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Neurociência

Neurociência

Os inibidores de neurociência são compostos projetados para modular a atividade de proteínas, enzimas ou receptores específicos no sistema nervoso. Esses inibidores são cruciais para estudar os mecanismos moleculares subjacentes à função neural, transmissão sináptica e doenças neurodegenerativas. Ao direcionar receptores de neurotransmissores, canais iônicos e vias de sinalização, os inibidores de neurociência ajudam na exploração da função cerebral e no desenvolvimento de estratégias terapêuticas para distúrbios neurológicos como Alzheimer, Parkinson e epilepsia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de neurociência de alta qualidade para apoiar sua pesquisa em neurobiologia, neurofarmacologia e ciências cognitivas.

Subcategorias de "Neurociência"

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Foram encontrados 5398 produtos de "Neurociência"

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  • Carlina oxide
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    Carlina oxide

    CAS:
    <p>Carlina oxide is both an AChE inhibitor and an antioxidant, effective in eliminating mosquito larvae (LC50=1.39 μg/mL). Furthermore, Carlina oxide exhibits cytotoxicity in vertebrate cells, human dermis, and HCT116 and MDA-MB231 cell lines.</p>
    Fórmula:C13H10O
    Cor e Forma:Solid
    Peso molecular:182.22

    Ref: TM-T88796

  • LRRK2-IN-2
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    LRRK2-IN-2

    CAS:
    <p>LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.</p>
    Fórmula:C23H23Cl2F3N6O2
    Cor e Forma:Solid
    Peso molecular:543.37

    Ref: TM-T63824

  • CPPG
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    CPPG

    CAS:
    <p>CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.</p>
    Fórmula:C11H14NO5P
    Cor e Forma:Solid
    Peso molecular:271.21

    Ref: TM-T10880

  • PXS-5153A monohydrochloride
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    PXS-5153A monohydrochloride

    CAS:
    <p>PXS-5153A is an oral, fast-acting LOXL2/3 inhibitor with IC50 &lt;40 nM for LOXL2 and 63 nM for LOXL3, potentially treating fibrosis.</p>
    Fórmula:C20H25Cl2FN4O2S
    Pureza:98%
    Cor e Forma:Odour Solid
    Peso molecular:475.41

    Ref: TM-T12585L

  • FP0429
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    FP0429

    CAS:
    <p>FP0429 is an agonist of mGlu4.</p>
    Fórmula:C10H12N2O7
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:272.21

    Ref: TM-T27355

  • VU6005806
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    VU6005806

    CAS:
    <p>VU6005806 is a potent M4 PAM with EC50s: 94 nM (human), 28 nM (rat), 87 nM (dog), 68 nM (cyno); studied for neuropsychiatric disorders.</p>
    Fórmula:C17H16F3N7O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:439.41

    Ref: TM-T13322

  • Buntanetap L-Tartrate
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    Buntanetap L-Tartrate

    CAS:
    <p>Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].</p>
    Fórmula:C24H29N3O8
    Cor e Forma:Solid
    Peso molecular:487.50

    Ref: TM-T85929

  • CVN766
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    CVN766

    CAS:
    <p>CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and &gt;10 μM for OX2R. CVN766 can be used to study schizophrenia [1].</p>
    Fórmula:C20H21F3N8O
    Cor e Forma:Solid
    Peso molecular:446.43

    Ref: TM-T86110

  • Logotipo do CymitQuimica
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    MAO-B-IN-6

    <p>MAO-B-IN-6 is a selective, potent, orally active MAO-B inhibitor (IC50: 0.019 μM). MAO-B-IN-6 is superior to Safinamide both in vitro and in vivo.</p>
    Cor e Forma:Solid

    Ref: TM-T64271

  • γ-secretase modulator 6
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    γ-secretase modulator 6

    CAS:
    <p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>
    Fórmula:C25H26N6O2
    Cor e Forma:Solid
    Peso molecular:442.513

    Ref: TM-T206107

  • LB-102
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    LB-102

    CAS:
    <p>LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.</p>
    Fórmula:C18H29N3O4S
    Cor e Forma:Solid
    Peso molecular:383.51

    Ref: TM-T200914

  • MAO-IN-4
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    MAO-IN-4

    CAS:
    <p>MAO-IN-4 (Compound 2l), a monoamine oxidase (MAO) inhibitor, demonstrates IC50 values of 0.07 μM for MAO-A and 0.75 μM for MAO-B. This compound is utilized in studying depression and Parkinson's disease (PD) [1].</p>
    Fórmula:C18H11Cl2N3OS
    Cor e Forma:Solid
    Peso molecular:388.27

    Ref: TM-T86859

  • AChE/Aβ-IN-5
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    AChE/Aβ-IN-5

    CAS:
    <p>Compound AV-2, also known as AChE/Aβ-IN-5, is a bifunctional inhibitor that acts on AChE and auto-induced Aβ (Amyloid-β) aggregation. This compound has demonstrated significant efficacy in mitigating cognitive impairment in mice induced by scopolamine and Aβ [1].</p>
    Fórmula:C25H24N4
    Cor e Forma:Solid
    Peso molecular:380.48

    Ref: TM-T85551

  • AChE/BuChE-IN-3
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    AChE/BuChE-IN-3

    CAS:
    <p>AChE/BuChE-IN-3 inhibits AChE (IC50: 0.65 μM), BuChE (IC50: 5.77 μM), crosses BBB, and hinders Aβ1-42 aggregation for Alzheimer's research.</p>
    Fórmula:C30H30F3N3O6
    Cor e Forma:Solid
    Peso molecular:585.57

    Ref: TM-T64137

  • AChE-IN-63
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    AChE-IN-63

    CAS:
    <p>AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].</p>
    Fórmula:C18H19N5O
    Cor e Forma:Solid
    Peso molecular:321.38

    Ref: TM-T85555

  • Logotipo do CymitQuimica
    Targetmol
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    AChE/BChE-IN-1

    <p>AChE/BChE-IN-1: dual AChE/BChE inhibitor, IC50 of 1.06 nM/7.3 nM, crosses blood-brain barrier, with antioxidant properties for Alzheimer's research.</p>
    Fórmula:C32H35ClN6O3
    Cor e Forma:Solid
    Peso molecular:587.11

    Ref: TM-T64156

  • 25B-NBOH hydrochloride
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    25B-NBOH hydrochloride

    CAS:
    <p>25B-NBOH hydrochloride is a phenethylamine that exhibits high affinity for serotonin (5-HT) receptors 5-HT2A and 5-HT2C, with pKi values of 8.3 and 9.4, respectively.</p>
    Fórmula:C17H21BrClNO3
    Cor e Forma:Solid
    Peso molecular:402.711

    Ref: TM-T204858

  • AChE-IN-84
    Targetmol
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    AChE-IN-84

    CAS:
    <p>AChE-IN-84 (compound 21) is an inhibitor of AChE.</p>
    Fórmula:C6H15Br2N
    Cor e Forma:Solid
    Peso molecular:260.998

    Ref: TM-T205413

  • Logotipo do CymitQuimica
    Targetmol
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    AChE-IN-8

    <p>AChE-IN-8 (Compound 19), potent acetylcholinesterase blocker; IC50 = 1.95 μM; potential Alzheimer's treatment.</p>
    Fórmula:C20H22N4O2S
    Cor e Forma:Solid
    Peso molecular:382.48

    Ref: TM-T61648

  • GABA-IN-4
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    GABA-IN-4

    CAS:
    <p>GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.</p>
    Fórmula:C17H13ClN2O2
    Cor e Forma:Solid
    Peso molecular:312.75

    Ref: TM-T205501