JAK/STAT signaling
JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.
Read more
Products of "JAK/STAT signaling"
JAK2-IN-4
CAS:1438284-00-4
JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM …
Formula:
C23H27N5O4S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
469.56
Ref: TM-T11708
| 25mg | 1,827.00 € | ||
| 50mg | 2,413.00 € | ||
| 100mg | 3,180.00 € |
Estimated delivery in United States, on Monday 3 Feb 2025
GNE-955
CAS:1527523-39-2
GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, …
Formula:
C22H24N8O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
416.48
Ref: TM-T15406
| 25mg | 1,822.00 € | ||
| 50mg | 2,413.00 € | ||
| 100mg | 3,180.00 € |
Estimated delivery in United States, on Monday 3 Feb 2025
HS94
CAS:1892594-93-2
HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value …
Formula:
C15H15N5O2S
Purity:
95.04%
Color and Shape:
Liquid
Molecular weight:
329.38
Ref: TM-T77777
| 1mg | 40.00 € | ||
| 5mg | 85.00 € | ||
| 10mg | 116.00 € | ||
| 25mg | 224.00 € | ||
| 50mg | 333.00 € | ||
| 100mg | 494.00 € | ||
| 500mg | 1,058.00 € |
Estimated delivery in United States, on Monday 3 Feb 2025
Ginsenoside Rk1
CAS:494753-69-4
Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.
Formula:
C42H70O12
Purity:
99.13%
Color and Shape:
Solid
Molecular weight:
767
Ref: TM-T4S1499
| 5mg | 91.00 € |
Estimated delivery in United States, on Monday 3 Feb 2025
JAK-IN-31
CAS:2597016-88-9
JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 …
Formula:
C21H19N7O2S2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
465.55
Ref: TM-T79882
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 3 Feb 2025
JAK-IN-27
CAS:2673176-36-6
JAK-IN-27, also known as compound 1, is an orally active, potent inhibitor of the JAKS …
Formula:
C20H21F2N7O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
413.42
Ref: TM-T79110
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 3 Feb 2025
DPP
CAS:2668267-47-6
DPP, a Platinum(IV) complex with a pterostilbene-derived axial ligand, inhibits the JAK2-STAT3 pathway in breast …
Formula:
C36H40Cl2N2O10Pt
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
926.7
Ref: TM-T79608
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 3 Feb 2025
QL-1200186
CAS:2848664-42-4
QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ …
Formula:
C26H27N7O3
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
485.54
Ref: TM-T81331
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 3 Feb 2025
PIM1-IN-4
CAS:2762767-48-4
PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.
Formula:
C27H25BrCl2CuN6O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
663.88
Ref: TM-T73247
| 25mg | 1,549.00 € | ||
| 50mg | 2,038.00 € | ||
| 100mg | 2,617.00 € |
Estimated delivery in United States, on Monday 3 Feb 2025
JAK-IN-25
CAS:2127110-22-7
JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, …
Formula:
C19H17N5O4
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
379.37
Ref: TM-T78175
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 3 Feb 2025
PIM-IN-2
CAS:1006699-45-1
PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) …
Formula:
C19H22N4O2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
338.4
Ref: TM-T81460
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 3 Feb 2025
JAK-IN-5
CAS:2096999-92-5
JAK-IN-5 is a JAK inhibitor.
Formula:
C27H31FN6O
Purity:
97.78% - 98.78%
Color and Shape:
Solid
Molecular weight:
474.57
Ref: TM-T11710
| 1mg | 183.00 € | ||
| 5mg | 385.00 € | ||
| 10mg | 570.00 € | ||
| 25mg | 907.00 € | ||
| 50mg | 1,230.00 € | ||
| 100mg | 1,660.00 € | ||
| 500mg | 3,316.00 € | ||
| 1mL*10mM (DMSO) | 564.00 € |
Estimated delivery in United States, on Monday 3 Feb 2025
Brepocitinib
CAS:1883299-62-4
Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits …
Formula:
C18H21F2N7O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
389.4
Ref: TM-TQ0010
| 1mg | 35.00 € | ||
| 5mg | 69.00 € | ||
| 10mg | 102.00 € | ||
| 25mg | 212.00 € | ||
| 50mg | 383.00 € | ||
| 100mg | 614.00 € | ||
| 200mg | 859.00 € | ||
| 500mg | 1,270.00 € | ||
| 1mL*10mM (DMSO) | 117.00 € |
Estimated delivery in United States, on Monday 3 Feb 2025
AJI-100
CAS:844435-10-5
AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective …
Formula:
C17H14FN5O
Color and Shape:
Liquid
Molecular weight:
323.32
Ref: TM-T200052
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 3 Mar 2025
GDC-0339
CAS:1428569-85-0
GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - …
Formula:
C20H22F3N7OS
Color and Shape:
Solid
Molecular weight:
465.5
Ref: TM-T15376
| 25mg | 1,531.00 € | ||
| 50mg | 2,013.00 € | ||
| 100mg | 3,491.00 € |
Estimated delivery in United States, on Monday 3 Mar 2025
Londamocitinib
CAS:2241039-81-4
Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.
Formula:
C28H31F2N7O4S
Purity:
99.47%
Color and Shape:
Solid
Molecular weight:
599.65
Ref: TM-T11706
| 1mg | 176.00 € | ||
| 5mg | 430.00 € | ||
| 10mg | 584.00 € | ||
| 25mg | 884.00 € | ||
| 50mg | 1,141.00 € | ||
| 100mg | 1,531.00 € | ||
| 1mL*10mM (DMSO) | 554.00 € |
Estimated delivery in United States, on Monday 3 Mar 2025
JDTic dihydrochloride
CAS:785835-79-2
JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced …
Formula:
C28H41Cl2N3O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
538.55
Ref: TM-T11721L
| 2mg | 102.00 € | ||
| 25mg | 620.00 € | ||
| 50mg | 813.00 € | ||
| 100mg | 1,208.00 € |
Estimated delivery in United States, on Monday 3 Mar 2025
JBJ-02-112-05
CAS:2748162-29-8
JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC …
Formula:
C27H20N4O2S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
464.54
Ref: TM-T11713
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Monday 3 Mar 2025
CP-352664
CAS:1097883-05-0
CP-352664 is a JAK inhibitor with potency against JAK3, exhibiting an EC50 value of 210 …
Formula:
C18H18N4
Color and Shape:
Liquid
Molecular weight:
290.36
Ref: TM-T200202
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 3 Mar 2025
MM-589
CAS:2097887-20-0
MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) …
Formula:
C28H44N8O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
572.7
Ref: TM-T12091
| 25mg | 2,801.00 € | ||
| 50mg | 3,722.00 € | ||
| 100mg | 5,144.00 € |
Estimated delivery in United States, on Monday 3 Mar 2025
