Immunology and Inflammation

Theralizumab (TGN1412) is a monoclonal antibody for treating leukemia and arthritis by stimulating T cells.

Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.

Sutimlimab: monoclonal antibody, inhibits complement protein C1, treats cold agglutinin-induced hemolysis.

Briakinumab (ABT-874) is a monoclonal antibody targeting IL-12, used in the research of psoriasis multiple sclerosis.

Imsidolimab (ANB 019) is a humanized anti-IL-36R monoclonal antibody that inhibits IL-36 signaling and can be used to study systemic pustular psoriasis.

CP-28888 (CP 28888-27) is an interferon inducer, a lipoamine with antitumor activity.

Cobolimab (TSR-022) is a TIM-3 antibody with IC50 of 0.4464 nM, showing antitumor effects in melanoma and liver cancer studies.

Enoblituzumab is a humanized IgG1 κmab monoclonal antibody that recognizes human B7-H3 protein and can be used to study solid tumors such as non-small cell lung

Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!

Xeligekimab (GR 1501) is a fully humanized monoclonal antibody that neutralizes IL-17A and has anti-inflammatory activity for the study of plaque psoriasis.

Cendakimab (RPC4046) is a humanized monoclonal antibody targeting IL-13, useful in research on atopic dermatitis.

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) acts as a stable inhibitor of platelet aggregation, is a nitric oxide donor and .

Anifrolumab（MEDI-546） is a potent type I interferon (IFN) receptor antagonist, a human monoclonal antibody that targets IFN.Anifrolumab inhibits the activity of

Hydroxocobalamin acetate treats B12 deficiency and cyanide poisoning; FDA-approved with few side effects.

Urabrelimab (SRF-231) is a humanized antibody targeting CD47, with anticancer activity, blocking the CD47-SIRP interaction.

Melrilimab (GSK 3772847), an IgG2-kappa monoclonal antibody targeting IL1RL1/ST2/IL33R/DER4/FIT-1, is utilized in asthma research [1].

Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central

Amatuximab is a chimeric humanized IgG1/k antibody targeting MSLN with antitumor effects for solid tumors.

AR-9281 (APAU) is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes

Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.

IMD-0560 is a novel inhibitor of IκB kinase β.

SN50 acetate is a cell permeable inhibitor of NF-κB translocation.

AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-

CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.

TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.

Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.

Bismuth Subsalicylate, Pepto-Bismol's active ingredient, treats nausea, heartburn, indigestion, diarrhea, and stomach upset.

Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targeting Fibroblast Activating Protein (FAP).Sibrotuzumab is used in the study of colorectal

Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.

AA147 is an ER proteostasis regulator that selectively activates the ATF6 arm of UPR as a prodrug.

Tiopronin (Acadione), a sulfhydryl acylated derivative of glycine, leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone

Valdecoxib (SC 65872), an NSAID, treats osteoarthritis, rheumatoid arthritis, and menstrual pain. Not for NSAID allergies.

Sulfinpyrazone (NSC-75925) is a uricosuric drug that is used to reduce the serum urate levels in gout therapy.

Ibuprofen, an NSAID, reduces pain, inflammation, and fever by limiting prostaglandin production.

Azobenzene, an aryl azo compound with a N=N bond between two phenyl rings, represents a broad molecule class.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CD248. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CD248. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human CD248, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human CD248 in the samples is then determined by comparing the OD of the samples to the standard curve.