MEK
MEK is a dual-specificity kinase that plays a central role in the MAPK/ERK signaling pathway by activating ERK through phosphorylation. MEK signaling is crucial for regulating cell growth, survival, and differentiation. Aberrant MEK activity has been implicated in various cancers and developmental disorders, making it an important therapeutic target. At CymitQuimica, we provide a variety of MEK inhibitors and modulators to support your research in oncology, cell signaling, and therapeutic development.
Found 72 products of "MEK"
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Midkine Protein, Human, Recombinant (His & Avi), Biotinylated
<p>Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as</p>Color and Shape:Lyophilized PowderMolecular weight:16.46 kDa (predicted) same as Tris-Bis PAGE result.Pimasertib
CAS:<p>Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.</p>Formula:C15H15FIN3O3Purity:98.25% - 99.57%Color and Shape:SolidMolecular weight:431.2zapnometinib
CAS:<p>Zapnometinib (ATR-002) is a MEK inhibitor.</p>Formula:C13H7ClF2INO2Purity:99.67%Color and Shape:SolidMolecular weight:409.55Ro 5126766
CAS:<p>RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.</p>Formula:C21H18FN5O5SPurity:98.3% - 98.81%Color and Shape:SolidMolecular weight:471.46anemarsaponin B
CAS:<p>Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity</p>Formula:C45H74O18Purity:99.06% - 99.81%Color and Shape:SolidMolecular weight:903.06BIX02189
CAS:<p>BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).</p>Formula:C27H28N4O2Purity:97.84%Color and Shape:SolidMolecular weight:440.54PD98059
CAS:<p>PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.</p>Formula:C16H13NO3Purity:98.63% - >99.99%Color and Shape:Yellow SolidMolecular weight:267.28CI-1040
CAS:<p>CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM).</p>Formula:C17H14ClF2IN2O2Purity:99.64%Color and Shape:Off-White To Pale Beige SolidMolecular weight:478.66Refametinib
CAS:<p>Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).</p>Formula:C19H20F3IN2O5SPurity:99.53% - >99.99%Color and Shape:SolidMolecular weight:572.34RGB-286638 free base
CAS:<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Formula:C29H35N7O4Purity:98% - 99.91%Color and Shape:SolidMolecular weight:545.63Selumetinib
CAS:<p>Selumetinib (AZD6244) is a selectivity and non-ATP-competitive MEK1/2 inhibitor. Selumetinib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C17H15BrClFN4O3Purity:98.1% - 99.90%Color and Shape:White Or Pale White SolidMolecular weight:457.68TAK-733
CAS:<p>TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.</p>Formula:C17H15F2IN4O4Purity:98.31% - 99.53%Color and Shape:SolidMolecular weight:504.23APS-2-79
CAS:<p>APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.</p>Formula:C23H21N3O3Color and Shape:SolidMolecular weight:387.43Trametinib (DMSO solvate)
CAS:<p>Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)</p>Formula:C28H29FIN5O5SPurity:98.82% - 99.92%Color and Shape:SolidMolecular weight:693.53Binimetinib
CAS:<p>Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C17H15BrF2N4O3Purity:98.03% - >99.99%Color and Shape:SolidMolecular weight:441.23GW 284543 hydrochloride
CAS:<p>GW 284543 hydrochloride is a selective inhibitor of MEK5 .</p>Formula:C23H21ClN2O3Purity:99.73%Color and Shape:SolidMolecular weight:408.87Mirdametinib
CAS:<p>Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.</p>Formula:C16H14F3IN2O4Purity:99.11% - 99.63%Color and Shape:White PowderMolecular weight:482.19GDC-0623
CAS:<p>GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.</p>Formula:C16H14FIN4O3Purity:98.95% - 99.02%Color and Shape:SolidMolecular weight:456.21AZD8330
CAS:<p>AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.</p>Formula:C16H17FIN3O4Purity:98.72%Color and Shape:SolidMolecular weight:461.23Aurothiomalate sodium
CAS:<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Formula:C4H3AuNa2O4SPurity:99.66%Color and Shape:SoildMolecular weight:390.07
