Salts and Derivatives of Active Pharmaceutical Ingredients (API)
The salts of Active Pharmaceutical Ingredients (APIs) are compounds formed by the reaction of an acid with a base, resulting in an ionic equilibrium. These salts often improve the solubility and stability of APIs, facilitating their absorption in the body. API derivatives are chemical variants of an active ingredient that may have enhanced or modified properties to optimise therapeutic efficacy. API salts are used in the formulation of oral, injectable, and topical medications. Additionally, API derivatives can improve the pharmacokinetics of drugs, such as enabling controlled release of active substances.
At CymitQuimica, we provide API salts and derivatives with the necessary purity and quality for research and pharmaceutical formulation development.
Found 79464 products of "Salts and Derivatives of Active Pharmaceutical Ingredients (API)"
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Levosimendan
CAS:<p>Applications Bioactive enantiomer of racemate, Simendan. Positive inotropic agent with vasodilating activity. Cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995), Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996),<br></p>Formula:C14H12N6OColor and Shape:Yellow To Dark YellowMolecular weight:280.28Ethyl-S-(+)-Clopidogrel Sulfate
CAS:Controlled Product<p>Stability Very Hygroscopic<br>Applications Ethyl-(S)-(+)-Clopidogrel Sulfate is an analogue of S-(+)-Clopidogrel Hydrogen Sulfate (C587250) which is used as an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Formula:C17H20ClNO6S2Color and Shape:White To Off-WhiteMolecular weight:433.93Iomeprol-d3
CAS:Controlled Product<p>Applications Diagnostic aid (radiopaque medium).<br>References Gallotti, A., et al.: Eur. J. Radiol., 18, Suppl 1 S1(1994), Morisetti, A., et al.: Eur. J. Radiol., 18, Suppl 1 S21(1994).<br></p>Formula:C17H19D3I3N3O8Color and Shape:Off-WhiteMolecular weight:780.10Argatroban monohydrate
CAS:Controlled ProductFormula:C23H36N6O5S·H2OColor and Shape:NeatMolecular weight:526.65Latanoprost
CAS:<p>Applications Prostaglandin analog, used to treat glaucoma and other degenerative diseases of the eye.<br>References Rhee, D.J., et al.: Clinic. Ophthalmol., 2, 313 (2008), Hernandez, M., et al.: Exp. Eye Res., 86, 798 (2008), Nagata, T., et al.: J. Pharmacol. Sci., 106, 423 (2008), Ikeda, Y., et al.: J. Ocular Pharmacol. Ther., 24, 230 (2008),<br></p>Formula:C26H40O5Color and Shape:Light YellowMolecular weight:432.595-Methylisoxazole-4-carboxylic Acid
CAS:Controlled ProductFormula:C5H5NO3Color and Shape:NeatMolecular weight:127.10Apixaban PG Ester-I
CAS:Controlled Product<p>Applications Apixaban PG Ester-I is one of the multiple constituents extracted from Biebersteinia multifida, that exhibits inhibitory activity on acetylcholinesterase.<br>References Xiang, F., et al.: Faming Zhuanli Shenqing (2019), CN 109432093 A 20190308.<br></p>Formula:C28H30N4O6Color and Shape:NeatMolecular weight:518.56Ramipril (1 mg/mL in Methanol)
CAS:Formula:C23H32N2O5Color and Shape:Single SolutionMolecular weight:416.51Brinzolamide
CAS:Controlled Product<p>Applications Carbonic anhydrase inhibitor. Antiglaucoma agent.<br>References Silver, L.H., et al.: Am. J. Ophthalmol., 126, 400 (1998), Davies, N., et al.: Clin. Exp. Pharmacol. Physiol., 27, 558 (2000), Stave, J., et al.: Ophthalmologe, 99, 276 (2002),<br></p>Formula:C12H21N3O5S3Color and Shape:NeatMolecular weight:383.51Repaglinide Acyl-β-D-glucuronide
CAS:<p>Applications A metabolite of Repaglinide (M7).<br></p>Formula:C33H44N2O10Color and Shape:NeatMolecular weight:628.71Dihydro Cyclosporin A
CAS:Controlled Product<p>Applications A Cyclosporin A (C988900) analog, an immunosuppressant.<br>References Emmer, G., et al.: J. Med. Chem., 37, 1918 (1994), High, K., et al.: J. Biol. Chem., 269, 9105 (1994),<br></p>Formula:C62H113N11O12Color and Shape:WhiteMolecular weight:1204.63Tolvaptan
CAS:Controlled Product<p>Applications Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006);<br></p>Formula:C26H25ClN2O3Color and Shape:White To Off-WhiteMolecular weight:448.94Ramiprilat Acyl-β-D-glucuronide >65%
CAS:Controlled ProductFormula:C27H36N2O11Purity:>65%Color and Shape:NeatMolecular weight:564.58Allopurinol-d2
CAS:Controlled Product<p>Applications Labelled xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Formula:C52H2H2N4OColor and Shape:Light BrownMolecular weight:138.12Repaglinide
CAS:Controlled Product<p>Applications Non-sulfonylurea oral hypoglycemic agent. Used as an antidiabetic.<br>References Wolffenbuttel, B.H.R., et al.: Eur. J. Clin. Pharmacol., 45, 113 (1993), Ampudia-Blasco, F.J., et al.: Diabetologia, 37, 703 (1994),<br></p>Formula:C27H36N2O4Color and Shape:White To Off-WhiteMolecular weight:452.59Cyclosporin B
CAS:<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Formula:C61H109N11O12Purity:>80%Color and Shape:NeatMolecular weight:1188.583-Chloro-1,2-propanediol-d5
CAS:Controlled ProductFormula:C32H5H2ClO2Color and Shape:ColourlessMolecular weight:115.57Pentoxifylline
CAS:Controlled ProductFormula:C13H18N4O3Color and Shape:White To Off-WhiteMolecular weight:278.31Ramipril Acyl-β-D-glucuronide
CAS:Controlled Product<p>Applications A metabolite of Ramipril (R111000). This compound is not stable in an aqueous solution.<br></p>Formula:C29H40N2O11Color and Shape:NeatMolecular weight:592.63Geranylgeraniol (Natural)
CAS:Controlled Product<p>Stability Light Sensistive, Temperature Sensitive<br>Applications Geranylgeraniol, a precursor to Geranylgeranylpyrophosphate (G367600), is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-adsorption, inhibition of osteoclast formation, and kinase activation in vitro.<br>References Aiuchi, T., et al.: J. Biochem., 124, 300 (1998), Fisher, J.E., et al.: Proc. Natl. Acad. Sci. U.S.A. 96, 133 (1999), Montero, M.T., et al.: J. Immunol., 173, 4936 (2004), Campia, I., et al.: Br. J. Pharmacol., 158, 1777 (2009),<br></p>Formula:C20H34OColor and Shape:NeatMolecular weight:290.48Hydroxy Brimonidine Trifluoroacetic Acid Salt
CAS:<p>Impurity Brimonidine EP Impurity G<br>Applications A possible metabolite of Brimonidine (B677520).<br></p>Formula:C11H12BrN5O·C2HF3O2Color and Shape:NeatMolecular weight:424.1732Travoprost
CAS:<p>Stability Light Sensitive<br>Applications Travoprost is a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).<br>References (1) Hellberg, M.R., et al.: J. Ocul. Pharmacol. Ther., 17, 421 (2001) (2) Schuman, J.S., et al.: Am. J. Ophthalmol., 140, 242 (2005)<br></p>Formula:C26H35F3O6Color and Shape:Colourless To BeigeMolecular weight:500.55Cyclosporin AM 1 (>80%)
CAS:Controlled Product<p>Applications A cyclosporine metabolite specifically inhibits growth of renal cells in culture.<br>References Schultz, J.C.; et al.: Biochem. Pharma., 42, 1403 (1991), Johnson, B., et al.: Drug Metab. Dispos., 34, 556 (2006), Westley, I.S., Drug Metab. Dispos., 36, 46 (2008).<br></p>Formula:C62H111N11O13Purity:>80%Color and Shape:NeatMolecular weight:1218.61(2R,3aR,6aR)-Ramipril
CAS:Controlled Product<p>Impurity Ramipril EP Impurity N<br>Applications (2R,3aR,6aR)-Ramipril (Ramipril EP Impurity N) is an isomer of the angiotensin-converting enzyme (ACE) inhibitor Ramipril (R111000). Ramipril impurity N.<br>References Hogan, B.L. et al.: J. Pharmac. Biomed. Anal., 23, 637 (2000); Ito, M. et al.: J. Liq. Chrom., 13, 991 (1990);<br></p>Formula:C23H32N2O5Color and Shape:White To Off-WhiteMolecular weight:416.51Probenecid
CAS:Controlled Product<p>Applications Uricosuric.<br>References McKinney, S.E., et al.: J. Pharmacol. Exp. Ther., 102, 208 (1951), Israili, Z.H., et al.: J. Med. Chem., 15, 709 (1972), Al-Badr, A.A., et al.: Anal. Profiles Drug Subs., 10, 639 (1981), Cunningham, R.F., et al.: Clin. Pharmacokinet., 6, 135 (1981),<br></p>Formula:C13H19NO4SColor and Shape:WhiteMolecular weight:285.36Octenidine Dihydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Octenidine is an antiseptic (topical). Octenidine is a cationic surfactant and bis-(dihydropyridinyl)-decane derivative.<br>References Slee, A.M., et al.: Antimicrob. Agents Chemother., 23, 531 (1983), Ghannoum, M.A., et al.: J. Antimicrob. Chemother., 25, 237 (1990), Allen, M., et al.: Microbiology, 152, 989 (2006), Ojha, A., et al.: Mol. Microbiol., 66, 468 (2007),<br></p>Formula:C36H62N4·2HClColor and Shape:White To Off-WhiteMolecular weight:623.833’-Hydroxy Repaglinide (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications A metabolite of Repaglinide (R144500).<br>References Jarvis, B., et al.: Drugs, 59, 891 (2000), Niemi, M., et al.: Clin. Pharmacol. Ther., 70, 58 (2001), Hatorp, V., et al.: Clin. Pharmacokinet., 41, 471 (2002), Walsky, R., et al.: Drug Metab. Dispos., 33, 413 (2005),<br></p>Formula:C27H36N2O5Color and Shape:NeatMolecular weight:468.59Tolvaptan-d7
CAS:Controlled Product<p>Applications Labelled Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>Formula:C26H18D7ClN2O3Color and Shape:NeatMolecular weight:455.98Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
CAS:Formula:C14H13NO4SColor and Shape:NeatMolecular weight:291.32Selexipag
CAS:Controlled Product<p>Applications Selexipag is an orally available, highly selective, long-acting prostacyclin (IP) receptor agonist prodrug. It is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.<br>References Kuwano, K., et al.: J. Pharm. Exp. Ther., 322, 1181 (2007);<br></p>Formula:C26H32N4O4SColor and Shape:Light YellowMolecular weight:496.625-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).<br>References Mochizuki, A., et al.: Jpn. Kokai Tokkyo Koho. JP 2010120852 A 20100603. Jun 3, 2010; Mochizuki, A., et al.: PCT Int. Appl. WO 2008123017 A1 20081016. Oct 16, 2008<br></p>Formula:C8H11ClN2O2SColor and Shape:Light BrownMolecular weight:234.76-Hydroxy Warfarin β-D-Glucuronide D Disodium Salt Hydrate
CAS:Controlled Product<p>Applications 6-Hydroxy Warfarin β-D-Glucuronide Disodium Salt Hydrate, is a metabolite of Warfarin (W498500) in humans.<br>References Barbato, F., et al.: J. Pharm. Sci., 86, 225 (1997), Kavana, M., et al.: Biochemistry, 42, 10238 (2003), Franco, A., et al.: Environ. Toxicol. Chem., 28, 458 (2009),<br></p>Formula:C25H22Na2O11•xH2OColor and Shape:NeatMolecular weight:544.421802Apixaban
CAS:<p>Applications A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J. M., et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T., et al.: J. Thromb. Thrombol., 31, 310 (2011); Barrett, Y. C., et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Formula:C25H25N5O4Color and Shape:White To Off-WhiteMolecular weight:459.50Apixaban PG Ester-II
CAS:Controlled Product<p>Applications Apixaban PG Ester-II is one of the multiple constituents extracted from Biebersteinia multifida, that exhibits inhibitory activity on acetylcholinesterase.<br>References Xiang, F., et al.: Faming Zhuanli Shenqing (2019), CN 109432093 A 20190308.<br></p>Formula:C28H30N4O6Color and Shape:NeatMolecular weight:518.56(R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
CAS:Controlled Product<p>Applications A metabolite of Levosimendan.<br>References Rubinstein, A., et al.: J. Pharmacol. Met., 19, 213 , (1988), Pollesello, P., et al.: J. Biol. Chem., 269, 28584 (1994), Yokoshiki, H., et al.: Eur. J. Pharmacol., 333, 249 (1997)<br></p>Formula:C11H13N3OColor and Shape:NeatMolecular weight:203.24Allopurinol-13C,15N2
CAS:Controlled Product<p>Applications Allopurinol-13C,15N2, is the labeled analogue of Allopurinol (A547300), acting as an Xanthine oxidase inhibitor, and used in treatment of hyperuricemia and chronic gout.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Formula:C413CH4N215N2OColor and Shape:NeatMolecular weight:139.09Febuxostat-d7
CAS:Controlled Product<p>Applications Febuxostat-d7, is the labeled analogue of Febuxostat-d7 (F229000), a Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Formula:C16H9D7N2O3SColor and Shape:NeatMolecular weight:323.427-Hydroxy Warfarin
CAS:Controlled ProductFormula:C19H16O5Color and Shape:Off WhiteMolecular weight:324.333’-Amino-2’-Hydroxy-[1,1’]biphenyl-3-carboxylic Acid
CAS:Controlled Product<p>Applications 3’-Amino-2’-Hydroxy-[1,1’]Biphenyl-3-carboxylic Acid is used in the synthesis of monoethanolamine salts. A hydrazine cleavage product from Eltrombopag (E508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Formula:C13H11NO3Color and Shape:NeatMolecular weight:229.231N-(R)-Glycidyl Phthalimide
CAS:Controlled Product<p>Applications Reagent used for the simultaneous preparation of amino alcohol solvating agents as well as preparation of orally available anticoagulants.<br>References Roehrig, S. et al: J. Med. Chem., 48, 5900 (2005); Bozkurt, S. et al: Tetra: Asymm., 22, 541 (2011);<br></p>Formula:C11H9NO3Color and Shape:NeatMolecular weight:203.19R-(+)-Warfarin
CAS:Controlled Product<p>Applications The R-(+)-form of Warfarin (W498500). Coumarin anticoagulant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),<br></p>Formula:C19H16O4Color and Shape:NeatMolecular weight:308.33Mivacurium Chloride (mixture of isomers)
CAS:Controlled ProductFormula:C58H80N2O14·2ClColor and Shape:NeatMolecular weight:1100.17Eltrombopag Ethyl Ester
Controlled Product<p>Applications Eltrombopag Ethyl Ester, is a metabolite of Eltrombopag (E508000), which is an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Formula:C27H26N4O4Color and Shape:NeatMolecular weight:470.52Diclofenac Dimer Impurity
CAS:<p>Applications Diclofenac Dimer Impurity, is an metabolite of Diclofenac (D436450), which is nonsteroidal anti-inflammatory compound acting as decycloxygenase (COX) inhibitor.<br>References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004), Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008), Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009),<br></p>Formula:C28H20Cl4N2O4Color and Shape:Light Orange Colour To RedMolecular weight:590.2824,32-Bis-O-(tert-butyldimethylsilyl)-FK-506-13C, D2 (Major)
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications An intermediate in the preparation of labelled FK-506 (Tacrolimus)<br>References Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., et al.: Brit. Med. J., 318, 1104 (1999),<br></p>Formula:C5513CH95D2NO12Si2Color and Shape:NeatMolecular weight:1035.54Diethyl Phthalate
CAS:<p>Applications A phthalate metabolite with genotoxic effect. This compound is a contaminant of emerging concern (CECs).<br>References Reyes, F., et al.: J. Clin. Endocrinol. Metab., 37, 74 (1973), Engel, S., et al.: Neurotoxicology, 30, 522 (2009),<br></p>Formula:C12H14O4Color and Shape:ColourlessMolecular weight:222.244’-Hydroxy Diclofenac-D4
CAS:Controlled ProductFormula:C142H4H7Cl2NO3Color and Shape:NeatMolecular weight:316.17(5E)-Bimatoprost
CAS:<p>Applications The trans-isomer used in the improved process for the production and purification of Bimatoprost (B386800).<br></p>Formula:C25H37NO4Color and Shape:NeatMolecular weight:415.565,6-trans Travoprost
CAS:<p>Applications An 5,6-trans isomeric impurity of the selective FP prostaglandin receptor agonist Travoprost (T715600).<br></p>Formula:C26H35F3O6Color and Shape:NeatMolecular weight:500.552-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic Acid Ethyl Ester
CAS:<p>Applications 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic Acid Ethyl Ester, can be used for the synthesis of Febuxostat (F229000), an antipodagrics.<br>References Zheng, F., et al.: Zhongguo Yiyao Gongye Zazhi, 40, 726 (2009);<br></p>Formula:C14H12N2O3SColor and Shape:NeatMolecular weight:288.32ent-Rivaroxaban
CAS:<p>Applications ent-Rivaroxaban is the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C19H18ClN3O5SColor and Shape:White To Off-WhiteMolecular weight:435.88Desbutyl Dronedarone Hydrochloride
CAS:<p>Impurity Dronedarone USP Related Compound A<br>Applications A metabolite of Dronedarone (D679445). Dronedarone impurity D. Dronedarone USP Related Compound A.<br>References Bolderman, R.W. et al.: J Chrom. B:Anal. Tech. Biomed. Life Sci., 887, 1727 (2009); Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008); Hoy, S., et al.: Drugs, 69, 1647 (2009);<br></p>Formula:C27H36N2O5S·ClHColor and Shape:NeatMolecular weight:537.11(4-Carboxy-3-ethoxy)phenyl Acetic Acid
CAS:Controlled Product<p>Impurity Repaglinide EP Impurity A<br>Applications (4-Carboxy-3-ethoxy)phenyl Acetic Acid (Repaglinide EP Impurity A) is a Repaglinide impurity.<br>References Owens, D., et al.: Eur. J. Clin. Invest., 29, 30 (1999), Wolffenbuttel, B., et al.: Neth. J. Med., 55, 229 (1999),<br></p>Formula:C11H12O5Color and Shape:NeatMolecular weight:224.2115-Keto Travoprost
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications An impurity of the selective FP prostaglandin receptor agonist Travoprost (T715600) used as an ocularly applied intraocular pressure reducing agent.<br></p>Formula:C26H33F3O6Color and Shape:NeatMolecular weight:498.533-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide
CAS:Controlled Product<p>Impurity Allopurinol EP Impurity C / Allopurinol USP Related Compound C<br>Applications 3-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide (Allopurinol EP Impurity C) is an impurity of Allopurinol (A547300).<br></p>Formula:C6H6N6OColor and Shape:Off-WhiteMolecular weight:178.15Bis-[Des(5-Chloro-2-carboxythienyl)] Rivaroxaban Phthalamide
CAS:Controlled ProductFormula:C36H36N6O10Color and Shape:NeatMolecular weight:712.71Ticagrelor Epimer
Controlled Product<p>Applications Ticagrelor Epimer is an epimer impurity of Ticagrelor (T437700). Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formula:C23H28F2N6O4SColor and Shape:NeatMolecular weight:522.576-Amino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dihydro-8H-purin-8-one
CAS:Controlled Product<p>Applications 6-Amino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dihydro-8H-purin-8-one is derived from 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-6-triamine (F595655), which is a metabolite of stimulators of soluble guanylate cyclase for the treatment of pulmonary hypertension;Also, it is an impurity of Riociguat (R520000), which is used in the treatment for pulmonary hypertension.<br>References Mittendorf, J., et al.: ChemMedChem, 4, 853 (2009); Straub, A., et al.: Bioorg. Med. Chem., 10, 1711 (2002); Straub, A., et al.: Bioorg. Med. Chem., 10, 3075 (2002);Frey, R. et al.: J. Clin. Pharmacol., 51, 1051 (2011);<br></p>Formula:C18H13FN8OColor and Shape:NeatMolecular weight:376.347Perindoprilat Lactam B
CAS:<p>Impurity Perindopril EP Impurity D<br>Applications Perindoprilat Lactam B (Perindopril EP Impurity D) is the active metabolite of Perindopril (P287500) in plasma and urine.<br>References Hillaert, S., et al.: J. Pharm. Biomed. Anal., 25, 775 (2001), Ozoemena, K., et al.: Talanta, 62, 681 (2004),<br></p>Formula:C17H26N2O4Color and Shape:White To Off-WhiteMolecular weight:322.40Levosimendan Cyanoacetate Hydrazone Impurity
Controlled Product<p>Applications Levosimendan Cyanoacetate Hydrazone is an impurity of Levosimendan (L378000); a positive inotropic agent with vasodilating activity. Also cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995); Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996)<br></p>Formula:C16H17N5O3Color and Shape:NeatMolecular weight:327.34trans-Latanoprost Acid
CAS:Controlled Product<p>Applications The trans metabolite of Latanoprost (L177280), Prostaglandin analog.<br>References Botchkareva, N., et al.: FASEB J., 115, 645 (2001),<br></p>Formula:C23H34O5Color and Shape:NeatMolecular weight:390.5134-Ethoxycarbonyl-3-ethoxyphenylacetic Acid
CAS:Controlled Product<p>Applications Repaglinide intermediate.<br>References Wolfenbuttel, B., et al.: Eur. J. Clin. Pharmacol., 45, 113 (1993), Grell, W., et al.: J. Med. Chem., 41, 5219 (1998), Anon., et al.: Drugs Future, 24, 815 (1999),<br></p>Formula:C13H16O5Color and Shape:NeatMolecular weight:252.26N-Nitrosodiclofenac
CAS:Formula:C14H10Cl2N2O3Color and Shape:Off-White To Light YellowMolecular weight:325.15Cyclosporin H
CAS:<p>Applications Cyclosporin is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Formula:C62H111N11O12Color and Shape:NeatMolecular weight:1202.612-Oxo-ivabradine Hydrochloride
CAS:Controlled ProductFormula:C27H34N2O6·ClHColor and Shape:NeatMolecular weight:519.034-[4-[(5S)-5-Phthalimidomethyl-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone
CAS:Controlled ProductFormula:C22H19N3O6Color and Shape:NeatMolecular weight:421.40N-Nitroso Moexipril
CAS:Controlled ProductFormula:C27H33N3O8Color and Shape:Off-WhiteMolecular weight:527.572-(Cyanomethyl)indole
CAS:Controlled Product<p>Applications Intermediate in the preparation of carcinogenic indole derivatives.<br>References Kato, M., et al.: Chem. Pharm. Bull., 42, 2556 (1994),<br></p>Formula:C10H8N2Color and Shape:NeatMolecular weight:156.182-(4-(Methylsulfonamido)phenoxy)acetic Acid
CAS:Controlled Product<p>Applications 2-(4-(Methylsulfonamido)phenoxy)acetic Acid is a metabolite of antiarrhythmic drug Dofetilide (D525700), which is a is a potassium channel blocker.<br>References Smith, D., et al.: Xenobiotica, 22, 709 (1992); Carmeliet, D., et al.: J. Pharmacol. Exp. Ther., 262, 809 (1992); Walker, D., et al.: Drug Metab. Dispos., 24, 447 (1996); Norgaard, B.L., et al.: Am. Heart J., 137, 1062 (1999); Torp-Pedersen, C., et al.: N. Engl. J. Med. 341, 857 (1999);<br></p>Formula:C9H11NO5SColor and Shape:NeatMolecular weight:245.25Diclofenac Alcohol (Diclofenac Impurity)
CAS:<p>Impurity Diclofenac EP Impurity C<br>Applications Diclofenac Alcohol (Diclofenac EP Impurity C) is a Diclofenac impurity. Anti-inflammatory.<br>References Brogden, R., et al.: Drugs, 20, 24 (1980), Orienti, I., et al.: Eur. J. Pharm. Biopharm., 37, 110 (1991), Sagara, K., et al.: Chem. Pharm. Bull., 40, 3303 (1992), Connors, K., et al.: J. Pharm. Sci., 84, 843 (1995),<br></p>Formula:C13H11Cl2NOColor and Shape:WhiteMolecular weight:268.14O-Deshydroxyethyl Bosentan
CAS:<p>Impurity Bosentan USP Related Compound B<br>Applications O-Deshydroxyethyl Bosentan (Bosentan USP Related Compound B) is an impurity of Bosentan (B675900); a mixed endothelin receptor antagonist. Used as a vasodilator and antihypertensive.<br>References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994); Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996); Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996); Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)<br></p>Formula:C25H25N5O5SColor and Shape:BeigeMolecular weight:507.56N1-[2-(1-Piperazinyl)ethyl]-1,2-ethanediamine Hydrochloride
CAS:Controlled ProductFormula:C8H20N4•x(HCl)Color and Shape:NeatMolecular weight:172.2736465-Desisobutyl,5-(2-Methyl-prop-1-en-1-yl) Butalbital
CAS:Controlled Product<p>Applications 5-(2-Methyl-1-propen-1-yl)-5-(2-propen-1-yl)-2,4,6(1H,3H,5H)-pyrimidinetrione is a potential impurity of Butalbital (B690100), a controlled substance (depressant). Sedative, hypnotic.<br>References Inaba, T., et al.: Clin. Pharmacol. Ther., 18, 558 (1975), Fritch, D., et al.: J. Anal. Toxicol., 33, 569 (2009), Wille, S., et al.: Ther. Drug Monit., 31, 511 (2009),<br></p>Formula:C11H14N2O3Color and Shape:NeatMolecular weight:222.242-[(2,6-Dichlorophenyl)amino]benzaldehyde (Diclofenac impurity)
CAS:<p>Impurity Diclofenac EP Impurity B<br>Applications 2-[(2,6-Dichlorophenyl)amino]benzaldehyde (Diclofenac EP Impurity B) is an impurity of Diclofenac (D436450).<br>References Brogden, R., et al.: Drugs, 20, 24 (1980), Orienti, I., et al.: Eur. J. Pharm. Biopharm., 37, 110 (1991), Sagara, K., et al.: Chem. Pharm. Bull., 40, 3303 (1992), Connors, K., et al.: J. Pharm. Sci., 84, 843 (1995),<br></p>Formula:C13H9Cl2NOColor and Shape:YellowMolecular weight:266.121-Chloroethyl Cyclohexyl Carbonate
CAS:<p>Applications 1-Chloroethyl Cyclohexyl Carbonate is a genotoxic impurity used in the synthesis of Candesartan Cilexetil. an angiotensin II receptor antagonist.<br>References Kakasaheb, N. et al.: Int. J. Pharm. Sci., 6, 370 (2014); Mao, Y. et al.: Heterocycles, 81, 1503 (2010);<br></p>Formula:C9H15ClO3Color and Shape:NeatMolecular weight:206.67O-Desmethyl Brinzolamide
CAS:Controlled Product<p>Impurity Brinzolamide O-Desmethyl Impurity<br>Applications O-Desmethyl Brinzolamide is a derivative of Brinzolamide (B677601), a carbonic anhydrase inhibitor that is used as an ocular topical treatment for patients experiencing intraocular pressure. Brinzolamide reduces pressure by reducing the rate of aqueous humour formation.<br>References Cvetkovic, R. & Perry, C.: Drugs & Aging, 20, 919 (2003); Ermis, S., et al.: Eye, 19, 303 (2005); Silver, L., et al.: Surv. Ophthalmol., 44, S147 (2000)<br></p>Formula:C11H19N3O5S3Color and Shape:NeatMolecular weight:369.4807N-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-acetamide
CAS:Controlled Product<p>Applications N-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-acetamide is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C16H19N3O5Color and Shape:NeatMolecular weight:333.34Diclofenac Methyl Ester
CAS:Controlled Product<p>Impurity Aceclofenac EP Impurity B<br>Applications Diclofenac Methyl Ester is the methyl ester analogue of Diclofenac (D436450), a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. Aceclofenac EP Impurity B<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dannhardt, G., et al.: Eur. J. Med. Chem., 36, 109 (2001), Sorbera, L., et al.: Drug Future, 26, 133 (2001), Sorbera, L., et al.: Drug Future, 26, 133 (2001),<br></p>Formula:C15H13Cl2NO2Color and Shape:NeatMolecular weight:310.18Diclofenac Ethyl Ester
CAS:Controlled Product<p>Impurity Aceclofenac EP Impurity C<br>Applications A Diclofenac derivative as anti-inflammatory and analgesic agent. Aceclofenac EP Impurity C<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dannhardt, G., et al.: Eur. J. Med. Chem., 36, 109 (2001), Sorbera, L., et al.: Drug Future, 26, 133 (2001), Sorbera, L., et al.: Drug Future, 26, 133 (2001),<br></p>Formula:C16H15Cl2NO2Color and Shape:White To Light BrownMolecular weight:324.20Diclofenac Amide-13C6 (~5% unlabelled)
CAS:Controlled Product<p>Applications Diclofenac Amide-13C6 is a labelled analogue of Diclofenac Amide (D436440), which is a potential prodrug of Diclofenac and possible impurity during its commercial synthesis. Diclofenac Amide-13C6 is also an intermediate in synthesizing Diclofenac-13C6 Sodium Salt (D436453), which is a labelled analogue of Diclofenac Sodium Salt (D436450).<br>References Gaudiano, M.C., et al.: J. Pharm. Biomed. Anal., 32, 151 (2003); De Castro, W.V., et al.: Drug Develop. Ind. Pharm., 32, 1103 (2006); Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004), Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008); Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009)<br></p>Formula:C813C6H9Cl2NOColor and Shape:White To Light YellowMolecular weight:284.092-Chloroethylamine Hydrochloride
CAS:Controlled Product<p>Applications 2-Chloroethylamine Hydrochloride is used as a reagent in the synthesis of 6-desfluoroquinolones as potential anti-HIV drugs. Also used as a reagent in the synthesis of ellipticine derivatives as anticancer agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sancineto, L., et al.: Bioorg. Med. Chem., 22, 4658 (2014); Mori, R., et al.: Eur. J. Med. Chem., 82, 16 (2014)<br></p>Formula:C2H6ClN·ClHColor and Shape:NeatMolecular weight:115.99O-Desisobutyl-O-n-propyl Febuxostat
CAS:Formula:C15H14N2O3SColor and Shape:NeatMolecular weight:302.35Ivermectin B1 Monosaccharide
CAS:Controlled Product<p>Applications Ivermectin B1 Mono-sugar Derivative is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.<br>References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178<br></p>Formula:C41H62O11Color and Shape:NeatMolecular weight:730.922-Amino-5-(trifluoromethoxy)phenyl Thiocyanate
CAS:<p>Applications An impurity of Riluzole (R510000).<br></p>Formula:C8H5F3N2OSColor and Shape:NeatMolecular weight:234.20Oxindole (2-Indolone)
CAS:Controlled Product<p>Applications Indole analogue; shows pharmacological activity.<br>References Mohammadi, M., et al.: Science, 276, 955 (1997), Bramson, H., et al.: J. Med. Chem., 44, 4339 (2001), Lane, M., et al.: Cancer Res., 61, 6170 (2001), Yu, B., et al.: Biochem. Pharmacol., 64, 1091 (2002),<br></p>Formula:C8H7NOColor and Shape:Light RedMolecular weight:133.152-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid
CAS:Controlled Product<p>Applications 2-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid is an impurity of Febuxostat (F229000), an xanthine oxidase/ xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout.<br>References Kadivar, M.H.,e t al.: J. Pharm. Biomed. Anal., 56, 749 (2011);<br></p>Formula:C16H17NO5SColor and Shape:White SolidMolecular weight:335.37Ramipril Methyl Ester(>85%)
CAS:<p>Applications Ramipril Methyl Ester is an impurity of Ramipril (R111000). Ramipril Impurity A.<br>References Eckert, H., et al.: Arzneim.-Forsch./Drug Res., 35, 1251 (1985), Aboul-Enein, H., et al.: Anal. Lett., 24, 2217 (1991), Bonazzi, D., et al.: J. Pharm. Biomed. Anal., 16, 431 (1997),<br></p>Formula:C22H30N2O5Purity:>85%Color and Shape:NeatMolecular weight:402.48Rivaroxaban Pseudodimer
CAS:<p>Applications Rivaroxaban Pseudodimer is an impurity of Rivaroxaban (R538000), a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C38H36Cl2N6O10S2Color and Shape:NeatMolecular weight:871.76N,N’-Bis[Des(5-chloro-2-carvoxythienyl) Rivaroxaban] Urea
CAS:Controlled ProductFormula:C29H32N6O9Color and Shape:WhiteMolecular weight:608.60Disalicylimide
CAS:<p>Applications Disalicylimide is an impurity of Deferasirox (D228650), an orally active tridentate iron chelator.<br>References Hershko, C., et al.: Blood, 97, 1115 (2001), Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003), Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003),<br></p>Formula:C14H11NO4Color and Shape:NeatMolecular weight:257.25Bimatoprost 13,14-Epoxide
<p>Applications Bimatoprost 13,14-Epoxide is the impurity of Bimatoprost (B386800), which is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.<br>References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004)<br></p>Formula:C25H37NO5Color and Shape:ColourlessMolecular weight:431.562-(9H-Carbazol-1-yl)acetic Acid
CAS:Controlled ProductFormula:C14H11NO2Color and Shape:NeatMolecular weight:225.243Ethyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
CAS:Controlled Product<p>Applications Ethyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate is an impurity of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Nevuluri, N. et al.: Monat. fuer Chem., 148, 1477 (2017);<br></p>Formula:C22H22N4O4Color and Shape:NeatMolecular weight:406.43Ticagrelor Acetonide
CAS:<p>Stability Hygroscopic<br>Applications 2-[[(3aS,4R,6S,6aa)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol is an intermediate in the synthesis of Ticagrelor (T437700) which is an anticoagulant.<br>References Qiao, D., et al.: Preparation of anticoagulant Ticagrelor, China Patent 104592237, May 6, 2015;<br></p>Formula:C26H32F2N6O4SColor and Shape:NeatMolecular weight:562.63Deferasirox Methyl Ester
CAS:Controlled Product<p>Applications Deferasirox Methyl Ester is a derivative of Deferasirox (D228650); an orally active tridentate iron chelator.<br>References Hershko, C., et al.: Blood, 97, 1115 (2001); Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003); Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003)<br></p>Formula:C22H17N3O4Color and Shape:White To BeigeMolecular weight:387.39N-Mesyldronedarone
CAS:Controlled Product<p>Applications N-Mesyldronedarone is an impurity of Dronedarone (D679445, HCl); a drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008); Hoy, S., et al.: Drugs, 69, 1647 (2009); Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009); Mahender, M., et al.: Org. Process Res. Dev., 18, 157 (2014)<br></p>Formula:C32H46N2O7S2Color and Shape:NeatMolecular weight:634.85N-Formyl Apixaban
CAS:Controlled Product<p>Applications N-Formyl Apixaban is derived from Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Formula:C26H25N5O5Color and Shape:NeatMolecular weight:487.51L-(2S,3aS,7aS)-Octahydroindole-2-carboxylic Acid
CAS:Formula:C9H15NO2Color and Shape:White To Off-WhiteMolecular weight:169.22AR-C133913XX
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications AR-C133913XX is an metabolte of Ticagrelor (T437700) which is the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004); Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>Formula:C14H22N6O4SColor and Shape:NeatMolecular weight:370.433-Hydroxy-1-methyl-pyridinium Bromide
CAS:<p>Applications 3-Hydroxy-1-methyl-pyridinium Bromide is a degradation product of Pyridostigmine Bromide (P991705), which is a cholinergic and it is used in the treatment of myasthenia gravis, and is a pre-exposure antidote to chemical warfare agents.<br>References Kayihan, G., et al.: Toxicol. Environ. Chem., 92, 1783 (2010), Yu, Q., et al.: Bioorg. Med. Chem., 18, 4687 (2010), Voicu, V., et al.: J. Pharm. Biomed. Anal., 52, 508 (2010)<br></p>Formula:C6H8BrNOColor and Shape:NeatMolecular weight:190.04Scopine Di(2-thienylglycolate)
CAS:<p>Impurity Tiotropium EP Impurity B<br>Applications Scopine Di(2-thienylglycolate) (Tiotropium EP Impurity B) is a precursor to Tiotropium Bromide.<br>References Buchwald, P., et al.: Pharmazie., 55, S210 (2000),<br></p>Formula:C18H19NO4S2Color and Shape:NeatMolecular weight:377.48(S)-Repaglinide Ethyl Ester (Repaglinide Impurity)
CAS:Controlled Product<p>Applications Repaglinide impurity.<br>References Grell, W., et al.: J. Med. Chem., 41, 5219 (1998),<br></p>Formula:C29H40N2O4Color and Shape:NeatMolecular weight:480.64Simendan
CAS:Controlled Product<p>Applications Simendan is the racemic mixture of Levosimendan (L378000) which is a positive inotropic agent with vasodilating activity.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995); Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996)<br></p>Formula:C14H12N6OColor and Shape:Yellow SolidMolecular weight:280.283-Amino-4-carbamoylpyrazole Hemisulfate
CAS:Controlled Product<p>Impurity Allopurinol EP Impurity A / Allopurinol USP Related Compound A<br>Stability Hygroscopic<br>Applications 3-Amino-4-carbamoylpyrazole Hemisulfate (Allopurinol EP Impurity A) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.<br>References Nicolin, A. et al.: Cancer, Chemother. Rep., 57, 3 (1973); Bonmassar, E. et al.: Cancer Res., 35, 1957 (1975);<br></p>Formula:C4H6N4O·H2O4SColor and Shape:White To Light BrownMolecular weight:350.31
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