MEK
MEK is a dual-specificity kinase that plays a central role in the MAPK/ERK signaling pathway by activating ERK through phosphorylation. MEK signaling is crucial for regulating cell growth, survival, and differentiation. Aberrant MEK activity has been implicated in various cancers and developmental disorders, making it an important therapeutic target. At CymitQuimica, we provide a variety of MEK inhibitors and modulators to support your research in oncology, cell signaling, and therapeutic development.
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BI-847325
CAS:1207293-36-4
BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values …
Formula:
C29H28N4O2
Purity:
97.13% - 97.54%
Color and Shape:
Solid
Molecular weight:
464.56
Ref: TM-T6785
| 1mg | 49.00 € | ||
| 2mg | 62.00 € | ||
| 5mg | 100.00 € | ||
| 10mg | 168.00 € | ||
| 25mg | 339.00 € | ||
| 50mg | 506.00 € | ||
| 100mg | 730.00 € | ||
| 1mL*10mM (DMSO) | 106.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
U0126-EtOH
CAS:1173097-76-1
U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).
Formula:
C18H16N6S2·C2H6O
Purity:
98.65% - 99.82%
Color and Shape:
Solid
Molecular weight:
426.6
Ref: TM-T6223
| 5mg | 35.00 € | ||
| 10mg | 51.00 € | ||
| 25mg | 70.00 € | ||
| 50mg | 84.00 € | ||
| 100mg | 95.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
trans-Zeatin
CAS:1637-39-4
trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which …
Formula:
C10H13N5O
Purity:
97.13% - 98%
Color and Shape:
White To Light Yellow Crystal Powder
Molecular weight:
219.24
Ref: TM-TMS2181
| 25mg | 54.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Cobimetinib
CAS:934660-93-2
Cobimetinib (GDC-0973) is a MEK1 inhibitor with selective and oral activity. Cobimetinib exhibits antitumor activity. …
Formula:
C21H21F3IN3O2
Purity:
100% - 99.98%
Color and Shape:
Solid
Molecular weight:
531.31
Ref: TM-T3623
| 1mg | 40.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 83.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 170.00 € | ||
| 50mg | 271.00 € | ||
| 100mg | 445.00 € | ||
| 500mg | To inquire | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
U0126
CAS:109511-58-2
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with …
Formula:
C18H16N6S2
Purity:
98%
Color and Shape:
White Solid
Molecular weight:
380.49
Ref: TM-T21332
| 1mg | 151.00 € | ||
| 5mg | 358.00 € | ||
| 10mg | 660.00 € | ||
| 25mg | 1,139.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
APS-2-79 hydrochloride
CAS:2002381-31-7
APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing …
Formula:
C23H21N3O3·HCl
Purity:
97.08% - 98.64%
Color and Shape:
Solid
Molecular weight:
423.89
Ref: TM-T6760
| 1mg | 43.00 € | ||
| 2mg | 55.00 € | ||
| 5mg | 72.00 € | ||
| 10mg | 106.00 € | ||
| 25mg | 250.00 € | ||
| 50mg | 402.00 € | ||
| 100mg | 563.00 € | ||
| 500mg | 1,203.00 € | ||
| 1mL*10mM (DMSO) | 72.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Isorhamnetin
CAS:480-19-3
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.
Formula:
C16H12O7
Purity:
92.82% - 98.97%
Color and Shape:
Solid
Molecular weight:
316.26
Ref: TM-T2836
| 1mg | 40.00 € | ||
| 5mg | 81.00 € | ||
| 10mg | 118.00 € | ||
| 25mg | 230.00 € | ||
| 50mg | 386.00 € | ||
| 100mg | 548.00 € | ||
| 500mg | 1,179.00 € | ||
| 1mL*10mM (DMSO) | 85.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
zapnometinib
CAS:303175-44-2
Zapnometinib (ATR-002) is a MEK inhibitor.
Formula:
C13H7ClF2INO2
Purity:
99.66%
Color and Shape:
Solid
Molecular weight:
409.55
Ref: TM-T9321
| 5mg | 48.00 € | ||
| 10mg | 66.00 € | ||
| 25mg | 80.00 € | ||
| 50mg | 136.00 € | ||
| 100mg | 257.00 € | ||
| 200mg | 374.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Ro 5126766
CAS:946128-88-7
RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 …
Formula:
C21H18FN5O5S
Purity:
98.13% - 98.3%
Color and Shape:
Solid
Molecular weight:
471.46
Ref: TM-T6971
| 1mg | 57.00 € | ||
| 2mg | 81.00 € | ||
| 5mg | 113.00 € | ||
| 10mg | 169.00 € | ||
| 25mg | 324.00 € | ||
| 50mg | 515.00 € | ||
| 100mg | 744.00 € | ||
| 1mL*10mM (DMSO) | 118.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
anemarsaponin B
CAS:139051-27-7
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the …
Formula:
C45H74O18
Purity:
99.06% - 99.81%
Color and Shape:
Solid
Molecular weight:
903.06
Ref: TM-T7030
| 1mg | 90.00 € | ||
| 5mg | 183.00 € | ||
| 10mg | 275.00 € | ||
| 25mg | 464.00 € | ||
| 50mg | 676.00 € | ||
| 1mL*10mM (DMSO) | 309.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
BIX02189
CAS:1265916-41-3
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and …
Formula:
C27H28N4O2
Purity:
97.84%
Color and Shape:
Solid
Molecular weight:
440.54
Ref: TM-T21295
| 2mg | 34.00 € | ||
| 5mg | 49.00 € | ||
| 10mg | 72.00 € | ||
| 25mg | 122.00 € | ||
| 50mg | 203.00 € | ||
| 100mg | 301.00 € | ||
| 200mg | 435.00 € | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
PD98059
CAS:167869-21-8
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.
Formula:
C16H13NO3
Purity:
100% - 99.66%
Color and Shape:
Yellow Solid
Molecular weight:
267.28
Ref: TM-T2623
| 5mg | 45.00 € | ||
| 10mg | 57.00 € | ||
| 25mg | 88.00 € | ||
| 50mg | 111.00 € | ||
| 100mg | 183.00 € | ||
| 200mg | 269.00 € | ||
| 500mg | 449.00 € | ||
| 1mL*10mM (DMSO) | 58.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Pimasertib
CAS:1236699-92-5
Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential …
Formula:
C15H15FIN3O3
Purity:
98.15% - 98.25%
Color and Shape:
Solid
Molecular weight:
431.2
Ref: TM-T6131
| 2mg | 37.00 € | ||
| 5mg | 49.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 92.00 € | ||
| 50mg | 148.00 € | ||
| 100mg | 220.00 € | ||
| 200mg | 285.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Refametinib
CAS:923032-37-5
Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 …
Formula:
C19H20F3IN2O5S
Purity:
100% - 99.84%
Color and Shape:
Solid
Molecular weight:
572.34
Ref: TM-T6636
| 1mg | 39.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 107.00 € | ||
| 25mg | 182.00 € | ||
| 50mg | 276.00 € | ||
| 100mg | 415.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
RGB-286638 free base
CAS:784210-88-4
RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.
Formula:
C29H35N7O4
Purity:
97.29% - 99.91%
Color and Shape:
Solid
Molecular weight:
545.63
Ref: TM-T2378
| 1mg | 46.00 € | ||
| 2mg | 60.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 144.00 € | ||
| 25mg | 263.00 € | ||
| 50mg | 396.00 € | ||
| 100mg | 554.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Selumetinib
CAS:606143-52-6
Selumetinib (AZD6244) is a selectivity and non-ATP-competitive MEK1/2 inhibitor. Selumetinib has antitumor activity. Cost-effective and …
Formula:
C17H15BrClFN4O3
Purity:
98.1% - 99.46%
Color and Shape:
White Or Pale White Solid
Molecular weight:
457.68
Ref: TM-T6218
| 1g | 276.00 € | ||
| 25mg | 51.00 € | ||
| 50mg | 68.00 € | ||
| 100mg | 88.00 € | ||
| 200mg | 122.00 € | ||
| 500mg | 185.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
CI-1040
CAS:212631-79-3
CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM).
Formula:
C17H14ClF2IN2O2
Purity:
99.1%
Color and Shape:
Off-White To Pale Beige Solid
Molecular weight:
478.66
Ref: TM-T2443
| 5mg | 57.00 € | ||
| 10mg | 88.00 € | ||
| 25mg | 150.00 € | ||
| 50mg | 221.00 € | ||
| 100mg | 363.00 € | ||
| 200mg | 453.00 € | ||
| 1mL*10mM (DMSO) | 58.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
PD318088
CAS:391210-00-7
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region …
Formula:
C16H13BrF3IN2O4
Purity:
99.81%
Color and Shape:
Solid
Molecular weight:
561.09
Ref: TM-T6152
| 1mg | 51.00 € | ||
| 5mg | 105.00 € | ||
| 10mg | 163.00 € | ||
| 25mg | 332.00 € | ||
| 50mg | 500.00 € | ||
| 100mg | 759.00 € | ||
| 1mL*10mM (DMSO) | 130.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Trametinib
CAS:871700-17-3
Trametinib (GSK1120212), an ATP-noncompetitive MEK 1/2 inhibitor (IC50: 0.7/0.9 nM), weakly inhibits >180 kinases.
Formula:
C26H23FIN5O4
Purity:
98% - 99.88%
Color and Shape:
Solid
Molecular weight:
615.39
Ref: TM-T2125
| 5mg | 36.00 € | ||
| 10mg | 54.00 € | ||
| 50mg | 69.00 € | ||
| 100mg | 96.00 € | ||
| 200mg | 135.00 € | ||
| 1mL*10mM (DMSO) | 54.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
RO4987655
CAS:874101-00-5
RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for …
Formula:
C20H19F3IN3O5
Purity:
98.21%
Color and Shape:
Solid
Molecular weight:
565.28
Ref: TM-T5412
| 1mg | 80.00 € | ||
| 2mg | 104.00 € | ||
| 5mg | 182.00 € | ||
| 10mg | 280.00 € | ||
| 25mg | 468.00 € | ||
| 50mg | 650.00 € | ||
| 100mg | 1,009.00 € | ||
| 1mL*10mM (DMSO) | 225.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
