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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3905 products of "Cell Cycle/Checkpoint"

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  • 3'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine


    3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolent lymphoid
    Formula:C38H43N5O9
    Color and Shape:Solid
    Molecular weight:713.78

    Ref: TM-T75205

    5mg
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    50mg
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  • 5'-O-DMT-N4-Ac-2'-F-dC

    CAS:
    5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.
    Formula:C32H32FN3O7
    Color and Shape:Solid
    Molecular weight:589.61

    Ref: TM-T37136

    50mg
    47.00€
    1mL*10mM (DMSO)
    52.00€
  • 5'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite


    5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.
    Formula:C44H49F2N4O7P
    Color and Shape:Solid
    Molecular weight:814.85

    Ref: TM-T75190

    5mg
    To inquire
    50mg
    To inquire
  • α2β1 Integrin Ligand Peptide TFA


    α2β1 Integrin Ligand Peptide TFA interacts with the integrin receptor on the cell membrane and enters the cell to mediate extracellular signaling.It is a
    Formula:C16H23F3N4O11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:504.37

    Ref: TM-TP1374

    1mg
    92.00€
    5mg
    259.00€
    10mg
    409.00€
  • Lorutengitide

    CAS:
    Lorutengitide is a transcription-regulating peptide with antiproliferative activity.
    Formula:C30H50N8O12
    Color and Shape:Solid
    Molecular weight:714.764

    Ref: TM-TP3135

    10mg
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    50mg
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  • Brr2-IN-2


    Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.
    Formula:C21H25FN4O2
    Color and Shape:Solid
    Molecular weight:384.45

    Ref: TM-T205260

    10mg
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    50mg
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  • CDK2-IN-43


    CDK2-IN-43 (Compound 3a) is a CDK2-cyclin E2 inhibitor with an IC50 value of 6.0 nM. It is applicable to cancer research.
    Formula:C19H27N7O
    Color and Shape:Solid
    Molecular weight:369.464

    Ref: TM-T206067

    10mg
    To inquire
    50mg
    To inquire
  • [pThr3]-CDK5 Substrate

    CAS:
    [pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate.[pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM[1].
    Formula:C53H100N15O15P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1218.43

    Ref: TM-TP1602

    100mg
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    500mg
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  • 13-TP


    13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.
    Formula:C12H19F2N6O12P3
    Color and Shape:Solid
    Molecular weight:570.23

    Ref: TM-T205409

    10mg
    To inquire
    50mg
    To inquire
  • (1S,3R,5R)-PIM447 dihydrochloride


    (1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).
    Formula:C24H25Cl2F3N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:513.38

    Ref: TM-T13425

    25mg
    2,300.00€
    50mg
    3,022.00€
    100mg
    4,085.00€
  • CDK7-IN-21

    CAS:
    CDK7-IN-21 (compound A22) is a potent CDK7 inhibitor [1] .
    Formula:C33H36FN9O2
    Color and Shape:Solid
    Molecular weight:609.7

    Ref: TM-T75121

    25mg
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    50mg
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    100mg
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  • Trimethoprim hydrochloride

    CAS:
    Trimethoprim hydrochloride: oral, broad-spectrum antibiotic, DHFR inhibitor, treats UTIs, shigellosis, pneumocystis pneumonia, may block Influenza A with zinc.
    Formula:C14H19ClN4O3
    Color and Shape:Solid
    Molecular weight:326.78

    Ref: TM-T75291

    25mg
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    50mg
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    100mg
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  • Obtustatin


    Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.
    Formula:C184H284N52O57S8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4393.07

    Ref: TM-TP1974

    1mg
    800.00€
  • CDK4/6-IN-5

    CAS:
    CDK4/6-IN-5 inhibits CDK4/6; Ki: 0.2 nM (CDK4/D1) & 4.4 nM (CDK6/D3). (WO2019207463A1, A93)
    Formula:C22H28ClFN6O4S
    Color and Shape:Solid
    Molecular weight:527.01

    Ref: TM-T39956

    5mg
    873.00€
  • Gly-Arg-Gly-Asp-Ser

    CAS:
    Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.
    Formula:C17H30N8O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:490.47

    Ref: TM-TP1459

    2mg
    50.00€
    5mg
    88.00€
    10mg
    126.00€
    25mg
    195.00€
  • Solidagonic acid

    CAS:
    Solidagonic acid inhibits HSET, prevents fission yeast cell death, and hinders L. sativa and L. multiflorum seedling growth.
    Formula:C22H34O4
    Color and Shape:Solid
    Molecular weight:362.5

    Ref: TM-T75576

    5mg
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    50mg
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  • Rev 2'-O-MOE-A(Bz)-5'-amidite


    'Rev 2’-O-MOE-A(Bz)-5’-amidite is a nucleoside analog specifically categorized within the purine subset, renowned for its wide-ranging antitumor efficacy
    Formula:C50H58N7O9P
    Color and Shape:Solid
    Molecular weight:932.01

    Ref: TM-T75210

    5mg
    To inquire
    50mg
    To inquire
  • MS7131


    MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.
    Color and Shape:Odour Solid

    Ref: TM-T206796

    10mg
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    50mg
    To inquire
  • MYC-IN-2

    CAS:
    MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.
    Formula:C25H17N3O2S
    Color and Shape:Solid
    Molecular weight:423.49

    Ref: TM-T39751

    5mg
    873.00€
  • Pseudorabies virus-IN-1


    Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.
    Formula:C27H23ClF2N4O2
    Color and Shape:Solid
    Molecular weight:508.947

    Ref: TM-T206101

    10mg
    To inquire
    50mg
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  • ONX 0801 trisodium

    CAS:
    ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.
    Formula:C32H30N5Na3O10
    Color and Shape:Solid
    Molecular weight:713.58

    Ref: TM-T38490

    5mg
    3,295.00€
  • DHFR-IN-11


    DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.
    Color and Shape:Odour Solid

    Ref: TM-T82570

    5mg
    To inquire
    50mg
    To inquire
  • HDAC-IN-85


    HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.
    Formula:C24H27FN4O5
    Color and Shape:Solid
    Molecular weight:470.49

    Ref: TM-T205411

    10mg
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    50mg
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  • BIO5192 hydrate


    BIO5192 hydrate: potent α4β1 inhibitor, binds selectively (Kd<10 pM, IC50=1.8 nM), boosts murine HSPC mobilization 30x.
    Color and Shape:Solid

    Ref: TM-T36296

    50mg
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    100mg
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  • N4-(n-Palmitoyl)-4'-azido-2'-deoxy-2'-fluoro-arabinocytidine


    N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine is a cytidine nucleoside analog.
    Formula:C25H41FN6O5
    Color and Shape:Solid
    Molecular weight:524.63

    Ref: TM-T75032

    5mg
    To inquire
    50mg
    To inquire
  • WAY-322243

    CAS:
    WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer's disease.
    Formula:C18H18N2O2S
    Purity:99.88%
    Color and Shape:Soild
    Molecular weight:326.41

    Ref: TM-T77619

    2mg
    39.00€
    5mg
    56.00€
    10mg
    92.00€
    25mg
    167.00€
    50mg
    251.00€
    100mg
    380.00€
    500mg
    862.00€
  • Ganodermaones B


    Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .
    Formula:C21H26O5
    Color and Shape:Solid
    Molecular weight:358.43

    Ref: TM-T72798

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • 3'-β-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine


    3’-Beta-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine is an adenosine analog.
    Formula:C20H18F3N5O4
    Color and Shape:Solid
    Molecular weight:449.38

    Ref: TM-T75048

    5mg
    To inquire
    50mg
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  • L-5-Methyluridine

    CAS:
    L-5-Methyluridine, an L-configuration of 5-Methyluridine, is an endogenous methylated nucleoside present in human fluids.
    Formula:C10H14N2O6
    Color and Shape:Solid
    Molecular weight:258.23

    Ref: TM-T74653

    5mg
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    50mg
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  • S-MGB-234

    CAS:
    S-MGB-234 treats AAT, effective against T. congolense and T. vivax, no cross-resistance or shared transport with diamidines.
    Formula:C30H32N8O4
    Color and Shape:Solid
    Molecular weight:568.638

    Ref: TM-T39397

    25mg
    1,369.00€
  • EFdA-TP tetraammonium


    EFdA-TP tetraammonium is a potent HIV-1 RT inhibitor and DNA synthesis blocker, acting as an ICT or DCT.
    Formula:C12H27N9O12P3
    Color and Shape:Solid
    Molecular weight:601.31

    Ref: TM-T35649

    1mg
    432.00€
    5mg
    1,071.00€
  • Evybactin


    Evybactin: a selective DNA gyrase inhibitor for Mycobacterium tuberculosis (MIC 0.25 µg/mL), first of its kind.
    Formula:C64H89N21O21
    Color and Shape:Solid
    Molecular weight:1488.52

    Ref: TM-T76266

    5mg
    To inquire
    50mg
    To inquire
  • DSPE-PEG2000-iRGD


    DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.
    Color and Shape:Odour Solid

    Ref: TM-TCL-01137

    10mg
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    50mg
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  • FF-10502

    CAS:
    FF-10502, a pyrimidine analog of Gemcitabine, inhibits DNA polymerases α/β, targeting dormant cancer cells.
    Formula:C9H12FN3O3S
    Color and Shape:Solid
    Molecular weight:261.27

    Ref: TM-T39290

    25mg
    1,369.00€
  • N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium

    CAS:

    N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].

    Formula:C21H35N12O17P3
    Color and Shape:Solid
    Molecular weight:820.49

    Ref: TM-T74135

    5mg
    To inquire
    50mg
    To inquire
  • STX-100


    PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.
    Purity:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)
    Color and Shape:Odour Liquid
    Molecular weight:145.12 kDa

    Ref: TM-T9901A-062

    1mg
    233.00€
    5mg
    754.00€
    10mg
    1,228.00€
    25mg
    2,257.00€
    50mg
    3,046.00€
  • RNA splicing modulator 1

    CAS:
    RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1].
    Formula:C19H20N6OS
    Color and Shape:Solid
    Molecular weight:380.47

    Ref: TM-T74884

    5mg
    To inquire
    50mg
    To inquire
  • R-1479

    CAS:
    R-1479 (4'-Azidocytidine) is an RdRp inhibitor with an IC50 value of 1.28 μM for HCV RNA replication in the HCV subgenomic replicon system.
    Formula:C9H12N6O5
    Purity:98.11% - 99.95%
    Color and Shape:Solid
    Molecular weight:284.23

    Ref: TM-TQ0162

    1mg
    104.00€
    5mg
    258.00€
    10mg
    358.00€
    25mg
    595.00€
    50mg
    842.00€
    100mg
    1,134.00€
    200mg
    1,521.00€
    1mL*10mM (DMSO)
    318.00€
  • AD16

    CAS:
    AD16 (Acetamide) acts as an inhibitor of LINE-1 retrotransposon endonuclease, exhibiting an IC50 value of 4.7 μM. It decreases LINE-1 retrotransposition in senescent cells and mitigates the resulting DNA damage and inflammation.
    Formula:C24H20N14O3S2
    Color and Shape:Solid
    Molecular weight:616.64

    Ref: TM-T88160

    25mg
    To inquire
    50mg
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    100mg
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  • CBP501 Affinity Peptide

    CAS:
    CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].
    Formula:C68H119N21O25S
    Color and Shape:Solid
    Molecular weight:1662.86

    Ref: TM-T80132

    5mg
    To inquire
    50mg
    To inquire
  • Apcin A HCL

    CAS:

    Apcin A HCL is an Apcin-derived APC inhibitor that binds Cdc20 and hinders ubiquitination, useful for synthesizing PROTAC CP5V.

    Formula:C10H15Cl4N5O2
    Purity:99.59%
    Color and Shape:Solid
    Molecular weight:379.07

    Ref: TM-T64339

    1mg
    87.00€
    5mg
    192.00€
    10mg
    281.00€
    25mg
    449.00€
    50mg
    638.00€
    100mg
    848.00€
    200mg
    1,121.00€
  • Bimosiamose disodium

    CAS:
    Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.
    Formula:C46H52Na2O16
    Purity:98%
    Color and Shape:Solid
    Molecular weight:906.88

    Ref: TM-T14573

    25mg
    1,369.00€
  • RP-1664

    CAS:
    RP-1664,PLK4 inhibitor (IC50=3 nM). Disrupts centriole biogenesis. Antitumor activity in breast cancer, neuroblastoma.
    Formula:C23H24F2N8O2S
    Purity:99.04%
    Color and Shape:Soild
    Molecular weight:514.55

    Ref: TM-T206047

    1mg
    219.00€
    5mg
    530.00€
    10mg
    772.00€
    25mg
    1,153.00€
    50mg
    1,549.00€
  • dCeMM3 

    CAS:

    dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.

    Formula:C14H11ClN4OS
    Purity:98.48% - 99.41%
    Color and Shape:Solid
    Molecular weight:318.78

    Ref: TM-T9758

    5mg
    51.00€
    10mg
    88.00€
    25mg
    160.00€
    50mg
    250.00€
    100mg
    406.00€
  • 5'-O-TBDMS-Bz-dA

    CAS:
    5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.
    Formula:C23H31N5O4Si
    Color and Shape:Solid
    Molecular weight:469.617

    Ref: TM-T37142

    50mg
    47.00€
    1mL*10mM (DMSO)
    52.00€
  • (S)-DI-87

    CAS:
    (S)-DI-87 is an isomer of DI-87, a oral dCK inhibitor,reduce dNTP production and cell cycle arrest. significantly inhibits tumor growth with thymidine.
    Formula:C23H30N6O3S2
    Purity:99.42%
    Color and Shape:Soild
    Molecular weight:502.65

    Ref: TM-T39550L

    1mg
    175.00€
    5mg
    434.00€
    10mg
    622.00€
    25mg
    973.00€
    50mg
    1,341.00€
    100mg
    1,773.00€
    200mg
    2,422.00€
  • 5'(R)-C-Methyl-5-fluorouridine


    5’(R)-C-Methyl-5-fluorouridine, a uridine analogue, possesses potential antiepileptic properties.
    Formula:C10H13FN2O6
    Color and Shape:Solid
    Molecular weight:276.22

    Ref: TM-T75079

    5mg
    To inquire
    50mg
    To inquire
  • ROCK-IN-32

    CAS:
    ROCK-IN-32 is an effective Rho-kinase inhibitor.
    Formula:C20H17Cl2N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:402.27

    Ref: TM-T24722

    25mg
    To inquire
    50mg
    To inquire
    100mg
    To inquire
  • Aclacinomycin A

    CAS:
    Aclacinomycin A has a wide range of applications in life science related research.
    Formula:C42H53NO15
    Purity:99.43%
    Color and Shape:Solid
    Molecular weight:811.87

    Ref: TM-T21502

    1mg
    269.00€
  • CPS2

    CAS:
    CPS2: potent, selective PROTAC CDK2 degrader. IC50=24nM, targets acute myeloid leukemia research.
    Formula:C38H42N12O10S2
    Color and Shape:Solid
    Molecular weight:890.94

    Ref: TM-T74181

    5mg
    623.00€
    10mg
    1,161.00€