereby inhibiting their activity and preventing potassium ion flow across neuronal membranes. This results in changes to neuronal excitability and membrane potential.</p>

<p>Tafluprost is a prostaglandin F2-alpha analog that has been shown to be an activator of the human EP4 receptor. Tafluprost binds to the EP4 receptor, which is found in many tissues and cells, including the eye. This binding activates the receptor, which causes increased levels of cAMP and PKA. These increase levels of cAMP and PKA cause vasodilation and reduced intraocular pressure. Tafluprost is used as an ophthalmic medication for the treatment of glaucoma.</p>

<p>Gemcabene calcium is a fatty acid that inhibits the formation of proteins and has been shown to be effective against atherosclerosis in animals. Gemcabene calcium also inhibits soluble guanylate cyclase and fibrinogen, which are regulatory proteins in the cell that are involved in blood clotting. The drug has been shown to have a positive effect on cardiovascular disease by reducing cholesterol levels, improving high-density lipoprotein (HDL) levels, and lowering low-density lipoprotein (LDL) levels. Gemcabene calcium analogs have been shown to be effective for treating metabolic disorders such as obesity. The drug is metabolized through hepatic cytochrome P450 enzymes, although there is no evidence of toxicity or teratogenicity from gemcabene calcium at doses up to 20 mg/kg per day.</p>

<p>Stanniocalcin-1 is a protein that belongs to the stanniocalcin family of proteins. It is expressed by a variety of tissues and has been shown to have chemotactic, pleiotropic, and adipogenic effects. Stanniocalcin-1 also regulates luteinization and homologous differentiation in cells. The recombinant form of this protein has been shown to stimulate the growth of cells in culture with high levels of expression. Additives such as deionized water and chromatographic techniques can be used to purify this protein.</p>

<p>PHA-680632 is a potent and selective small-molecule inhibitor of Aurora kinases, which are serine/threonine kinases involved in crucial processes during mitosis. Sourced from synthesized chemical compounds, this inhibitor specifically targets Aurora kinases A, B, and C, disrupting their role in cell cycle regulation. The mode of action involves binding to the ATP-binding site of these kinases, leading to the inhibition of their activity and subsequently arresting cell cycle progression at the mitotic phase.</p>

<p>An inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that reduces total cholesterol and low-density lipoprotein (LDL). Cerivastatin is cardioprotective and anti-atherosclerotic. Cerivastatin inhibits the expression of the atherosclerotic genes monocyte chemoattractant protein-1 (MCP-1) and C-C chemokine receptor type 2 (CCR2), whilst inducing the expression of Kruppel-like factor 2 (KLF2).</p>

<p>Leptin ELISA Kit is a sandwich ELISA for the quantitative measurement of mouse leptin in rat serum. Leptin is a 16-kDa peptide hormone that regulates energy balance and body weight. It is produced by adipose tissue, and circulates in the blood as a protein complex with high-density lipoprotein (HDL). The assay employs monoclonal antibodies (MAbs) to measure mouse leptin in rat serum. The Mabs are specific for the mouse leptin sequence, which allows them to selectively bind to the mouse leptin in rat serum. Quantitative measurements of mouse leptin can be made using standard colorimetric procedures.</p>

<p>16:0-09:0 (Aldo) pc is a metabolite of hexadecanoyl. It is produced from the oxidation of hexadecanoic acid and can be found in human urine. Hexadecanoyl is a fatty acid that can be found in various animal fats, including butter and cheese. 16:0-09:0 (Aldo) pc has been shown to have antioxidant properties, which may be due to its ability to inhibit lipid peroxidation by binding reactive oxygen species.</p>

<p>Niraparib hydrochloride is an inhibitor of poly (ADP-ribose) polymerase, which is a key enzyme in the repair of DNA. It also inhibits the phosphorylation of histone H2AX at serine 139, which leads to cell cycle arrest and apoptosis. Niraparib hydrochloride has been shown to be effective against inflammatory lesions caused by radiation and platinum-resistant ovarian cancer. This drug has a synergistic effect with cisplatin in preclinical models for platinum-resistant ovarian cancer. Niraparib hydrochloride has also been evaluated as a potential biomarker for primary breast cancers by measuring its serum concentration in vivo using fluorescence imaging.</p>

<p>UNC3866 is a small molecule inhibitor that is synthetically derived. It acts specifically on the methyl-lysine binding activity of the chromatin-associated proteins CBX7 and CBX8. This particular mode of action involves mimicking the natural binding partners of these proteins, thereby disrupting their normal interaction with chromatin. Consequently, this inhibition modulates the transcriptional regulation associated with these proteins.</p>

<p>AMZ30 is a chemical inhibitor of the phosphatase enzyme, which plays an important role in the regulation of cell proliferation and differentiation. It is also a potential drug for cancer treatment. The effective dose was found to be 10 μM in clinical studies using cultured human muscle cells. AMZ30 was shown to inhibit the proliferation of tumor cells, showing promising results as a potential anticancer drug. AMZ30 has been shown to reduce cardiac hypertrophy by inhibiting the phosphatase that regulates cell growth and differentiation. This inhibition may be due to demethylation, which leads to activation of genes linked with cardiac hypertrophy.</p>

<p>Cblc000 trifluoroacetate is a synthetic peptide, which is derived from chemical synthesis with trifluoroacetic acid as a counterion. It functions by selectively interacting with target proteins, thereby modulating their activity. This interaction is influenced by its specific amino acid sequence, allowing it to bind with high specificity and affinity to particular protein domains, often disrupting or enhancing their biological function.</p>

<p>PTC299 is a monoclonal antibody that binds to the CD20 protein on the surface of lymphocytes. This binding prevents CD20 from transmitting signals, leading to apoptotic cell death. PTC299 has been shown to be effective in treating chronic lymphocytic leukemia and eye disorders. The most common side effects are headache, nausea, vomiting, diarrhea, dizziness, and fatigue.</p>

<p>YE-120 is a monoclonal antibody that binds to the extracellular domain of human Kv1.3 ion channel. It has been shown to inhibit the activity of this channel in vitro and in vivo. YE-120 is also an excellent research tool, which can be used for the study of protein interactions, ion channels, receptor pharmacology, peptides and ligands, or activation and inhibition mechanisms. YE-120 has high purity, which makes it suitable for cell biology and pharmacological experiments.</p>

<p>(24R)-MC 976 is a research tool that binds to the activator protein. It is a ligand for the receptor and has been shown to interact with ion channels, cell biology, and antibody. (24R)-MC 976 can be used as an anti-inflammatory agent, which may be due to its inhibition of prostaglandin synthesis.</p>

<p>SM 324405 is a long-acting ligand that has been shown to activate the toll-like receptor (TLR) and induce programmed cell death in cancer cells. SM 324405 has been shown to be an inhibitor of PD-L1 and inhibit the proliferation of tumor cells. It is also used as a treatment method for cancer, through immunotherapy, which increases the patient’s immune response to cancer cells. This drug is being studied for its ability to target specific types of cancers, such as melanoma and lung cancer.</p>

<p>Inhibitor of phosphodiesterase isoenzymes PDE3 and PDE4</p>

<p>VU0255035 is a drug that blocks the muscarinic acetylcholine receptor, which is used to treat diabetic neuropathy. The development of VU0255035 was based on the identification of a monoclonal antibody that selectively binds to the M1 muscarinic acetylcholine receptor and blocks its activity. VU0255035 has been shown to inhibit locomotor activity in animals, which may be due to its ability to inhibit acetylcholine release from cholinergic nerve endings. This drug also inhibits the production of inflammatory molecules such as nitric oxide and prostaglandin E2 in animal models. VU0255035 has also been shown to be effective in treating autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and psoriasis. In addition, it may have potential for cancer therapy as it has been shown to inhibit tumor growth and induce apoptosis in various cancer cell lines.</p>

<p>Tracazolate is a benzodiazepine-like drug that binds to the GABAA receptor and enhances the activity of GABA. It has anxiolytic effects in animals, which may be due to its ability to enhance the uptake of GABA into neurons. Tracazolate also has low bioavailability and is metabolized by esterases, leading to a short half-life. Tracazolate has been shown to inhibit locomotor activity in mice and antagonizes flunitrazepam binding sites with an IC50 of 6.5 μM.</p>

<p>A-674563 is an inhibitor that binds to the active site of the enzyme pyrazole ring and inhibits its activity. A-674563 has shown biological properties in vivo and in vitro, which may be due to its ability to inhibit cell signaling pathways. This molecule has been shown to inhibit tumor growth in xenograft models, inhibiting fetal bovine hepatocyte-like cells as well as human hepatocyte-like cells in vitro. A-674563 also inhibits the activity of radiation on cancer cells by inducing apoptosis. Structural analysis of this compound supports its binding mode at the pyrazole ring active site.</p>

<p>MRS 2179 is a novel, potent and selective antagonist of the P2Y1 receptor. It inhibits intracellular Ca2+ levels and neuronal death in vitro. MRS 2179 is also an antagonist of toll-like receptor 4 (TLR4), which has been implicated in the regulation of immune responses. MRS 2179 has been shown to inhibit axonal growth and energy metabolism in vitro, as well as receptor activity.</p>

<p>SR121566A is an inhibitor of the beta-adrenergic receptor. It is a peptide that binds to the alpha helix of the beta-adrenergic receptor. This binding prevents the agonist from binding to and activating the receptor. SR121566A has been shown to inhibit Gs protein activation, which results in a decrease in cAMP production, lowering cellular levels of cAMP. The peptide has also been shown to activate Gi protein, which leads to an increase in cyclic AMP hydrolysis and a decrease in intracellular calcium levels.<br>SR121566A is used as a research tool for investigating protein interactions and has been used as a ligand for understanding how receptors work. It is also used for studying ion channels and antibodies.br&gt;</p>

<p>Poly(ethylene glycol) bisazide is a ligand that is used in research and as a pharmacological tool. It has been shown to inhibit the receptor for peptides, which may be due to its ability to bind with antibodies. Poly(ethylene glycol) bisazide can also be used as a research tool to study protein interactions. This ligand is known to activate ion channels and receptors. Poly(ethylene glycol) bisazide has CAS number 82055-94-5 and is of high purity.</p>

<p>9-Epi-cinchonine is an alkaloid, which is a stereoisomer of cinchonine derived from the bark of cinchona trees. It is primarily used in studies related to stereochemistry and organic synthesis due to its unique molecular configuration. As a stereochemical analog, this compound plays a crucial role in the understanding of chiral interactions and reaction mechanisms. Scientists utilize 9-Epi-cinchonine in research settings to explore its behavior and interactions as it pertains to enantioselectivity and synthesis pathways. This compound's mode of action involves interacting with chiral molecules, allowing researchers to investigate its potential for asymmetric synthesis and chemical resolution processes.</p>

<p>Ispronicline is a nicotinic acetylcholine receptor (nAChR) agonist that binds to the α7-nAChR subtype. It has been shown to reduce the symptoms of cancer, such as depression and anxiety, by increasing the release of neurotrophic factors. Ispronicline may also be used in combination with other drugs, such as dimethyl fumarate or acetylcholinesterase inhibitors, for the treatment of neurodegenerative disorders. Ispronicline binds to nAChRs on central nervous system neurons and peripheral nerves. This binding enhances neurotransmitter release from nerve endings, which stimulates nicotinic receptors on adjacent cells, leading to an increased release of dopamine. Ispronicline has a terminal half-life of about 2 hours and is metabolized by CYP3A4 enzymes in the liver. Metformin hydrochloride can inhibit CYP3A4 enzyme activity and increase blood levels of is</p>

<p>(R)-Ranolazine is a potent inhibitor of kinases that has shown promise as an anticancer agent. It has been found to be effective against a variety of tumor cells, including those derived from human urine and Chinese hamster ovaries. (R)-Ranolazine works by inhibiting the activity of protein kinase C, which plays a key role in cancer cell growth and proliferation. This drug has also been shown to induce apoptosis in cancer cells, leading to their death. In addition to its anticancer properties, (R)-Ranolazine has been found to inhibit elastase, an enzyme involved in the breakdown of proteins. This inhibition may have potential therapeutic applications for conditions such as chronic obstructive pulmonary disease (COPD) and other inflammatory diseases. Overall, (R)-Ranolazine is a promising analog with potential therapeutic applications for cancer and other diseases involving abnormal kinase activity or inflammation.</p>

<p>ONO-8130 is a new, potent and selective agonist of the prostanoid receptor EP2. It has been shown to have a concentration-dependent antinociceptive effect in both anesthetized and non-anesthetized animals. In functional studies, ONO-8130 inhibits the spontaneous firing of neurons from the dorsal root ganglia (DRG) in a dose-dependent manner, which may be mediated by an action on EP2 receptors. ONO-8130 also inhibits the release of nociceptive neurotransmitters such as histamine from rat peritoneal mast cells. The drug has been found to have antihistaminic activity in rats but not in guinea pigs or mice. This may be due to its ability to activate EP2 receptors in the bladder muscle and/or its affinity for vascular endothelial cells that express EP2 receptors. These actions may account for its antihistaminic effects observed in rats but not mice or</p>

<p>Please enquire for more information about Protein kinase C (19-36) trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>PLX5622 is a small molecule that binds to the integrin receptor, which is a calcium-binding protein. It has shown efficacy in suppressing chronic oral irritation and restoring locomotor activity in animals. PLX5622 also reduces microglial activation and neuronal death. This drug also blocks the response of cells to colony-stimulating factor (CSF) by inhibiting CSF binding to its receptors on the cell surface. The effects of PLX5622 have been tested using fluorescein angiography and histological analysis in rats with experimental glaucoma.</p>

<p>Apelin-36 is a peptide that is a ligand for the APJ receptor. It has been shown to activate this receptor in vitro, as well as in vivo in rats and mice. Apelin-36 has also been shown to act as an inhibitor of the activity of the enzyme phosphodiesterase 4 (PDE4), which is involved in inflammatory responses.</p>

<p>Isofagomine is a chiral molecule that has been used as a model system for studying the stereochemical effects of enzyme inhibition. It is an inhibitor of the enzyme glucosylceramide synthase, which is involved in the synthesis of glucosylceramide (a major component of the myelin sheath). Isofagomine binds to an allosteric site on this enzyme and inhibits its activity. The binding site on glucosylceramide synthase has been mapped using X-ray crystallography and NMR spectroscopy. Isofagomine also inhibits other enzymes, such as phosphatidylethanolamine N-methyltransferase, which catalyzes the transfer of methyl groups from S-adenosylmethionine to phosphatidylethanolamine. Isofagomine has been shown to have neuroprotective properties against oxidative injury by reducing lipid peroxidation in rat brain cells. This may</p>