Angiogenesis
Angiogenesis inhibitors are compounds that interfere with the formation of new blood vessels, a process critical in cancer growth and metastasis. By inhibiting angiogenesis, these compounds can restrict the blood supply to tumors, slowing or halting their growth. Angiogenesis inhibitors are essential in cancer research and therapeutic development, providing insights into the mechanisms of tumor progression and offering potential treatments for cancer and other angiogenesis-related diseases. At CymitQuimica, we offer a wide range of high-quality angiogenesis inhibitors to support your research in oncology and vascular biology.
Subcategories of "Angiogenesis"
- BTK(145 products)
- Bcr-Abl(102 products)
- EGFR(572 products)
- FAK(72 products)
- FLT(92 products)
- Fibroblast Growth Factor Receptor (FGFR)(170 products)
- JAK(245 products)
- PDGFR(126 products)
- RAAS(86 products)
- Src(78 products)
- Syk(38 products)
- Thrombin(47 products)
- VDA(2 products)
- VEGFR(268 products)
Show 6 more subcategories
Found 1414 products of "Angiogenesis"
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Merestinib dihydrochloride
CAS:<p>Merestinib dihydrochloride (LY2801653 dihydrochloride) is a kinase inhibitor with antitumor activity that inhibits MET and MKNK1/2.</p>Formula:C30H24Cl2F2N6O3Color and Shape:SolidMolecular weight:625.45Canertinib
CAS:<p>Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.</p>Formula:C24H25ClFN5O3Purity:98% - >99.99%Color and Shape:White Or Similar To White Crystalline PowderMolecular weight:485.94SKLB4771
CAS:<p>SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.</p>Formula:C25H27N7O3S2Purity:98% - >99.99%Color and Shape:SolidMolecular weight:537.66HG-14-10-04
CAS:<p>HG-14-10-04 is a potent and specific ALK inhibitor.</p>Formula:C29H34ClN7OPurity:99.75% - >99.99%Color and Shape:SolidMolecular weight:532.08Zorifertinib
CAS:<p>Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.</p>Formula:C22H23ClFN5O3Purity:98.20% - 99.36%Color and Shape:White To Off-White SolidMolecular weight:459.9Vadimezan
CAS:<p>Vadimezan (NSC 640488) is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity.</p>Formula:C17H14O4Purity:97.38% - 99.8%Color and Shape:SolidMolecular weight:282.29Coumarin-3-carboxylic acid
CAS:<p>The combination of Valproic acid with Coumarin-3-carboxylic acid (3-Carboxycoumarin) suppresses the proliferation and migration of lung cancer cells via EGFR/</p>Formula:C10H6O4Purity:99.88%Color and Shape:Light Brown Crystalline PowderMolecular weight:190.15Desmethylanethol trithione
CAS:<p>Desmethylanethol trithione (ADT-OH), a synthetic H2S donor, modulates tPA effects, reduces stroke damage, and improves recovery in mice.</p>Formula:C9H6OS3Purity:98.05% - 98.41%Color and Shape:SolidMolecular weight:226.34FGFR2-IN-3 hydrochloride
CAS:<p>FGFR2-IN-3 hydrochloride is a selective, orally active FGFR2 inhibitor.</p>Formula:C28H25ClFN7O2Color and Shape:SolidMolecular weight:546.0PP 3
CAS:<p>PP 3 is a Negative control for the Src kinase inhibitor PP 2</p>Formula:C11H9N5Purity:98.61%Color and Shape:Whit To Off-White SolidMolecular weight:211.22Trastuzumab
CAS:<p>Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.</p>Purity:98% - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Color and Shape:LiquidMolecular weight:Approximately 145.53 kDaOglufanide
CAS:<p>Oglufanide (H-Glu-Trp-OH) is a naturally occurring thymic immunomodulator,and inhibits vascular endothelial growth factor (VEGF).</p>Formula:C16H19N3O5Purity:99.80%Color and Shape:SolidMolecular weight:333.34Oritinib mesylate
CAS:<p>Oritinib mesylate (SH-1028), an oral pyrimidine EGFR blocker with 18 nM IC50, targets both sensitive and T790M resistant mutations.</p>Formula:C32H41N7O5SColor and Shape:SolidMolecular weight:635.78NVP-BSK805 trihydrochloride
CAS:<p>NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.</p>Formula:C27H31Cl3F2N6OColor and Shape:SolidMolecular weight:599.93Lapatinib tosylate
CAS:<p>Lapatinib tosylate (GW572016) is an oral ErbB-2/EGFR inhibitor with IC50s of 10.2 nM (EGFR) & 9.8 nM (ErbB-2).</p>Formula:C36H34ClFN4O7S2Color and Shape:SolidMolecular weight:753.26Vatalanib succinate
CAS:<p>Vatalanib succinate is a VEGFR, PDGFR-β, c-Kit, c-Fms, and aromatase inhibitor.</p>Formula:C24H21ClN4O4Color and Shape:SolidMolecular weight:464.91Arnebin 1
CAS:<p>(Rac)-Arnebin 1 (beta, beta-dimethylacrylshikonin) has anti-tumor, anti-inflammatory, anti-immune deficiency and protecting liver.</p>Formula:C21H22O6Purity:98.76% - 99.81%Color and Shape:SolidMolecular weight:370.396Avitinib maleate
CAS:<p>Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.</p>Formula:C30H30FN7O6Purity:98% - 99.74%Color and Shape:SolidMolecular weight:603.61Silymarin
CAS:<p>Silymarin, a liver-aiding polyphenolic flavonoid, is extracted from milk thistle seeds.</p>Formula:C25H22O10Purity:98%Color and Shape:Yellow And Brown PowderMolecular weight:482.44GDC-0214
CAS:<p>GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).</p>Formula:C28H28ClF2N9O3Purity:99.75%Color and Shape:SolidMolecular weight:612.03Atopaxar hydrochloride
CAS:<p>Atopaxar hydrochloride is used in the Treatment of Cardiovascular Disorders.</p>Formula:C29H39ClFN3O5Color and Shape:SolidMolecular weight:564.1Afatinib Dimaleate
CAS:<p>Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.</p>Formula:C32H33ClFN5O11Purity:98.11% - 99.87%Color and Shape:SolidMolecular weight:718.08Naluzotan
CAS:<p>Naluzotan（PRX 00023） is a novel and potent 5-HT1A agonist with IC50 and Ki values of approximately 20 nM and 5.1 nM, respectively.Naluzotan is a potent hERG K+</p>Formula:C23H38N4O3SPurity:>99.99%Color and Shape:SolidMolecular weight:450.64AC1NS4RE
CAS:<p>It is a tyrosine kinase inhibitor.</p>Formula:C15H13ClN2OPurity:99.53%Color and Shape:SolidMolecular weight:272.73KX2-361
CAS:<p>KX2-361 is a orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma</p>Formula:C24H24FN3O2Purity:99.64% - 99.68%Color and Shape:SolidMolecular weight:405.46SB-431542
CAS:<p>SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective.</p>Formula:C22H16N4O3Purity:99.035% - >99.99%Color and Shape:SolidMolecular weight:384.39AG-1557 hydrochloride (189290-58-2(free base))
<p>AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>Formula:C16H15ClIN3O2Purity:98.64%Color and Shape:SolidMolecular weight:443.66CP-380736
CAS:<p>CP-380736 (PF-00520893) inhibits EGFR, a kinase key in cancer-signaling pathways like MAPK, JNK, and Akt.</p>Formula:C14H18N2O5Purity:99.68%Color and Shape:White To Off-White SolidMolecular weight:294.34SC-203
CAS:<p>4SC-203 is a multi-kinase inhibitor with potential anti-tumor activity.Cost-effective and quality-assured.</p>Formula:C33H38N8O4SPurity:96.4% - 99.67%Color and Shape:SolidMolecular weight:642.77CGP77675 hydrate
<p>CGP77675 hydrate: Oral Src family kinase inhibitor with IC50s of 5-20/40 nM (Src auto/phosphorylation) and has anticancer properties.</p>Color and Shape:SolidLificiguat
CAS:<p>Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha</p>Formula:C19H16N2O2Purity:98.85% - 99.92%Color and Shape:SolidMolecular weight:304.34Dapagliflozin
CAS:<p>Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.</p>Formula:C21H25ClO6Purity:99.5% - 99.93%Color and Shape:SolidMolecular weight:408.87(Z)-LFM-A13
CAS:<p>(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.</p>Formula:C11H8Br2N2O2Purity:99.88%Color and Shape:SolidMolecular weight:360Fostamatinib
CAS:<p>Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.</p>Formula:C23H26FN6O9PPurity:93.08% - 99.38%Color and Shape:SolidMolecular weight:580.46MELK-8a
CAS:<p>MELK-8a inhibits MELK kinase crucial for cancer cell mitosis (IC50: 2 nM).</p>Formula:C25H32N6OColor and Shape:SolidMolecular weight:432.56JK-P3
CAS:<p>JK-P3: a pyrazole inhibitor of VEGFR-2 (IC50: 7.8 μM), stalls FGFR 1/3 in vitro, halts HUVEC wound healing/tube formation, not cell growth.</p>Formula:C18H17N3O3Purity:99.57%Color and Shape:SolidMolecular weight:323.35CZC-8004
CAS:<p>CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.</p>Formula:C17H16FN5Purity:99.29%Color and Shape:SolidMolecular weight:309.34A-419259
CAS:<p>A-419259 (RK-20449) is an apoptosis inducer that selectively inhibits the Src family of kinases, including Src,LCK, and Lyn, with an IC50=3 to 9 nM.</p>Formula:C29H34N6OPurity:99.48%Color and Shape:SolidMolecular weight:482.627BIO
CAS:<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Formula:C16H10BrN3O2Purity:99.67%Color and Shape:SolidMolecular weight:356.17CA-4948
CAS:<p>CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.</p>Formula:C24H25N7O5Purity:99.35% - 99.88%Color and Shape:SolidMolecular weight:491.5Ramucirumab
CAS:<p>Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors.</p>Formula:C285H434N74O88S2Purity:98.2% (SDS-PAGE); 99.2% (SEC-HPLC) - 99.20%Color and Shape:LiquidMolecular weight:143.77 kDaQuizartinib HCl
CAS:<p>Quizartinib (AC220/AC010220) is an oral FLT3/STK1 inhibitor for treating AML, blocking kinase-driven cell proliferation and promoting apoptosis.</p>Formula:C29H34Cl2N6O4SColor and Shape:SolidMolecular weight:633.59GN44028
CAS:<p>GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.</p>Formula:C18H15N3O2Purity:99.52%Color and Shape:SolidMolecular weight:305.33VEGFR2-IN-2
CAS:<p>VEGFR2-IN-2 has anti-inflammatory and analgesic activities.</p>Formula:C15H11BrN2OPurity:99.504%Color and Shape:SolidMolecular weight:315.16Endoxifen (Z-isomer)
CAS:<p>Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.</p>Formula:C25H27NO2Purity:99.19% - 99.81%Color and Shape:SolidMolecular weight:373.49Cabozantinib hydrochloride
CAS:<p>Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6</p>Formula:C28H25ClFN3O5Purity:99.97%Color and Shape:SolidMolecular weight:537.96Bevacizumab
CAS:<p>Ipilimumab targets CTLA-4, an immune checkpoint inhibitor. Bevacizumab binds to VEGF-A isoforms.</p>Purity:95.40% - CE-SDS:97.5% SEC-HPLC:98.0%Color and Shape:LiquidMolecular weight:146.53 kDaKRCA-0008
CAS:<p>KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.</p>Formula:C30H37ClN8O4Purity:96.19%Color and Shape:SolidMolecular weight:609.12MCB-613
CAS:<p>MCB-613 is an effective steroid receptor coactivator (SRC) stimulator.</p>Formula:C20H20N2OPurity:98.17% - 99.754%Color and Shape:SolidMolecular weight:304.39Dovitinib
CAS:<p>Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.</p>Formula:C21H21FN6OPurity:99.35% - 99.92%Color and Shape:SolidMolecular weight:392.43BMS817378
CAS:<p>BMS817378 is a potent and selective inhibitor of MET(IC50 : 1.7 nM).</p>Formula:C24H18ClF2N4O7PPurity:>99.99%Color and Shape:SolidMolecular weight:578.85AG1557
CAS:<p>AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>Formula:C16H14IN3O2Purity:98.61% - 99.23%Color and Shape:SolidMolecular weight:407.21Tranilast
CAS:<p>Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of</p>Formula:C18H17NO5Purity:99.67% - >99.99%Color and Shape:White With Light Yellow Crystalline PowderMolecular weight:327.33Belzutifan
CAS:<p>"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."</p>Formula:C17H12F3NO4SPurity:99.34% - 99.88%Color and Shape:SolidMolecular weight:383.34Afatinib
CAS:<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Formula:C24H25ClFN5O3Purity:98.56% - 99.9%Color and Shape:Off-White SolidMolecular weight:485.94Ensartinib
CAS:<p>Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).</p>Formula:C26H27Cl2FN6O3Purity:99.92%Color and Shape:SolidMolecular weight:561.44UF010
CAS:<p>UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively.</p>Formula:C11H15BrN2OPurity:98.03% - 99.68%Color and Shape:SolidMolecular weight:271.15Dasatinib N-oxide
CAS:<p>Dasatinib N-oxide is a key metabolite and potential impurity of the kinase inhibitor dasatinib.</p>Formula:C22H26ClN7O3SPurity:98.54% - 99.94%Color and Shape:SolidMolecular weight:504(E/Z)-Zotiraciclib citrate
<p>(E/Z)-Zotiraciclib ((E/Z)-TG02) citrate is a potent inhibitor of CDK2, JAK2 and FLT3 and can be used in cancer research.</p>Formula:C29H32N4O8Color and Shape:SolidMolecular weight:564.59NRC-2694 hydrochloride
CAS:<p>NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.</p>Formula:C24H27ClN4O3Color and Shape:SolidMolecular weight:454.95Syk Inhibitor II dihydrochloride dihydrate
CAS:<p>Potent, selective ATP-competitive Syk Inhibitor II (IC50: 41 nM), with anti-allergic properties, in dihydrochloride dihydrate form.</p>Formula:C14H21Cl2F3N6O3Color and Shape:SolidMolecular weight:449.26Cevidoplenib dimesylate hydrochloride
CAS:<p>Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.</p>Formula:C90H132Cl5N27O12Purity:97.52%Color and Shape:SolidMolecular weight:1957.9ZINC13466751
CAS:<p>ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).</p>Formula:C20H21N5O2Purity:99.8%Color and Shape:SolidMolecular weight:363.41Adaphostin
CAS:<p>Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.</p>Formula:C24H27NO4Purity:98.29%Color and Shape:SolidMolecular weight:393.48Verteporfin
CAS:<p>Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions.</p>Formula:C41H42N4O8Purity:95.37% - 99.82%Color and Shape:Dark Green To Black SolidMolecular weight:718.79Brigatinib
CAS:<p>Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.</p>Formula:C29H39ClN7O2PPurity:97.18% - >99.99%Color and Shape:SolidMolecular weight:584.09Semaxinib
CAS:<p>Semaxinib (SU5416): potent VEGFR2 inhibitor, 20x more selective over PDGFRβ, not active on InsR/EGFR/FGFR, blocks ATP on VEGFR2, may reduce tumor vessels.</p>Formula:C15H14N2OPurity:99.84%Color and Shape:Yellow To Yellow OrangeMolecular weight:238.28Cabozantinib
CAS:<p>Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).</p>Formula:C28H24FN3O5Purity:99.68% - 99.88%Color and Shape:SolidMolecular weight:501.51N-piperidine Ibrutinib
CAS:<p>N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.</p>Formula:C22H22N6OPurity:96.65%Color and Shape:SolidMolecular weight:386.45Ritlecitinib tosylate
CAS:<p>Ritlecitinib (PF-06651600) is a potent, selective JAK3 inhibitor with proven in vivo efficacy, low clearance, and has undergone clinical trials.</p>Formula:C22H27N5O4SColor and Shape:SolidMolecular weight:457.549Isoliquiritin apioside
CAS:<p>Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.</p>Formula:C26H30O13Purity:98.84% - 99.27%Color and Shape:SolidMolecular weight:550.51WS6
CAS:<p>WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>Formula:C29H31F3N6O3Purity:97.65% - 99.95%Color and Shape:SolidMolecular weight:568.59GluR6 antagonist-1
CAS:<p>GluR6 antagonist-1 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.</p>Formula:C15H11ClN2OSPurity:99.89%Color and Shape:SolidMolecular weight:302.78SU 4313
CAS:<p>SU 4313 is a bioactive chemical.</p>Formula:C18H17NOPurity:99.51% - 99.89%Color and Shape:SolidMolecular weight:263.33ALK kinase inhibitor-1
CAS:<p>SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.</p>Formula:C28H32FN5O3SPurity:99.84%Color and Shape:SolidMolecular weight:537.65Theliatinib tartrate
CAS:<p>Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.</p>Formula:C29H32N6O8Color and Shape:SolidMolecular weight:592.6Syk Inhibitor II dihydrochloride
CAS:<p>Syk inhibitor II selectively blocks Syk (IC50 = 41 nM), impacting platelet function and inflammation, with lower potency against other kinases.</p>Formula:C14H17Cl2F3N6OPurity:98.53%Color and Shape:SolidMolecular weight:413.22Vorolanib
CAS:<p>Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.</p>Formula:C23H26FN5O3Purity:97.35%Color and Shape:SolidMolecular weight:439.48AZ 5104
CAS:Controlled Product<p>Applications AZ 5104 is a derivative of AZD 9291 (A808075) is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).<br>References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);<br></p>Formula:C27H31N7O2Color and Shape:Off-WhiteMolecular weight:485.58Behenamide
CAS:Controlled Product<p>Applications Behenamide is a fatty acid amide as an angiogenic. The mechanism of angiogenic activity is unknown and this lipid does not promote proliferation of endothelial cells or induce inflammatory effects.<br>References Wakamatsu, K., et al.: Biochem. Biophysical Res. Comm., 168, 423 (1990),<br></p>Formula:C22H45NOColor and Shape:White To Off-WhiteMolecular weight:339.6Cavutilide
CAS:<p>Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.</p>Formula:C22H26FN3O3Purity:99.82% - 99.85%Color and Shape:SolidMolecular weight:399.458Glycerol 1-Monobutyrate (Technical Grade)
CAS:<p>Applications Glycerol 1-Monobutyrate functions as a key regulatory molecule in angiogenic process.<br>References Dobson, D. E., et al.: Cell (Cambridge, MA, U. S.), 61, 223 (1990)<br></p>Formula:C7H14O4Color and Shape:NeatMolecular weight:162.18AZ 12799734
CAS:<p>AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.</p>Formula:C18H18N4O3SPurity:98.23%Color and Shape:SolidMolecular weight:370.43rac-Clopidogrel Hydrochloride
CAS:<p>Impurity Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B<br>Applications Clopidogrel Related Compound B (Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B) is a tetrahydrothienopyridine as inhibitor of angiogenesis.<br>References Maffrand, J. P., et al.: Eur. J. Med. Chem., 9, 483 (1974), Thebault, J.J., et al.: Clin. Pharmacol. Ther., 18, 485 (1975),<br></p>Formula:C16H16ClNO2S·ClHColor and Shape:NeatMolecular weight:358.28CCT241161
CAS:<p>CCT241161: oral pan-RAF inhibitor; IC50s: LCK (3 nM), CRAF (6), SRC (10), V600E-BRAF (15), BRAF (30); fights BRAF/NRAS melanomas, anti-proliferative.</p>Formula:C28H27N7O3SPurity:99.76% - 99.77%Color and Shape:SolidMolecular weight:541.62rac trans-3-Hydroxy Apatinib Dihydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Dihydrochloride salt of trans-3-Hydroxy Apatinib, a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br>References Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>Formula:C24H25Cl2N5O2Color and Shape:NeatMolecular weight:486.39Cpd27
CAS:<p>Cpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and can be used to study glaucoma.</p>Formula:C20H13F4N5O2Purity:98.89%Color and Shape:SolidMolecular weight:431.34TG 100801
CAS:<p>TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).</p>Formula:C33H30ClN5O3Purity:99.28% - 99.61%Color and Shape:SolidMolecular weight:580.08N-Acryloyl Osimertinib (>85%)
CAS:<p>Applications N-Acryloyl Osimertinib is used in the preparation of pyrimidinyl indole derivative as EGFR inhibitor for targeted therapy of cancer<br>References Rao, Y., et al.: Faming Zhuanli Shenqing (2016), CN 105777716 A 20160720<br></p>Formula:C31H35N7O3Purity:>85%Color and Shape:Off White SolidMolecular weight:553.65Donafenib
CAS:<p>Donafenib(Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3,</p>Formula:C21H13ClD3F3N4O3Purity:99.88%Color and Shape:SolidMolecular weight:467.84Seribantumab
CAS:<p>Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting cancer cell proliferation.</p>Purity:>95%Color and Shape:LiquidMolecular weight:143.2 (kDa)Dapolsertib
CAS:<p>Dapolsertib (SEL24-B489) is an orally active and efficient PIM and FLT3-ITD inhibitor, reducing PIM-specific substrate phosphorylation.</p>Formula:C15H18Br2N4O2Purity:99.61%Color and Shape:SolidMolecular weight:446.14Tirabrutinib
CAS:<p>Tirabrutinib, an oral Btk inhibitor (IC50=6.8 nM), crosses the BBB and halts B cell signaling for autoimmune and hematologic studies.</p>Formula:C25H22N6O3Purity:99.64%Color and Shape:SolidMolecular weight:454.48Itacnosertib
CAS:<p>Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.</p>Formula:C26H28N8OPurity:99.38%Color and Shape:SolidMolecular weight:468.55α-Eudesmol
CAS:<p>Applications α-Eudesmol is an isomer of β-Eudesmol (E938600), a sesquiterpenoid known to induce neurite outgrowth. β-Eudesmol exhibits antiangiogenic activity.<br>References Obara, Y. et al.: J. Pharmacol. Exp . Ther., 30, 803 (2011); Tsuneki, H. et al.: Eur. J. Pharmacol., 512, 105 (2005);<br></p>Formula:C15H26OColor and Shape:White To Off-WhiteMolecular weight:222.37Amivantamab
CAS:<p>Amivantamab (JNJ-61186372) is an antibody that recognizes EGFR and MET and has anticancer and antitumor activities.</p>Purity:97.24% (SEC-HPLC) - 99.74%Color and Shape:LiquidMolecular weight:145.88 kDaSB-505124 hydrochloride
CAS:<p>SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.</p>Formula:C20H22ClN3O2Purity:98.71%Color and Shape:SolidMolecular weight:371.86SB 203580 hydrochloride
CAS:<p>SB 203580 hydrochloride (Adezmapimod hydrochloride) is a p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy.</p>Formula:C21H17ClFN3OSPurity:97.79%Color and Shape:SolidMolecular weight:413.9Syk Inhibitor II
CAS:<p>Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).</p>Formula:C14H15F3N6OPurity:97.63%Color and Shape:SolidMolecular weight:340.3Canertinib dihydrochloride
CAS:<p>Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and</p>Formula:C24H27Cl3FN5O3Purity:99.13% - >99.99%Color and Shape:SolidMolecular weight:558.86BIBF 1202
CAS:<p>BIBF 1202 is a VEGFR2 kinase inhibitor (IC50 = 62 nM).</p>Formula:C30H31N5O4Purity:98.04%Color and Shape:SolidMolecular weight:525.6BMS-690514
CAS:<p>BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.</p>Formula:C19H24N6O2Purity:99.08%Color and Shape:SolidMolecular weight:368.43Methyl 6-[[[(2-Chloroethyl)amino]carbonyl]amino]-6-deoxy-α-D-glucopyranoside
CAS:Controlled ProductFormula:C10H19ClN2O6Color and Shape:NeatMolecular weight:298.72(5E)-5-(4-Hydroxybenzylidene)-1,3-thiazolidine-2,4-dione
CAS:Controlled Product<p>Applications 5-[(4-Hydroxyphenyl)methylene]-2,4-thiazolidinedione is a 5-Benzylidene-2,4-thiazolidenedione derivative designed as inhibitors of angiogenesis targeting VEGFR-2. Also, it is an intermediate used in the synthesis of MSDC 0602 (M755420), which is an analogue of thiazolidinediones, exhibits low affinity for binding and activation of peroxisome proliferator-activated receptor γ (PPARγ). Thiazolidinediones are effective insulin-sensitizing drugs for treating various metabolic and inflammatory diseases.<br>References Bhanushali, U., et al.: Bioorg. Chem., 67, 139-147 (2016); Chen, Z., et al.: J. Biol. Chem. 287, 23537 (2012); Fukunaga, T., et al.: J. Bone Miner. Res., 30, 508 (2015)<br></p>Formula:C10H7NO3SColor and Shape:NeatMolecular weight:221.23Serclutamab
CAS:<p>Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).</p>Purity:98%Color and Shape:LiquidElgemtumab
CAS:<p>Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation antitumour.</p>Purity:95%Color and Shape:LiquidFidasimtamab
CAS:<p>Fidasimtamab, a recombinant human IgG1 bispecific antibody, targets both HER2 and PD-1, bridging T cells and tumor cells to modulate immune responses.</p>Purity:95% - 95%Color and Shape:LiquidSolrikitug
CAS:<p>Solrikitug,Anti-CRLF2 humanized IgG1κ monoclonal antibody.</p>Purity:95%Color and Shape:LiquidBafisontamab
CAS:<p>Bafisontamab (EMB-01) is a bispecific antibody that targets EGFR and cMET, displaying antitumor activity [1].</p>Color and Shape:LiquidZanidatamab
CAS:<p>Zanidatamab (ZW25) is a bispecific, humanized monoclonal antibody that targets two distinct epitopes (ECD2 and ECD4) of the HER2 receptor, exhibiting anti-tumor</p>Color and Shape:LiquidVanucizumab
CAS:<p>Vanucizumab is a bispecific humanised monoclonal antibody that simultaneously inhibits the receptor interactions of VEGF-A and Angiopoietin-2 (Ang-2)</p>Purity:95%Color and Shape:LiquidPonezumab
CAS:<p>Ponezumab (PF-04360365), a humanized IgG2 antibody, lowers Aβ in the CNS & boosts mice memory. Used in Alzheimer's research.</p>Color and Shape:LiquidFaricimab
CAS:<p>Faricimab,Bispecific antibody targeting Ang-2/VEGF-A. Prevents retinal I/R injury. Improves vision in w-AMD, DME, RVO.</p>Purity:95% - 95%Color and Shape:LiquidAnti-Mouse VEGFR-2 Antibody (DC101)
<p>Anti-Mouse VEGFR-2 Antibody (DC101) is a rat-derived monoclonal antibody against mouse VEGFR2/KDR/Flk-1, serving as a mouse analogue of ramucirumab.</p>Purity:99%Color and Shape:Odour LiquidDepatuxizumab
CAS:<p>Depatuxizumab is a humanised monoclonal antibody targeting EGFR with blood-brain barrier (BBB) permeability, inhibit tumor growth,GBM,SCCHN.</p>Purity:95%Color and Shape:LiquidFutuximab
CAS:<p>Futuximab, a chimeric monoclonal antibody, targets distinct epitopes on the epidermal growth factor receptor (EGFR), exhibiting antineoplastic activity [1].</p>Purity:95% - 95%Color and Shape:LiquidImgatuzumab
CAS:<p>Imgatuzumab (RG 7160) is a humanized anti-EGFR monoclonal antibody and immunomodulator for cancer research.</p>Color and Shape:LiquidMolecular weight:145.0 (kDa)Tovetumab
CAS:<p>Tovetumab (MEDI-575) is an anti-PDGFRα mAb inhibiting its signaling, in trials for glioblastoma and NSCLC.</p>Purity:95%Color and Shape:LiquidIvonescimab
CAS:<p>Ivonescimab (AK112) is a PD-1/VEGF bispecific antibody with cancer immunotherapy and anti-angiogenic effects, NSCLC).</p>Purity:95% - 95%Color and Shape:LiquidIzalontamab
CAS:<p>Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers.</p>Purity:95%+ - 95%+Color and Shape:LiquidTarcocimab
CAS:<p>Tarcocimab (OG1953) is a humanized IgG1 monoclonal antibody targeting VEGFA, researched for RVO and wet AMD.</p>Color and Shape:LiquidZalutumumab
CAS:<p>Zalutumumab is a high-affinity fully human monoclonal antibody ,the extracellular domain of the EGFR squamous cell carcinoma of the head and neck (SCCHN).</p>Purity:95%Color and Shape:LiquidAnbenitamab
CAS:<p>Anbenitamab (KN-026) is a bispecific HER2 antibody for metastatic breast cancer research, blocking HER2 pathways and mediating ADCC.</p>Color and Shape:LiquidBecotatug
CAS:<p>Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib and Osimertinib, functioning as a synthetic antibody-drug conjugate</p>Purity:95% - 95%Color and Shape:LiquidDilpacimab
CAS:<p>Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.</p>Purity:95% - 95%Color and Shape:LiquidIbrutinib-d5
CAS:<p>Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor.</p>Formula:C25H24N6O2Purity:98%Color and Shape:SolidMolecular weight:445.53Dasatinib-d8
CAS:<p>Dasatinib D8 is deuterium-labeled dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.</p>Formula:C22H26ClN7O2SPurity:98%Color and Shape:SolidMolecular weight:496.06MAPK-IN-2
<p>MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cell</p>Formula:C20H11Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:380.23EGFR-IN-117
CAS:<p>EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutations, specifically targeting the tumor environment and inducing apoptosis in cancer cells. This compound effectively inhibits the proliferation of H1975, PC-9, and mutant EGFR cells including BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 values of 13 nM, 19 nM, 1.2 nM, and 1.3 nM respectively. Additionally, EGFR-IN-117 demonstrates anti-tumor activity in mouse models.</p>Formula:C25H30BrN7O2SColor and Shape:SolidMolecular weight:572.52EGFR-IN-109
CAS:<p>EGFR-IN-109 (compound 4), an EGFR inhibitor, displays IC 50 values of 25.8 nM for EGFR WT and 182.3 nM for EGFR T790M. This compound halts the growth of cancer cells at the G2/M phase and triggers both early and late apoptosis. It is applicable in cancer research [1].</p>Formula:C12H16N4OSColor and Shape:SolidMolecular weight:264.35IGF-1R modulator 1
CAS:<p>IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.</p>Formula:C22H17N3O4Color and Shape:SolidMolecular weight:387.39AD1058
CAS:<p>AD1058 is a selective ATR inhibitor that crosses the blood-brain barrier with in vivo anticancer activity, used in the study of brain and CNS metastasis.</p>Formula:C19H20N6O3SPurity:98.24%Color and Shape:SolidMolecular weight:412.47(3S,4S)-Tofacitinib
CAS:<p>(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.</p>Formula:C16H20N6OPurity:98%Color and Shape:SolidMolecular weight:312.37ZM39923
CAS:<p>ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).</p>Formula:C23H25NOPurity:98%Color and Shape:SolidMolecular weight:331.45HVH-2930
CAS:<p>HVH-2930 is an inhibitor of Heat Shock Protein 90 (HSP90). It suppresses the cell viability of BT474 (Trastuzumab sensitive) and JIMT-1 (Trastuzumab resistant) by downregulating HSP90 client proteins such as HER2, p-HER2, AKT, p-AKT, cyclin D1, and survivin, with IC50 values of 6.86 μM and 4.42 μM, respectively. Additionally, HVH-2930 demonstrates antitumor efficacy in a mouse model and exhibits favorable pharmacokinetic properties in vivo.</p>Formula:C29H36N4O3Color and Shape:SolidMolecular weight:488.62GZD856 formic
CAS:<p>GZD856 formic inhibits PDGFRα/β (IC50: 68.6, 136.6 nM) & Bcr-Abl (IC50: 19.9, 15.4 nM), with antitumor properties.</p>Formula:C30H29F3N6O3Color and Shape:SolidMolecular weight:578.58Erlotinib mesylate
CAS:<p>Erlotinib: reversible inhibitor binding to ATP site of epidermal growth factor receptor.</p>Formula:C23H27N3O7SPurity:98%Color and Shape:SolidMolecular weight:489.54ALK5-IN-79
CAS:<p>ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.</p>Formula:C23H27N7OColor and Shape:SolidMolecular weight:417.51Tyrphostin AG 112
CAS:Controlled Product<p>Applications Tyrphostin AG 112 is an EGFR inhibitor.<br></p>Formula:C13H8N4OColor and Shape:NeatMolecular weight:236.23Atrasentan
CAS:Controlled Product<p>Applications Atrasentan is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.<br>References Bax, W., et al.: Trends Pharmacol. Sci., 15, 379 (1994); Winn, M., et al.: J. Med. Chem., 39, 1039 (1996); Wu-Wong, J., et al.: J. Pharmacol. Exp. Ther., 281, 791 (1997);<br></p>Formula:C29H38N2O6Color and Shape:Off-WhiteMolecular weight:510.62Tyrphostin AG 1478
CAS:Controlled Product<p>Applications Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.<br></p>Formula:C16H14ClN3O2Color and Shape:NeatMolecular weight:315.75N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine
CAS:Controlled ProductFormula:C20H16FN5O3Color and Shape:Light Yellow To YellowMolecular weight:393.37Des-(4-(dimethylamino)-2-butenoyl)-Neratinib
CAS:Controlled Product<p>Applications 6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile, is used in the synthetic preparation of aminopropanamides which is used in irreversible inhibition of epidermal growth factor receptor (EGFR) for potential use in cancer therapy.<br>References Carmi, C., et al.: J. Med. Chem., 55, 2251 (2012)<br></p>Formula:C24H20ClN5O2Color and Shape:NeatMolecular weight:445.94-Fmoc-3(R)-morpholinecarboxylic Acid
CAS:Controlled Product<p>Applications 4-Fmoc-3(R)-morpholinecarboxylic Acid is used to prepare 125I-labeled morpholine-containing RGD ligand of αvβ3 integrin as angiogenesis imaging probe.<br>References Bianchini, F., et al.: J. Med. Chem., 55, 5024 (2012)<br></p>Formula:C20H19NO5Color and Shape:NeatMolecular weight:353.372,3-Naphthalic Anhydride
CAS:Controlled Product<p>Stability Moisture Sensitive<br>Applications 2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumour necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma.<br>References D’Amato, R., et al.: Proc. Nat. Acad. Sci., 91, 4082 (1994); Ehrenpreis, E., et al.: Gastroenterology, 117, 1271 (1999); Parma, T., et al.: Nat. Med., 5, 582 (1999); Singhal, S., et al.: New Engl. J. Med., 341, 1565 (1999)<br></p>Formula:C12H6O3Color and Shape:NeatMolecular weight:198.17LB 42708
CAS:Controlled Product<p>Applications LB 42708 is a selective nonpeptidic Farnesyltransferase (FTase) inhibitor.LB42708 suppresses tumor growth and tumor angiogenesis in both xenograft tumor models of Ras-mutated HCT116 cells and its wild-type Caco-2 cells, indicating its potential application in the treatment of both Ras-mutated and wild type tumors.<br>References Kim, C., et. al.: Mol. Pharmacol., 78, 142 (2010)<br></p>Formula:C30H27BrN4O2Color and Shape:NeatMolecular weight:555.462-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide
CAS:Controlled Product<p>Applications 2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide is an intermediate Apatinib 25-N-Oxide (A726160), a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br></p>Formula:C18H16ClN3OColor and Shape:NeatMolecular weight:325.79Dehydrodivanillin (~90%, contains up to 10% unknown inorganics)
CAS:Formula:C16H14O6Color and Shape:NeatMolecular weight:302.279Pulsatilla Saponin D (90%)
CAS:Controlled Product<p>Applications Pulsatilla Saponin D shows antiangiogenic and antitumor activity.<br>References Sang-Won, H. et al.: Carcinogen., 34, 2156 (2013);<br></p>Formula:C47H76O17Purity:90%Color and Shape:NeatMolecular weight:913.1E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Formula:C21H30O6Purity:99.52%Color and Shape:SolidMolecular weight:378.46Bucillamine
CAS:<p>Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF.</p>Formula:C7H13NO3S2Purity:99.47%Color and Shape:SolidMolecular weight:223.31YLT192
CAS:<p>YLT192 is an orally active and bioavailable VEGFR2 inhibitor. It also has potent antiangiogenic activity and antitumor efficacy.</p>Formula:C21H19N3O4Purity:98%Color and Shape:SolidMolecular weight:377.39TGFBR1-IN-1
CAS:<p>TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).</p>Formula:C23H17N5O2SPurity:98%Color and Shape:SolidMolecular weight:427.48Antiproliferative agent-30
CAS:<p>Antiproliferative agent-30 (Compound 8g) demonstrates broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM against</p>Formula:C24H26N4O4Color and Shape:SolidMolecular weight:434.49BTK-IN-24
CAS:<p>BTK-IN-24 is a Bruton's tyrosine kinase (BTK) inhibitor with potential anticancer activity, and it can be used in the study of myeloproliferative disorders.</p>Formula:C26H19F4N5O2Purity:99.61%Color and Shape:SolidMolecular weight:509.46THS-044
CAS:<p>THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity</p>Formula:C11H12F3N3O3Purity:99.89%Color and Shape:SolidMolecular weight:291.23DMPQ dihydrochloride
CAS:<p>PDGFRβ inhibitor</p>Formula:C16H16Cl2N2O2Purity:99.51%Color and Shape:SolidMolecular weight:339.22EGFR-IN-68
CAS:<p>EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.</p>Formula:C24H22N2OColor and Shape:SolidMolecular weight:354.44FM19G11
CAS:<p>FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).</p>Formula:C23H17N3O8Purity:99.70%Color and Shape:SolidMolecular weight:463.4BKI-1369
CAS:<p>BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).</p>Formula:C23H27N7OColor and Shape:SolidMolecular weight:417.51ACP-5862
CAS:<p>ACP-5862, active metabolite of Acalabrutinib, is a BTK inhibitor with an IC50 of 5.0 nM.</p>Formula:C26H23N7O3Color and Shape:SolidMolecular weight:481.51NSC114126
CAS:<p>NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>Formula:C22H20O4Color and Shape:SolidMolecular weight:348.39EGFR-IN-50
CAS:<p>EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.</p>Formula:C24H26BrN3O4S2Color and Shape:SolidMolecular weight:564.51FLT3-IN-15
CAS:<p>FLT3-IN-15 is an orally active and potent FLT3 inhibitor, capable of acting on FLT3 (IC50: 0.87 nM) and FLT3/D835Y (IC50: 0.32 nM).</p>Formula:C22H23ClFN5O2Color and Shape:SolidMolecular weight:443.91ALK5-IN-30
CAS:<p>ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).</p>Formula:C24H25FN8Color and Shape:SolidMolecular weight:444.51AG-183
CAS:<p>(Z)-Tyrphostin A51, a Z-isomer of Lanoconazole A51, is a strong PTK inhibitor blocking [3 H]taurine release and tyrosyl phosphorylation.</p>Formula:C13H8N4O3Color and Shape:Brown SolidMolecular weight:268.23NSC81111
CAS:<p>NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].</p>Formula:C19H16O4Color and Shape:SolidMolecular weight:308.33Naphazoline
CAS:<p>Naphazoline (Naphcon-a) is a sympathomimetic compound with marked alpha adrenergic activity.</p>Formula:C14H14N2Purity:99.79%Color and Shape:White Crystalline Powder SolidMolecular weight:210.27CJ-2360
CAS:<p>CJ-2360 is a potent ALK inhibitor, effective on wild-type and various mutants, with IC50 values ranging from 2.2 to 8.9 nM, also targeting 468 kinases.</p>Formula:C27H30FN5O2Color and Shape:SolidMolecular weight:475.56SJF620
CAS:<p>SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).</p>Formula:C41H44N8O7Purity:98%Color and Shape:SolidMolecular weight:760.84Flonoltinib
CAS:<p>Flonoltinib (JAK2/FLT3-IN-1) is an orally active and efficient JAK2/FLT3 inhibitor with anti-cancer properties.</p>Formula:C25H34FN7OPurity:99.52%Color and Shape:SolidMolecular weight:467.58J-1048
CAS:<p>J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/</p>Formula:C23H17FN6S2Color and Shape:SolidMolecular weight:460.55BTK inhibitor 10
CAS:<p>BTK inhibitor 10, an oral drug from patent WO2018145525, may treat rheumatoid arthritis.</p>Formula:C25H23N5O3Purity:98%Color and Shape:SolidMolecular weight:441.48Peficitinib hydrochloride
CAS:<p>Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).</p>Formula:C18H23ClN4O2Color and Shape:SolidMolecular weight:362.86JAK-IN-20
CAS:<p>JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.</p>Formula:C28H30FN7O2Color and Shape:SolidMolecular weight:515.58TX-1918
CAS:<p>TX-1918, a tyrphostin, blocks eEF-2K to hinder HepG2, HCT116 cell growth.</p>Formula:C14H12O3Color and Shape:SolidMolecular weight:228.24TK4b
CAS:<p>TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) & 19.40 nM (JAK2).</p>Formula:C21H22N2O2Color and Shape:SolidMolecular weight:334.41FLT3/ITD-IN-2
CAS:<p>FLT3/ITD-IN-2: Powerful FLT3/ITD, FLT3D835Y, and FLT3 inhibitor; hinders AML cell growth. IC50s: 0.3-1.0 nM.</p>Formula:C23H26F3N7O2Color and Shape:SolidMolecular weight:489.49KL-1156
CAS:<p>KL-1156 is an NF-κB inhibitor. It is also a lipopolysaccharide (LPS)-induced nitric oxide production inhibitor.</p>Formula:C17H17NO4Purity:98%Color and Shape:SolidMolecular weight:299.32DB07107
CAS:<p>DB07107 is a potent inhibitor of drug resistant T315I mutant Bcr-Abl tyrosine kinase and a potent Akt1 inhibitor (IC50: 360 nM).</p>Formula:C23H22N4OPurity:98%Color and Shape:SolidMolecular weight:370.45PD180970
CAS:<p>PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit.</p>Formula:C21H15Cl2FN4OPurity:98.67%Color and Shape:SolidMolecular weight:429.27T338C Src-IN-2
CAS:<p>T338C Src-IN-2: Potent c-Src T338C kinase inhibitor; IC50: 317 nM, T338C/V323A: 57 nM, T338C/V323S: 19 nM.</p>Formula:C17H18FN5OPurity:98%Color and Shape:SolidMolecular weight:327.36TK4g
CAS:<p>TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) & 15.80 nM (JAK3); promising for lymphoid diseases & leukemia research.</p>Formula:C19H19N3O4SColor and Shape:SolidMolecular weight:385.44EGFR-IN-67
CAS:<p>EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].</p>Formula:C18H17N3SColor and Shape:SolidMolecular weight:307.41Squarunkin A hydrochloride
CAS:<p>Squarunkin A HCl inhibits UNC119-cargo binding, specifically blocks Src kinase activation, IC50=10 nm.</p>Formula:C25H33ClF3N5O4Color and Shape:SoildMolecular weight:560.02JAK-2/3-IN-2
CAS:<p>JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).</p>Formula:C19H19ClN2OSColor and Shape:SolidMolecular weight:358.89JNJ-47117096 hydrochloride
CAS:<p>JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.</p>Formula:C21H23ClN4O2Color and Shape:SolidMolecular weight:398.89c-ABL-IN-2
CAS:<p>C-ABL-IN-2 is a potent c-Abl protein inhibitor, promising for research in cancer and neurodegenerative diseases like ALS and PD.</p>Formula:C21H20N4OColor and Shape:SolidMolecular weight:344.41MS 154N
CAS:<p>MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.</p>Formula:C47H56ClFN8O8Color and Shape:SolidMolecular weight:915.45Esuberaprost Sodium
CAS:<p>Famitinib (SHR1020), an oral drug, inhibits c-kit, VEGFR-2, and PDGFRβ (IC50: 2.3/4.7/6.6 nM) and triggers apoptosis in gastric cancer.</p>Formula:C23H27FN4O2Color and Shape:SolidMolecular weight:410.48OD36 hydrochloride
CAS:<p>OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently</p>Formula:C16H16Cl2N4O2Purity:99.85%Color and Shape:SolidMolecular weight:367.23TYK2-IN-12
CAS:<p>TYK2-IN-12: selective oral TYK2 inhibitor (Ki: 0.51 nM), blocks IL-12-induced IFNγ; IC50: human 2.7 µM, mouse 7.0 µM, used for psoriasis research.</p>Formula:C24H20F2N4O2Color and Shape:SolidMolecular weight:434.44PDE5-IN-3
CAS:<p>PDE5-IN-3: Inhibits PDE5 (1.57 nM), EGFR (5.827 μM), Wnt pathway (1286.96 ng/mL), induces apoptosis, and has antitumor effects.</p>Formula:C21H14BrN5O2Color and Shape:SolidMolecular weight:448.27PDGFR-IN-1
CAS:<p>PDGFR-IN-1 is a platelet-derived growth factor receptor (PDGFR) inhibitor, strongly inhibiting PDGFRα and PDGFRβ, useful for studying solid tumors.</p>Formula:C25H30N8OPurity:99.13% - 99.49%Color and Shape:SolidMolecular weight:458.56IHMT-TRK-284
CAS:<p>IHMT-TRK-284: Oral type II TRK inhibitor; targets TRKA, TRKB, TRKC (IC50s: 10.5, 0.7, 2.6 nM); selective and anti-tumor effective.</p>Formula:C25H27N7OSColor and Shape:SolidMolecular weight:473.59FGFR3-IN-2
CAS:<p>FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor that inhibits FGFR3 (IC50: 4.1 nM) and VEGFR2 (IC50: 570 nM).</p>Formula:C28H39N9O4SColor and Shape:SolidMolecular weight:597.73CpCDPK1/TgCDPK1-IN-1
CAS:<p>CpCDPK1/TgCDPK1-IN-1 is a inhibitor of CpCDPK1 and TgCDPK1, inhibits Abl and Src, and has antiparasitic activity for the study of Toxoplasma infections.</p>Formula:C18H17N5Purity:99.61%Color and Shape:SolidMolecular weight:303.36AG-370
CAS:<p>AG 370, an indole tyrphostin, functions as a powerful inhibitor of PDGF-induced mitogenesis, demonstrating an IC50 of 20 μM.</p>Formula:C15H9N5Color and Shape:SolidMolecular weight:259.27ALK-IN-22
CAS:<p>ALK-IN-22 suppresses ALK and mutants (IC50: 2.3-3.7 nM), hinders phosphorylation, and induces apoptosis in tumor studies.</p>Formula:C24H24ClN7O2Color and Shape:SolidMolecular weight:477.95
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