Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65630 products of "Quinazoline and Quinoline Derivatives"
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Quinoxyfen
CAS:Controlled Product<p>Applications Agricultural fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Corrales, M., et al.: Food Chem. Toxicol., 48, 3471 (2010), Lagunas-Allue, L., et al.: Anal. Bioanal. Chem., 398, 1509 (2010), Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010),<br></p>Formula:C15H8Cl2FNOColor and Shape:Off-WhiteMolecular weight:308.13(S)-Ibrutinib
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications (S)-Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br>References Pan, Z., et. al.: ChemMedChem, 2, 58 (2007)<br></p>Formula:C25H24N6O2Color and Shape:NeatMolecular weight:440.5Apixaban Dimer
CAS:Controlled Product<p>Applications Apixaban Dimer is an impurity compound of Apixaban (A726700). Apixaban is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful in the prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J. M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Formula:C40H34N10O6Color and Shape:NeatMolecular weight:750.78N-Nitroso-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-L-valine Methyl Ester-d8
Formula:C20H13D8N3O3Color and Shape:NeatHydroxy Nefazodone Dihydrochloride
CAS:Controlled Product<p>Applications A metabolite of Nefazodone (N389100), an antidepressant.<br>References Barbhaiya, R., et al.: Eur. J. Clin. Pharmacol., 49, 221 (1995), Greene, D., et al.: Clin. Pharmacokinet., 33, 260 (1997), Kalgutkar, A., et al.: Drug Metab. Dispos., 33, 243 (2005),<br></p>Formula:C25H34Cl3N5O3Color and Shape:NeatMolecular weight:558.93[3-[[[2-(Diaminomethyleneamino)-4-thiazolyl]methyl]thio]propionyl]sulfamide Hydrochloride
CAS:Controlled Product<p>Impurity Famotidine EP Impurity C<br>Applications An intermediate in the synthesis of the metabolite of the drug Famotidine.<br>References Yanagisawa, I., et al.: J. Med. Chem., 30, 1787 (1987), Singh, S., et al.: J. Pharm. Sci., 91, 253 (2002),<br></p>Formula:C8H14N6O3S3·ClHColor and Shape:Off-WhiteMolecular weight:374.89Ondansetron Hydrochloride Dihydrate
CAS:Formula:C18H19N3O·ClH·2H2OColor and Shape:Off-WhiteMolecular weight:365.853-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
CAS:Controlled Product<p>Impurity Risperidone EP Impurity L<br>Applications 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (Risperidone EP Impurity L) is an intermediate in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br>References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988), Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990), Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)<br></p>Formula:C11H15ClN2OColor and Shape:NeatMolecular weight:226.70Selexipag
CAS:Controlled Product<p>Applications Selexipag is an orally available, highly selective, long-acting prostacyclin (IP) receptor agonist prodrug. It is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.<br>References Kuwano, K., et al.: J. Pharm. Exp. Ther., 322, 1181 (2007);<br></p>Formula:C26H32N4O4SColor and Shape:Light YellowMolecular weight:496.62Cabozantinib (Phenylene-d4) L-Malate Salt
CAS:Controlled Product<p>Applications Cabozantinib-d4 L-Malate Salt, is the labeled analogue of Cabozantinib L-Malate Salt (C051500), which is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and has been shown to reduce tumor growth, metastasis, and angiogenesis.<br>References Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010),<br></p>Formula:C28D4H20FN3O5·C4H6O5Color and Shape:NeatMolecular weight:639.62N-Nitrosocarvedilol
CAS:Controlled ProductFormula:C24H25N3O5Color and Shape:NeatMolecular weight:435.4725-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).<br>References Mochizuki, A., et al.: Jpn. Kokai Tokkyo Koho. JP 2010120852 A 20100603. Jun 3, 2010; Mochizuki, A., et al.: PCT Int. Appl. WO 2008123017 A1 20081016. Oct 16, 2008<br></p>Formula:C8H11ClN2O2SColor and Shape:Light BrownMolecular weight:234.7trans-4-Aminocyclohexanol
CAS:<p>Applications trans-4-Aminocyclohexanol, used in the preparation of potential hypertensive agents and other biologically active compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chan, K.L. et al.: As. J. Pharmacol. Sci., 1, 91 (1979);<br></p>Formula:C6H13NOColor and Shape:NeatMolecular weight:115.1742'-[(1H-Tetrazol-5-yl)biphenyl-4-yl]methanol
CAS:Controlled Product<p>Applications Losartan (L470500) impurity.<br>References Huskey, S., et al.: Drug Metab. Dispos., 22, 651 (1994), Herr, R., et al.: Bioorg. Med. Chem., 10, 3379 (2002),<br></p>Formula:C14H12N4OColor and Shape:NeatMolecular weight:252.271-(4-(Trifluoromethoxy)phenyl)-2-thiourea
CAS:Controlled ProductFormula:C8H7F3N2OSColor and Shape:NeatMolecular weight:236.21Regorafenib (Pyridine)-N-oxide
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications Regorafenib (Pyridine)-N-oxide is a synthetic metabolite of Regorafenib (R143000) and is used for treatment and prevention of cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011<br></p>Formula:C21H15ClF4N4O4Color and Shape:NeatMolecular weight:498.81Roflumilast
CAS:<p>Applications Roflumilast is a selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; used in treatment of chronic obstructive pulmonary disease.<br>References Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001); Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001); Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002); Rabe, K.F., et al.: Lancet, 366, 563 (2005);<br></p>Formula:C17H14Cl2F2N2O3Color and Shape:NeatMolecular weight:403.21Rivaroxaban Pseudodimer
CAS:<p>Applications Rivaroxaban Pseudodimer is an impurity of Rivaroxaban (R538000), a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C38H36Cl2N6O10S2Color and Shape:NeatMolecular weight:871.766-chloro-2-(3-hydroxyphenyl)quinoline-4-carboxylic acid
CAS:Purity:95.0%Molecular weight:299.70999145507815-Chloro-Vortioxetine Hydrobromide
CAS:Controlled Product<p>Applications 5-Chloro-Vortioxetine is an impurity of Vortioxetine (V766000), a multimodal serotonergic agent. Vortioxetine inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT.<br>References Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011); Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012); Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013)<br></p>Formula:C18H22BrClN2SColor and Shape:NeatMolecular weight:413.87-(4-Chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 7-(4-Chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone is used in the synthesis of aripiprazole, an antipsychotic oral drug used in the treatment of Schizophrenia.<br>References Bonacorsi, S. et al.: J. Label. Comp. Radiopharm., 49, 1 (2006); Morita, Seiji; K. et al.: Tetrahedron, 54, 4811 (1998);<br></p>Formula:C13H16ClNO2Color and Shape:Off-WhiteMolecular weight:253.72cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-Tolylsulfonate
CAS:<p>Impurity Ketoconazole EP Impurity E<br>Applications cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl p-Tolylsulfonate (Ketoconazole EP Impurity E) is an intermediate in the synthesis of the drug Ketoconazole (K186000).<br>References McManus, O., et al.: Biochemistry, 32, 6128 (1993), Olesen, S., et al.: Eur. J. Pharmacol., 251, 53 (1994), Assano, M., et al.: J. Pharm. Exp. Ther., 275, 775 (1995), Hewawasam, P., et al.: J. Med. Chem., 45, 1487 (2002),<br></p>Formula:C21H20Cl2N2O5SColor and Shape:NeatMolecular weight:483.36Vildagliptin Carboxylic Acid Lithium Salt Hydrate
CAS:Controlled Product<p>Applications The major metabolite of Vildagliptin (V305000).<br>References Reimer, M.K., et al.: Eur. J. Endocrinol., 146, 717 (2002), Villhauer, E.B., et al.: J. Med. Chem., 46, 2774 (2003), Ahren, B., et al.: J. Clin. Endocrinol. Metab., 85, 2078 (2004), He, H., et al.: Drug Metab. Dispos., 37, 545 (2009),<br></p>Formula:C17H25LiN2O4Color and Shape:NeatMolecular weight:328.33Tezacaftor
CAS:<p>Applications Tezacaftor is used as a combination therapy with Ivacaftor for the treatment of patients with cystic fibrosis.<br>References Rowe, S. M., et al.: N. Engl. J. Med., 377, 2024 (2017); Dhooghe, B., et al.: Exp. Opin. Investig. Drugs, 25, 423 (2016)<br></p>Formula:C26H27F3N2O6Color and Shape:White To Light YellowMolecular weight:520.5Fluconazole N-Oxide
CAS:Controlled ProductFormula:C13H12F2N6O2Color and Shape:Off WhiteMolecular weight:322.27((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol
CAS:Controlled Product<p>Applications ((3s,4r)-4-(4-Fluorophenyl)Piperidin-3-Yl)Methanol (cas# 125224-43-3) is a useful research chemical.<br></p>Formula:C12H16FNOColor and Shape:Light YellowMolecular weight:209.26Chlorpromazine N-Oxide Maleic Acid Salt
CAS:Controlled Product<p>Applications Chlorpromazine N-Oxide Maleic Acid Salt is an impurity of Chlorpromazine (C424750) which has antiemetic; antipsychotic properties.<br>References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970), Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990)<br></p>Formula:C21H23ClN2O5SColor and Shape:NeatMolecular weight:450.945-Hydroxy Dantrolene-d4
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A labelled metabolite of Dantrolene (D185000) that has shown to have muscle relaxant effects.<br>References Ellis, K.O., et al.: J. Med. Chem., 21, 127 (1977), Jayyosi, Z., et al.: Drug Metab. Dispos., 21, 939 (1993),<br></p>Formula:C14H6D4N4O6Color and Shape:NeatMolecular weight:334.28Bumadizon
CAS:<p>Applications Bumadizon, is a non-steroidal anti-inflammatory (NSAID) drug.<br>References Okada, Y., et al.: Yakugaku Zasshi, 106, 240 (1986;<br></p>Formula:C19H22N2O3Color and Shape:NeatMolecular weight:326.39(E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
CAS:Controlled ProductFormula:C18H15NO4Color and Shape:Light YellowMolecular weight:309.32Olanzapine-d3
CAS:Controlled Product<p>Applications Deuterated Olanzapine, a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic.<br>References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)<br></p>Formula:C172H3H17N4SColor and Shape:Yellow To BrownMolecular weight:315.45Primidone
CAS:<p>Applications Primidone is an Anticonvulsant.<br>References Bogue, C., et al.: Br. J. Pharmacol., 8, 230 (1953), Daley, R.D., Anal. Profiles Drug Subs., 2, 409 (1973),<br></p>Formula:C12H14N2O2Color and Shape:White To Off-WhiteMolecular weight:218.258-Chlorotheophylline
CAS:<p>Applications A stimulant drug. It can be used as a binding agent to form stable salts of pharmaceutical drugs.<br>References Lyles, M. et al.: J. Med. Chem. 44, 4650 (2001).<br></p>Formula:C7H7ClN4O2Color and Shape:WhiteMolecular weight:214.61(3S,3'S)-4,4'-(7-Chloropyrido[2,3-d]pyrimidine-2,4-diyl)bis(3-methylmorpholine)
CAS:Purity:95.0%Molecular weight:363.85000610351565,5',5''-(1,3,5-Triazine-2,4,6-triyl)tris(pyridin-2-amine)
CAS:Purity:95%Color and Shape:SolidMolecular weight:357.381011962890610-Oxo Mirtazapine (Mirtazapine Impurity F)
CAS:Controlled Product<p>Impurity Mirtazapine EP Impurity F<br>Applications 10-Oxo Mirtazapine (Mirtazapine Impurity F) is an impurity of Mirtazapine. Mirtazapine EP Impurity F.<br>References De Boer, T., et al.: Neuropharmacol., 27, 399 (1988), Vindevogel, J., et al.: Anal. Chem., 63, 1530 (1991), Wynia, G., et al.: J. Chromatogr., 773, 339 (1997),<br></p>Formula:C17H17N3OColor and Shape:NeatMolecular weight:279.34Desfluoro Ezetimibe
CAS:Controlled Product<p>Impurity Ezetimibe Desfluoroaniline Analog (USP)<br>Stability Hygroscopic<br>Applications An impurity of the cholesterol absorption inhibitor Ezetimibe (E975000). Ezetimibe Desfluoroaniline Analog (USP).<br>References Anon.: IP.com J., 7, 4 (2007);<br></p>Formula:C24H22FNO3Color and Shape:White To Off-WhiteMolecular weight:391.435-Chloro-N-cyclohexylpentanamide
CAS:<p>Stability Hygroscopic<br>Applications 5-Chloro-N-cyclohexylpentanamide (cas# 15865-18-6) is a compound useful in organic synthesis.<br></p>Formula:C11H20ClNOColor and Shape:NeatMolecular weight:217.7363-Picoline
CAS:Controlled Product<p>Applications A useful precursor to agrochemicals and antidotes for organophosphate poisoning.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Qiao, L., et al.: Bioorg. Med. Chem. Lett., 19, 6122 (2009), Giri, A., et al.: Food Chem., 120, 621 (2010), Farrer, N., et al.: Chem. Res. Toxicol., 23, 413 (2010),<br></p>Formula:C6H7NColor and Shape:ColourlessMolecular weight:93.134'-Methylbiphenyl-2-carbonitrile
CAS:Controlled Product<p>Applications 4'-Methylbiphenyl-2-carbonitrile is an intermediate in the synthesis of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase 3α.<br>References Lo Monte, F., et al.: J. Med. Chem., 55, 4407 (2012); Schaarschmidt, D., et al.: ACS. Catalysis., 1, 411 (2011);<br></p>Formula:C14H11NColor and Shape:NeatMolecular weight:193.24Hexametazidine
CAS:Controlled Product<p>Impurity Trimetazidine dihydrochloride EP impurity B<br>Applications Hexametazidine is an impurity of Trimetazidine (T795610). Trimetazidine impurity B. Hexametazidine can protect the myocardium from injury by ischemia and reperfusion.<br></p>Formula:C24H34N2O6Color and Shape:NeatMolecular weight:446.54N-(2,3-Dichlorophenyl)piperazine Hydrochloride
CAS:Controlled ProductFormula:C10H12Cl2N2·ClHColor and Shape:WhiteMolecular weight:267.58(R)-Crizotinib-d5 (piperidine-3,3,4,5,5-d5)
CAS:Controlled Product<p>Applications (R)-Crizotinib-d5 (piperidine-3,3,4,5,5-d5) (CAS# 1395950-84-1) is a useful isotopically labeled research compound.<br></p>Formula:C21D5H17Cl2FN5OColor and Shape:NeatMolecular weight:455.3675Naloxegol Oxalate
CAS:<p>Applications Naloxegol Oxalate is an oxalate form of Naloxegol (N284470) which is a peripherally-selective opioid antagonist.<br>References Seifert, R., et al.: G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity, 227 (2012)<br></p>Formula:C34H53NO11•C2H2O4Color and Shape:NeatMolecular weight:651.799003Rilpivirine
CAS:Controlled Product<p>Applications A novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.<br>References Sun, et al.: J. Med. Chem., 41, 4648 (1998), Kashiwada, et al.: Bioorg. Med. Chem. Lett., 11, 183 (2001),<br></p>Formula:C22H18N6Color and Shape:YellowMolecular weight:366.4210,11-Dihydro-10-hydroxy Carbamazepine-D4 (Major)
CAS:Controlled ProductFormula:C152H4H10N2O2Color and Shape:BrownMolecular weight:258.31Pefloxacin Mesylate
CAS:Controlled Product<p>Applications Pefloxacin is a fluorinated quinolone antibacterial; analog of Norfloxacin.<br>References Barre, J., et al.: J. Pharm. Sci., 73, 1379 (1984), Contrepois, A., et al.: J. Antimicrob. Chemother., 14, 51 (1984),<br></p>Formula:C17H20FN3O3·CH4O3SColor and Shape:Off-WhiteMolecular weight:429.46rac-Paroxetine-d4 Hydrochloride
CAS:Controlled Product<p>Applications rac-Paroxetine-d4 Hydrochloride is a racemic labeled analogue of Paroxetine Hydrochloride (P205750), a selective serotonin reuptake inhibitor. Used as an antidepressant.<br>References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978); Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982)<br></p>Formula:C19H17D4ClFNO3Color and Shape:White To Light BrownMolecular weight:369.853,5-Dinitrosalicylhydrazide-15N2
CAS:Controlled Product<p>Applications Labelled Nifursol (N458700) metabolite.<br>References Shen, Y. et al.: Faming Zhuanli Shenqing 13 (2009)<br></p>Formula:C7H6N215N2O6Color and Shape:Light YellowMolecular weight:244.132,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]
CAS:Controlled Product<p>Applications An impurity in the synthesis of Silodosin (S465000), an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.<br>References Barve, I. et al.: Tetra., 69, 2834 (2013); Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995), Murata, S., et al.: J. Urol., 164, 578 (2000),<br></p>Formula:C25H30F3N3O3Color and Shape:Light YellowMolecular weight:477.523-Hydroxy Ropivacaine
CAS:Controlled Product<p>Applications A major metabolite of Ropivacaine (R675000).<br>References Ekstrom, G., et al.: Drug Metab. Dispos., 24, 955 (1996), Arvidsson, T., et al.: Biomed. Chromatogr., 13, 286 (1999), Shah, V., et al.: Pharm. Res., 17, 1551 (2000),<br></p>Formula:C17H26N2O2Color and Shape:NeatMolecular weight:290.4R-(-)-Deprenyl Hydrochloride
CAS:Controlled Product<p>Applications Monoamine oxidase-B inhibitor related structurally to Pargyline. Used to alleviate the symptoms of Parkinsons disease.<br>References Magyar, K., et al.: Acta Physiol. Acad. Sci. Hung., 32, 377 (1967), Heinonen, E.H., et al.: Acta Neurol. Scand., 84, 44 (1991), Schneider, L.S., et al.: Am. J. Psychiatry, 150, 321 (1993),<br></p>Formula:C13H17N·ClHColor and Shape:White To Off-WhiteMolecular weight:223.74O-Desisopropyl-O-methoxyethyl Nimodipine
CAS:Controlled Product<p>Impurity Nimodipine EP Impurity C; Nimodipine USP Related Compound B<br>Applications O-Desisopropyl-O-methoxyethyl Nimodipine (Nimodipine EP Impurity C) is an impurity in the synthesis of Nimodipine (A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Nimodipine USP Related Compound B.<br>References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),<br></p>Formula:C21H26N2O8Color and Shape:NeatMolecular weight:434.44(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran
CAS:Controlled Product<p>Applications (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran is used as a reactant in the efficient synthesis of empagliflozin inhibitor of SGLT-2 utilizing AlCl3-promoted silane reduction of β-glycopyranoside.<br>References Wang, X., et al.: Org. Lett., 16, 4090 (2014);<br></p>Formula:C17H16BrClO2Color and Shape:Off-WhiteMolecular weight:367.66Fenoterol-d6 Hydrobromide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Labelled Fenoterol (F248850). An β2-adrenergic agonist. Bronchodilator; tocolytic.<br>References Schuster, B., et al. Arzneim.-Forsch., 19, 1905 (1969), Gerris, J., et al.: Eur. J. Clin. Pharmacol., 18, 443 (1980), Heel, R.C., et al.: Drugs, 15, 3 (1978),<br></p>Formula:C17D6H15NO4·BrHColor and Shape:Off White To BrownMolecular weight:390.30Pefloxacin Mesylate Dihydrate
CAS:Controlled Product<p>Applications Pefloxacin Mesylate Dihydrate is an analog of norfloxacin that inhibits topoisomerase.<br></p>Formula:C17H20FN3O3·CH4O3S·2H2OColor and Shape:Light YellowMolecular weight:465.49Dehydronitrendipine
CAS:Controlled Product<p>Applications Dehydronitrendipine is a derivative of Nitrendipine (N490150), a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.<br>References Ventura, H.O., et al.: Am. J. Cardiol., 51, 783 (1983); Kann, J. et al.: Brit. J. Clin. Pharmacol., 33, 51 (1992);<br></p>Formula:C18H18N2O6Color and Shape:NeatMolecular weight:358.35Nadolol-d9
CAS:Controlled Product<p>Applications Labelled Nadolol (N201052). β-Adrenergic blocker. Antihypertensive; antianginal.<br>References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977), Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978), Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980),<br></p>Formula:C17H18D9NO4Color and Shape:NeatMolecular weight:318.46Levofloxacin Ethyl Ester
CAS:Controlled Product<p>Impurity Levofloxacin USP Related Compound C<br>Applications Levofloxacin Ethyl Ester (Levofloxacin USP Related Compound C) is an impurity of Levofloxacin (L360000).<br>References Lalitha Devi, M. et al.: J. Pharrm. Biomed. ANal., 50, 710 (2009); Mehta, J. et al.: Int. J. PharmTech Res., 2, 1932 (2010);<br></p>Formula:C20H24FN3O4Color and Shape:White To Off-WhiteMolecular weight:389.423,5,6-Trihydroxy-1-isopropylindole
CAS:Controlled Product<p>Applications 3,5,6-Trihydroxy-1-isopropylindole is an impurity of Isoproterenol (I874200), which is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator.<br>References Kikkawa, H. et al.: Biol. Pharmac. Bull., 17, 1047 (1994); Kral, P. et al.: Psychopharmacologia, 26, 79 (1972); Giles, R.E. et al.: J. Pharmacol. Exp. Ther., 186, 472 (1973);<br></p>Formula:C11H13NO3Color and Shape:NeatMolecular weight:207.2267-(But-2-yn-1-yl)-3-methyl-8-(methylamino)-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
CAS:Controlled Product<p>Applications 7-(But-2-yn-1-yl)-3-methyl-8-(methylamino)-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione is an impurity of Linagliptin (L465900), a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.<br>References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);<br></p>Formula:C21H21N7O2Color and Shape:NeatMolecular weight:403.437N-(p-Chlorobenzoyl)-p-anisidine
CAS:Controlled Product<p>Applications N-(p-Chlorobenzoyl)-p-anisidine is a COX-1 inhibitor analgesics that do not cause gastric damage.<br>References Kakuta, H., et al.: J. Med. Chem., 51, 2400 (2008);<br></p>Formula:C14H12ClNO2Color and Shape:White To Off-WhiteMolecular weight:261.7(S)-Bicalutamide
CAS:Controlled Product<p>Applications (S)-Enantiomer of Bicalutamide. Used as an antiandrogen, antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>Formula:C18H14F4N2O4SColor and Shape:WhiteMolecular weight:430.37Enzalutamide Carboxylic Acid
CAS:<p>Applications Enzalutamide Carboxylic Acid is used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer.<br>References Tomasz, M.B., et al.: New Engl, J. Med., 424, 371 (2014);<br></p>Formula:C20H13F4N3O3SColor and Shape:NeatMolecular weight:451.39Nifursol-15N2,d2
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Labelled Nifursol (N458702). A medicinal, prophylactic additive in animal feeds, protecting poultry from histomoniasis.Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Kowalski, P., et al.: J. Pharm. Biomed. Anal., 32, 937 (2003), Khlebnikov, A., et al.: Bioorg. Med. Chem., 16, 9302 (2008), Schepetkin, I., et al.: Mol. Pharmacol., 74, 392 (2008),<br></p>Formula:C12H5D2N315N2O9Color and Shape:NeatMolecular weight:369.21N-Nitroso Fluoxetine-D5
CAS:Controlled ProductFormula:C17H12D5F3N2O2Color and Shape:Colourless To Light YellowMolecular weight:343.36ABT 199 (>99%)(Venetoclax)
CAS:Controlled Product<p>Applications ABT 199 (>99%) is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.<br>References Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);<br></p>Formula:C45H50ClN7O7SColor and Shape:Light Yellow To YellowMolecular weight:868.444-Demethoxy-4-hydroxy Apixaban
CAS:Controlled Product<p>Applications 4-Demethoxy-4-hydroxy Apixaban is a metabolite of Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa.<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Formula:C24H23N5O4Color and Shape:NeatMolecular weight:445.472(R,S)-Hydroxy-4[[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]methylamino]-4-oxo-butanoic Acid
CAS:Controlled ProductFormula:C13H17NO6Color and Shape:NeatMolecular weight:283.28Menbutone
CAS:<p>Applications Menbutone is a cholerectic compound which is used for stimulating gastro-intestinal function by promoting secretory processes in animals including that of cattle, sheep, goats, horses and dogs. It is used in treatment of hepatic dysfunction of dogs by promoting bile secretion.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Symonds, H., et al.: Vet. Rec., 110, 423 (1982); Kumri, K., et al.: Indian Vet. J., 75, 1124 (1998);<br></p>Formula:C15H14O4Color and Shape:Off White SolidMolecular weight:258.27Ethylenediamine P-Toluenesulfonate
CAS:Controlled Product<p>Impurity Xylometazoline EP Impurity E<br>Stability Hygroscopic<br>Applications Ethylenediamine P-Toluenesulfonate is a reactant used in the synthesis of antitumor agents. Also is an impurity of Xylometazoline (X749950), a vasoconstrictor involved in signal transduction, also used as a nasal decongestant. May be used in treatments involving ischemic injury due to the ability to shift energy metabolism from mitochondrial to glycolysis (2).<br>References 1. Fliri, A. et al.: J. Med. Chem. 2009 Dec 24;52(24):8038-46.2. Gohil, V. et al.: Nat Biotechnol. 2010 Mar;28(3):249-55.<br></p>Formula:C7H8O3S·C2H8N2Color and Shape:NeatMolecular weight:232.29993’-[3-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)propyl] Domperidone(Domperidone Impurity E) (>90%)
CAS:Formula:C32H34ClN7O3Purity:>90%Color and Shape:White To Off-WhiteMolecular weight:600.11Salbutamon Hydrochloride
CAS:<p>Impurity Salbutamol EP Impurity J<br>Applications Salbutamon Hydrochloride (Salbutamol EP Impurity) is a related impurity of Albuterol (A514500) (Salbutamol) (EP).<br>References Price, A., et al.: Drugs, 38, 77 (1989), Beaulieu, N., et al.: J. Pharm. Biom. Anal., 8, 583 (1990), Sagar, K., et al.: J. Pharm. Biomed. Anal., 11, 533 (1993),<br></p>Formula:C13H19NO3·ClHColor and Shape:NeatMolecular weight:273.764-(4-Methylpiperazinomethyl)benzoic Acid, Dihydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 4-(4-Methylpiperazinomethyl)benzoic Acid, Dihydrochloride (cas# 106261-49-8) is a compound useful in organic synthesis.<br></p>Formula:C13H18N2O2·2ClHColor and Shape:NeatMolecular weight:307.22S-Hydroxy Topiramate
CAS:Controlled Product<p>Applications A metabolite of Topiramate.<br>References Maryanoff, B., et al.: J. Med. Chem., 30, 880 (1987), Shank, R., et al.: Epilepsia, 35, 450 (1994), Streeter, A., et al.: Drug Metab. Disp., 23, 90 (1995),<br></p>Formula:C12H21NO9SColor and Shape:Off-White To BeigeMolecular weight:355.36trans-Hydroxy Perhexiline (Mixture of Diastereomers)
CAS:Controlled ProductFormula:C19H35NOColor and Shape:NeatMolecular weight:293.49N-Isopropyl-2-methyl-2-propyl-3-hydroxypropyl Carbamate
CAS:Controlled Product<p>Applications An intermediate in the synthesis of Carisoprodol.<br></p>Formula:C11H23NO3Color and Shape:NeatMolecular weight:217.31Defluoro Dolutegravir (>85%)
CAS:<p>Applications Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.<br>References Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);<br></p>Formula:C20H20FN3O5Purity:>85%Color and Shape:NeatMolecular weight:401.393-Desamino-3,4-dehydro Sitagliptin
CAS:<p>Impurity Sitagliptin Tablets EP Impurity FP-C<br>Applications 3-Desamino-3,4-dehydro Sitagliptin is an impurity of Sitagliptin (S491000); a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem. 48, 141 (2005); Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005); Bergman, A., et al: Clin. Ther. 28, 55 (2006)<br></p>Formula:C16H12F6N4OColor and Shape:White To Off-WhiteMolecular weight:390.28(±)-Rolipram
CAS:Controlled Product<p>Applications (±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor.<br>References Xin, W., et. al.: J. Pharmacol. Exp. Ther., 349, 56 (2014);<br></p>Formula:C16H21NO3Color and Shape:NeatMolecular weight:275.34ent Atomoxetine-d3, Hydrochloride
CAS:Controlled ProductFormula:C17H19D3ClNOColor and Shape:NeatMolecular weight:294.831,3-Bis([1,1’-Biphenyl]-4-ylphenylmethyl)-1H-imidazolium Chloride
CAS:Controlled Product<p>Impurity Bifonazole EP Impurity D<br>Applications 1,3-Bis([1,1’-Biphenyl]-4-ylphenylmethyl)-1H-imidazolium Chloride (Bifonazole EP Impurity D) is a Bifonazole (B383400), an anti-fungal agent used in the treatment of skin diseases. Causes an increase in Ca2+ concentration and triggers cell death in PC3 human prostate cancer cells.<br>References Cheng, J. et al.: J. Recep. Sign. Transduct., 34, 493 (2014); Chen, Z. et al.: Mol. Pharm., 12, 590 (2015);<br></p>Formula:C41H33N2·ClColor and Shape:NeatMolecular weight:589.17Nifedipine Monoamide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Nifedipine Monoamide is an impurity of Nifedipine (N457000); a dihydropyridine calcium channel blocker. Also used as an antihypertensive and antianginal.<br>References Zhu, P., et al.: Sepu, 30, 1026 (2012); Karancsi, T., et al.: Acta Pharm. Hung., 66, 21 (1996); Ali, S.L., et al.: Anal. Profiles Drug Subs., 18, 221 (1989); Soons, P.A., et al.: J. Pharm. Biomed. Anal., 9, 475 (1991); Brown, M.J., et al.: Lancet, 356, 366 (2000)<br></p>Formula:C16H17N3O5Color and Shape:Orange SolidMolecular weight:331.32
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