Tirosina Quinase/Adaptador
Os inibidores de tirosina quinase e adaptadores são compostos que têm como alvo as tirosina quinases e suas proteínas adaptadoras associadas, que desempenham papéis fundamentais na sinalização celular, crescimento e diferenciação. Esses inibidores são ferramentas essenciais na pesquisa sobre o câncer, pois muitas tirosina quinases estão envolvidas nas vias de sinalização que impulsionam o crescimento e a metástase dos tumores. Ao inibir as tirosina quinases, esses compostos podem bloquear cascatas de sinalização críticas, oferecendo potenciais estratégias terapêuticas para vários tipos de câncer e outras doenças que envolvem sinalização celular anormal. Na CymitQuimica, oferecemos uma ampla gama de inibidores de tirosina quinase e adaptadores de alta qualidade para apoiar sua pesquisa em oncologia, biologia molecular e desenvolvimento de terapias direcionadas.
Subcategorias de "Tirosina Quinase/Adaptador"
- ALK(116 produtos)
- CSF-1R(42 produtos)
- EGFR(572 produtos)
- Receptor de Efrina(23 produtos)
- FLT(91 produtos)
- Receptor do Factor de Crescimento Fibroblasto (FGFR)(169 produtos)
- HER(5 produtos)
- Hck(3 produtos)
- IGF-1R(92 produtos)
- PDGFR(126 produtos)
- PYK2(7 produtos)
- Src(80 produtos)
- Receptor TAM(32 produtos)
- Tie-2(21 produtos)
- Receptor TrK(59 produtos)
- Tirosina Quinases(26 produtos)
- VEGFR(262 produtos)
- c-Fms(108 produtos)
- c-Kit(102 produtos)
- c-Met/HGFR(129 produtos)
- c-RET(51 produtos)
Exibir 13 mais subcategorias
Foram encontrados 1342 produtos de "Tirosina Quinase/Adaptador"
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SU 4313
CAS:SU 4313 is a bioactive chemical.Fórmula:C18H17NOPureza:99.51% - 99.89%Cor e Forma:SolidPeso molecular:263.33ISCK03
CAS:<p>ISCK03 is a selective SCF/c-Kit inhibitor.</p>Fórmula:C19H21N3O2SPureza:98.39%Cor e Forma:SolidPeso molecular:355.45Tyrphostin A1
CAS:Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .Fórmula:C11H8N2OPureza:98.32%Cor e Forma:SolidPeso molecular:184.19WZ4002
CAS:<p>WZ4002 is a mutant-selective EGFR inhibitor for EGFR(L858R) and EGFR(T790M) with IC50 of 2 nM/8 nM.</p>Fórmula:C25H27ClN6O3Pureza:97.51%Cor e Forma:SolidPeso molecular:494.97Epitinib
CAS:<p>Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).</p>Fórmula:C24H26N6O2Cor e Forma:SolidPeso molecular:430.5PP121
CAS:<p>PP-121 inhibits PDGFR, Hck, mTOR, VEGFR2, Src, Abl, and DNA-PK with IC50 values ranging from 2 to 60 nM.</p>Fórmula:C17H17N7Pureza:98.45% - 99.67%Cor e Forma:SolidPeso molecular:319.36AZ304
CAS:<p>AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).</p>Fórmula:C27H25N5O2Pureza:99.82%Cor e Forma:SolidPeso molecular:451.52Gefitinib-based PROTAC 3
CAS:<p>Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).</p>Fórmula:C47H57ClFN7O8SPureza:97.29% - 98.25%Cor e Forma:SolidPeso molecular:934.51Derazantinib dihydrochloride
CAS:<p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>Fórmula:C29H31Cl2FN4OCor e Forma:SolidPeso molecular:541.49Almonertinib
CAS:<p>Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.</p>Fórmula:C30H35N7O2Pureza:99.99%Cor e Forma:SolidPeso molecular:525.64Merestinib
CAS:<p>Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity.</p>Fórmula:C30H22F2N6O3Pureza:95% - 99.71%Cor e Forma:SolidPeso molecular:552.53Sotuletinib
CAS:<p>Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor, >1000-fold selective against its closest receptor tyrosine kinase homologs.</p>Fórmula:C20H22N4O3SPureza:97.43% - 99.82%Cor e Forma:SolidPeso molecular:398.48SU5408
CAS:<p>SU5408 (VEGFR2 Kinase Inhibitor I) is a potent, cell-permeable inhibitor of the VEGFR2 kinase.</p>Fórmula:C18H18N2O3Pureza:99.35%Cor e Forma:SolidPeso molecular:310.35Linsitinib
CAS:<p>OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.</p>Fórmula:C26H23N5OPureza:99.71% - ≥95%Cor e Forma:SolidPeso molecular:421.49CH5424802 analog
CAS:<p>CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.</p>Fórmula:C28H30N4O2Pureza:98.96%Cor e Forma:SolidPeso molecular:454.56DMH-1
CAS:<p>DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.</p>Fórmula:C24H20N4OPureza:98% - 99.92%Cor e Forma:SolidPeso molecular:380.44Entospletinib
CAS:<p>Entospletinib (GS-9973) is a Syk inhibitor (IC50=7.7 nM) with selective, oral activity. High-Quality, Low-Cost!</p>Fórmula:C23H21N7OPureza:98.54% - 99.51%Cor e Forma:SolidPeso molecular:411.46Pexmetinib
CAS:<p>Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.</p>Fórmula:C31H33FN6O3Pureza:99.07% - 99.66%Cor e Forma:SolidPeso molecular:556.63ZM 306416
CAS:<p>ZM 306416 (CB 676475), a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM).</p>Fórmula:C16H13ClFN3O2Pureza:99.37% - ≥95%Cor e Forma:SolidPeso molecular:333.74AMG-47a
CAS:AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Fórmula:C29H28F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:535.56Oritinib mesylate
CAS:<p>Oritinib mesylate (SH-1028), an oral pyrimidine EGFR blocker with 18 nM IC50, targets both sensitive and T790M resistant mutations.</p>Fórmula:C32H41N7O5SCor e Forma:SolidPeso molecular:635.78Decernotinib
CAS:<p>Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.</p>Fórmula:C18H19F3N6OPureza:99.28% - >99.99%Cor e Forma:SolidPeso molecular:392.38Theliatinib tartrate
CAS:<p>Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.</p>Fórmula:C29H32N6O8Cor e Forma:SolidPeso molecular:592.6G5-7
CAS:<p>G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.</p>Fórmula:C22H19F2NO3Pureza:97.3%Cor e Forma:SolidPeso molecular:383.39AG-494
CAS:<p>AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.</p>Fórmula:C16H12N2O3Pureza:98.69%Cor e Forma:SolidPeso molecular:280.28(E/Z)-Zotiraciclib
CAS:<p>(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.</p>Fórmula:C23H24N4OPureza:97.75% - 99.92%Cor e Forma:SolidPeso molecular:372.46Neratinib
CAS:<p>Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.</p>Fórmula:C30H29ClN6O3Pureza:96.17% - 99.85%Cor e Forma:SolidPeso molecular:557.04Osimertinib mesylate
CAS:<p>Osimertinib mesylate (AZD-9291 mesylate) is an EGFR third-generation inhibitor. Osimertinib mesylate has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C29H37N7O5SPureza:99.46% - >99.99%Cor e Forma:SolidPeso molecular:595.71PF-6274484
CAS:<p>PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.</p>Fórmula:C18H14ClFN4O2Pureza:97.71%Cor e Forma:SolidPeso molecular:372.78RG13022
CAS:<p>RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).</p>Fórmula:C16H14N2O2Pureza:98.38%Cor e Forma:SolidPeso molecular:266.29Scutellarein
CAS:<p>Scutellarein (6-Hydroxyapigenin) reduces inflammatory responses by inhibiting Src kinase activity.</p>Fórmula:C15H10O6Pureza:98.02% - 99.63%Cor e Forma:SolidPeso molecular:286.24PRT-060318
CAS:<p>PRT-060318 (P142-76) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.</p>Fórmula:C18H24N6OPureza:99.98%Cor e Forma:SolidPeso molecular:340.42LDN-192960
CAS:<p>LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).</p>Fórmula:C18H20N2O2SPureza:98.01% - 99.51%Cor e Forma:SolidPeso molecular:328.43SU14813
CAS:<p>SU14813: inhibits multiple kinases (VEGFR2, VEGFR1, PDGFRβ, KIT) with IC50s of 50, 2, 4, 15 nM; antiangiogenic and antitumor.</p>Fórmula:C23H27FN4O4Pureza:98.13%Cor e Forma:SolidPeso molecular:442.48AIM-100
CAS:<p>AIM-100 is a Ack1 inhibitor (IC50: 24 nM).</p>Fórmula:C23H21N3O2Pureza:98.91%Cor e Forma:SolidPeso molecular:371.43NRC-2694 hydrochloride
CAS:<p>NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.</p>Fórmula:C24H27ClN4O3Cor e Forma:SolidPeso molecular:454.95Baricitinib
CAS:<p>Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.</p>Fórmula:C16H17N7O2SPureza:99% - >99.99%Cor e Forma:SolidPeso molecular:371.42Src Inhibitor 1
CAS:<p>Src Inhibitor 1 (Src Kinase Inhibitor 1) is a potent and selective dual site Src tyrosine kinase inhibitor.</p>Fórmula:C22H19N3O3Pureza:99.68% - >99.99%Cor e Forma:SolidPeso molecular:373.4Vimseltinib
CAS:Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).Fórmula:C23H25N7O2Pureza:99.05% - 99.57%Cor e Forma:SolidPeso molecular:431.49WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Fórmula:C28H30F3N7O3Pureza:97.93% - 99.94%Cor e Forma:SolidPeso molecular:569.58CL-387785
CAS:<p>CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.</p>Fórmula:C18H13BrN4OPureza:99.56% - 99.62%Cor e Forma:SolidPeso molecular:381.23Remibrutinib
CAS:<p>Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood.</p>Fórmula:C27H27F2N5O3Pureza:99.5% - 99.81%Cor e Forma:SolidPeso molecular:507.53Savolitinib
CAS:<p>Savolitinib (Volitinib) (AZD-6094) is an effective, selective, and orally bioavailable c-Met inhibitor (IC50s: 5 nM/3 nM for c-Met/p-Met).</p>Fórmula:C17H15N9Pureza:98.12%Cor e Forma:SolidPeso molecular:345.36Ribociclib
CAS:<p>Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor (IC50：10/39 nM).</p>Fórmula:C23H30N8OPureza:97.91% - >99.99%Cor e Forma:SolidPeso molecular:434.54(S)-Sunvozertinib
CAS:<p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>Fórmula:C29H35ClFN7O3Pureza:99.64%Cor e Forma:SolidPeso molecular:584.08BI-4020
CAS:<p>BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.</p>Fórmula:C30H38N8O2Pureza:97.21% - >99.99%Cor e Forma:SolidPeso molecular:542.68Avitinib
CAS:<p>Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,</p>Fórmula:C26H26FN7O2Pureza:99.81% - >99.99%Cor e Forma:SolidPeso molecular:487.53Pyridone 6
CAS:<p>Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).</p>Fórmula:C18H16FN3OPureza:97.1% - 98.74%Cor e Forma:SolidPeso molecular:309.34AG-1557 hydrochloride (189290-58-2(free base))
AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).Fórmula:C16H15ClIN3O2Pureza:98.64%Cor e Forma:SolidPeso molecular:443.66SRI 31215 TFA
CAS:<p>SRI 31215 TFA acts as a triplex inhibitor of matriptase, hepsin and HGFA and mimics the activity of HAI-1/2, endogenous inhibitors of HGF activation.</p>Fórmula:C27H34F3N5O3Pureza:98.25% - 99.97%Cor e Forma:SolidPeso molecular:533.6
