Acids and Synthetic Reagents

<p>Applications 2,3-Dichloroquinoxaline is a dichlorinated quinoxaline derivative with antimicrobial activity. 2,3-Dichloroquinoxaline is used in the preparation of quinoxaline derivatives of cancer chemopreventive activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Metzner, J. et al.: Pharmazie, 36, 368 (1981); Galal, S.A&gt; et al.: Eur. J. Med. Chem., 46, 327 (2011);<br></p>

<p>Applications 2,6-Dichloro-1,4-benzoquinone is a disinfection byproduct in drinking water and a halobenzoquinone (HBQ) that has been reported to be cytotoxic to T24 bladder cancer cells.<br>References Huang, H., et al.: Huanjing Yu Jiankang Zazhi, 31, 471 (2014); Du, H., et al.: Environ. Sci. Technol., 47, 2823 (2013)<br></p>

<p>Applications Used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.<br>References Leeman, M. et al.: Angew. Chem. Int. Ed., 47, 1287 (2008); Eur. J. Med. Chem., 45, 3564 (2010);<br></p>

<p>Applications 3-Bromopropionic Acid is used as a reagent in the synthesis of nitrogen containing diselenides which exhibit antioxidant activity. Also used as a reagent in the synthesis of indolin-2-one-based multi-targeted receptor tyrosine kinase inhibitors as potential anticancer agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nascimento, V., et al.: Eur. J. Med. Chem., 87, 131 (2014); Zhang, L., et al.: Eur. J. Med. Chem., 82, 139 (2014)<br></p>

<p>Applications 3'-Bromoacetophenone is a chemical reagent used in the synthesis of chalcone derivatives as anti-cancer agents. Also used in the preparation of biphenyl pyridazinone deriatives as PDE4 inhibitors in anti-inflammatory treatments.<br>References Madhavi, S. et al.: Lett. Org. 13, 682 (2016); Gracia, J. et al.: J. Med. Chem., 59, 10479 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Niperoditine is a H2 antagonists used in the treatment intestinal disorders.<br>References Mannino, S. et al.: Pharmacoepidemiol. Drug Safety, 7, 233 (1998); Miyaji, Y. et al.: Bioanalysis., 4, 263 (2012);<br></p>

<p>Applications 2-Cl-IB-MECA acts as an A3 adenosine receptor-selective nucleoside.<br>References Tosh, D. et al.: J. Med. Chem., 55, 4847 (2012);<br></p>

<p>Applications 1-Phenyl-1-cyclohexene is metabolite of Phencyclidine (P295500), an anesthetic.<br>References Wong, L.K., et al.L Biomed. Sci. Spec., 2, 204 (1975); Chen, G., et al.: J. Pharmacol. Exp. Ther., 127, 241 (1959); Bailey, K., et al.: J. Pharm. Pharmacol., 28, 713 (1976); Balster, R.L., J. Psychedelic Drugs., 10115 (1978); Johnson, K.M., et al.: Annu. Rev. Pharmacol. Toxicol., 30, 707 (1990)<br></p>

<p>Applications Silver Acetate is used as a reagent in chemical synthesis in reaction such as carbonylation of primary and secondary amines as well as in woodward cis-hydroxylation converting alkenes into cis-diols. Also used in gum, lonzenges and sprays that are targeted to assist people in quitting the habit of smoking since it produces a bad taste when combined with cigarettes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wright, L., et al.: J. Phys. Chem., 59, 1060 (1955); Woodward, R., et al.: J. Am. Chem. Soc., 80, 209 (1958); Lancaster, T., et al.: Cochrane DB Syst. Rev., 2, 191 (2000);<br></p>

<p>Applications NU6027 is a potent cyclin-dependent kinase (CDK) and Rad3-related kinase (ATR) inhibitor. NU6027 has been shown to inhibit tumor cell growth. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors<br>References Arris, C.E., et. al.: J. Med. Che., 43, 2797 (2000); Peasland, A., et. al.: Brit. J. Cancer, 105, 372 (2011)<br></p>

<p>Applications 4-(Aminomethyl)-Cyclohexanecarboxylic Acid (cas# 701-54-2) is a useful research chemical.<br></p>

<p>Applications Tetramethylammonium Tetrafluoroborate (cas# 661-36-9) is a useful research chemical.<br></p>

<p>Applications Silver benzoate is an aromatic salt that is used as a catalyst to prepare β-amino acids (such as N-Acetyl-β-alanine [A168070]) from α-amino acids (such as D-Alanine [A480995]). Silver benzoate is also used as a catalyst in Wolff rearrangement reactions.<br>References Barnes, R. &amp; Prochaska, R.: J. Am. Chem. Soc., 72, 3188 (1950); Ogilvie, W., et al.: Bioorg. Med. Chem., 7, 1521 (1999); Podlech, J. &amp; Seebach, D.: Lieb. Ann., 1995, 1217 (1995)<br></p>

<p>Applications N-Phenylglycinonitrile is a useful building block used in the preparation of purine derivatives with ability to inhibit protein kinases by competitive displacement of ATP.<br>References Laufer, S., et al.: J. Med. Chem.: 48, 710 (2005);<br></p>

<p>Applications 1-Chloro-3-methyl-2-butene is a reactive allylic chloride that is used as an alkylating agent in synthetic chemistry. 1-Chloro-3-methyl-2-butene is also used as a reagent to synthesize Hyperforin, an antibiotic originating from St. John’s wort that has the ability to inhibit growth of tumour cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hatch, L. &amp; Gerhardt, L.: J. Am. Chem. Soc., 71, 1679 (1949); Lee, M., et al.: Org. Lett., 6, 1241 (2004); Reitsema, R. &amp; Hunter, J.: J. Am. Chem. Soc., 71, 1680 (1949); Schempp, C., et al.: Oncogene, 21, 1242 (2002); Sparling, B., et al.: J. Am. Chem. Soc., 135, 644 (2013)<br></p>

<p>Applications Ciliobrevin D is an inhibitor of the AAA+ ATPase motor cytoplasmic dynein.<br>References Firestone, A., et al.: Nature, 484, 125 (2012)<br></p>

<p>Applications Bis(pinacolato)diboron is used as a condensation agent in the preparation poly(arylene)s. Bis(pinacolato)diboron is an organoboranate with potential use as matrix metallo-proteinase (MMP-2) inhibitor.<br>References Ali, H.A. et al.: Arch. Pharm., 337, 183 (2004); Izumi, A. et al.: Chem. Lett., 7, 728 (2000);<br></p>

<p>Applications AMG 337 is a potent and selective inhibitor of mesencymal epethelial transition factor (MET factor) which has been implicated in several cancers.<br>References Boezio, A. et al.: J. Med. Chem., 59, 2326 (2016);<br></p>

<p>Applications LY 2874455 is a pan-FGFR inhibitor which remain the focus of research for use in lung and bladder cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gozgit, J. et al.: Mol. Cancer Ther., 11, 690 (2012); Zhao, G. et al.: Mol. Cancer Ther., 10, 2200 (2011);<br></p>

<p>Applications N-Carbethoxyphthalimide is used in the synthetic preparation of a novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.<br>References Hua, Z., et al.: J. Med. Chem., 56, 10003 (2013);<br></p>

<p>Applications Savolitinib is a potent and highly selective c-Met inhibitor. Savoltinib demonstrated anti-tumor efficacy in a panel of cMet-dysregulated gastric cancer PDX models. Savolitinib also demonstrated good antitmuor activities.<br>References Gavine, P., et al.: Mol. Oncol., 9, 323 (2015); Jia, H., et al.: J. Med. Chem., 57, 7577 (2014);<br></p>

<p>Applications 2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors.<br></p>

<p>Stability Light Sensitive<br>Applications Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kajikawa, N., et al.: Arzneim.-Forsch., 39, 495 (1989), Demolis, J.-L., et al.: J. Cardiovasc. Pharmacol., 22, 711 (1993), Okuda, Y., et al.: Prostaglandins, 52, 375 (1996),<br></p>

<p>Applications 7-Methoxy-2-naphthol is used as a reactant in the preparation of 9-hydroxy benzopyrene (H829410). It is also used in the preparation of (pyridyl)naphthalenes as highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.<br>References Pinto-Bazurco Mendieta, M.A.E., et al.: J. Med. Chem. 56, 6101 (2013)<br></p>

<p>Applications 1-Bromooctadecane is a reagent in the preparation of branched glycosyl phosphatidyl inositol (GPI) anchors of rat brain Thy-1.<br>References Pekari, K., et al.: J. Org. Chem., 68, 1295 (2003);<br></p>

<p>Applications 2-Bromoacetic Acid Phenylmethyl Ester is used in the synthesis of somatostatin analogues with tumor-targeting properties . Also used in the synthesis of inhibitors of phospholipase A2, indolizine and indene derivatives.<br>References Heppeler, A. et al.: Chem. A. Eur. J., 5, 1974 (1999); Hagishita, S. et al.: J. Med. Chem., 39, 3636 (1996);<br></p>

<p>Applications 4-(t-Boc-amino)-1-butyl Bromide (cas# 164365-88-2) is a compound useful in organic synthesis.<br>References Bendale, P., et al.: J. Med. Chem., 50, 4585 (2007), Lansdell, M., et al.: Bioorg. Med. Chem. Lett., 18, 4944 (2008), Imaeda, Y., et al.: Bioorg. Med. Chem., 16, 2243 (2008),<br></p>

<p>Applications (-)-B-Methoxydiisopinocampheylborane hydrate is an intermediate used in the synthesis of homoallylic alcohol's and several complex natural products.<br>References Mishra, V. K., et al.: J. Org. Chem., 81, 9728 (2016); Jonnalagadda, S. C., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis 1, (2009); Bailey, A. M., et al.: Angew. Chem. Int. Ed., 55, 639 (2016)<br></p>

<p>Applications γ-Butyrobetaine is a synthetic carnitine related compound used as a transporter substrate in the cloning and sequencing of human carnitine transporter 2 (CT2).<br>References Enomoto, A. et al.: J. Biol. Chem., 277, 36262 (2002);<br></p>

<p>Applications N-(tert-Butoxycarbonyl)-D-prolinol is used to prepare (azetidinyl)methoxy]pyridines and 2-(aryloxymethyl) azacyclic analogs with therapeutic potetials for the treatment of central nervous system (CNS) disorders.<br>References Abreo, M., et al.: J. Med. Chem., 39, 817 (1996); Elliott, R., et al.: Bioorg. Med. Lett., 6, 2283 (1996)<br></p>

<p>Applications LY2157299 is a TGF-β type I receptor kinase inhibitor. LY2157299 has been used to inhance chemotherapy action against triple negative breast cancer (TNBC).<br>References Bhola, N.E., et. al.: J. Clin. Invest., 123, 1348 (2013)<br></p>

<p>Applications An antineoplastic. A derivative of Cytarabine.<br>References Aoshima, M., et al.: Cancer Res., 36, 2726 (1976), Akiyama, M., et al.: Chem. Pharm. Bull., 26, 981 (1978),<br></p>

<p>Applications (S)-5,6-Dehydro Pregabalin is derived from rac 5,6-Dehydro Pregabalin (D230055), which is an impurity of the anti-convulsant, Pregabalin (P704800).<br>References Dousa, M, et al.: J. Pharmac. Biomed. Anal., 53, 717 (2010);<br></p>

<p>Applications 5-Methylindole is used in the synthesis of novel protein kinase inhibitors.<br>References Guengerich, F. et al.: J. Med. Chem., 47, 3236 (2004);<br></p>

<p>Applications o-Chloramine T (cas# 110076-44-3) is a useful research chemical.<br></p>

<p>Applications Manganese is a transition metal which is used as a component in alloys such as stainless steels. Manganese is also a component of many pigments and is used to make catalysts for reduction reactions.<br>References Tambat, S., et al.: World J. Pharm. Res., 6, 1570-1585 (2017); Leonard, D., et al.: ACS Catal., 9, 11125-112129 (2019)<br></p>

<p>Applications N-Boc-6-hydroxyhexylamine (cas# 75937-12-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Calcium Sulfate Dihydrate is obtained from gypsum, a naturally occurring compound. Also used in the preparation of calcium sulfate and calcium sulfoaluminate.<br>References Strydom, C. et al.: J. Therm. Anal., 49, 1501 (1997); Winnefeld, F. et al.: DGCh-Monograph., 44, 30 (2011);<br></p>

<p>Applications Mercury(II) acetate is a reagent that is used in the investigation of diastereoselective acyclic α-alkoxydithioacetal substitutions involving thiacarbenium intermediates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prevost, M., et al.: J. Org. Chem. 79, 10504 (2014);<br></p>

<p>Applications 1,5-Difluoro-2,4-dinitrobenzene acts as an oleanolic acid NO-releasing derivative used towards the treatment of colon cancer. Also used in the synthesis of beta blockers used as bronchodialators.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fu, J. et al.: RSC. Adv., 5,19445 (2015); Bhushan, R. et al.: Anal. Lett., 47, 202 (2014);<br></p>

<p>Applications N-(Benzyloxycarbonyl)ethylenediamine Hydrochloride is a reagent used to synthesize new opioid ligand as an analgesics with mixed agonist and antagonist properties to induce tolerance and dependence.<br>References Salvadori, S., et al.: Bioorg. Med. Chem., 15, 6876-6881 (2007);<br></p>

<p>Applications 4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hardtmann, G.E. et al.: J. Med. Chem., 18, 447 (1975); Bartl, V. et al.: Coll. Czechoslov. Chem. Comm., 45, 3182 (1980);<br></p>

<p>Stability Hygroscopic<br>Applications Magnesium acetate tetrahydrate (cas# 16674-78-5) is a useful research chemical.<br></p>

<p>Applications 1-Acetyl-1H-pyrazole-4-boronic acid, pinacol ester<br></p>

<p>Applications ethyl 3-aminobutanoate (cas# 5303-65-1) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ammonium Hexafluorophosphate is commonly available form of the hexafluorophosphate anion, inert and hence a suitable counterion. It is a useful synthetic intermediate. It can be used to prepare organometallic diphenols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Powell, C., et al.: J. Am. Chem. Soc., 125, 602 (2003); Macchioni, A., et al.: Organometallics, 18, 3061 (1999)<br></p>

<p>Applications Copper oxychloride<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,3-Dibromopropene is used in preparation of Quaternary Ammonium Salt derivatives for use as Trimethylamine production inhibitors.Also, used in preparation of Boron containing compounds as Phosphodiesterase PDE4 inhibitors.<br>References Nudel, K., et al.:PCT Int. Appl., (2020); Strohbach, Joseph W., et al.: PCT Int. Appl., (2020);<br></p>

<p>Impurity Atomoxetine EP Impurity C<br>Applications p-Methyl Atomoxetine Hydrochloride (Atomoxetine EP Impurity C) is an impurity of Atomoxetine (A791400), a norepinephrine reuptake inhibitor.<br>References Farid, N.A., et al.: J. Clin. Pharmacol., 25, 296 (1985), Gehlert, D.R., et al.: J. Neurochem., 64, 2792 (1995), Hwamg. et al.: Neurosci. Lett., 265, 151 (1999), Ring, B.J., et al.: Drug Metab. Dispos., 30, 319 (2002),<br></p>

<p>Applications (S)-(-)-Propylene Carbonate is used in the synthesis of β-hydroxy sulfides.<br>References Upare, P. et al.: Green, Chem. Lett. Rev. et al.: 5, 19 (2012<br></p>

<p>Stability Moisture Sensitive<br>Applications Zinc Di[bis(trifluoromethylsulfonyl)imide] is a reactant used in the assembly of pyrene-based Schiff base MII4L6 architectures.<br>References Ronson, T. et al.: J. Am. Chem. Soc., 137, 14502 (2015); Riddell, I. et al.: Chem. Sci., 6, 3533 (2015);<br></p>

<p>Applications 5-Chloro-2-methylaminopyridine is used in the preparation of aminosulfuranes with N-heterocyclic groups.<br>References Pashinnik, V.E. et al.: Ukr. Khim. Zhur., 73, 45 (2007);<br></p>

<p>Stability Hygroscopic<br>Applications Omeprazole Sodium Salt is the salt analogue of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>

<p>Applications 1,2,4,5-BENZENETETRACARBOXYLIC ACID (cas# 89-05-4) is a useful research chemical.<br></p>

<p>Applications Tetrapropylammonium bromide (cas# 1941-30-6) is a useful research chemical.<br></p>

<p>Applications (4R,5R)-2,2-Dimethyl-α,α,α',α'-tetra-2-naphthalenyl-1,3-dioxolane-4,5-dimethanol, is a privileged ligand analogue of TADDOLs. It can be broadly used in asymmetric synthesis. It is also shown that the titanium TADDOLate catalysts have broad application towards carbonyl addition and cycloaddition.<br>References Seebach, D., et al.: Ange. Chem. Inter. Ed., 40, 92, (20010;<br></p>

<p>Stability Moisture Sensitive<br>Applications N,N′-Disuccinimidyl Carbonateis a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of ligands to proteins. The coupling reagent property of N,N’-Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity.<br>References Rebane, R., et al.: J. Chromatography., 904, 99 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications SIPr is used as a reagent in the synthesis of mononuclear [(η6-arene)Ni(N-heterocyclic carbene)] complexes which are useful precursors of the Ni0-NHC unit.<br>References Hoshimoto, Y., et al.: Organometallics, 33, 1276 (2014)<br></p>

<p>Applications Used in the preparation of antibacterial oxazolidinones.<br>References Kim, J. et al.: 19, 550 (2009); Michael R. et al.: J. Med. Chem., 50, 5886 (2007)<br></p>

<p>Applications (S)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane is often used in biosynthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spelberg, J.H., Tetrahedron, Asy., 10, 2863 (1999);<br></p>

<p>Applications Manganese(II) chloride monohydrate (cas# 64333-01-3) is a useful research chemical.<br></p>

<p>Applications ABT 925 Fumerate is a dopamine D3 receptor antagonist that is used in the treatment of acute schizophrenia (1).<br>References (1) Redden, L., et al.: J. Clin. Psychopharmacol, 31, 221 (2011)<br></p>

<p>Applications N-Methylcyclohexanamine is a chemical reagent used in the synthesis of Mps1 kinase inhibitors used in cancer research. Also used in the synthesis of antituberculosis agents as indole-2-carboxamides.<br>References Bursavich, M. et al.: Bioorg. Med. Chem. Lett., 23, 6829 (2013); Kondreddi, R. et al.: J. Med. CHem., 56, 8849 (2013);<br></p>