Metabolismo
Gli inibitori del metabolismo sono composti che interferiscono con le vie metaboliche, alterando la produzione e l'utilizzo dell'energia all'interno delle cellule. Questi inibitori sono utilizzati per studiare la regolazione del metabolismo, il ruolo delle vie metaboliche in malattie come il cancro e il diabete e per sviluppare nuove strategie terapeutiche. Gli inibitori del metabolismo possono bersagliare vari enzimi e processi coinvolti nella glicolisi, nell'ossidazione degli acidi grassi e in altre funzioni metaboliche. Presso CymitQuimica, offriamo una vasta gamma di inibitori del metabolismo di alta qualità per supportare la tua ricerca in biochimica, disturbi metabolici e sviluppo di farmaci.
Sottocategorie di "Metabolismo"
- AhR(42 prodotti)
- Aminopeptidasi(76 prodotti)
- CETP(20 prodotti)
- Anidrasi carbonica(197 prodotti)
- Caseina chinasi(137 prodotti)
- DHFR(34 prodotti)
- Decarbossilasi(4 prodotti)
- Deidrogenasi(303 prodotti)
- FAAH(66 prodotti)
- FXR(62 prodotti)
- Fattore Xa(87 prodotti)
- Sintasi degli acidi grassi(37 prodotti)
- Ferroptosi(226 prodotti)
- GR(3 prodotti)
- GSNOR(4 prodotti)
- Glucokinasi(57 prodotti)
- Prolil-idrossilasi HIF/HIF(146 prodotti)
- Reduttasi HMG-CoA(33 prodotti)
- Idrossilasi(35 prodotti)
- IDO(84 prodotti)
- LDL(8 prodotti)
- Lipasi(107 prodotti)
- Lipidi(61 prodotti)
- Lipossigenasi(134 prodotti)
- MAO(87 prodotti)
- MPO(2 prodotti)
- NAMPT(40 prodotti)
- P450(6 prodotti)
- PAI-1(26 prodotti)
- PDE(167 prodotti)
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- PKM(17 prodotti)
- PPAR(169 prodotti)
- Fosfolipasi(83 prodotti)
- ROR(47 prodotti)
- Recettore dei retinoidi(28 prodotti)
- SGK(11 prodotti)
- Tioredossina(12 prodotti)
- Transferasi(29 prodotti)
- Trasportatore(46 prodotti)
- UGT(4 prodotti)
- Inibitori della xantina ossidasi (XO)(9 prodotti)
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Trovati 9282 prodotti di "Metabolismo"
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DGAT2-IN-3
CAS:DGAT2-IN-3 (compound 9) is an inhibitor of DGAT2 with an IC50 value of 0.4 nM. It is utilized in research related to fatty liver disease, diabetes, and cardiovascular diseases.Formula:C21H20F4N4O5SColore e forma:SolidPeso molecolare:516.47Anticancer agent 143
CAS:Anticancer Agent 143 (Compound 369), a potent dual inhibitor targeting PTPN2 and PTP1B, exhibits IC50 values below 2.5 nM.Formula:C19H15BrF2N3O6PS2Purezza:98%Colore e forma:SolidPeso molecolare:594.34QGC583
CAS:QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.Formula:C13H20NO5PColore e forma:SolidPeso molecolare:301.28S-15176
CAS:<p>S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). It effectively suppresses mitochondrial swelling induced by tert-butyl hydroperoxide, with an IC50 value of 45.7 μM. S-15176 prevents the opening of PTP, thus averting the dissipation of mitochondrial membrane potential and the oxidation of NAD(P)H, while enhancing mitochondrial calcium loading capacity. It holds potential for research into ischemia-reperfusion injury.</p>Formula:C31H48N2O4SColore e forma:SolidPeso molecolare:544.79MGAT2-IN-1
CAS:MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).Formula:C27H21ClF5N7O3SColore e forma:SolidPeso molecolare:654.01Diacylglycerol acyltransferase inhibitor-2
CAS:Diacylglycerolacyltransferaseinhibitor-2 (Example 8) acts as an inhibitor for diacylglycerol acyltransferase 2 (DGAT2), exhibiting an IC50 value of 3.7 nM.Formula:C21H20FN5O4Colore e forma:SolidPeso molecolare:425.41MAGL-IN-18
CAS:<p>MAGL-IN-18 (compound 118) serves as a highly potent inhibitor of Monoacylglycerol lipase (MAGL), demonstrating an IC 50 value of 0.03nM.</p>Formula:C23H28F3N7OColore e forma:SolidPeso molecolare:475.51h15-LOX-2 inhibitor 3
CAS:Compound 13, identified as h15-LOX-2 inhibitor 3, exhibits inhibitory activity against h15-LOX, with IC50 and Ki values of 25 μM and 15.1 μM, respectively.Formula:C22H13N5O3Colore e forma:SolidPeso molecolare:395.37SelB-1
CAS:SelB-1 acts as a dual inhibitor of Topoisomerase I/II (TopoisomeraseI/II), exhibiting anticancer activity suitable for research on prostate and colon cancers. Additionally, SelB-1 can induce the expression of autophagy (autophagy) genes and lipid peroxidation while reducing GSH levels.Formula:C32H24O5Colore e forma:SolidPeso molecolare:488.53MK-3168 (12C)
CAS:MK-3168 (12C) functions as a FAAH inhibitor, exhibiting IC50 values of 1.0 nM, 5.5 nM, and 1.7 nM for human, rhesus, and rat respectively. It demonstrates effective brain uptake and FAAH-specific signaling. Additionally, 11 C MK-3168 is applicable as a FAAH PET tracer.Formula:C21H21ClN4OSColore e forma:SolidPeso molecolare:412.94α-Glucosylrutin
CAS:α-Glucosylrutin is an effective antioxidant known for its activity in scavenging free radicals. Due to its high epidermal bioavailability, it is commonly utilized in studies related to skin aging.Formula:C33H40O21Colore e forma:SolidPeso molecolare:772.66Urobilin hydrochloride
CAS:Urobilin hydrochloride, a metabolic byproduct of Hemoglobin, is excreted through urine and feces in various mammals. It also serves as an indicator of human waste contamination.Formula:C33H43ClN4O6Colore e forma:SolidPeso molecolare:627.17RWJ 22108
CAS:RWJ 22108 is a bronchial-selective calcium channel (calcium channel) blocker that exhibits an IC50 of 5.7 nM in dog bronchial smooth muscle calcium-dependent contractions.Formula:C27H30ClFN2O4SColore e forma:SolidPeso molecolare:533.06IDO1-IN-25
CAS:IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.Formula:C14H8Cl3NO2SColore e forma:SolidPeso molecolare:360.646′SLN
CAS:6′SLN is a characteristic glycan found on the surface of cancer-related extracellular vesicles (EVs) and serves as the primary form of protein glycosylation within EVs. Additionally, 6′SLN, a derivative of sialic acid, interacts with hemagglutinins (HAs) from both human and avian influenza strains, making it relevant in the study of anti-influenza drugs.Formula:C25H42N2O19Colore e forma:SolidPeso molecolare:674.65-LOX/MAOs-IN-1
CAS:Compound 3, known as 5-LOX/MAOs-IN-1, acts as an inhibitor of 5-LOX/MAOs and is an effective free radical scavenger, displaying antioxidant characteristics. It has demonstrated neuroprotective effects in cell models damaged by oxidative stress and is capable of activating the neurogenesis microenvironment in adult mouse neural stem cells. This compound is utilized in research focused on neurodegenerative diseases.Formula:C18H18N2O2Colore e forma:SolidPeso molecolare:294.35D-Citrulline
CAS:D-Citrulline (H-D-Cit-OH), a stereoisomer of L-citrulline, effectively reduces cardiac contractile dysfunction caused by polymorphonuclear leukocyte (PMN) in isolated perfused rat hearts undergoing ischemia/reperfusion. This protective effect is mediated through a non-NO-mediated mechanism.Formula:C6H13N3O3Colore e forma:SolidPeso molecolare:175.19DDO-3733
CAS:DDO-3733 is a conformational activator of Protein Phosphatase 5 (PP5) that functions independently of TRP, facilitating the dephosphorylation of downstream substrates.Formula:C10H6F2N2OSColore e forma:SolidPeso molecolare:240.23α-Amylase/α-Glucosidase-IN-19
CAS:α-Amylase/α-Glucosidase-IN-19 (compound 10) is a dual inhibitor of α-amylase and α-glucosidase, with an IC50 of 170.7 μM and 60.37 μM, respectively.Formula:C17H14BrClN2OColore e forma:SolidPeso molecolare:377.663Nampt-IN-14
CAS:Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).Formula:C33H35N7O2Colore e forma:SolidPeso molecolare:561.68
