Building Blocks

<p>Applications 1,4-Butane-d8-dithiol (CAS# 1219805-46-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-​Bromo-propane-​1,​1,​2,​2-​d4 is a useful reagent in studying rate coefficient and product branching for OH + bromopropane reaction from 230 to 360 K.<br>References Gilles, M., et al.: J. Phys. Chem. A, 106, 5358 (2002);<br></p>

<p>Applications δ-Carboline is a tricyclic product derived from cryptolepine that contains antibacterial properties.<br>References Mazu, T., et. al.: Eur. J. Med. Chem., 46, 2378 (2011)<br></p>

<p>Applications 7-Methylindole is a reactant in the synthesis of α-amino amides that are found in a variety of biological-active compounds.<br>References Box, H.K., et. al.: Tetrahedron, 70, 9709 (2014)<br></p>

<p>Applications Carbon(isothiocyanatidic)acid Ethyl Ester (cas# 16182-04-0) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Used in the synthesis of peptides. Contains up to 10% imidazole.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pierschbacher, M., et al.: Nature, 309, 30 (1984),<br></p>

<p>Applications 4'-Chloroacetophenone-2',3',5',6'-d4 (CAS# 284474-50-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Chloroacetophenone is a chemical warfare agent commonly known as ‘Mace’ affects the oral, nasal and conjunctival mucous membranes also causing loss of balance and disorientation. Also a chemical building block for organic synthesis.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br> E0<br>References Ballantyne, B. et al.: Arch. Toxicol., 40, 75 (1978);<br></p>

<p>Applications 4-(2-Chloroethyl)-N-methoxy-N,α,α-trimethyl-benzeneacetamide is an impurity of Bilastine (B385000), which is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.<br>References Van Cauwenberge, P., et al.: Clin. Exp. Allergy, 30, 891 (2000), Bauchau, V., et al.: Eur. Respir. J., 24, 758 (2004), Lehman, J., et al.: Drugs, 66, 2309 (2006),<br></p>

<p>Applications S-Phenyl Benzenethiosulfonate is an high potency antifungal thiosulfonate that were tested against Aspergillus niger and Aspergillus flavus.<br>References Baeriocher, F.J., et al.: Aus. J. Chem., 53, 399 (2000);<br></p>

<p>Applications 2-Chloroisonicotinic Acid is a derivative of Isonicotinic Acid (I821760) and is used as a reagent in the synthesis of (phenylmorpholinyl)pyrimidinones as selective and orally active glycogen synthase kinase-3β inhibitors.<br>References Fukunaga, K., et al.: Bioorg. Med. Chem. Lett., 23, 6933 (2013)<br></p>

<p>Applications 5-Chloroisoquinoline (cas# 5430-45-5) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1-Chlorobutane-d9 (CAS# 175540-76-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6-Chloro-1-hexyl-3,3,4,4,5,5-d6 Alcohol (CAS# 1219794-83-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Methyl-d3-3-butyn-1,1,1-d3-2-ol (CAS# 57444-27-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Chloroethyl Ethyl Sulfide is used as a reagent in the synthesis of furfuryl xanthines as adenosine receptor antagonists. It is also used as a reagent in the synthesis of methoxypropyl xanthines as putative A2B receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Balo, M.C., et al.: Bioorg. Med. Chem., 17, 6755 (2009); Nieto, M.I., et al.: Bioorg. Med. Chem., 17, 3426 (2009)<br></p>

<p>Applications Methyl 6-Chloronicotinate is used in the determination of Acetamiprid (A150800) and its metabolites in crop and soil.<br>References Tokieda, M., et al.: Nippon Noyaku Gakkaishi, 24, 115 (1999)<br></p>

<p>Applications 1-Chlorohexane-d13 (CAS# 1219798-45-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Chlorotoluene-3,4,5,6-d4 (CAS# 362049-57-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Chlorotoluene-d7 (CAS# 84344-05-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5alpha-Cholestane-3,3-d2 (CAS# 122241-86-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Chloro-2-fluorophenylacetic acid (cas# 194240-75-0) is a useful research chemical.<br></p>

<p>Applications Coumarin-3-carboxylic acid (cas# 531-81-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Cyano-5-nitrophenylboronic acid, pinacol ester<br></p>

<p>Applications Cyclopropane-1,2,2,3,3-d5-carbonyl chloride is a useful building block for organic synthesis<br></p>

<p>Applications 1-Cyclopentenecarboxylic Acid can be used for enantioselective 1,3-dipolar cycloadditions of diazoacetates and solid-phase synthesis of substituted indolines. It can also be used to develop antagonists for A1- and A2-adenosine receptors.<br>References Sibi, M. P., et al.: Org Lett. 9, 1553 (2007); Nicolaou, K. C., et al.: J. Am. Chem. Soc. 122, 2966 (2000); Jacobson, K. A., et al.: Biochem. Pharmacol. 37, 3653 (1988)<br></p>

<p>Applications Cyclohexylacetic acid<br></p>

<p>Applications 2-Cyclohexen-1-Ol (cas# 822-67-3) is a useful research chemical.<br></p>

<p>Applications 4-(Cyclohex-1-en-1-yl)morpholine (cas# 670-80-4) is a useful research chemical.<br></p>

<p>Applications DL-Proline-2-d1 (CAS# 282729-06-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Thiopheneethanol is a thiophene derivative used in the preparation of oligothiophene isothiocyanates as fluorescent markers for biopolymers. 2-Thiopheneethanol is also used in the preparation of other biologically active compounds such as the analgesic Sulfentanyl and the antithrombotic Clopidogrel Hydrogen Sulfate (C587250).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Barbarella, G. et al.: J. Am. Chem. Soc., 123, 11600 (2001); Yang, Z.: Yiy. Gong., 16, 241 (1985); Lin, Z. et al.: Ship. Yu Yao., 12, 235 (2010):<br></p>

<p>Applications Dehydroacetic Acid Sodium is used as a food additive, preservative, and antimicrobial agent.<br>References Sakaguchi, Y., et. al.: J. Appl. Toxicol., 28, 524 (2008); Sipes, N.S., et. al.: Chem. Res. Toxicol., 26, 878 (2013);<br></p>

<p>Applications methyl amino(2-bromophenyl)acetate hydrochloride (cas# 1219408-44-2) is a useful research chemical.<br></p>

<p>Applications 2-Methyl-4-nitrobenzoic acid is used as a reagent to synthesize amino-1H-pyrazole amide derivatives, compounds that act as Raf kinase inhibitors in melanoma cells. 2-Methyl-4-nitrobenzoic acid is also used as a reagent to synthesize fluorogenic substrates, compounds that can be used for activity imaging within living cells.<br>References Fujikawa, Y., et al.: J. Am. Chem. Soc., 130, 14533 (2008); Kim, M., et al.: Bioorg. Med. Chem., 19, 1915 (2011)<br></p>

<p>Applications 2-(N-Benzyl-N-methyl)aminoethanol-1,1,2,2-d4 (CAS# 1219803-10-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,5-Dibromosalicylic Acid<br></p>

<p>Applications 1,3-Dichloropropene-d4 (cis/trans mixture) (CAS# 202656-23-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,4-Dichlorobenzoic-d3 Acid (CAS# 350818-53-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications N,N-Diethylacetoacetamide is an intermediate in the synthesis of Phosphamidon (E/Z mixture) (P353730), an organophosphate insecticide that acts as a cholinesterase inhibitor.<br>References Jacques, R., et al.: Archiv fuer Toxikologie 18: 316 (1960); Bachmann, F.: Proc. Intern. Cong. Crop. Protection, 4th Congr., 2, 1153 (1960)<br></p>

<p>Applications 4-(Diethylamino)benzaldehyde is a mechanism-based inhibitor for human aldehyde dehydrogenase isoenzymes. Potent and reversible inhibitor of mouse and human class I aldehyde dehydrogenase.<br>References Morgan, C. A., et al.: Chem. Biol. Interact., 234, 18 (2015); Russo, J., et al.: Biochem. Pharmacol., 50, 399 (1995)<br></p>

<p>Applications Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is a useful synthetic intermediate in the synthesis of Sitagliptin (S491000); a trizolopyrazine dipeptidyl peptidase (DPP) IV inhibitor for the treatment of type II diabetes.<br>References Liu, F., et al.: J. Chem. Res., 34, 230 (2010); Ahn, J. H., et al.: Bioorg. Med. Chem. Lett., 17, 2622 (2007); Hansen, K. B., et al.: Org. Process Res. Dev., 9, 634 (2005)<br></p>

<p>Applications 3,3-Diethoxy-1-propanol is used as a reactant in the synthesis of nanoparticles.<br>References Sumitani, Shogo, et al.: Reactive &amp; Func. Polymers, 71(7), 684-693 (2011);Kanakubo, Yurie, et al.: Colloids and Surfaces, B, 78(1), 85-91 (2010)<br></p>

<p>Applications (±)-7-Methyl-d3-nonanoic Acid is labelled (±)-7-Methylnonanoic Acid which is a component of colistin.<br>References Orwa, J., et al.: J. Antibiotics, 54, 595 (2001);<br></p>

<p>Applications Diethyl-d10-amine HCl (CAS# 285132-87-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl 4-Methoxyacetoacetate is a reactant in the formation of an abiotic poorphyrinogen in aqueous solution.<br>References Lindsey, J.S., et. al.: Origins Life Evol. B., 39, 495 (2009)<br></p>

<p>Applications 1,10-Dibromodecane-d20 (CAS# 150017-88-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl Decanoate-d19 is a useful isotopically labeled compound of Ethyl Decanoate (E911480)<br></p>

<p>Applications 1-(2,5-Dihydroxyphenyl)ethanone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.<br>References Zhao, W., et al.: Bioorg. Med. Chem., 19, 3192 (2011); Jayashree, B.S., et al.: Asian. J. Chem., 22, 1055 (2010); Benites, J., et al.: Bioorg. Med. Chem., 16, 862 (2008);<br></p>

<p>Stability Hygroscopic<br>Applications 5-(4-methylpiperazin-1-yl)pyridin-2-amine (cas# 571189-49-6) is a useful research chemical.<br></p>

<p>Applications 3-methylpyrrolidin-3-ol hydrochloride (cas# 921592-91-8) is a useful research chemical.<br></p>

<p>Applications Methyl 2-Mercapto-2-methylpropionate (cas# 87123-08-8) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications Ethyl 3,3-diethoxypropionate<br></p>

<p>Applications 2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-hydroxymethyl Thiazole (cas# 317319-27-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,6-DIMETHYLBENZOQUINONE (cas# 527-61-7) is a useful research chemical.<br></p>

<p>Applications 2-[Di(methylthio)methylidene]malononitrile is a useful reagent for synthesis of isoxazolo[5,4-b]pyridine, pyrrolo[3,2-d]isoxazole, isoxazolo[5,4-b]-azepine-4,7-dione and isoxazole derivatives that could possess anti-cancer properties.<br>References El-Mekabaty, A., &amp; Ibrahim, M. E.: Heterocycles, 100, 901 (2020)<br></p>

<p>Applications 2-Ethyl-d5-toluene is a useful isotopically labeled compound of 2-Ethyl Toluene (E926634)<br></p>

<p>Applications 1-(1-methyl-1H-1,2,3-triazol-5-yl)ethan-1-one (cas# 194209-18-2) is a useful research chemical.<br></p>

<p>Applications 2-(1-Methyl-1H-pyrazol-4-yl)ethanamine (cas# 796845-58-4) is a useful research chemical in the development of DNA-compatible methodology for generating novel highly functionalized imidazoles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Geigle, S. N., et al.: Org. Lett., 21, 9001 (2019)<br></p>

<p>Applications N-Benzoylglycine-2,2-d2 (CAS# 208928-78-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6,6-Dimethyl-5,7-dioxaspiro[2.5]octan-4,8-dione is used as a reagent to synthesize Bis-benzimidazoles, compounds that act as inhibitors of Type II Dihydrofolate reductase (an enzyme that is produced by bacteria in response to Trimethoprim [T795615]as a defense mechanism).<br>References Bastien, D., et al.: J. Med. Chem., 55, 3182 (2012)<br></p>

<p>Applications 2,3-Dimethyl-1-butene is used in reactions to convert fatty acids to flavor compounds. It is also used in reactions with asymmetric glyoxylate to form α-hydroxy esters.<br>References Mikami, K. et al.: J. Am. Chem., 112, 3949 (1990);<br></p>

<p>Applications 2,4-Dimethylbenzenesulfonyl Chloride is used as a reagent in the synthesis of dimethyl benzimidazolones as potent and selective inhibitors of BRPF1 bromodomain. 2,4-Dimethylbenzenesulfonyl Chloride is also used as a reagent in the synthesis of quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for the treatment of Gaucher disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Demont, E.H., et al.: ACS Med. Chem. Lett., 5, 1190 (2014); Marugan, J.J., et al.: J. Med. Chem., 54, 1033 (2011)<br></p>

<p>Applications Methyl trans-Cinnamate-d5 (phenyl-d5) (CAS# 61764-82-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl trans-Cinnamate-d7 (CAS# 2022152-96-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications [1-(3-Fluorophenyl)-1-tosyl]methyl isocyanide (cas# 321345-36-2) is a useful research chemical.<br></p>