Carboxylic Acids

<p>Applications 4-CYANO-4-[(ETHYLSULFANYLTHIOCARBONYL)SULFANYL]PENTANOIC ACID (cas# 1137725-46-2) is a useful research chemical.<br></p>

<p>Applications 4,5-dimethylthiophene-3-carboxylic acid (cas# 19156-52-6) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Tetrahydrophthalic acid is a useful building block in organic synthesis.<br></p>

<p>Applications Hexahydro-4-oxo-1(2H)-azocinecarboxylic Acid 1,1-Dimethylethyl Ester is a chemical reagent used in organic synthesis.<br></p>

<p>Applications 1,4-Cubanedicarboxylic acid<br></p>

<p>Applications TERT-BUTYL N-(DIAMINOMETHYLIDENE)CARBAMATE (cas# 219511-71-4) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Ethyl (Z)-[2-amino-4-thiazolyl](methoxyimino)acetate is used in the preparation of ceftriaxone-d3 (C245002), which is a labelled antibacterial.<br>References Reiner, R., et al.: J. Antibiot., 33, 783 (1980)<br></p>

<p>Applications Bis[2-​(1-​methylethyl)​phenyl] Ester Phosphorochloridic Acid is an intermediate in the synthesis of Bis(2-isopropylphenyl) Phenyl Phosphate (B451445), which is a triaryl phosphate used as plasticizers in polyvinyl chloride (PVC) as well as a flame retardant. Studies show that Bis(2-isopropylphenyl) Phenyl Phosphate inhibits the human androgen receptor.<br>References Duke, A.J.: Chimia, 32, 457 (1978); Honkakoski, P. et al.: Biochem. Pharmacol., 67, 97 (2004); Nobile, E.R. et al.: Bull. Environ. Contam. Toxicol., 25, 755 (1980);<br></p>

<p>Applications Ethyl 3,4-dihydro-2H-pyran-2-carboxylate (cas# 83568-11-0) is a useful research chemical.<br></p>

<p>Applications (1S,2S)-1,2-Cyclopropanedicarboxylic acid is an reagent used in the synthesis of bleomycin (B595800), a antitumor and antibiotic agent.<br>References Huang, L., et al.: Heterocycles., 41, 1181 (1995); Umezawa, et al.: J. Antibiot., 19, 200 (1966); Burger, R.M., et al.: Life Sci., 28, 715 (1981); Marugesan, N., et al.: J. Biol. Chem., 257, 8600 (1982); Saito, S., et al.: J. Antibiot., 36, 92 (1983);<br></p>

<p>Applications B-(9-Phenyl-9H-carbazol-3-yl)boronic Acid is used in the synthesis of alkyl-functionalized organic dyes.<br>References Lee, E. et al.: Bull. Kor. Chem. Soc., 33, 293 (2012);<br></p>

<p>Applications 3-Formylphenylboronic Acid is a reactant in the synthesis of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gosmini, R., et. al.: J. Med. Chem., 57, 8111 (2014)<br></p>

<p>Applications Penta-2,4-dienoic acid (cas# 626-99-3) is a useful research chemical.<br></p>

<p>Applications 3,4-Bis(phenylmethoxy)-benzoic Acid is a useful synthetic intermediate. It is an intermediate used to synthesize Jaboticabin (J210370) which is minor bioactive depside potent to treat chronic obstructive pulmonary disease.<br>References Wu, S., et al.: J. Agri. Food Chem., 61, 4035 (2013); Reynertson, K., et al.: J. Nat. Prod., 69, 1228 (2006)<br></p>

<p>Stability Moisture Sensitive, Air Sensitive<br>Applications As-Methyl Arsonothioic Acid is used as a standard for arsenic inspection. It is used as an aid to help in determining the level of toxicity in humans. Metabolite in some mammals and microbiota.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Naranmandura, H. et al.: Chem. Res. Toxicol., 24, 1586 (2011); Bu, N. et al.: Metallom., 3, 1064 (2011);<br></p>

<p>Applications 3-Formylbenzene-1,2-disulfonoic Acid is derived from 5,6-Difluoro Anthranilic Acid (D445550), which is used in the preparation of 2-[[2-(phenylamino)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]benzamide derivatives as inhibitors of IGF-1R and IR receptor tyrosine kinase as anticancer agents.<br>References Rubinstein, E., et al.: Chemotherapy, 47, 3 (2001), Grohs, P., et al.: Antimicrob. Agents Chemother., 47, 3542 (2003),<br></p>

<p>Applications 5-​Bromopentyl Acetate is used to model the toxicity of haloesters on marine bacterium such as Vibrio fischeri.<br>References Cornin, M.T.D, et. al.: SAR QSAR Environ. Res., 11, 301 (2000)<br></p>

<p>Applications tert-Butyl N-Tosyloxycarbamate is a sulfhydroxylamine that, when used in combination with Lithium, functions as an efficient electrophile in the amination of chiral amide cuprate compounds. tert-Butyl N-Tosyloxycarbamate is also used as a reagent to synthesize N-Boc protected primary amines (e.g. N-Boc-ethylenediamine [B655000]).<br>References Chiba, S. &amp; Narasaka, K.: Amin. Grou. Chem: Synth. Life Sci., No vol. given (2008); Gallou, I. &amp; Senanayake, C.: Chem. Rev.: 106, 2843 (2006); Genet, J., et al.: Tetrahedron Lett., 32, 2359 (1991); Zheng, N., et al.: ChemInform, 28, No pp. given (1997)<br></p>

<p>Applications (S)-tert-butyl 4-aminoazepane-1-carboxylate (cas# 878630-84-3) is a useful research chemical.<br></p>

<p>Applications L-Menthyl 2,2-Dihydroxyacetate is used as a reagent in the synthesis of Lamivudine (L172500); a potent nucleoside reverse transcriptase inhibitor used for the treatment of chronic hepatitis B. L-Menthyl 2,2-Dihydroxyacetate is also used as a reagent in the synthesis of 4-acetoxy-3-hydroxyethylazetidin-2-one, a key intermediate for the preparation of penem and carbapenem antibiotics.<br>References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944); Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997); Perry, C.M., et al.: Drugs, 53, 657 (1977); Goodyear, M.D., et al.: Tetrahedron Lett., 46, 8535 (2005); Kametani, T., et al.: Heterocycles, 25, 241 (1987)<br></p>

<p>Stability Moisture Sensitive<br>Applications Methyl (chlorosulfonyl)acetate<br></p>

<p>Stability Light Sensitive<br>Applications Azobenzene-4,4'-dicarboxylic Acid (cas# 586-91-4) is a useful research chemical.<br></p>

<p>Applications 3-[(2-Hydroxyethyl)Amino]Propanoic Acid (cas# 5458-99-1) is a useful research chemical.<br></p>

<p>Applications N-Propylboronic Acid is a chemical reagent used in the synthesis of pharmaceutical agents such as inhibitors of mTOR for use in anti-tumor treatments. Also used to synthesize endothelial lipase inhibitors<br>References Takeuchi, C. et al.: J. Med. Chem., 56, 2218 (2013); O'Connell, D. et al.: Bioorg. Med. Chem. Lett., 22, 1397 (2012);<br></p>

<p>Applications 4-(Methylamino)-3-nitrobenzoic Acid (cas# 41263-74-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,5-Dimethylterephthalic acid<br></p>

<p>Applications Formamidine Acetate is a versatile reactant used in the tetrazine-based cycloadditions applied to pretargeted live cell imaging with norbornene modified monoclonal antibody.<br>References Devaraj, N., et al.: Bioconjugate Chem., 19, 2297 (2008);<br></p>

<p>Applications Reagent used in the addition of cyclopropane.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cave, C., et al.: Eur. J. Med. Chem., 25, 75 (1990), Kiyama, R., et al.: Chem. Pharm. Bull., 43, 960 (1995), Humphries, P., et al.: Bioorg. Med. Chem. Lett., 16, 6120 (2006),<br></p>

<p>Applications GAMMA-CHLOROCROTONIC ACID (cas# 26340-58-9) is a useful research chemical.<br></p>

<p>Applications Ethyl trans-2-(4-aminocyclohexyl)acetate, HCl<br></p>

<p>Applications 4,4'-Dithiobisbenzoic Acid Dimethyl Ester (cas# 35190-68-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(methylamino)octanoic acid (cas# 101080-67-5) is a useful research chemical.<br></p>

<p>Applications (E)-2-Thiopheneacrylic Acid is used in the synthesis of anti-HIV HEPT analogs. Also used in the synthesis of benzimidazole and caffeine (C080100) analogs as inhibitors of monoamine oxidase B.<br>References Pontikis, R. et al.: J. Med. Chem., 40, 1845 (1997); van den Berg, D. et al.: Bioorg. Med. Chem., 15, 1692 (2007);<br></p>

<p>Applications 3-Hydroxy-2-nitrobenzoic Acid (cas# 602-00-6) is a compound useful in organic synthesis.<br></p>

<p>Stability Store FROZEN<br>Applications Material that was assayed to be approximately 80% pure was diluted to 5% in benzene.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications A caged, photolabile Nitric Oxide donor that is useful for delivering nitric oxide into intracellular compartments in microsecond time scale without any cytotoxic effects.<br>References Namiki, S., et al.: Bioorg. Med. Chem., 7, 1695 (1999),<br></p>

<p>Applications 3-((1-Oxo-1-(3-(trimethylsilyl)propoxy)propan-2-yl)thio)propanoic acid is useful reagent for organic reactions and synthesis.<br></p>

<p>Applications 9-Hydroxydecanoic Acid is an intermediate in the synthesis of Monocarboxyisodecyl Phthalate (M525575), a metabolite of Dibutyl phthalate (DBP) (D429495), which is found widely in consumer products.<br>References Weber, A. E., et al.: J. Med. Chem., 35, 3755 (1992);<br></p>

<p>Applications Methacrylic Acid And Methyl Methacrylate Copolymer (cas# 25086-15-1) is a useful research chemical.<br></p>

<p>Applications 2-(Propylthio)nicotinic acid (cas# 175135-22-5) is a useful research chemical.<br></p>

<p>Applications 4-N-OCTYLOXYBENZOIC ACID (cas# 2493-84-7) is a useful research chemical.<br></p>

<p>Applications Phenyl[2-phenylthio)phenyl]carbamate is an intermediate utilized for the synthesis of Quetiapine Hemifumarate (Q510000), an atypical antipsychotic agent used for the treatment of patients with schizophrenia, biopolar disorder and to treat major depressive disorder.<br>References Niphade, N.C., et al.: Org. Proc. Rsch. Dev., 13, 792 (2009); Stolarczyk, E.U., et al.: Pharm. Dev. Tech., 14, 27 (2009);<br></p>

<p>Applications N-Phenylanthranilic acid is used in biological studies for inhibitors of aldo-keto reductase 1C3 based on N-phenyl-aminobenzoates.<br>References Adeniji, A. O., et al.: J. Med. Chem., 55, 2311 (2012);<br></p>

<p>Applications Tetronic Acid (cas# 4971-56-6) is a useful research chemical.<br></p>

<p>Applications Glycolic Anhydride Diacetate, is the product of reaction involving Lead tetraacetate as an oxidizing agent It is also an intermediate in the synthesis of Chrysogine, a metabolite of Penicillium chrysogenum and some related 2-substituted 4-(3H)-quinazolinones.<br>References Dimroth, O., et al: Berichte der Deutschen, 56B, 1375 (1923); Bergman, J., et al.: Tetrahedron, 46, 1295 (1990);<br></p>

<p>Stability Store Under Argon; Air Sensitive<br>Applications 4-Mercaptobenzoic Acid (cas# 1074-36-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References J. Org. Chem., 2835 (1962)<br></p>

<p>Applications Bromosuccinic acid is prepared from Succinic acid (S688765), an important precursor in many chemicals used in the food, chemical and pharmaceutical fields. Bromosuccinic acid is also used as a reagent to prepare L-Hydrazinosuccinic acid.<br>References Gutowsky, H., et al.: J. Chem. Phys., 31, 1278 (2004); Song, H. &amp; Lee, S.: Enzyme Microb. Tech., 39, 352 (2006); Yamada, R., et al.: BBA-Prot. Struc. Mol. Enzym., 831, 82 (1985)<br></p>

<p>Applications Ethoxyacetic acid<br></p>

<p>Stability Hygroscopic<br>Applications Tetrahydrofuran-2,5-dicarboxylic Acid (cas# 2240-81-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-anilinobutanoic acid (cas# 67832-70-6) is a useful research chemical.<br></p>

<p>Applications (2,5-Dimethylphenyl)boronic Acid is a useful synthetic intermediate. It can be used to prepare fluorenones/indenofluorenediones.<br>References Liu, T., et al.: Org. Lett., 13, 2452 (2011)<br></p>

<p>Applications 4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoic acid (cas# 189365-92-2) is a useful research chemical.<br></p>

<p>Applications 2,3-Dimethylphenylacetic Acid (cas# 30981-98-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Acetylphenylboronic acid<br></p>

<p>Applications Methyl 2-Cyclopentanonecarboxylate is used in the synthesis of functionalized ketones.<br>References Mashima, K. et al.: J. Org. Chem., 59, 3064 (1994); Hamashima, Y. et al.: J. Am. Chem. Soc., 124, 11240 (2002);<br></p>

<p>Applications An intermediate in the production of Zolpidem metabolites<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Klupsch, F., et al.: Chem. Pharm. Bull., 54, 1318 (2006), Epple, R., et al.: Bioorg. Med. Chem. Lett., 16, 5488 (2006),<br></p>

<p>Impurity Lubiprostone Impurity VI<br>Applications 7-((1R,2R,3R)-3-(cyclohexylmethoxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic Acid is a useful chemical reagent.<br></p>

<p>Applications 3-(Cyclopropylaminocarbonyl)phenylboronic acid<br></p>

<p>Applications 3-Cyclohexylbutanoic Acid (cas# 4361-38-0) is a useful reagent for the preparation of oxoheterocyclylalkyl hydroxypiperidinylketones as USP19 inhibitors for treating diseases.<br>References Hewitt, P., et al.: PCT Int. Appl. (2018), WO 2018020242 A1<br></p>

<p>Applications Used for production of peptide thioester.<br>References Gaeta, A., et al.: Bioorg. Med. Chem. Lett., 20, 4649 (2010),<br></p>

<p>Applications exo-2,3-Norbornanedicarboxylic Acid Monoamide is an impurity in the synthesis of Lurasidone (L474920) an antipsychotic used for treatment of schizophrenia.<br>References Ishiyama, T., et al.: Eur. J. Pharmacol., 572, 160 (2007), Cole, P., et al.: Drugs of the Fut., 33, 316 (2008),<br></p>

<p>Applications 5-Chlorohexanoic acid CAS#: 112176-22-4 is a building block used in organic synthesis.<br>References Liang, S., et al., Green Chemistry., 20, 680 (2018)<br></p>