Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65615 products of "Quinazoline and Quinoline Derivatives"
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Bumadizon
CAS:<p>Applications Bumadizon, is a non-steroidal anti-inflammatory (NSAID) drug.<br>References Okada, Y., et al.: Yakugaku Zasshi, 106, 240 (1986;<br></p>Formula:C19H22N2O3Color and Shape:NeatMolecular weight:326.391,1’-[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol(Mixture of Diastereomers)
CAS:Controlled Product<p>Impurity Metoprolol EP Impurity O<br>Applications 1,1’-[(1-Methylethyl)imino]bis[3-[4-(2-methoxyethyl)phenoxy]-2-propanol (Metoprolol EP Impurity O) is an impurity of Metoprolol.<br>References Gyllenhaal, O., et al.: J. Biochem. Biophys. Methods, 43, 135 (2000), Chester, T., et al.: Anal. Chem., 74, 2801 (2002),<br></p>Formula:C27H41NO6Color and Shape:NeatMolecular weight:475.62Methocarbamol-d5
CAS:Controlled ProductFormula:C112H5H10NO5Color and Shape:NeatMolecular weight:246.272,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone
CAS:Controlled Product<p>Impurity Voriconazole EP Impurity A; Voriconazole USP Related Compound C<br>Applications 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone (Voriconazole EP Impurity A; Voriconazole USP Related Compound C) is an antifungal activity, particularly toward Candida albicans and Candida parapsilosis<br>References Upadhayaya, R., et al.: Eur. J. Med. Chem., 39, 579 (2004), Sheng, C., et al.: J. Med. Chem., 49, 2512 (2006),<br></p>Formula:C10H7F2N3OColor and Shape:BeigeMolecular weight:223.18(3’R)-Ezetimibe
CAS:Controlled Product<p>Applications Azetidinone Ezetimibe (E975000) analog. A cholesterol absorption inhibitor.<br>References Hauser, H., et al.: Biochemistry, 37, 17843 (1998), Davis, et al.: Metabolism, 50, 1234 (2001), Berger., et al.: Therapeutics, 4, 163 (2002),<br></p>Formula:C24H21F2NO3Color and Shape:Off-WhiteMolecular weight:409.433-(1H-2-INDOLYL)-4-(4-METHOXYPHENYL)-1-METHYL-1H-2-QUINOLINONE
CAS:Purity:97.0%Molecular weight:380.4469909667969De-4-fluoro 5-Fluoro Chidamide
CAS:<p>Applications De-5-fluoro 4-Fluorochidamide is an analogue of Chidamide (CAS 743420-02-0), a hitsone deacetylase inhibitor (HDACI) that enhances gemcitabine (G305000) cytotoxicity in pancreatic cancer cells.<br>References Qiao, Z., et. al.: Biochem. Bioph. Res. Co., 434, 95 (2013)<br></p>Formula:C22H19FN4O2Color and Shape:Off White PowderMolecular weight:390.41Hexametazidine
CAS:Controlled Product<p>Impurity Trimetazidine dihydrochloride EP impurity B<br>Applications Hexametazidine is an impurity of Trimetazidine (T795610). Trimetazidine impurity B. Hexametazidine can protect the myocardium from injury by ischemia and reperfusion.<br></p>Formula:C24H34N2O6Color and Shape:NeatMolecular weight:446.543-Phenyl-1-propanol
CAS:Controlled Product<p>Impurity Alverine EP Impurity B<br>Applications 3-Phenyl-1-propanol is used as a reagent in the synthesis of Dihydrocinnamyl Cilnidipine (D448605) and is a potent aroma biotransformation product.<br>References Bosse, A.K., et al.: Food Chem., 141, 2952 (2013)<br></p>Formula:C9H12OColor and Shape:ColourlessMolecular weight:136.19N1,N3-Bis[2-(3,4-dimethoxyphenyl)ethyl]-N1,N3-dimethyl-1,3-propanediamine Dihydrochloride
CAS:Controlled Product<p>Impurity Verapamil EP Impurity A DIHCL<br>Stability Hygroscopic<br>Applications N1,N3-Bis[2-(3,4-dimethoxyphenyl)ethyl]-N1,N3-dimethyl-1,3-propanediamine Dihydrochloride (Verapamil EP Impurity A DIHCL) is an impurity of Verapamil (V125000), a calcium channel blocker. Antihypertensive; antianginal; antiarrhythmic (class IV).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Atlas, D, and Adler, M.: Proc. Natl. Acad. Sci. USA, 78, 1237 (1981), Janis, R., et al.: Adv. Drug. Res., 16, 309 (1987)<br></p>Formula:C25H38N2O4·2ClHColor and Shape:NeatMolecular weight:503.51(R)-Tamsulosin-d4 Hydrochloride
CAS:Controlled Product<p>Applications (R)-Tamsulosin-d4 Hydrochloride is the labeled analogue of (R)-Tamsulosin Hydrochloride (T006350), a specific α1-adrenoceptor antagonist. It is used in the treatment of benign prostatic hypertrophy.<br>References Kawabe, K., et al.: J. Urol., 144, 908 (1990); Abrams, P., et al.: Br. J. Urol., 76, 325 (1995); Michel, M.C., Expert Opin. Pharmacother., 5, 151 (2004)<br></p>Formula:C20H25D4ClN2O5SColor and Shape:NeatMolecular weight:449.0Methyl 4-Acetamido-5-bromo-2-methoxybenzoate
CAS:Controlled Product<p>Applications Methyl 4-Acetamido-5-bromo-2-methoxybenzoate is an impurity of bromopride (B686645), which is an antimetic.<br>References Fontaine, J., et al.: Arch. Int. Pharmacodyn. Ther., 213, 322 (1975), Lucker, P.W., et al.: Arzneim.-Forsch., 33, 453 (1983)<br></p>Formula:C11H12BrNO4Color and Shape:Off-WhiteMolecular weight:302.12Apixaban PG Ester-II
CAS:Controlled Product<p>Applications Apixaban PG Ester-II is one of the multiple constituents extracted from Biebersteinia multifida, that exhibits inhibitory activity on acetylcholinesterase.<br>References Xiang, F., et al.: Faming Zhuanli Shenqing (2019), CN 109432093 A 20190308.<br></p>Formula:C28H30N4O6Color and Shape:NeatMolecular weight:518.56Naproxen-d3
CAS:Controlled Product<p>Applications Naproxen-d3 is an isotopic compound of Naproxen (N377520). Naproxen is a a nonsteroidal anti-inflammatory compound with analgesic and antipyretic properties.<br>References Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970)<br></p>Formula:C14H11D3O3Color and Shape:Off-White To BeigeMolecular weight:233.284-Desmethyl-4-ethylimidazolyl Nilotinib
CAS:Controlled ProductFormula:C29H24F3N7OColor and Shape:Light Beige To Light BrownMolecular weight:543.54Pefloxacin Mesylate
CAS:Controlled Product<p>Applications Pefloxacin is a fluorinated quinolone antibacterial; analog of Norfloxacin.<br>References Barre, J., et al.: J. Pharm. Sci., 73, 1379 (1984), Contrepois, A., et al.: J. Antimicrob. Chemother., 14, 51 (1984),<br></p>Formula:C17H20FN3O3·CH4O3SColor and Shape:Off-WhiteMolecular weight:429.46rac-Paroxetine-d4 Hydrochloride
CAS:Controlled Product<p>Applications rac-Paroxetine-d4 Hydrochloride is a racemic labeled analogue of Paroxetine Hydrochloride (P205750), a selective serotonin reuptake inhibitor. Used as an antidepressant.<br>References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978); Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982)<br></p>Formula:C19H17D4ClFNO3Color and Shape:White To Light BrownMolecular weight:369.853,5-Dinitrosalicylhydrazide-15N2
CAS:Controlled Product<p>Applications Labelled Nifursol (N458700) metabolite.<br>References Shen, Y. et al.: Faming Zhuanli Shenqing 13 (2009)<br></p>Formula:C7H6N215N2O6Color and Shape:Light YellowMolecular weight:244.132,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]
CAS:Controlled Product<p>Applications An impurity in the synthesis of Silodosin (S465000), an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.<br>References Barve, I. et al.: Tetra., 69, 2834 (2013); Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995), Murata, S., et al.: J. Urol., 164, 578 (2000),<br></p>Formula:C25H30F3N3O3Color and Shape:Light YellowMolecular weight:477.523-Hydroxy Ropivacaine
CAS:Controlled Product<p>Applications A major metabolite of Ropivacaine (R675000).<br>References Ekstrom, G., et al.: Drug Metab. Dispos., 24, 955 (1996), Arvidsson, T., et al.: Biomed. Chromatogr., 13, 286 (1999), Shah, V., et al.: Pharm. Res., 17, 1551 (2000),<br></p>Formula:C17H26N2O2Color and Shape:NeatMolecular weight:290.4R-(-)-Deprenyl Hydrochloride
CAS:Controlled Product<p>Applications Monoamine oxidase-B inhibitor related structurally to Pargyline. Used to alleviate the symptoms of Parkinsons disease.<br>References Magyar, K., et al.: Acta Physiol. Acad. Sci. Hung., 32, 377 (1967), Heinonen, E.H., et al.: Acta Neurol. Scand., 84, 44 (1991), Schneider, L.S., et al.: Am. J. Psychiatry, 150, 321 (1993),<br></p>Formula:C13H17N·ClHColor and Shape:White To Off-WhiteMolecular weight:223.74O-Desisopropyl-O-methoxyethyl Nimodipine
CAS:Controlled Product<p>Impurity Nimodipine EP Impurity C; Nimodipine USP Related Compound B<br>Applications O-Desisopropyl-O-methoxyethyl Nimodipine (Nimodipine EP Impurity C) is an impurity in the synthesis of Nimodipine (A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Nimodipine USP Related Compound B.<br>References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),<br></p>Formula:C21H26N2O8Color and Shape:NeatMolecular weight:434.44(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran
CAS:Controlled Product<p>Applications (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran is used as a reactant in the efficient synthesis of empagliflozin inhibitor of SGLT-2 utilizing AlCl3-promoted silane reduction of β-glycopyranoside.<br>References Wang, X., et al.: Org. Lett., 16, 4090 (2014);<br></p>Formula:C17H16BrClO2Color and Shape:Off-WhiteMolecular weight:367.66Fenoterol-d6 Hydrobromide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Labelled Fenoterol (F248850). An β2-adrenergic agonist. Bronchodilator; tocolytic.<br>References Schuster, B., et al. Arzneim.-Forsch., 19, 1905 (1969), Gerris, J., et al.: Eur. J. Clin. Pharmacol., 18, 443 (1980), Heel, R.C., et al.: Drugs, 15, 3 (1978),<br></p>Formula:C17D6H15NO4·BrHColor and Shape:Off White To BrownMolecular weight:390.302-Carboxybenzoyl Amlodipine
CAS:Controlled Product<p>Impurity Amlodipine EP Impurity H<br>Applications Amlodipine Besilate (A633500) impurity. Used in the process for preparing Amlodipine benzenesulfonate. Amlodipine EP Impurity H<br></p>Formula:C28H29ClN2O8Color and Shape:NeatMolecular weight:556.99Varenicline N-Glucoside
CAS:Controlled Product<p>Applications A metabolite of Varenicline. Metabolite M7.<br>References Dow, J., et al.: Drug Metab. Dispos., 22, 738 (1994), Toide, K., et al.: Biochem. Pharmacol., 67, 1269 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Doll, R., et al.: Br. J. Cancer, 92, 426 (2005),<br></p>Formula:C19H23N3O5Color and Shape:NeatMolecular weight:373.40Meloxicam- 13CD3
CAS:Controlled Product<p>Applications iMeloxicam- 13CD3 is an isotopic labeled form of Meloxicam(M216100). Meloxicam is a preferential cyclooxygenase (COX-2) inhibitor. Sudoxicam and Meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) from the enol-carboxamide class.<br>References Hawkey, C., et al.: Br. J. Rheumatol., 35, Suppl. 1, 1 (1996), Fleischmann, R., et al.: Expert Opin. Pharmacother., 3, 1501 (2002),<br></p>Formula:C1313CH10D3N3O4S2Color and Shape:Off-White To Light BrownMolecular weight:355.41N-Demethyl Vandetanib
CAS:<p>Applications A major metabolite of Vandetanib (V097100).<br>References Gustafson, D.L. et al.: J. Pharmacol. Exp. Therap., 318, 872 (2006); Weil, A. et al.: Clin. Pharmakin., 49, 607 (2010); Stephen, R. et al.: J. Med. Chem., 45, 1300 (2002);<br></p>Formula:C21H22BrFN4O2Color and Shape:NeatMolecular weight:461.327rac-trans Paroxol
CAS:Controlled Product<p>Applications Racemic Paroxetine intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C13H18FNOColor and Shape:NeatMolecular weight:223.294-(4-Methylpiperazinomethyl)benzoic Acid, Dihydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 4-(4-Methylpiperazinomethyl)benzoic Acid, Dihydrochloride (cas# 106261-49-8) is a compound useful in organic synthesis.<br></p>Formula:C13H18N2O2·2ClHColor and Shape:NeatMolecular weight:307.22S-Hydroxy Topiramate
CAS:Controlled Product<p>Applications A metabolite of Topiramate.<br>References Maryanoff, B., et al.: J. Med. Chem., 30, 880 (1987), Shank, R., et al.: Epilepsia, 35, 450 (1994), Streeter, A., et al.: Drug Metab. Disp., 23, 90 (1995),<br></p>Formula:C12H21NO9SColor and Shape:Off-White To BeigeMolecular weight:355.36trans-Hydroxy Perhexiline (Mixture of Diastereomers)
CAS:Controlled ProductFormula:C19H35NOColor and Shape:NeatMolecular weight:293.49N-Isopropyl-2-methyl-2-propyl-3-hydroxypropyl Carbamate
CAS:Controlled Product<p>Applications An intermediate in the synthesis of Carisoprodol.<br></p>Formula:C11H23NO3Color and Shape:NeatMolecular weight:217.31Defluoro Dolutegravir (>85%)
CAS:<p>Applications Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.<br>References Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);<br></p>Formula:C20H20FN3O5Purity:>85%Color and Shape:NeatMolecular weight:401.39Elexacaftor-D3
CAS:Controlled ProductFormula:C26D3H31F3N7O4SColor and Shape:NeatMolecular weight:600.671a,a,a’,a’-Tetramethyl-5-methyl-1,3-benzenediacetonitrile
CAS:Controlled Product<p>Impurity Anastrozole EP Impurity H<br>Applications α,α,α’,α’-Tetramethyl-5-methyl-1,3-benzenediacetonitrile (Anastrozole EP Impurity H) is an intermediate in the synthesis of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic.<br>References Jackson, T., et al.: Org. Biomolec. Chem., 5, 3368 (2007),<br></p>Formula:C15H18N2Color and Shape:White To YellowMolecular weight:226.321-Methyl-12-thioxopyrido[1,2,3,4]imidazole-[1,2-a]benzimidazole-2(12H)-one
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications Lansoprazole (L175000) impurity .<br></p>Formula:C14H9N3OSColor and Shape:Orange To RedMolecular weight:267.31β-D-Glucose Pentaacetate
CAS:Controlled Product<p>Applications D-Glucose pentaacetate was reported to stimulate insulin release in rat pancreatic islets. Only α-D-glucose pentaacetate caused an immediate increase in insulin output. The β-anomer of D-glucose pentaacetate first transiently inhibited insulin release, this initial effect being followed by a secondary rise in secretory rate.<br>References Carpinelli, A., et al.: Mol. Cell Endocrinol., 17, 103 (1980), Hellman, B., et al.: Diab. Metab., 20, 123 (1994), Malaisse, W., et al.: Int. J. Mol. Med., 2, 331 (1998), Sener, A., et al.: Mol. Gen. Metab., 64, 135 (1998),<br></p>Formula:C16H22O11Color and Shape:WhiteMolecular weight:390.34Pimobendan-d3
CAS:Controlled Product<p>Applications Pimobendan-d3, is the labeled analogue of Pimobendan (P447500), a cardiotonic agent.<br>References Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992); Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996); Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998);<br></p>Formula:C19H15D3N4O2Color and Shape:White To Light YellowMolecular weight:337.39Rac Albuterol-d9
CAS:Controlled Product<p>Applications A labelled β2-adrenoceptor agonist. Bronchodilator; tocolytic.<br>References Miyagawa, N., et al.: Biol. Pharm. Bull., 31, 2260 (2008), Gonzalez-Munoz, C., et al.: Eur. J. Pharmacol., 607, 151 (2009), Kern, C., et al.: J. Med. Chem., 52, 1773 (2009),<br></p>Formula:C132H9H12NO3Color and Shape:White To YellowMolecular weight:248.37Mildronate-d3
CAS:Controlled Product<p>Stability Very Hygroscopic<br>Applications Mildronate-d3 is the labeled analogue of Mildronate (M344450), a novel pharmaceutical composition based on a reverse transcriptase inhibitor and meldonium. May contain a significant amount of water.<br></p>Formula:C6H11D3N2O2Color and Shape:White To Off-WhiteMolecular weight:149.211-Descarbamoyl-2-carbamoyl Methocarbamol
CAS:Controlled Product<p>Applications An impurity of the muscle relaxant Methocarbamol (M225950) with lysosomal acid lipase inhibitory effects.<br>References Topliss, J., et al.: J. Med. Chem., 22, 1238 (1979); Rosenbaum, A.I. et al.: J. Med. Chem., 52, 5281 (2010);<br></p>Formula:C11H15NO5Color and Shape:NeatMolecular weight:241.240Benzydamine N-Oxide
CAS:<p>Applications A metabolite of Benzydamine (B209950).<br>References Beaty, N., et al.: J. Biol. Chem., 255, 3817 (1980), Tugnait, M., et al.: Drug Metab. Dispos., 25, 524 (1997), Ubeaud, G., et al.: Eur. J. Pharm. Sci., 8, 255 (1999),<br></p>Formula:C19H23N3O2Color and Shape:NeatMolecular weight:325.45-Benzyl Benzydamine Hydrochloride
CAS:<p>Applications 5-Benzyl Benzydamine is an impurity of Benzydamine hydrochloride (B209950). Benzydamine impurity B.<br></p>Formula:C26H29N3O·ClHColor and Shape:NeatMolecular weight:435.99Loratadine
CAS:Controlled Product<p>Applications A nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989), Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Formula:C22H23ClN2O2Color and Shape:WhiteMolecular weight:382.88N-Nitroso Frovatriptan 1
Formula:C14H16N4O2Color and Shape:Off-White To Light YellowMolecular weight:272.3Valsartan n-Propyl Impurity
CAS:Controlled Product<p>Impurity Valsartan Related Compound B<br>Applications Valsartan n-Propyl is an impurity in the synthesis of Valsartan (V095750). Valsartan USP Related Compound B.<br>References Hillaert, S., et al.: J. Pharm. Biomed. Anal., 31, 329 (2003), Carlucci, G., et al.: Anal. Lett., 33, 2491 (2000), Cagigal, E., et al.: Talanta, 54, 1121 (2001),<br></p>Formula:C23H27N5O3Color and Shape:WhiteMolecular weight:421.49Omeprazole-d3
CAS:Controlled Product<p>Applications Labelled Omeprazole, which binds covalently to proton pump, it inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983), Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984), Morii, M., et al.: J. Biol. chem., 268, 21553 (1993), Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Formula:C172H3H16N3O3SColor and Shape:NeatMolecular weight:348.43Edoxaban 4-Carboxylic Acid Hydrochloride
CAS:Controlled ProductFormula:C22H25ClN6O5S·xHClColor and Shape:NeatMolecular weight:520.99 + x(36.46)Hydroxy Atrazine
CAS:Controlled Product<p>Applications Hydroxy Atrazine is a major metabolite of Atrazine (A794600).<br>References Thurman, E., et al.: Environ. Sci. Technol., 26, 2440 (1992), Evgenidou, E., et al.: J. Agric. Food Chem., 50, 6423 (2002), Namiesnik, J., et al.: Anal. Bioanal. Chem., 381, 279 (2005), Hultgren, S., et al.: Anal. Bioanal. Chem., 393, 929 (2009),<br></p>Formula:C8H15N5OColor and Shape:White To Off-WhiteMolecular weight:197.24Spiromesifen
CAS:Controlled Product<p>Applications Spiromesifen is a useful insecticide and miticide in plant breeding. Also useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C23H30O4Color and Shape:Light BrownMolecular weight:370.48N-Methyl-N,N-bis(2-pyridylethyl)amine
CAS:<p>Impurity Betahistine EP Impurity C (Free Base)<br>Applications N-Methyl-N,N-bis(2-pyridylethyl)amine is used as a reagent in the preparation of copper pyridylmethylethylenediamine dicyanamido polymeric complexes.<br>References Mautner, F.A. et al.: Inorg. Chim. Acta, 362, 4073 (2009);<br></p>Formula:C15H19N3Color and Shape:NeatMolecular weight:241.33Clonidine-d4 Hydrochloride
CAS:Controlled Product<p>Applications α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983), Glassman, A.H., et al.: Science, 226, 864 (1984), Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992),<br></p>Formula:C92H4H5Cl2N3·ClHColor and Shape:Off White SolidMolecular weight:270.58(R)-Pramipexole-d3 Dihydrochloride
CAS:Controlled Product<p>Applications Labelled (R)-Pramipexole enantiomer. A dopamine-D2-receptor agonist. Antiparkinsonian.<br>References Mierau, J., et al.: J. Med. Chem., 30, 494 (1987), Schilling, J.C., et al.: Clin. Pharmacol. Ther., 51, 541 (1992), Kieburtz, K., et al.: J. Am. Med. Assoc., 278, 125 (1997)<br></p>Formula:C10H16D3Cl2N3SColor and Shape:NeatMolecular weight:287.27Acetohydrazide
CAS:Controlled Product<p>Applications Acetohydrazide is a metabolite of Isoniazid (I821450) an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Metushi, I.G., et al.: Chem. Res. Toxciol., 25, 2567 (2012); Fukino, K., et al.: J. Toxicol. Sci., 33, 667 (2008);<br></p>Formula:C2H6N2OColor and Shape:Off-WhiteMolecular weight:74.08Empagliflozin R/S-Furanose
CAS:<p>Applications Empagliflozin R/S-Furanose is a mixture of R and S isomers of Empagliflozin Furanose. Both are byproducts in the synthesis of Empagliflozin drug (E521510), which is potent and selective inhibitor of sodium glucose co-transporter-2 (SGLT-2).<br>References Thomas, L., et al.: Diabetes. Obesity. Metabol. 14, 94 (2012); Grempler, R., et al.: Diabetes. Obesity. Metabol., 14, 83 (2012); Wang, X., et al.: Org. Lett., 16, 4090 (2014);<br></p>Formula:C23H27ClO7Color and Shape:White To Off-WhiteMolecular weight:450.909Aripiprazole Hydrate
CAS:Controlled Product<p>Applications Aripiprazole Hydrate is an agonist at the dopamine autoreceptor and an antagonist at the postsynaptic D2 receptor (1,2,3,4). Aripiprazole is an antipsychotic and a potential drug candidate for treating psychoses such as schizophrenia.<br>References Pan, B., et al.: Psychopharmacology, PagesAhead of Print( 2019), Kim, J. Y., et al.: Anticancer Res., 38, 5101 (2018)<br></p>Formula:C23H27Cl2N3O2·xH2OColor and Shape:NeatMolecular weight:448.39 + 36.02rac-Methyl Ephedrine-d3 Hydrochloride
CAS:Controlled Product<p>Applications Labelled Ephedrine derivative for controlling respiratory tract goblet cell hyperplasia in respiratory diseases including infection and bronchitis.<br>References Tan, Z., et al.: J. Therm. Anal., 45, 59 (1995), van Berkel, G., et al.: Anal. Chem., 76, 479 (2004), Di, Y., et al.: Chin. Phy., 17, 3276 (2008),<br></p>Formula:C112H3H14NO·ClHColor and Shape:NeatMolecular weight:218.743-Vinylpyridine (>90%)
CAS:Controlled ProductFormula:C7H7NPurity:>90%Color and Shape:Light Yellow To Dark OrangeMolecular weight:105.144-Hydroxy-N-desbutyl Bupivacaine
CAS:Controlled Product<p>Applications Bupivacaine metabolite.<br>References Goehl, T. J. et al.: Xenobiotica 3, 761 (1973)<br></p>Formula:C14H20N2O2Color and Shape:NeatMolecular weight:248.32N-Nitroso Varenicline
CAS:Controlled Product<p>Applications N-Nitroso Varenicline is a derivative of Varenicline (V215635(M)), which is a useful medication for smoking cessation.<br>References Hart, E., et al.: Behavioural Brain Research, 397, 112887 (2021)<br></p>Formula:C13H12N4OColor and Shape:NeatMolecular weight:240.261α,α,α’,α’-Tetramethyl-5-(dibromomethyl)-1,3-benzenediacetonitrile
CAS:Controlled Product<p>Impurity Anastrozole EP Impurity D / Anastrozole USP Related Compound E<br>Applications α,α,α’,α’-Tetramethyl-5-(dibromomethyl)-1,3-benzenediacetonitrile (Anastrozole EP Impurity D) an impurity of Anastrozole (A637425) (impurity E).<br>References Ge, Z., et al.: J. Med. Chem., 13, 146 (2003),<br></p>Formula:C15H16Br2N2Color and Shape:WhiteMolecular weight:384.113-Acetamidophthalic Acid
CAS:<p>Impurity Apremilast EP Impurity B<br>Applications 3-Acetamidophthalic Acid is an impurity of Apremilast (A729700); an oral phosphodiesterase 4 inhibitor used in the treatment of psoriatic arthritis. Apremilast EP Impurity B<br>References Gan, E. et al.: BioDrugs, 27, 359 (2013); Pathan, E. et al.: Annal. Rheum. DIs., 72, 1475 (2013); Hoffmann, M., et al.: Xenobiotica, 41, 1063 (2011)<br></p>Formula:C10H9NO5Color and Shape:NeatMolecular weight:223.18Chlorpromazine-d6 Oxalate (N,N-dimethyl-d6)
CAS:Controlled Product<p>Applications Chlorpromazine-d6 Oxalate (N,N-dimethyl-d6) (CAS# 1276197-23-9) is a useful isotopically labeled research compound.<br></p>Formula:C17D6H13ClN2S·C2H2O4Color and Shape:Off-WhiteMolecular weight:414.93Sodium Borohydride
CAS:<p>Applications Sodium Borohydride is used as a reagent in the reduction of amino acids and their derivatives. Also used in the catalysis of ammonia borane dehydrogenation.<br> E0<br>References McKennon, M. et al.: J. Org. Chem., 58, 3568 (1993); Denney, M. et al.: J. Am. Chem. Soc., 128, 12048 (2006);<br></p>Formula:BH4NaColor and Shape:White To Off-WhiteMolecular weight:37.83Ticagrelor Sulfoxide (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications Ticagrelor Sulfoxide is an impurity of ticagrelor (T437700). Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formula:C23H28F2N6O5SColor and Shape:NeatMolecular weight:538.57N-Formyl Varenicline
CAS:Controlled Product<p>Applications A metabolite of Varenicline. Metabolite M5.<br>References Dow, J., et al.: Drug Metab. Dispos., 22, 738 (1994), Toide, K., et al.: Biochem. Pharmacol., 67, 1269 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Doll, R., et al.: Br. J. Cancer, 92, 426 (2005),<br></p>Formula:C14H13N3OColor and Shape:NeatMolecular weight:239.27Cyamemazine
CAS:<p>Applications Cyamemazine is an anxiolytic antipsychotic, which reduces ethanol withdrawal symptoms.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Robinson, et al.: J. Pharm. Pharmacol., 18, 19 (1966), Miller, L., et al.: J. Pharmacol. Exp. Ther., 246, 170 (1988), Podhorna, J., et al.: Curr. Pharm. Des., 8, 23 (2002), Hameg, A., et al.: Biochem. Pharmacol., 65, 435 (2003),<br></p>Formula:C19H21N3SColor and Shape:Green YellowMolecular weight:323.46N-Desmethyl 8-Chloro-5H-dibenzo[b,e][1,4]diazepine Clozapine
CAS:Controlled Product<p>Impurity CLOZAPINE EP IMPURITY B<br>Applications N-Desmethyl 8-Chloro-5H-dibenzo[b,e][1,4]diazepine Clozapine is a Clozapine (C587500) impurity, an antipsychotic.<br>References Stille, et al: Farnaco, Ed. Prat., 26, 603 (1971), Hane, J.M., et al.: Psychopharmacol. Bull., 24, 62 (1988), Meltzer, H.Y.: J. Clin. Psychiatry, 55, Suppl. B, 47 (1994)<br></p>Formula:C30H24Cl2N6Color and Shape:NeatMolecular weight:539.46Dolutegravir (0.1 mg/mL in Methanol)
CAS:Formula:C20H19F2N3O5Color and Shape:ColourlessMolecular weight:419.38(S)-Efavirenz
CAS:<p>Applications A nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>Formula:C14H9ClF3NO2Color and Shape:NeatMolecular weight:315.68Ketanserin
CAS:<p>Applications An antihypertensive, with affinity for multiple GPCR receptors.<br>References Zhu, Y., et al.: Biol. Pharm. Bull., 32, 1173 (2009), Shen, K., et al.: J. Pharm. Pharmacol., 61, 517 (2009), Brea, J., et al.: Mol. Pharmacol., 75, 1380 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),<br></p>Formula:C22H22FN3O3Color and Shape:NeatMolecular weight:395.43N-Boc-piperazine
CAS:<p>Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.<br></p>Formula:C9H18N2O2Color and Shape:NeatMolecular weight:186.253-[5-(1,5-Dioxo-5-(p-fluophenylpentyl]-4(S)-phenyl-2-oxazolidinone
CAS:Controlled ProductFormula:C20H18FNO4Color and Shape:NeatMolecular weight:355.3596Desmethyl Mirtazapine-d6 Dihydrochloride
CAS:Controlled Product<p>Impurity Mirtazapine<br>Applications A labelled metabolite of Mirtazapine, α2-adrenergic blocker.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990)<br></p>Formula:C16H11D6N3·2HClColor and Shape:NeatMolecular weight:330.29Celiprolol-d9 Hydrochloride
CAS:Controlled Product<p>Applications Labelled Celiprolol. Cardioselective β1-adrenergic blocker. Antihypertensive, antianginal.<br>References Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 20, 237 (1991), Meininger, C., et al.: Biochem. J., 349, 353 (2000), Ruan, H., et al.: Diabetes, 51, 1319 (2002), Liao, Y., et al.: Circulation, 110, 692 (2004),<br></p>Formula:C20H25D9ClN3O4Color and Shape:NeatMolecular weight:425.012,4-Diamino-6-piperidinopyrimidine (Desoxyminoxidil)
CAS:<p>Impurity Minoxidil EP Impurity E<br>Applications 2,4-Diamino-6-piperidinopyrimidine (Desoxyminoxidil) (Minoxidil EP Impurity E) is an analogue of Minoxidil (M345000).<br>References Cox, J., et al.: Adv. Drug Res., 5, 115 (1970), Watanabe., et al.: Microbiol. Immunol., 23, 1009 (1979), Nakai, H., et al.: J. Med. Chem., 31, 84 (1988), Shiraishi, M., et al.: J. Med. Chem., 32, 2214 (1989),<br></p>Formula:C9H15N5Color and Shape:Off-White To BeigeMolecular weight:193.25Telmisartan-d7
CAS:Controlled Product<p>Applications Labelled Telmisartan (T017000). Telmisartan is an angiotensin II receptor antagonist.<br>References Wienen, W. et al.: Br. J. Pharmacol., 110, 245 (1993); Neutel, J.M. et al: Adv. Therap., 15, 206 (1998);<br></p>Formula:C33H23D7N4O2Color and Shape:NeatMolecular weight:521.663(R)-(+)-Carvedilol
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications The optically active isomer of Carvedilol (C184625), a nonselective ß-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990),<br></p>Formula:C24H26N2O4Color and Shape:Off White SolidMolecular weight:406.47Granisetron Hydrochloride
CAS:Controlled Product<p>Applications A specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptor<br>References Kilpatrick, G.J., et al.: Nature, 330, 746 (1987), Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997), Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996),<br></p>Formula:C18H24N4O·ClHColor and Shape:NeatMolecular weight:348.872-Amino-5-methylthiazole
CAS:Controlled Product<p>Impurity Meloxicam EP Impurity B<br>Applications 2-Amino-5-methylthiazole (Meloxicam EP Impurity B) is an aminothiazole derivative used in characterization and DNA-interaction studies via formation of metal complexes that bind competitively to DNA. 2-Amino-5-methylthiazole can be used in solar cells to influence the interaction with the TiO2 photoelectrode, which in turn alters the dye-sensitized solar cell performance.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kusama, H. et al.: Sol. Energy Mat. Sol. Cells, 82, 457 (2004); Cox, P.J. et al.: Bioorg. Med. Chem., 17, 6054 (2009);<br></p>Formula:C4H6N2SColor and Shape:Brown To Dark BrownMolecular weight:114.17DL-Fenfluramine
CAS:Controlled Product<p>Applications Anorectic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pinder, et al.: Drugs, 10, 241 (1975); Caccia, S., et al.: Eur. J. Clin. Pharmacol., 29, 221 (1985); Finner, N., et al.: Curr. Ther. Res., 38, 847 (1985);<br></p>Formula:C12H16F3NColor and Shape:NeatMolecular weight:231.26Chlorpromazine N-Oxide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Chlorpromazine N-Oxide is a metabolite of Chlorpromazine. Chlorpromazine exhibits antiadrenergic, antiserotonergic, anticholinergic, and antihistaminergic properties, and commonly used to treat schizophrenia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, Z., et al.: Handbook of Metabolic Pathways of Xenobiotics, 3, 1102 (2014); Kigondu, E. M., et al.: MedChemComm, 5, 502 (2014); Yeung, P. K. F., et al.: Eur. J. Clin. Pharmacol., 45, 563 (1993)<br></p>Formula:C17H19ClN2OSColor and Shape:NeatMolecular weight:334.86Dipyridamole-d20 (Major)
CAS:Controlled Product<p>Applications Selective inhibitor of phosphodiesterase V (PDE 5); potent coronary vasodilator drug; adenosine transport inhibitor; inhibitor of platelet aggregation.A representative lot was: 36% d20; 25% d19; 13%d18; 24% d17; 1% d16.<br>References Buchalter, M.B., et al.: Postgrad. Med. J., 66, 531 (1990), Sundaram, M., et al.: J. Biol. Chem., 273, 21519 (1998), Denis, D., et al.: Eur. J. Pharmacol., 367, 343 (1999),<br></p>Formula:C24H20D20N8O4Color and Shape:NeatMolecular weight:524.754-Methoxy Moxonidine
CAS:Controlled ProductFormula:C10H15N5O2Color and Shape:GreyMolecular weight:237.26Aprepitant
CAS:Controlled Product<p>Applications Aprepitant is a neurokinin-1 antagonist and an antiemetic agent (1). It is used to prevent chemotherapy-induced nausea and vomiting (CINV) in colorectal cancer patients (2) Aprepitant has also been shown to induce apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells (3).<br>References (1) Takemoto, H., et al.: nt J Clin Oncol (2016) (2) Bayati, S., et al.: Eur J Pharmacol. 791, 274 (2016) (3) Navari, R.M.: Expert Rev Anticancer Ther. 4, 715 (2004)<br></p>Formula:C23H21F7N4O3Color and Shape:Off-WhiteMolecular weight:534.43Nocodazole
CAS:<p>M05733 - Nocodazole</p>Formula:C14H11N3O3SPurity:98%Color and Shape:Solid, Beige powderMolecular weight:301.320007324218754-(4-Morpholinyl)-1,2,5-thiadiazol-3(2H)-one 1-Oxide
CAS:Controlled Product<p>Impurity Timolol EP Impurity G; Timolol BP Impurity G<br>Stability Moisture Sensitive<br>Applications 4-(4-Morpholinyl)-1,2,5-thiadiazol-3(2H)-one 1-Oxide (Timolol EP Impurity G; Timolol BP Impurity G) is an impurity of Timolol (T4437005), an antihypertensive, an adrenergic blocking agent (1); antiarrhythmic (class II); antianginal; antiglaucoma (2) and antihypertensive (3) agent.<br>References 1. Wasson, B. et al.: J. Med. Chem. 1972 Jun;15(6):651-5.2. Heel, R. et al.: Drugs. 1979 Jan;17(1):38-55.3. Rofman, et al.: Hypertension. 1980 Sep-Oct;2(5):643-8.<br></p>Formula:C6H9N3O3SColor and Shape:WhiteMolecular weight:203.22Loratadine-d4
CAS:Controlled ProductFormula:C22H19D4ClN2O2Color and Shape:Off White PowderMolecular weight:386.91TERT-BUTYL METHYL(1-METHYL-1H-PYRAZOL-3-YL)CARBAMATE
CAS:Purity:95.0%Molecular weight:211.26499938964844Celecoxib-d7
CAS:Controlled Product<p>Applications Celecoxib-d7 is the labeled analogue of Celecoxib (C251000), a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998); Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000); Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000)<br></p>Formula:C17D7H7F3N3O2SColor and Shape:WhiteMolecular weight:388.42Bicalutamide-d4
CAS:Controlled Product<p>Applications Used as an antiandrogen, antineoplastic (hormonal). (94%d4; 5.7%d3, 0.1%d1, no d0)<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>Formula:C18H10D4F4N2O4SColor and Shape:NeatMolecular weight:434.4
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