Heterocyclic Compounds

<p>M02705 - 5-Bromo-3-indolyl-b-D-galactopyranoside</p>

<p>M02322 - Parthenolide</p>

<p>Applications Tetrahydrofuran-2,5-dicarboxylic acid (CAS# 6338-43-8) is a useful research chemical compound.<br></p>

<p>Impurity Abacavir - In House Impurity<br>Applications rac 2-Azabicyclo[2.2.1]hept-5-en-3-one (Abacavir - In House Impurity) is a useful reagent in the synthesis of carbocyclic sugar amines, carbanucleosides, and carbocyclic dinucleotide analogues (1). rac 2-Azabicyclo[2.2.1]hept-5-en-3-one is also an intermediate of Abacavir (A104990), a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Slama, J.T., et al.: Biochemistry, 27, 183 (1988) (2) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (3) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>

<p>Applications 4,4-dimethyldihydrofuran-2,3-dione (cas# 13031-04-4) is a useful research chemical.<br></p>

<p>Applications 6-Ethoxy-3-hydroxypyrazine-2-carboxamide is a useful intermediate for organic synthesis.<br></p>

<p>Applications N-Nitroso-4-hydroxy Pyrrolidone is an N-Nitroso impurity, Nitrosamines are known carcinogens in a wide range of animal species.<br>References Ohshima, H., et al.: Cancer Lett., 26, 153, (1985)<br></p>

<p>Applications oxazole-4-carbohydrazide (cas# 885274-12-4) is a useful research chemical.<br></p>

<p>Applications Phenazine methosulfate is a compound used to determine nitric oxide reductase activity. Used in the discovery of potent bromophenazine antibacterial agents against Staphylococcus.<br>References Watanabe, A. et al.: Neurosci., 339, 139 (2016);<br></p>

<p>Applications 2-(Thiophen-2-yl)acetamide is used in preparation of [18F]Maleimide-based Glycogen synthase kinase-3β ligands for positron emission tomography imaging.<br>References Lee, Katarzyna N., et al.: PCT Int. Appl., (2018);<br></p>

<p>Applications N-Nitroso-5-hydroxy Pyrrolidone is an N-Nitroso impurity, Nitrosamines are known carcinogens in a wide range of animal species.<br>References Ohshima, H., et al.: Cancer Lett., 26, 153, (1985);<br></p>

<p>Applications N,N'-Dimethylpiperazine is used in preparation of two-component raw material of high-strength Polyurethane Insulation pad for cold storage.Also, used in preparation of Methylaliphatic Amines from aliphatic Amines and Methanol.<br>References Dou, Z., et al.: Faming Zhuanli Shenqing, (2020); Li, F., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications N-Nitroso-3-hydroxy Pyrrolidone is an N-Nitroso impurity, Nitrosamines are known carcinogens in a wide range of animal species.<br>References Ohshima, H., et al.: Cancer Lett., 26, 153, (1985)<br></p>

<p>Applications Sulfinpyrazone sulfone can be used to help with atherosclerosis in various animals. This compound can be used in High Pressure-Liquid Chromatography.<br>References Lentjes,E.G., et.al., Pharm.Weekbl.7,252-259,(1986); Clopath, P.et.al., Cardiovasc.Actions Sulfinpyrazone: Basic Clin. Red., Proc.Int.Symp., 121-137,(1980);<br></p>

<p>Applications pyridazin-4-ylmethanol (cas# 50901-43-4) is a useful research chemical.<br></p>

<p>Applications N-2-Propyn-1-yl 1-Piperazinesulfonamide Hydrochloride is a chemical reagent used for synthesis of pharmaceuticals. Similar to 1-Prop-2-ynylpiperazine (P839243) a chemical reagent.<br>References Pajk, S. et al.: J. Enz. Inhib. Med. Chem., 35, 498 (2020);<br></p>

<p>Stability Hygroscopic<br>Applications 3-(1-Nitroethyl)-2-benzofuran-1(3H)-one (cas# 79017-08-6) is a useful research chemical.<br></p>

<p>Applications 2-Aminothiazole-4-carboxamide is a useful intermediate for organic synthesis and other chemical processes.<br>References Sanghvi, Y. S., et al.: J. Heterocycl. Chem., 25, 623 (1988); Wu, J., et al.: Bioorg. Med. Chem. Lett., 17, 4664 (2007)<br></p>

<p>Applications Methyl Hyroxy-2-(tetrahydro-2H-pyran-4-yl)acetate is a useful research intermediate for organic synthesis.<br></p>

<p>Applications Phenazine (cas# 92-82-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-carboxythiophene-3-boronic acid (cas# 5503-74-2) is a useful research chemical.<br></p>

<p>Applications Ethyl 1-Piperazine-d8-acetate 2HCl is a useful isotopically labeled compound<br></p>

<p>Applications (2,4-Dioxo-thiazolidin-3-yl)-acetic Acid is a useful compound for preparation of novel thiazolidinedione-​hydroxamates as Zmp1 inhibitors.<br>References Slachtova, V., et al.: Eur. J. Med. Chem., 185, 111812 (2020)<br></p>

<p>Applications 1-Ethylpyrrole (cas# 617-92-5) is a useful research chemical.<br></p>