Carboxylic Acids

<p>Applications Isostearic acid is a useful synthetic intermediate. It is used in the synthesis of methyl-branched poly(hydroxyalkanoate)s, biosurfactants and silver nanoparticles.<br>References Smyth, T., et al.: Appl. Microbio. Biotechnol., 87, 1347 (2010); Anand, M., et al.: J. Phys. Chem. B, 110, 14693 (2006); Hsieh, H., et al.: Langmuir, 26, 10031 (2010); Ashby, R., et al.: Appl. Microbio. Biotechnol., 85, 359 (2009)<br></p>

<p>Applications (E)-2-Thiopheneacrylic Acid is used in the synthesis of anti-HIV HEPT analogs. Also used in the synthesis of benzimidazole and caffeine (C080100) analogs as inhibitors of monoamine oxidase B.<br>References Pontikis, R. et al.: J. Med. Chem., 40, 1845 (1997); van den Berg, D. et al.: Bioorg. Med. Chem., 15, 1692 (2007);<br></p>

<p>Applications 6-Bromo-2-chloronicotinic acid<br></p>

<p>Applications Ethyl 3,4-dihydro-2H-pyran-2-carboxylate (cas# 83568-11-0) is a useful research chemical.<br></p>

<p>Applications B-[3-[[2-Hydroxy-3-[3-(triethoxysilyl)propoxy]propyl]amino]phenyl]boronic acid was prepared for the use as porous polymeric monolith for the specific capture of cis-​diol-​containing flavone under neutral condition.<br>References Pan, J., et al.: Chem. Eng. J., 317, 317-330 (2017);<br></p>

<p>Stability Moisture Sensitive<br>Applications Methyl (chlorosulfonyl)acetate<br></p>

<p>Applications 2-Hydroxy-5-(phenylethynyl)benzoic Acid has antiinflammatory activity.<br>References Shen, T.-Y., et al.: U.S. (1972), US 3657430 A<br></p>

<p>Applications Phenethyl Carbamate is an impurity in the synthesis of Felbamate (F231000), an antiepileptic, structurally similar to meprobamate.<br>References Swinyard, E.A., et al.: Epilepsia, 27, 27 (1986), Remmel, R.P., et al.: Ther. Drug Monit., 12, 90 (1990), Sofia, R.D., et al.: Epilepsy Res. Suppl., 3, 103 (1991),<br></p>

<p>Applications 4-(Methylamino)benzoic Acid (cas# 10541-83-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 9H-xanthen-9-ylacetic acid (cas# 1217-58-9) is a useful research chemical.<br></p>

<p>Applications Used in the preparation of herbicides.<br></p>

<p>Applications 3-Amino-3-(3-(p-tolyloxy)phenyl)propanoic Acid is a useful chemical reagent.<br></p>

<p>Applications Furan-2-boronic acid<br></p>

<p>Applications 3-(N,N-Dimethylamino)phenylboronic Acid (cas# 178752-79-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Acetylphenylboronic acid4-Acetylphenylboronic Acid is used in several metal catalyzed cross-coupling reaction studies.<br>References Saito, S., et al.: J. Org. Chem., 2, 8024 (1997); Sakai, M., et al.: Organomet., 16, 4229 (1997); Molander, G., et al.: J. Org. Chem., 68, 4302 (2003);<br></p>

<p>Applications 3-Furoic Acid, is metabolized by Corynebacterium fascians from soil, limonoid metabolism based on a biological studies.<br>References Hasegawa, S., et al.: J. Arg. Food Chem., 31, 807 (1983)<br></p>

<p>Applications 4-(dimethylamino)-3-nitrobenzoic Acid (cas# 28096-56-2) is a useful research chemical.<br></p>

<p>Applications 2,4-Diaminobenzenesulfonic acid (cas# 88-63-1) is a useful reagent for improving the chlorine resistance and water permeability of polyamide (PA) membrane in water treatment.<br>References Meng, Q. W., et al.: ACS Applied Mat., 12, 35393 (2020)<br></p>

<p>Applications 1H,1aH,6H,6aH-cyclopropa[a]indene-1-carboxylic acid (cas# 501418-06-0) is a useful research chemical.<br></p>

<p>Applications 6-Heptynoic Acid is used as a reagent in organic synthesis, inlcuding that of some novel triazole derivatives which display antiproliferative activity and also of acetylenic fatty acids and their esters.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pertino, M., et al.: Molecules, 19, 2523 (2014); Nakatani, M., et al.: B. Chem. Soc. Jpn., 59, 3535 (1986);<br></p>

<p>Applications Ethyl 2-Isopropylacetoacetate is a reactant in the preparation of nonracemic arylhydroxymethylpyrrolidinylmethylphenyl thiazoleacetamides and cyclopentathiazolecarboxamides as conformationally restricted β3-adrenoceptor agonists as a potential treatment for overactive bladder.<br>References Moyes, C.R., et. al.: J. Med. Chem., 57, 1437 (2014)<br></p>

<p>Applications Amino(3-​chlorophenyl)​acetic Acid functions as intermediate useful in the preparation of synthetic penicillins, also used in the structure-activity relationship examination of several drugs containing the benzyl moiety, their roles in biochemical and pharmacological processes.<br>References Hansch, C., et al.: J. Med. Chem., 13, 957 (1970); Holdrege, C. T., et al.: Can. (1975), CA 966853 A2 19750429;<br></p>

<p>Applications 3-(2-Oxo-cyclohexyl)-propionic Acid is an intermediate in the synthesis of Hexahydrocoumarin (H293905), a derivative of Coumarin (C755380) that is used as a fragrance ingredient.<br>References Letizia, C. S., et al.: Food and Chemical Toxicology, 38, S115 (2000);<br></p>

<p>Applications 4-Biphenylcarboxylic acid (cas# 92-92-2) is a useful research chemical.<br></p>

<p>Applications 5-(3-Benzyloxyphenyl)nicotinic acid<br></p>

<p>Applications 1,2-Ethanedisulfonic Acid Diethyl Ester is used in the industrial manufacturing process for the synthesis of alkyl disulfonate.<br>References Wu, M., et al.: Faming Zhuanli Shenqing, 2012:1569603 (2012)<br></p>

<p>Impurity Mesna EP Impurity C<br>Applications 2-Acetylthioethanesulfonic Acid (Mesna EP Impurity C) is an impurity in the synthesis of Mesna (M225750), used to protect the bladder wall from the harmful effects of some cancer-fighting drugs.<br>References Tekeres, M., et al.: Clin. Ther., 4, 56 (1981), Brock, N., et al.: Eur. J. Cancer Clin Oncol., 18, 1377 (1982), James, C.A., et al.: Br. J. Clin. Pharmacol., 23, 561 (1987);<br></p>

<p>Applications 8,13(15)-Abietadienoic Acid is a derivative of Methyl Abietate (M271910) and has cytotoxic, antimycotic, and antiviral activites.<br>References Gonzalez, Miguel A., et al.: Eur. J. Med. Chem., 44(6), 2468-2472 (2009); Agudelo-Gomez, Lee Solbay., et al.: Pharmacologyonline, 1, 36-42 (2012)<br></p>

<p>Applications 3-FERROCENOYLPROPIONIC ACID (cas# 1291-72-1) is a useful research chemical.<br></p>

<p>Applications Intermediate in the synthesis of angiotensin and fosinopril. Impurity in the preparation of Fosinopril Sodium.<br>References Anderson, N. et al.; Org. Proc Res. and Develop 1, 315 (1997)<br></p>

<p>Applications Ethyl (2Z)-2-[(Acetyloxy)imino]-2-amino-acetic Acid Ester is an intermediate used in the synthesis of N-(2-Hydroxyethyl)-5-methyl-1,2,4-oxadiazole-3-carboxamide (H942278), which is a photolysis product of Metronidazole (M338880), an antibiotic.<br>References Moore, Douglas E., et al.: Radiation Phy. and Chem., 36(4), 547-50 (1990)<br></p>

<p>Applications tert-Butyl 2-(3-Aminophenyl)acetate can be used as anti-heparanase to treat diseases and disorders associated with heparanase activity.<br>References Giannini, G., et.al.: PCT Int. Appl., 103, (2018);<br></p>

<p>Applications Used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.<br>References Leeman, M. et al.: Angew. Chem. Int. Ed., 47, 1287 (2008); Eur. J. Med. Chem., 45, 3564 (2010);<br></p>

<p>Applications Chromane-2-carboxylic Acid is used in the synthesis of 4-quinazolinones as Rho kinase inhibitors for application towards glaucoma, hypertension and spinal cord injuries. It is also used in the preparation of chromanyl-benzamidazoles as anti-bacterial compounds.<br>References Fang, X. et al.: Bioorg. Med. Chem. Lett., 21, 1844 (2011); Raut, C. et al.: J. Hetero. Chem., 47, 582 (2010);<br></p>

<p>Applications 4-PROPYLPHENYLACETIC ACID (cas# 26114-12-5) is a useful research chemical.<br></p>

<p>Applications Dibenzo[b,d]furan-2-sulfonic acid (cas# 83863-63-2) is a useful research chemical.<br></p>

<p>Applications Used in the preparation of (+)-Lysergic acid and α-Ergocryptine (E597500).<br></p>

<p>Applications Carbamic Acid 2-​Hydroxypropyl Ester is an organic reagent used in the preparation of polyurethane foams.<br>References Mueller, E. et al.: Angew. Makri, Chem., 34, 111 (1973)<br></p>

<p>Applications Methyl Phenylacetate is used as a reagent in the synthesis of various organic reactions, one of which is the synthesis of Vulpinic Acid (V850000); a lichen metabolite with anti-inflammatory properties.<br>References Shachak, M., et al.: Science, 236, 1098 (1987); Froberg, L., et al.: Lichenologist, 25, 83 (1993); Hesbacher, S., et al.: J. Chem. Ecology, 21, 233 (1995)<br></p>

<p>Applications A more base-stable alternative to Ellman’s reagent for the quantification of thiol contents and enzymatic assays under basic pH conditions. . It reacts with free thiols similar to Ellman’s reagent but has dramatically improved stability under alkaline conditions, making it an excellent alternative to Ellman’s reagent.<br>References Zhang, H., et al.: Bioorg. Chem., 26, 356 (1998), Chen, Y., et al.: Biochem., 43, 11491 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications tert-Butyl (((mesityl)sulfonyl)oxy)carbamate is a useful reagent for the enantioselective aziridination of α,β-unsaturated aldehydes.<br>References Arai, H., et l.: Tetrahedron Lett., 50, 3329(2009)<br></p>

<p>Applications 2,2-Dimethyl-3-(4-mercaptophenyl)propionic Acid (cas# 887354-80-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Acetylthioisobutyric Acid (cas# 135937-96-1) is a compound useful in organic synthesis.<br>References Souers, A., et al.: Bioorg. Med. Chem. Lett., 8, 2297 (1998), Deaton, D., et al.: Bioorg. Med. Chem. Lett., 18, 732 (2008),<br></p>

<p>Applications tert-Butyl 3-Cyanomorpholine-4-carboxylate is used as a reactant for the synthesis of HIV integrase inhibitors.<br>References Gardelli, C., et. al.: J. Med. Chem., 50, 4953 (2007); Pace, P., et. al.: J. Med. Chem., 50, 2225 (2007); Summa, V., et. al.: J. Med. Chem., 49, 6646 (2006)<br></p>

<p>Applications Ethyl 4-Oxo-5-hexanoic Acid Ester is used in the synthesis of analogs of 5-aminolevulinic acid (ALA), which are potential inhibitors of ALA dehydratase (porphobilinogen synthase), an early enzyme of tetrapyrrole biosynthesis;Also, it is an intermediate of 4-Oxo-6-(2-oxo-5-vinylpyrrolidin-1-yl)hexanoic Acid (O858780), which is derived from Ethyl Succinoyl Chloride (E818230), which is used in the synthesis of bivalent ligands for D2/D3 dopamine receptors. Also used in the preparation of antimicrobial pyrrolo-isoquinolinones. Vigabatrin Impurity 2<br>References Appleton, D., et al.: J. Chem. Soc., Perkin Trans., 89-101 (1998); Gogoi, S. et al.: ACS Med. Chem. Lett., 3, 991 (2012)<br></p>

<p>Applications Benzothiophene-5-boronic acid<br></p>

<p>Applications 5-carbamoylpentanoic acid (cas# 334-25-8) is a useful research chemical.<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications 4-(2-Aminophenyl)-4-oxo-2-butenoic Acid is a novel human lens metabolite from normal and cataractous human lenses. A UV filter.<br>References Mizdrak, J., et al.: Tetrahedron, 63, 4990 (2007); Taylor, L. M., et al.: Exp. Eye Res., 75, 165 (2002)<br></p>

<p>Applications tert-Butyl N-(Benzyloxy)carbamate has been used in the synthesis of Deferoxamine Mesylate (D228980), an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients<br>References Bergeron RJ, et al. 1992. J Med Chem. Dec 11;35(25):4739-44Inati A, et al. 2010. Am J Hematol. Oct;85(10):782-6 Selim M, et al. 2010. Transl Stroke Res. Mar;1(1):35-9<br></p>

<p>Applications 2-Cyclohexylvinylboronic Acid is used in the synthesis of vinylbenziodoxolones, a novel type of hypervalent iodine(III) reagents.<br>References Stridfeldt, E., et al.: Chem. Eur. J., 22, 16066-16070 (2016)<br></p>

<p>Applications 5-Hydroxytoluene-2,4-disulfonic Acid acts as a synthetic reagent in the sulfonation of 2 and 3-Methylphenol.<br>References Strandlund, G., et al.: Acta Chem. Scand., 33, 261 (1979)<br></p>

<p>Applications 4-(Methylamino)-3-nitrobenzoic Acid (cas# 41263-74-5) is a compound useful in organic synthesis.<br></p>

<p>Stability Air Sensitive<br>Applications Ethyl 2-Mercapto-1-cyclohexenecarboxylate is a reagent used in the synthesis of anti-inflammatory compounds,<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lloret, G. et al.: J. Phys. Org. Chem., 22, 1188 (2009);<br></p>

<p>Applications Ethoxyacetic acid<br></p>

<p>Applications 6-Bromohexanoic Acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rosen, D. B., et al.: PCT Int. Appl. (2020), WO 2020254617 A1<br></p>

<p>Applications Dimethyl cyclopentane-1,3-dicarboxylate (cas# 2435-36-1) is a useful research chemical.<br></p>

<p>Applications 4-Ethylbenzoic acid<br></p>

<p>Applications Used in the synthesis of anti-tumor compounds comprising of hydroxyisovalerylshikonin analogs. Furthermore, the compound is a reagent in the synthesis of class II c-Met inhibitors, in the treatment of c-Met dependant tumors.<br>References Rao, Z. et al.: Eur. J. Med. Chem., 46, 3934 (2011); Liu, L. et al.: J. Med. Chem., 55, 1868 (2012);<br></p>

<p>Applications 1,3-Diethylbarbituric Acid can be used as reactant/reagent in green preparation of spiropyran derivatives via three-component cyclization of indantrione with active methylene compounds and cyclic diketones in the presence of compact fluorescent lamp.<br>References Rai, P., et al.: ChemistrySelect, 1, 4450 (2016)<br></p>

<p>Applications 4-Nitrobenzyl Acetoacetate acts as a reagent in the preparation of panipenem via esterification of nitrobenzyl alcohol followed by substitution, cyclizations and hydrogenation. Panipenem I is a new carbapenem antibiotic for the treatment of inflammation.<br>References Fang, H., et al.: hongguo Yaowu Huaxue Zazhi, 21, 216 (2011)<br></p>

<p>Applications Phosphorodichloridic Acid is an intermediate used in the synthesis of Cefotiam Dihydrochloride-13C, 15N2 (C243007), which is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.<br>References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)<br></p>

<p>Applications 2-PHENYLNICOTINIC ACID (cas# 33421-39-5) is a useful research chemical.<br></p>

<p>Applications 1,2,3,4-Cyclobutanetetracarboxylic Acid is a reagent used in the preparation of cobalt cyclobutanetetracarboxylate polymer.<br>References Diaz-Gallifa, P., et al.: Inorg.Chem., 53, 5674 (2014)<br></p>

<p>Applications (Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetic Acid can be used to synthesize cephalosporin derivatives and β-lactam antibiotics.<br>References Lee, H., et al.: Synth. Comm. 28, 1339 (1998); Bucourt, R., et al.: Tetrahedron 34, 2233 (1978); Borowwicz, P., et al.: PL 154681 B1 19910930 (1992); Hecker, S., et al.: US 5756493 A 19980526 (1998)<br></p>

<p>Applications 1-(1-phenylcyclobutanecarbonyl)piperidine-4-carboxylic acid (cas# 1099048-69-7) is a useful research chemical.<br></p>

<p>Applications Methyl 2-Chloro-1-cyclopentenecarboxylate is a versatile reactant that can be synthesized from Methyl 2-Cyclopentanonecarboxylate (M294705), which is used in the preparation of functionalized ketones.<br>References Mashima, K. et al.: J. Org. Chem., 59, 3064 (1994); Hamashima, Y. et al.: J. Am. Chem. Soc., 124, 11240 (2002);<br></p>