Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(114 products)
- CDK(545 products)
- Cell Cycle Arrest(5 products)
- Chk(48 products)
- DYRK(47 products)
- Dynamin(27 products)
- Ferroptosis(226 products)
- HSP(179 products)
- Integrin(249 products)
- Kinesin(87 products)
- LIM Kinase(20 products)
- Microtubule Associated(274 products)
- PKC(124 products)
- PLK(25 products)
- ROCK(62 products)
- Rho(6 products)
- Wee1(14 products)
- c-Myc(76 products)
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Found 3860 products of "Cell Cycle/Checkpoint"
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Ceftriaxone sodium hydrate
CAS:Ceftriaxone sodium hydrate is a broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.Formula:C18H16N8Na2O7S3·5H2OPurity:99.77% - 99.78%Color and Shape:White Or Almost White Crystalline Powder OdorlessMolecular weight:661.6CDK4/6-IN-2
CAS:CDK4/6-IN-2 是一种CDK4和CDK6抑制剂，IC50分别为 2.7 和 16 nM。Formula:C27H32F2N8Purity:99.47%Color and Shape:SolidMolecular weight:506.59CHK1-IN-4 hydrochloride
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).Formula:C18H19BrClN7O2Purity:99.29%Color and Shape:SoildMolecular weight:480.75Kira8
CAS:Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity (IC50: 5.9 nM).Formula:C31H29ClN6O3SPurity:98.07%Color and Shape:SolidMolecular weight:601.12Ref: TM-T11762L
1mg87.00€5mg202.00€10mg305.00€25mg567.00€50mg810.00€100mg1,111.00€1mL*10mM (DMSO)269.00€MBQ-167
CAS:MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Formula:C22H18N4Purity:98.07% - 99.52%Color and Shape:SolidMolecular weight:338.41Ref: TM-T16021
1mg34.00€2mg49.00€5mg74.00€10mg105.00€25mg197.00€50mg356.00€100mg537.00€1mL*10mM (DMSO)82.00€Danofloxacin mesylate
CAS:Danofloxacin mesylate (CP 76136-27) is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.
Formula:C19H20FN3O3·CH4O3SPurity:99.73%Color and Shape:Crystalline SolidMolecular weight:453.48ART558
CAS:ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM).Formula:C21H21F3N4O2Purity:99.18% - 99.67%Color and Shape:SolidMolecular weight:418.41Enoxacin
CAS:Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.Formula:C15H17FN4O3Purity:98.68% - 99.89%Color and Shape:Off-White To Yellow CrystalsMolecular weight:320.32Ribociclib succinate
CAS:Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Formula:C27H36N8O5Purity:99.9%Color and Shape:SolidMolecular weight:552.63Ref: TM-T15732
2mg34.00€5mg49.00€10mg70.00€25mg92.00€50mg109.00€100mg165.00€200mg258.00€500mg459.00€1mL*10mM (DMSO)60.00€Elarofiban TFA
CAS:Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.Formula:C26H34F6N4O8Purity:99.08%Color and Shape:SoildMolecular weight:644.56JH-RE-06
CAS:JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ.Formula:C20H16Cl3N3O4Purity:99.29%Color and Shape:SolidMolecular weight:468.72Ref: TM-T15611
1mg44.00€5mg93.00€10mg152.00€25mg334.00€50mg587.00€100mg1,044.00€1mL*10mM (DMSO)95.00€Enrofloxacin
CAS:Enrofloxacin (BAY-Vp2674) is a veterinary antibacterial agent, used in poultry.
Formula:C19H22FN3O3Purity:99.43% - >99.99%Color and Shape:Pale Yellow CrystalsMolecular weight:359.39MALAT1-IN-1
CAS:MALAT1-IN-1 is an effective dose-dependent Malat1 inhibitor, not altering Neat1 expression.Formula:C19H21N3O2Purity:99.58%Color and Shape:SolidMolecular weight:323.39Ref: TM-T16007
5mg39.00€10mg63.00€25mg120.00€50mg224.00€100mg432.00€200mg623.00€1mL*10mM (DMSO)44.00€Rifaximin
CAS:Rifaximin: an oral semi-synthetic antibiotic from rifamycin SV; targets bacterial RNA polymerase to halt growth.Formula:C43H51N3O11Purity:99.18% - 99.40%Color and Shape:Red-Orange Crystalline PowderMolecular weight:785.88Trimethoprim
CAS:Trimethoprim (NSC-106568) inhibits dihydrofolate reductase, CYP2C8, and OCT2 - an antibacterial agent.Formula:C14H18N4O3Purity:99.80% - 99.81%Color and Shape:White To Yellowish PowderMolecular weight:290.32TK216
CAS:TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.Formula:C19H15Cl2NO3Purity:97.22%Color and Shape:SolidMolecular weight:376.23MKC8866
CAS:MKC8866, a selective IRE1 RNase inhibitor with an IC50 of 0.29 μM, curbs breast and prostate cancer cell growth.Formula:C18H19NO7Purity:99.28% - 99.854%Color and Shape:SolidMolecular weight:361.35Ref: TM-T15594
1mg84.00€2mg109.00€5mg177.00€10mg250.00€25mg423.00€50mg557.00€100mg760.00€200mg1,018.00€1mL*10mM (DMSO)192.00€Orbofiban TFA
CAS:Orbofiban TFA is an orally active GPIIb/IIIa platelet receptor antagonist with inhibitory effects on platelet aggregation for the study of unstable coronaryFormula:C19H24F3N5O6Purity:97.21% - 98.72%Color and Shape:SolidMolecular weight:475.42Mps1-IN-3
CAS:Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).Formula:C26H31N7O4SPurity:99.25%Color and Shape:SolidMolecular weight:537.63Ref: TM-T16130
2mg34.00€5mg54.00€10mg87.00€25mg149.00€50mg255.00€100mg384.00€200mg538.00€1mL*10mM (DMSO)64.00€Pseudorabies virus-IN-1
Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.Formula:C27H23ClF2N4O2Color and Shape:SolidMolecular weight:508.947HEMTAC WEE1 degrader-1
CAS:HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Formula:C57H71N15O6Color and Shape:SolidMolecular weight:1062.27CW-2
CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).Formula:C43H42Cl2FN11O10PtColor and Shape:SolidMolecular weight:1156.21251Clofarabine-5'-triphosphate
CAS:Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.Formula:C10H14ClFN5O12P3Color and Shape:SolidMolecular weight:543.62ONX 0801 trisodium
CAS:ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Formula:C32H30N5Na3O10Color and Shape:SolidMolecular weight:713.58DNA Gyrase-IN-17
DNA Gyrase-IN-17 (Compound 5C) is an inhibitor of DNA gyrase. It demonstrates significant antimicrobial activity against a range of Gram-positive and Gram-negative strains, including Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa, with a MIC value of 62.5 μg/mL. By inhibiting bacterial DNA gyrase, DNA Gyrase-IN-17 disrupts DNA replication. This compound can be useful in the development of antibiotics, particularly for studying resistant strains.Formula:C18H15ClFN5OColor and Shape:SolidMolecular weight:371.09492c-Myc inhibitor 7
CAS:c-Myc inhibitor 7 degrades c-MYC, CK1α, GSPT1, IKZF1/2/3 proteins in tumors, for research on related diseases.Formula:C35H30N6O5Color and Shape:SoildMolecular weight:614.65WRN inhibitor 17
CAS:WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.Formula:C33H34F4N4O6SColor and Shape:SolidMolecular weight:690.71PROTAC MTP3 degrade-1
PROTACMTP3 degrade-1 is a PROTAC degrader for MYC.Formula:C44H38N6O8Color and Shape:SolidMolecular weight:778.27511Anticancer agent 263
Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.Formula:C13H20N2O6Color and Shape:SolidMolecular weight:300.30813-TP
13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.Formula:C12H19F2N6O12P3Color and Shape:SolidMolecular weight:570.23DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Color and Shape:Odour SolidMumefural
CAS:Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.
Formula:C12H12O9Color and Shape:SolidMolecular weight:300.22JB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formula:C43H45ClFN7O10SColor and Shape:SolidMolecular weight:906.3755-Iminodaunorubicin
CAS:5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.Formula:C27H30N2O9Color and Shape:SolidMolecular weight:526.54EFdA-TP
CAS:EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.Formula:C12H15FN5O12P3Color and Shape:SolidMolecular weight:533.195Clofarabine-5'-diphosphate trisodium
Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formula:C10H10ClFN5Na3O9P2Color and Shape:SolidMolecular weight:529.58Eesperamicin A1
CAS:Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.Formula:C59H80N4O22S4Color and Shape:SolidMolecular weight:1325.545'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.Formula:C44H49F2N4O7PColor and Shape:SolidMolecular weight:814.855'-O-TBDMS-dA
CAS:5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.
Formula:C16H27N5O3SiColor and Shape:SolidMolecular weight:365.509α-Methyl-DL-aspartic acid
CAS:α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.Formula:C5H9NO4Purity:99.91%Color and Shape:SolidMolecular weight:147.13TLR7 agonist 12
CAS:TLR7 agonist 12, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.Formula:C14H19N5O8Color and Shape:SolidMolecular weight:385.33DSPE-PEG3000-iRGD
DSPE-PEG3000-iRGD is a PEG compound comprising DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrin and undergoes proteolytic cleavage within tumors to produce CRGDK/R, interacting with neuropilin-1. This results in tumor targeting and penetration capabilities. DSPE-PEG3000-iRGD is applicable in drug delivery.Color and Shape:Odour SolidChrysomycin A
CAS:Chrysomycin A is an antibiotic that can be derived from Streptomyces.Formula:C28H28O9Color and Shape:SolidMolecular weight:508.52Ac-MRGDH-NH2
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.Formula:C25H41N11O8SColor and Shape:SolidMolecular weight:655.727Brr2-IN-2
Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.Formula:C21H25FN4O2Color and Shape:SolidMolecular weight:384.45N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS:N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].
Formula:C21H35N12O17P3Color and Shape:SolidMolecular weight:820.49IRE1-IN-2
IRE1-IN-2 (compound G15) functions as a potent inhibitor of IRE1. It effectively suppresses lipid accumulation induced by FFA, exhibiting an IC50 value of 2.06 μM.Formula:C16H20O6Color and Shape:SolidMolecular weight:308.12599Isocytosine
CAS:Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C4H5N3OColor and Shape:White To Off-White SolidMolecular weight:111.1Clofarabine-5'-diphosphate
CAS:Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formula:C10H13ClFN5O9P2Color and Shape:SolidMolecular weight:463.64Echistatin
CAS:Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).Formula:C217H341N71O74S9Purity:98%Color and Shape:SolidMolecular weight:5417.1
