Building Blocks

<p>(4-Fluorophenyl)(1H-indol-7-yl)methanone</p>

3-Fluoro-4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)aniline

<p>[1-(tert-Butoxycarbonyl)-4-(4-fluorophenyl)piperidin-4-yl]acetic acid</p>

5,7-Dichloro-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidine

<p>5-Chloro-3-(trifluoromethyl)-1,2,4-thiadiazole</p>

<p>tert-Butyl 6,6-difluoro-2-azaspiro[3.3]heptane-2-carboxylate</p>

2,2-Bis(trifluoromethyl)tetrachloro-1,3-dioxolane

<p>(2-Fluoro-benzyl)-methyl-piperidin-4-yl-amine hydrochloride</p>

(3-Fluoro-benzyl)-methyl-piperidin-4-yl-amine hydrochloride

<p>(4-Fluoro-benzyl)-methyl-piperidin-4-yl-amine hydrochloride</p>

<p>1-(5-Fluoro-pyrimidin-2-yl)-azetidine-3-carboxylic acid</p>

<p>1-(4-Fluoro-benzyl)-piperazine-2-carboxylic acid hydrochloride</p>

<p>1-(3-Fluoro-benzyl)-piperazine-2-carboxylic acid hydrochloride</p>

<p>4-(4-Fluoro-phenylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester</p>

<p>4-(4-Fluoro-phenylsulfanyl)-piperidine hydrochloride</p>

4-(6-Chloro-2-trifluoromethylpyrimidin-4-yl)morpholine

4-Chloro-1-(3-fluorobenzyl)-3-nitro-1H-pyrazole

1-[2-(4-Nitro-1H-pyrazol-1-yl)ethyl]-3-(trifluoromethyl)-1H-pyrazole

1-(2,5-Difluorophenyl)-N-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]methanamine

2-Trifluoromethylpyridine-5-boronic acid, pinacol ester

<p>Applications 3-Methyl-2-oxovaleric Acid is an α-ketomonocarboxylic acid that triggers insulin release by acting upon receptor sites which differ from those occupied by amino acids. 4-Methyl-2-oxovaleric Acid is an analogue of Isoleucine.<br>References Panten, U. et al.: Naun.-Schmied. Arch. Pharmacol., 291, 405 (1975); Funk, M.A. et al.: J. Nutrit., 117, 1550 (1987);<br></p>

<p>Applications cis-Aconitic Acid is the cis-isomer of Aconitic Acid. The conjugate base of cis-Aconitic Acid is an intermediate in the isomerization of citrate and isocitrate in the citric acid cycle.<br>References Suarez, M., et al.: Food. Nutri. Sci., 3, 705 (2012);<br></p>

<p>Applications A phytohormone.<br>References Quittenden, L., et al.: Plant Physiol., 151, 1130 (2009), Jiraskova, D., et al.: J. Phycol., 45, 108 (2009),<br></p>

<p>Applications Acrolein Diethyl Acetal is used as a reagent in quinoline synthesis by improved Skraup-Doebner-Von Miller reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1-(3-ACETYL-2-HYDROXY-5-METHYL-PHENYL)-ETHANONE (cas# 55108-28-6) is a useful research chemical.<br></p>

<p>Applications 1,3-Adamantanediol is used in the synthesis of novel dimethacrylate as possible dental monomers for dental resin mixtures.<br>References Wang, K. et al.: Mat. Sci. Eng. Mat. Biol. Appl., 32, 1141 (2012); Horino, Y. et al.: J. Mol. Catal. A. Chem.,<br></p>

<p>Impurity Ipratropium EP Impurity D<br>Stability Light Sensitive<br>Applications Atropic acid (Ipratropium EP Impurity D) is an impurity of Ipratropium bromide (I740500) and Atropine Sulfate (A794625).<br>References Lyon, R., et al.: J. Pharm. Sci., 95, 1549 (2006), Loch, M., et al.: Toxicology, 233, 229 (2007), John, H., et al.: Anal. Bioanal. Chem., 396, 751 (2010),<br></p>

<p>Applications Asiatic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Asiatic Acid is a neuroprotectant and induces of apoptosis in HepG2 human hepatoma cells.<br>References Zhou, J. et al.: Jiang. Dax. Xueb. Yixueb., 19, 475 (2009); Hsu, Y.L. et al.: J. Pharmacol. Exp. Ther., 313, 333 (2005);<br></p>

<p>Applications A naturally occurring nitrostable secondary amine found in tabacco smoke condensate.<br>References Singer, G.M. et al.: J. Agric. Food Chem. 24, 553(1976); Bush, L. P. et al.: Can. J. Plant Sci. 50, 289(1970).<br></p>

<p>Applications Arecoline has shown regulatory properties of controlling plasminogen activator inhibitor-1 expression in human buccal mucosa fibroblasts.<br>References Tsai, C.H., et al.: J. Oral. Pathol. Med., 44, 669 (2015);<br></p>

<p>Applications Shows some anti-viral activity due to the adamantane structure. In addition it shows anti-microbial activity and cytotoxic application.<br>References Aigami, K. et al.: J. Med. Chem., 18, 713 (1975); Aigami, K. et al.: J. Pharm. Res., 4, 1407 (2011);<br></p>

<p>Impurity Granisetron EP Impurity D<br>Applications Granisetron Impurity D.<br>References Bermudez, J., et al.: J. Med. Chem., 33, 1924 (1990),<br></p>

<p>Applications 1-Octyne was used as a mechanism-based inhibitor of AlkB (nonheme di-iron alkane monooxygenase).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Alonso, H., et al.: Appl. Environ. Microbio., 78, 7946 (2012)<br></p>

<p>Applications DIACETIN (cas# 25395-31-7) is a useful research chemical.<br></p>

<p>Applications An inhibitor of NADPH oxidase (an enzyme responsible for reactive oxygen species production) and is useful in the treatment of various inflammatory diseases.<br>References Imnpellizzeri, D. et al.: Biochem. Pharmac., 81, 636 (2011); Genovese, T. et al: Brain Res., 1372;<br></p>

<p>Applications Alizarin is used widely as a prominent red dye for textile facbrics. Alizarin red is now used in biochemical assay to determine quantitatively by colorimetry, the presence of calcific deposition by cells of the osteogenic lineage. Alzarine derivatives was evaluated as new inhibitors of the HIV-1 reverse transcriptase associated DNA polymerase and RNase H. Alizarin was also shown to inhibit proliferation, tumor growth and suppress tumorigenesis in human osteosarcoma and breast cancer cell representative for bone metastasis. Dyes and metabolites.<br>References Yuan, H.S., et al.: Mycol., 3, 100 (2012); Esposito, F. et al.: FEBS. J., 278, 1444 (2011); Fotia, Caterina, J. Orthop. Rsch. 30, 1486 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications Pentafluorobenzoyl Chloride is a useful analytical reagent in the derivatization amphetamines as well as other primary amines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koster, E. et al.: Analyst, 127, 598 (2002);<br></p>

<p>Stability Hygroscopic<br>Applications 1,6-Anhydrohexopyranoses have proven to be valuable synthons for the preparation of biologically important and structurally diverse products (e.g. rifamycin S, indanomycin, thromboxane B2, (+)-biotin, tetrodotoxin, quinone, and macrolide antibiotics) as well as for modified sugars.The chemical/physical/toxicological properties have not been thoroughly investigated. Since it is known to be a minor component of certain food materials it may be regarded as of relatively low toxicity.<br>References Fraser-Reid, B., et al. J. Am. Chem. Soc. 106, 731 (1984); Edwards, M.P., et al. J. Org. Chem. 49, 3503 (1984); Kelly, A.G., and Roberts, J.S. J. Chem. Soc., Chem. Commun. 228, (1980); Ogawa, T., et al. Carbohydr. Res. 57, C31 (1977); Isobe, M., et al. Tetrahedron Lett. 28, 6485 (1987); Fresnos, J.N. and Swenton, J.S. , J. Chem. Soc., Chem. Commun. 658, (1985); Kochetkov, N.K. et al., Tetrahedron Lett. 22, 4315, 4319 (1981); Georges, M. et al., Carbohydr. Res. 130, 115 (1984); Paulsen, et al., Chem. Ber. 114, 322 (1981).<br></p>

<p>Applications A nicotinic receptor agonist; brain rubidium efflux pharmacol.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Alkondon, M., et al.: J. Pharmacol. Exp. Ther., 271, 494 (1994); Wang, F., et al.: J. Biol. Chem., 271, 17656 (1996); Corringer, P., et al.: J. Neurosci., 18, 648 (1998);<br></p>

<p>Applications 1-AMINO-2-METHYLNAPHTHALENE (cas# 2246-44-8) is a useful research chemical.<br></p>

<p>Applications 4-Aminopiperidine is a useful reactant in organic synthesis.<br>References Park, Sun Jun, et al.: Bioorg. &amp; Med. Chem. Let., 27(18), 4399-4404 (2017);Le Manach, Claire, et al.: J. of Med. Chem., 59(21), 9890-9905 (2016)<br></p>

<p>Applications 4-(2-Amino-ethyl)-benzoic Acid is a useful reagent for the preparation of amino acid derivatives with anticancer activity.<br>References Kim, S., et al.: PCT Int. Appl. (2020), WO 2020204548 A1<br></p>

<p>Applications (3R)-3-Piperidinecarboxamide (cas# 168749-30-2) is a useful research chemical.<br></p>

<p>Applications 2-Aminothiazole is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds.<br>References Gallardo-Godoy, A., et al.: J. Med. Chem., 54, 1010 (2011); Lai, H., et al.: Antiviral. Res., 97, 74 (2013); Yamamoto, K.N., et al.: Environ. Molec. Mutagen., 52, 547 (2011);<br></p>

<p>Applications DL-Penicillamine is a penicillin metabolite used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.<br>References Marti-Prats, L., et al.: Neurosci. Lett., 483, 143 (2010); Singh, A., et al.: J. Pharm. Sci., 99, 3931 (2010); Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010)<br></p>

<p>Applications Pimelic Acid is a metabolite found in four biofluids from dairy cows that may be used as biomarkers of milk.<br>References Sun, H., et. al.: J. Proteome Res., 14, 1287 (2015)<br></p>

<p>Applications 2-Amino-4-(trifluoromethyl)benzenethiol Hydrochloride can be used as reactant/reagent in preparation of fused benzo-diazepinones/oxazocinone/thiazapines/diazapines/diazocins/thiazine/indoles via CuI-L-proline catalyzed SN2 reaction.<br>References Srinivasulu, V., et al.: Tetrahedron, 73, 2139 (2017)<br></p>

<p>Applications 1-Aminopyrene is used in the synthesis of novel fluorescent nanoscale ionic silicate platelets for use in bacterial detection and other biosensor applications.<br>References Lin, H.. et al.: ACS App. Mater. Inter., 7, 10771 (2015);<br></p>

<p>Applications 3-Methyluridine can be used in biological and analytical studies of comprehensive profiling of ribonucleosides modification by affinity zirconium oxide-​silica composite monolithic column online solid-​phase microextraction - mass spectrometry analysis.<br>References Jiang, H., et al.: J Chromatogr A, 1462, 90 (2016)<br></p>

<p>Applications A Penicillin metabolite used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.<br>References Marti-Prats, L., et al.: Neurosci. Lett., 483, 143 (2010); Singh, A., et al.: J. Pharm. Sci., 99, 3931 (2010); Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications 3-Amino-3-azabicyclo[3,3,0]octane is used as a reactant in the synthesis of Gliclazide (G409875), a sulfonylurea hypoglycemic agent. Used as an antidiabetic.<br>References Duhault, J., et al.: Arzneimittel-Forsch., 22, 1686 (1972); Holmes, B., et al.: Drugs, 27, 301 (1984)<br></p>

<p>Applications Intermediate in the preparation of P2X7 antagonists<br>References Donnelly-Roberts, D., et al.: Neuropharmacol., 56, 223 (2009), Perez-Medrano, A., et al.: J. Med. Chem., 52, 3366 (2009),<br></p>

<p>Applications Antitumor effect potentiator and antitumor agent.<br>References Chelbova, et al.: Biochem. Pharmacol., 19, 1785 (1970), Collins, J., et al.: Clin. Pharmacol. Ther., 28, 235 (1980), Hoff, P., et al.: Anticancer Drugs, 9, 479 (1998), Backus, H., et al.: Oncol. Res., 12, 231(2000), Peters, G., et al.: J. Clin. Oncol., 19, 4267 (2001).<br></p>

<p>Applications 1,3-Propanesultone (cas# 1120-71-4) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Uridine analog. Used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.<br>References Gratzner, H., et al.: Science, 218, 474 (1982), Jarvis, T., et al.: J. Biol. Chem., 271, 29107 (1996), Pavco, P., et al.: Clin. Cancer Res., 6, 2094 (2000),<br></p>

<p>Applications 4-Aminobenzamide (cas# 2835-68-9) is a useful research chemical.<br></p>

<p>Applications 2-​Amino-​3-​chloro-​5-​trifluoromethylpyrid​ine acts as a reactant in the synthesis of novel imidazo[1,2-a]pyridine-coumarin hybrid molecules as inhibitors of NS5B in potential treatment of Hepititis C.<br>References vManvar, P. et al.: Tetrahedron 72, 1293 (2016);<br></p>

<p>Applications 5,5-Dimethyl-1,3-dioxane is used in preparation of Neopentyl Glycol.<br>References Cao, S., et al.: Faming Zhuanli Shenqing, (2013);<br></p>

<p>Stability Unstable in Aqueous Solution<br>Applications 4-Amino-1-butanol is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Majumder, J. et al.: Langmuir, 29, 10254 (2013); Muth, A. et al.: J. Med. Chem., 56, 5819 (2013)<br></p>

<p>Applications 5-Amino-2-chlorobenzotrifluoride is a compound useful in organic synthesis. It also performs a radioprotective activity against ionizing radiations.<br>References Blickenstaff, R. T., et al.: J. Pharm. Sci., 83, 219 (1994); Kumari, P., et al.: Org. Biomol. Chem., 16, 2049 (2018)<br></p>

<p>Applications 1-aminoindan (cas# 34698-41-4) is a useful research chemical.<br></p>

<p>Applications 5-Aminomethyl-2-chloropyridine is a reagent that is used in the synthesis of macamides and analogs that have FAAH (fatty acid amide hydrolase) inhibitory activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wu, H., et al.: Bioorg. Med. Chem., 21, 5188 (2013);<br></p>

<p>Applications 1-Amino-imidazolidine-2,4-dione (cas# 6301-02-6) is a useful research chemical.<br></p>

<p>Impurity Atenolol Impurity 3; Atenolol Impurity 1<br>Applications Atenolol Impurity 3. Atenolol Impurity 1.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Lysine in human lens crystallins during aging and in diabetes.<br>References Pirie, A., et al.: Invest. Ophthalmol., 7, 634 (1968), Thornalley, P., et al.: Biochem. J., 375, 581 (2003), Peng, D., et al.: J. Biol. Chem., 280, 33775 (2005),<br></p>

<p>Applications 1-(4-Amino-3,5-dichlorophenyl)-2-ethanone (cas# 37148-48-4) is a compound useful in organic synthesis.<br></p>

<p>Applications An intermediate in the production of many biological inhibitors.<br>References Lambertucci, C., et al.: Bioorg. Med. Chem., 17, 2812 (2009), Lebsack, A., et al.: Bioorg. Med. Chem. Lett., 19, 40 (2009), Griffith, D., et al.: J. Med. Chem., 52, 234 (2009),<br></p>

<p>Applications Mono-Ethyl Malonate-1,2,3-13C3 (cas# 1189981-54-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Aminoethyl Sulfate, is a building block used for the synthesis of various pharmaceutical and biologically active compounds, including inhibitors and therapeutic compounds. It can be used in the preparation of Taurine (T007850).<br>References Wen-ru, Ch., et al.: Zhejiang Huagong, 42 (2011);<br></p>

<p>Applications 1,3-Divinylbenzene is a useful research chemical, a metabolites of diethenylbenzene in rat.<br>References Linhart, I., et al.: Xenobiotica, 22, 335 (1992)<br></p>

<p>Applications 3-Methylnonane-2,4-dione is a compound that possesses a butter-like and beany off flavour that is a result of flavour reversion of soya-bean oil. 3-Methylnonane-2,4-dione is also present in Japanese green tea and pressure-cooked hen meat.<br>References Farkaš, P., et al.: Food Chem., 60, 617 (1997); Guth, H. &amp; Grosch, W.: Flav. Chem., No vol. given, 377 (1999); Kumazawa, K. &amp; Masuda, H.: J. Agr. Food Chem., 47, 5169 (1999)<br></p>

<p>Applications 4-Methyldibenzothiophene, is an alkyldibenzothiophene present in crude oil. Research concerning the biodegradation of Dibenzothiophene by different types of bacteria is a currently being carried out, as these bacteria have the ability to breakdown other harmful PAH’s as well. This may be used in removing spilled oil from marine and terrestrial environments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boberg, F., et al.: Erdoel &amp; Kohle, Erdgas, Petrochemie, 47, 187 (1994); Tanaka, Y., et al.: Applied Microbiology and Biotech., 59 (2), 325 (2002); Prince, R., Spill Sci. Tech. Bulletin, 8 (2), 145 (2003);<br></p>

<p>Applications Trimebutine (T795605) impurity standard.<br>References Wang, J., et al.: Br. J. Pharmacol., 113, 945 (1994), Chen, D., et al.: Bioorg. Med. Chem., 5, 1715 (1997), Min, H., et al.: Bioorg. Med. Chem. Lett., 18, 523 (2008),<br></p>

<p>Applications 3,4-Dihydroxy-5-methoxybenzoic acid (cas# 3934-84-7) is a useful research chemical.<br></p>

<p>Applications 3,5-Dinitrosalicylic Acid (cas# 609-99-4) is a compound useful in organic synthesis.Dyes and metabolites.<br></p>

<p>Applications 2-Methyldibenzothiophene, is an alkyldibenzothiophene present in crude oil. Research concerning the biodegradation of Dibenzothiophene by different types of bacteria is a currently being carried out, as these bacteria have the ability to breakdown other harmful PAH’s as well. This may be used in removing spilled oil from marine and terrestrial environments.<br>References Boberg, F., et al.: Erdoel &amp; Kohle, Erdgas, Petrochemie, 47, 187 (1994); Tanaka, Y., et al.: Applied Microbiology and Biotech., 59 (2), 325 (2002); Prince, R., Spill Sci. Tech. Bulletin, 8 (2), 145 (2003);<br></p>

<p>Applications methyl 1-(2,4-difluorophenyl)-3-phenyl-1H-pyrazole-5-carboxylate (cas# 1202030-37-2) is a useful research chemical.<br></p>

<p>Applications A substituted benzene use in polypeptide sequencing (also referred to as Sanger’s reagent). Used in the derivitization of primary amines. Shown to inhibit the reductase activity of mitochondrial b-c1 complex isolated from beef heart mitochondria.<br>References Sanger, F. et al.: Biochem. J., 39, 507 (1945); Fariss, M.W. et al.: Methods Enzymol., 143, 101 (1987); Lorusso, M. et al.: FEBS Lett., 195, 298 (1986);<br></p>

<p>Applications An metabolite of Cotinine. In equilibrium with 5’-Hydroxycotinine the cyclized form.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Morselli, P.L, et al.: J. Med. Chem., 10, 1033 (1967); Murphy, S.E. et. al.: Chem. Res. Toxicol. 12, 639 (1999)<br></p>