Heterocycles with Nitrogen (N)

<p>Applications Methyl 5-Hydroxy-2-benzimidazolecarbamate-d3, is a labeled analogue of Methyl 5-Hydroxy-2-benzimidazolecarbamate (M312585), which is a derivative of Carbendazim (C175900).<br>References Zeng, Z., et al.: J. Agric. Food Chem., 44, 3374 (1996), Lewis, D., et al.: Xenobiotica, 28, 235 (1998), Hodgson, E., et al.: J. Biochem. Mol. Toxicol., 21, 182 (2007),<br></p>

<p>Applications 2,3,5,6-Tetramethylpyrazolo[1,2-a]pyrazole-1,7-dione (cas# 68654-22-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-isobutyl-1H-pyrazole-3-carboxylic acid (cas# 1006493-64-6) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-4-piperidinopyrimidine<br></p>

<p>Applications 1-(4-Chlorophenyl)-3-[(2-nitrophenyl)methoxy]pyrazole is an intermediate for the synthesis of Pyraclostrobin-d6 (P840402). Isotope labelled Pyraclostrobin is a fungicide for use in seed grass and food crops.<br>References Gyldenkaerne, S., et al.: Pestic Sci., 55, 1210 (1999), Pennington, D., et al.: Environ. Sci. Technol., 39, 1119 (2005), Wang, S., et al.: Food Control., 18, 731 (2007),<br></p>

<p>Applications A pyrimidine derivative as inhibitor of Streptococcus faecium, Lactobacillus casei, and Pediococcus cerevisiae.<br>References Coats, E.A., et al.: Eur. J. Med. Chem., 14, 261 (1979),<br></p>

<p>Applications 6-Desamino-6-oxo Phenazopyridine is a Phenazopyridine (P313751) degradation product/impurity, and is a useful synthetic intermediate.<br>References Nickerson, B., et al.: J. Liq. Chromatogr., 18, 3947 (1995)<br></p>

<p>Applications Intermediate in the production of mutagenic pyrolyzates.<br>References Grassy, G., et al.: Eur. J. Med. Chem., 17, 109 (1982),<br></p>

<p>Applications (αE)-α-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β-oxo-1-piperidinepropanenitrile is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.<br>References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),<br></p>

<p>Applications 3-Amino-7-chlorobenzo[e][1,2,4]triazine 1-oxide is used as an intermediate in the synthesis of heterocyclic N-oxides and 1,2,4-benzotriazine series.<br>References Mason, J. C., et al.: J. Chem. Soc. B., 5, 911 (1970); Jiu, J., et al.: J. Org. Chem., 24, 813 (1959)<br></p>

<p>Applications Intermediate in the preparation of Omeprazole metabolites<br></p>

<p>Applications 5-(BROMOMETHYL)-2-NITROPYRIDINE (cas# 448968-52-3) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 5-Benzyl-1H-imidazole (cas# 4238-72-6) is a useful research chemical.<br></p>

<p>Applications 5-Cyclohexyl-2-piperidinecarboxylic Acid is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Benzoyl-1H-pyrrole-2-carboxylic Acid (cas# 15372-84-6) is a useful research chemical.<br></p>

<p>Applications A substituted pyrimidine used in the study for prediction of relative potency of ketone protease inhibitors using molecular orbital theory.<br>References Chan, A. W. E., et al.: Bioorg. Med. Chem., 4, 1673 (1996),<br></p>

<p>Applications 7-Chloro-N-[1-(methylsulfonyl)-4-piperidinyl]-4-quinazolinamine, is a building block used in chemical synthesis.<br></p>

<p>Applications 1-(2-chloro-5-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione (cas# 313069-92-0) is a useful research chemical.<br></p>

<p>Applications 5-(trifluoromethyl)dihydropyrimidine-2,4(1H,3H)-dione (cas# 2145-56-4) is a useful research chemical.<br></p>

<p>Applications 1-ACETYL-2-PIPERIDINEACETIC ACID (cas# 25393-20-8) is a useful research chemical.<br></p>

<p>Applications 1,2-Bis(2-(4,5-dihydro-1H-imidazol-2-yl)propan-2-yl)diazene Dihydrochloride is used as an initiator in the synthesis of ultra heigh relative molecular mass polyarcrylamide.<br>References Wang, L., et. al.: Hecheng Shuzhi Ji Suliao, 31, 37 (2014)<br></p>

<p>Applications 1-(N,N-Dimethylsulfamoyl)-1H-imidazole is an Imidazole (I350200) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 receptor.<br>References Wijtmans, M. et al.: J. Med. Chem., 51, 2944 (2008); Georgsson, J. et al.: J. Med. Chem., 50, 1711 (2007)<br></p>

<p>Applications Ethyl 4-aminopiperidine-1-carboxylate is a reagent used in various biosynthetic reactions.<br>References Fang, R.Q., et al.: Bioorg. Medn. Chem. Letters., 22, 5134 (2012);<br></p>

<p>Applications Benzotriazol-1-ylacetic Acid is used as a reagent in the synthesis of benzotriazole imidazoline compounds which are used as metal corrosion inhibitors. Benzotriazol-1-ylacetic Acid is also a reagent in the synthesis of N-(benzo[1,2,3]triazol-1-yl)-N-((benzyl)acetamido)phenyl carboxamides which are used as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors.<br>References Turlington, M., et al.: Bioorg, Med. Chem. Lett., 23, 6172 (2013); Chen, Y., et al.: Faming Zhuanli Shenqing. CN 103664902 A 20140326. Mar 26, 2014<br></p>

<p>Applications Methyl 4-Methylpyrrole-2-carboxylate is a useful reagent for preparation of (E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives, a novel class of glycine site antagonists.<br>References Balsamini, C., et al.: J. Med. Chem., 41, 808 (1998);<br></p>

<p>Applications O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate is used in the synthesis of tetrapeptoid analogues of the antiprotocoal compound Apicidin (A726300). Also used in the synthesis of acid based t-antigen glycodendrimers.<br>References Murray, P. et al.: Bioorg. Med. Chem. Lett., 11, 773 (2001); Roy, R. et al.: J. Am. Chem. Soc., 123, 1809 (2001);<br></p>

<p>Applications Used in the preparation of indoline derivatives as PERK inhibitors.<br></p>

<p>Applications N-Boc-4-(aminomethyl)piperidine is a protected 4-substituted piperidinecarboxylate used in the preparation of orally active platelet-activating factor antagonists as well as other biologically active compounds.<br>References Carceller, E. et al.: J. Med. Chem., 39, 487 (1996);<br></p>

<p>Applications Phenyl 4-Bromo-2-(ethyl-d3)pyridine-1(2H)-carboxylate is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.<br>References Li, X., et al.: PCT Int. Appl., WO 2014183520 A1 20141120 (2014)<br></p>

<p>Applications 5-(3-fluorophenyl)-4H-1,2,4-triazol-3-amine (cas# 502685-67-8) is a useful research chemical.<br></p>

<p>Applications imidazo[1,2-a]pyridin-7-amine hydrobromide (cas# 1630906-80-7) is a useful research chemical.<br></p>

<p>Applications 6-Phenoxypyridin-3-amine (cas# 25194-67-6) is a useful research chemical.<br></p>

<p>Applications Methyl 5-Bromo-1H-pyrrole-2-carboxylate is a chemical reagent used in pharmaceutical synthesis.<br>References Wang, M. et al.: Org. Biomol. Chem., 11, 2574 (2013); Xiang, H. et al.: RSC Adv., 3, 5807 (2013);<br></p>

<p>Stability Shock sensitive, temperature sensitive, light sensitive<br>Applications 4-Bromopyridazine Hydrobromide is a mono-substituted pyridazine derivative used in the preparation of γ-secretase modulators.<br>References Luebbers, T. et al.: Bioorg. Med. Chem. Lett., 21, 6554 (2011);<br></p>

<p>Applications B-(5-Formyl-2-pyridinyl)boronic Acid is used as a reagent in the preparation of (hetero)biarylsulfonamides as κ opioid antagonists with selectivity over the μ receptor.<br>References Verhoest, P. R., et al.: J. Med. Chem., 54, 5868 (2011);<br></p>

<p>Applications N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine is used as a reactant in the synthesis of Pimavanserin.<br>References Wan, Yongqing, et al.: Faming Zhuanli Shenqing, CN 106588753 A 20170426 (2017)<br></p>

<p>Applications N-Boc-3-(1-cyano-2-ethoxy-2-oxoethylidene)-1-piperidine is a useful synthetic intermediate.<br></p>

<p>Applications 2-((5-Chloropyridin-2-yl)amino)-2-oxoacetic Acid is a reactant or reagent used in the synthesis of the blood coagulating enzyme factor Xa (FXa) inhibitor.<br>References Xue, T., et al.: J. Med. Chem., 57, 7770 (2014);<br></p>

<p>Applications 2-Amino-6-bromopyridine is a disubstituted pyridine used as a building block in the preparation of nitrogen containing bicyclic and polycylic compounds.<br>References Da Settimo, A. et al.: Farm. Ed. Sci., 33, 770 (1978); Cai, L. et al.: Synthesis, 1, 133 (2006);<br></p>

<p>Applications 3,5-Dimethyl-1-phenyl-1H-pyrazole is a reactant used in the synthesis of hedgehog enzyme inhibitors SANT-1 and GANT-61 as anticancer agents.<br>References Chenna, V., et. al.: J. Environ. Sci. Heal. A., 49, 641 (2014)<br></p>

<p>Applications N-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-carboxamide hydrochloride (cas# 1219957-27-3) is a useful research chemical.<br></p>

<p>Applications 5-fluoro-4-hydrazino-2-methoxypyrimidine (cas# 166524-64-7) is a useful research chemical.<br></p>

<p>Applications 3-Amino-5-ethyl-5-phenylimidazolidine-2,4-dione (cas# 1139-11-3) could be useful for biological studies. An anticonvulsant.<br>References Lange, J., et al.: Pol. (1982), PL 123138 B1<br></p>

<p>Applications 2,3-Dichloropyridine-5-boronic acid<br></p>

<p>Applications Intermediate in the preparation of Cycloserine (C988800).<br></p>

<p>Applications 1,2-Dimethylpiperazine (cas# 25057-77-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Miyamoto, T., et al.: J. Med. Chem., 33, 1645 (1990),<br></p>

<p>Applications 5-Amino-3-methylisoxazole is a widely used reactant. 5-Amino-3-methylisoxazole has been used as a reactant for the preparation of heterocycle fused pyridinecarboxylic acids.<br>References Volochnyuk, D.M., et. al.: J. Comb. Chem., 12, 510 (2010)<br></p>

<p>Applications 2-Aminopyrimidine-5-boronic Acid Pinacol Ester is used in the preparation of phosphoinositide-3-kinases (PI3K) inhibitors.<br>References Burger, M.T. et al.: ACS Med. Chem. Lett., 2, 774 (2011); Heffron, T.P. et al.: J. Med. Chdem., 55, 8007 (2012);<br></p>

<p>Applications 4-Amino-2,2,6,6-tetramethylpiperidine-d17; 1-15N-1-oxyl (CAS# 97461-87-5) is a useful isotopically labeled research compound that is used in various experiments, such as, synthesis of two cysteine-specific spin labels.<br>References Wu,G. J. Label. Compd.Radiopharm., 12,1173-1181,(1995);<br></p>