Proteases/Proteassoma
Os inibidores de proteases e proteassomas são compostos que bloqueiam a atividade das proteases e do proteassoma, que estão envolvidos na degradação e renovação de proteínas. Esses inibidores são vitais para estudar a regulação da homeostase de proteínas, controle do ciclo celular e apoptose. Inibidores de proteases e proteassomas também são utilizados no tratamento de doenças como o câncer, onde a degradação anormal de proteínas desempenha um papel na progressão da doença. Ao inibir proteases ou o proteassoma, esses compostos podem induzir a morte celular em células cancerígenas e são ferramentas essenciais tanto na pesquisa básica quanto no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteases e proteassomas de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Proteases/Proteassoma"
- Acetil- CoA Carboxilase(34 produtos)
- Cisteína Protease(96 produtos)
- DPP-4(20 produtos)
- Glutaminase(40 produtos)
- HIV Protease(449 produtos)
- PAI-1(25 produtos)
- Inibidores de Protease(50 produtos)
- Receptor activado por protease(53 produtos)
- Proteassoma(94 produtos)
- Protease serina(50 produtos)
- p97(14 produtos)
Exibir 3 mais subcategorias
Foram encontrados 1044 produtos de "Proteases/Proteassoma"
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Dabigatran
CAS:<p>Dabigatran (BIBR 953ZW), a thrombin inhibitor, prevents thrombus formation, reducing stroke and embolism risk in nonvalvular atrial fibrillation patients.</p>Fórmula:C25H25N7O3Pureza:97.44% - 98.7%Cor e Forma:Tan SolidPeso molecular:471.51CeMMEC13
CAS:<p>CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM).</p>Fórmula:C19H16N2O4Pureza:98.52%Cor e Forma:SolidPeso molecular:336.34Doravirine
CAS:<p>Doravirine (MK-1439) is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.</p>Fórmula:C17H11ClF3N5O3Pureza:99.65% - 99.79%Cor e Forma:SolidPeso molecular:425.75L-Albizziin
CAS:<p>L-Albizziin (L-beta-Ureidoalanine) is a glutamase inhibitor and is a glutaminyl-tRNA synthetase inhibitor.</p>Fórmula:C4H9N3O3Pureza:99.98%Cor e Forma:White PowderPeso molecular:147.13Anagliptin
CAS:<p>Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.</p>Fórmula:C19H25N7O2Pureza:97.59% - 99.98%Cor e Forma:SolidPeso molecular:383.45P-113 acetate
<p>P-113 acetate: AMP from histatin 5, treats gingivitis and HIV-related oral candidiasis safely and effectively.</p>Fórmula:C73H114N28O15Pureza:97.4%Cor e Forma:SolidPeso molecular:1623.86Samatasvir
CAS:<p>Samatasvir (ATOLIHZIXHZSBA-BTSKBWHGSA-N) is a pan-genotypic inhibitor of the HCV non-structural protein 5A.</p>Fórmula:C47H48N8O6S2Pureza:98.03%Cor e Forma:SolidPeso molecular:885.06Glutaminase C-IN-1
CAS:<p>Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor.</p>Fórmula:C27H27BrN2OPureza:99.68% - >99.99%Cor e Forma:SolidPeso molecular:475.422,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)-
CAS:<p>2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- (Ulinastatin) ,as an urinary trypsin inhibitor (UTI), is a glycoprotein that is isolated from healthy human urine</p>Fórmula:C13H16O3Pureza:99.53% - 99.81%Cor e Forma:SolidPeso molecular:220.26Ixazomib
CAS:<p>Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also affecting β1 and β2 sites.</p>Fórmula:C14H19BCl2N2O4Pureza:98% - 98.92%Cor e Forma:SolidPeso molecular:361.03Batimastat
CAS:<p>Batimastat (BB94) (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor.</p>Fórmula:C23H31N3O4S2Pureza:98.15% - 99.5%Cor e Forma:SolidPeso molecular:477.64Elvitegravir
CAS:<p>Elvitegravir (JTK-303) is an HIV integrase inhibitor and CYP2C9 inducer.</p>Fórmula:C23H23ClFNO5Pureza:98.43% - 99.57%Cor e Forma:SolidPeso molecular:447.88Telaprevir
CAS:<p>Telaprevir (Incivek) (VX-950) is an effective inhibitor of HCV NS3-4A serine protease (IC50: 0.35 μM).</p>Fórmula:C36H53N7O6Pureza:96.9% - 98.89%Cor e Forma:SolidPeso molecular:679.854-Chloro-2-(trifluoroacetyl)aniline hydrochloride
CAS:<p>4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is an inhibitor of HIV-1 RT (HIV reverse transcriptase) .</p>Fórmula:C8H6Cl2F3NOPureza:97.15%Cor e Forma:SolidPeso molecular:260.04Ceritinib
CAS:<p>Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C28H36ClN5O3SPureza:98.52% - 99.77%Cor e Forma:SolidPeso molecular:558.14CGS 27023A
CAS:<p>CGS 27023A is a non-peptidic, potent, and orally active stromelysin inhibitor.</p>Fórmula:C18H24ClN3O5SPureza:99.08%Cor e Forma:SolidPeso molecular:429.92Picolamine
CAS:<p>Picolamine acts as a potential inhibitor of DPP-4.</p>Fórmula:C6H8N2Pureza:98.3%Cor e Forma:Light Yellow LiquidPeso molecular:108.14SB-3CT
CAS:<p>SB-3CT is a potent and specific gelatinase inhibitor for MMP-2(Ki=13.9 nM) and MMP-9(Ki=600 nM).</p>Fórmula:C15H14O3S2Pureza:98% - 99.38%Cor e Forma:SolidPeso molecular:306.4S-methyl-KE-298
CAS:S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) productionFórmula:C13H16O3SPureza:97.33%Cor e Forma:SolidPeso molecular:252.33Tenofovir alafenamide hemifumarate
CAS:<p>Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir.</p>Fórmula:C21H29N6O5PC4H4O4Pureza:99.33% - 99.96%Cor e Forma:SolidPeso molecular:534.51Trelagliptin succinate
CAS:<p>Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (</p>Fórmula:C22H26FN5O6Pureza:99.27% - 99.92%Cor e Forma:SolidPeso molecular:475.47Ilomastat
CAS:<p>Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.</p>Fórmula:C20H28N4O4Pureza:97.04% - 99.51%Cor e Forma:SolidPeso molecular:388.462-Benzylsuccinic acid
CAS:<p>2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is a bacterial xenobiotic metabolite.</p>Fórmula:C11H12O4Pureza:99.01% - ≥95%Cor e Forma:SolidPeso molecular:208.21(R)-MG-132
CAS:<p>(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.</p>Fórmula:C26H41N3O5Pureza:98.45%Cor e Forma:SolidPeso molecular:475.62NBD-557
CAS:<p>NBD-557 is a potentially HIV-1 inhibitor.</p>Fórmula:C17H24BrN3O2Pureza:99.52%Cor e Forma:SolidPeso molecular:382.3Sofosbuvir
CAS:<p>Sofosbuvir (GS 7977) is a uridine monophosphate analog inhibitor of hepatitis C virus (HCV) polymerase NS5B that is used as an antiviral agent in the treatment</p>Fórmula:C22H29FN3O9PPureza:99.77% - 99.82%Cor e Forma:SolidPeso molecular:529.45Vesnarinone
CAS:<p>Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but</p>Fórmula:C22H25N3O4Pureza:96.69% - 98.13%Cor e Forma:SolidPeso molecular:395.45Lersivirine
CAS:<p>Lersivirine (UK-453061)(UK 453061) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for HIV infection therapy.</p>Fórmula:C17H18N4O2Pureza:98.01%Cor e Forma:SolidPeso molecular:310.35Boceprevir
CAS:<p>Boceprevir (SCH 503034), an oral HCV NS3 protease inhibitor, has a Ki of 14 nM and EC90 of 350 nM.</p>Fórmula:C27H45N5O5Pureza:95% - 99.16%Cor e Forma:SolidPeso molecular:519.68Trovirdine
CAS:<p>Trovirdine (LY300046) is a thiourea non-nucleoside reverse transcriptase inhibitor.</p>Fórmula:C13H13BrN4SPureza:98.12% - 98.50%Cor e Forma:SolidPeso molecular:337.24HCV-IN-31
CAS:<p>HCV-IN-31 is a HCV inhibitor with an EC50/EC95 of 15.7 μM.</p>Fórmula:C12H17FN6O3Pureza:99.83%Cor e Forma:SolidPeso molecular:312.3VCH-916
CAS:<p>VCH-916 is a new nonnucleoside inhibitor of HCV NS5B polymerase.</p>Fórmula:C26H36KNO4SPureza:98%Cor e Forma:SolidPeso molecular:497.732-PMPA
CAS:<p>2-PMPA (2-(Phosphonomethyl)pentanedioic acid) is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) (IC50=300 pM).</p>Fórmula:C6H11O7PPureza:97.4% - 99.5%Cor e Forma:SolidPeso molecular:226.12Bz-RS-ISer(3-Ph)-Ome
CAS:<p>Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) is a paclitaxel derivative that inhibits the HSV replication cycle.</p>Fórmula:C17H17NO4Pureza:99.36% - 99.89%Cor e Forma:White CrystalPeso molecular:299.32Ledipasvir (acetone)
CAS:<p>Ledipasvir (acetone) (GS-5885 acetone) is an HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection.</p>Fórmula:C52H60F2N8O7Pureza:99.72%Cor e Forma:SolidPeso molecular:947.08Methylchloroisothiazolinone/Methylisothiazolinone Mixture
CAS:<p>Methylchloroisothiazolinone/Methylisothiazolinone Mixture (Kathon 886MW),a preservative, activates MMPs in human bronchial epithelial cells.</p>Fórmula:C8H9ClN2O2S2Cor e Forma:SolidPeso molecular:264.75KP-457
CAS:<p>KP-457 is a ADAM17 and a TNFα converting enzyme TACE inhibitor that blocks the production of soluble TNF (sTNF).</p>Fórmula:C21H24N2O7S2Pureza:98.33%Cor e Forma:SolidPeso molecular:480.56Sitagliptin phosphate monohydrate
CAS:<p>Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.</p>Fórmula:C16H15F6N5O·H3PO4·H2OPureza:99.85% - 99.98%Cor e Forma:White Or Almost White Crystalline PowderPeso molecular:523.33(1S,2R)-Alicapistat
CAS:<p>(1S,2R)-Alicapistat inhibits calpains 1 and 2, shows promise for Alzheimer's, and has an IC50 of 395 nM.</p>Fórmula:C25H27N3O4Pureza:99.60%Cor e Forma:SoildPeso molecular:433.5Ledipasvir
CAS:<p>Ledipasvir (GS-5885) is a Hepatitis C Virus NS5A Inhibitor.</p>Fórmula:C49H54F2N8O6Pureza:99.96%Cor e Forma:SolidPeso molecular:889Rilpivirine HCl
CAS:<p>Rilpivirine HCl (Rilpivirine hydrochloride) is an NNRTI inhibitor with antiviral activity that inhibits the HIV virus.</p>Fórmula:C22H19ClN6Pureza:99.48%Cor e Forma:SolidPeso molecular:402.88(R)-Trolox
CAS:<p>(R)-Trolox is a selective tyrosinase inhibitor used in food, cosmetics, and pharmaceutical products.</p>Fórmula:C14H18O4Pureza:99.88%Cor e Forma:SolidPeso molecular:250.29Teneligliptin
CAS:<p>Teneligliptin (MP-513), potent DPP-4 inhibitor, IC50 ~1 nM, blocks DPP-4 in human/rat plasma and recombinant forms.</p>Fórmula:C22H30N6OSPureza:99.73%Cor e Forma:SolidPeso molecular:426.58Nelfinavir
CAS:<p>Nelfinavir (AG1341), with Ki=2 nM, is an HIV treatment and broad-spectrum anticancer drug.</p>Fórmula:C32H45N3O4SPureza:98.16% - 99.5%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:567.78Danoprevir
CAS:<p>Danoprevir (RG7227) is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV).</p>Fórmula:C35H46FN5O9SPureza:98% - 99.35%Cor e Forma:SolidPeso molecular:731.83PSI
CAS:<p>PSI is a proteasome inhibitor.</p>Fórmula:C32H50N4O8Pureza:97% - 98.33%Cor e Forma:SolidPeso molecular:618.76Lanadelumab
CAS:<p>Lanadelumab (SHP643), a humanized IgG1 antibody, inhibits plasma kallikrein and its interaction with HMWK, supporting hereditary angioedema research.</p>Pureza:95% - 95%Cor e Forma:LiquidGalegenimab
CAS:<p>Galegenimab (FHTR 2163; RG 6147; RO 7171009) is an HTRA1 antibody fragment for AMD research.</p>Pureza:95% - 95%Cor e Forma:LiquidKZR-504
CAS:KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).Fórmula:C21H23N3O6Cor e Forma:SolidPeso molecular:413.42Triton X-45(n=4)
CAS:<p>Triton X-45: nonionic, low HLB surfactant, dispersible in water, high Krafft point, relevant for HCV research.</p>Fórmula:C22H38O5Cor e Forma:SolidPeso molecular:382.53
