Membrane Transporter/Ion Channel
Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.
Subcategories of "Membrane Transporter/Ion Channel"
- ABC(3 products)
- ATPase(93 products)
- Adiponectin receptor(5 products)
- CFTR(64 products)
- CGRP Receptor(51 products)
- Calcium Channel(494 products)
- Chloride channel(49 products)
- GABA Receptor(336 products)
- Monoamine Transporter(23 products)
- Monocarboxylate transporter(17 products)
- NKCC(2 products)
- NPC1L1(3 products)
- Na-K-Cl cotransporter(8 products)
- OAT(27 products)
- OCT(7 products)
- P-gp(53 products)
- Potassium Channel(276 products)
- Proton pump(39 products)
- SGLT(30 products)
- Sodium Channel(202 products)
- TRP/TRPV Channel(93 products)
Show 13 more subcategories
Found 2280 products of "Membrane Transporter/Ion Channel"
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L 691121
CAS:<p>L 691121 is a class III antiarrhythmic compound. It also blocks potassium currents.</p>Formula:C22H25ClN4O5SPurity:98%Color and Shape:SolidMolecular weight:492.98FGIN-1-27
CAS:<p>FGIN-1-27 is a high-affinity agonist of the translocator protein and a specific peripheral benzodiazepine receptor (PBR) ligand(Ki = 5.0 nM).</p>Formula:C28H37FN2OPurity:99.86%Color and Shape:SolidMolecular weight:436.6BMS-986169
CAS:<p>BMS-986169 is a high-affinity and selective negative allosteric modulator of the NMDA receptor GluN2B subunit, depression.</p>Formula:C23H27FN2O2Purity:97.61%Color and Shape:SolidMolecular weight:382.47AC-4
CAS:<p>AC-4 is a blocker of photoswitchable TRPV1 channel.</p>Formula:C26H25F3N4O2SColor and Shape:SolidMolecular weight:514.56ADX71441
CAS:<p>ADX71441, a GABAB PAM, lengthens urinary latencies, lessens events & volume, and may aid in alcoholism and bladder pain.</p>Formula:C19H15ClF2N4O4Color and Shape:SolidMolecular weight:436.8Sudoterb free base
CAS:<p>Sudoterb free base (Sudoterb) , also known as LL3858, is an anti-tubercular drug candidate.</p>Formula:C29H28F3N5OPurity:97.26% - 98.85%Color and Shape:SolidMolecular weight:519.56PHP 501 trifluoroacetate
CAS:<p>GABAA antagonist</p>Formula:C20H21N3OPurity:98%Color and Shape:SolidMolecular weight:319.4PZ-II-029
CAS:<p>PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel.</p>Formula:C18H15N3O3Purity:99.79%Color and Shape:SolidMolecular weight:321.33URAT1 inhibitor 1
CAS:<p>URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 nM), has the potential to treat hyperuricemia associated with gout.</p>Formula:C19H15Br2N5O2S2Purity:98%Color and Shape:SolidMolecular weight:569.29JYL-273
CAS:<p>JYL-273 is a TRPV1 agonist.</p>Formula:C28H39NO4SColor and Shape:SolidMolecular weight:485.68Licostinel
CAS:<p>Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.</p>Formula:C8H3Cl2N3O4Purity:98.02%Color and Shape:SolidMolecular weight:276.03CGP36216 hydrochloride
CAS:<p>CGP36216 hydrochloride acts as a selective antagonist at the presynaptic GABA receptor, specifically binding to the GABAB receptor with a Ki value of 0.3 μM. This compound is leveraged in research focused on anxiety and trauma-related disorders [1] [2].</p>Formula:C5H15ClNO2PColor and Shape:SolidMolecular weight:187.6MK-8153
CAS:<p>MK-8153: Selective, potent ROMK inhibitor, orally active, IC50: ROMK EP 5 μM, hERG EP 34 μM; potential diuretic.</p>Formula:C24H28N2O6Color and Shape:SolidMolecular weight:440.49Etidocaine Hydrochloride
CAS:<p>Etidocaine Hydrochloride (W19053) is a long-acting anesthetic and a blocker of the voltage-gated sodium channel.</p>Formula:C17H29ClN2OPurity:99.86%Color and Shape:SolidMolecular weight:312.88GABAA receptor agent 2 TFA
CAS:<p>Potent GABAA antagonist; IC50: 24 nM (α1β2γ2), Ki: 28 nM (rat); inactive on human GABA transporters.</p>Formula:C22H22F3N3O3Color and Shape:SolidMolecular weight:433.42Kv3 modulator 4
CAS:<p>Kv3 modulator 4 is a Kv3.1 (pEC50=5.45) and Kv3.2 modulator .Cyclobutyl structure.</p>Formula:C20H24N2O4Purity:98%Color and Shape:SolidMolecular weight:356.42Glibornuride
CAS:<p>Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).</p>Formula:C18H26N2O4SPurity:99.5%Color and Shape:SolidMolecular weight:366.48Kv3 modulator 3
CAS:<p>Kv3 modulator 3 is a selective modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels .has analgesic activity for use in the prophylaxis o or treatment of pain.</p>Formula:C19H18N4O3Purity:98%Color and Shape:SolidMolecular weight:350.37RS 5773
CAS:<p>RS 5773 is a benzothiazepine derivative with antianginal effects.</p>Formula:C29H33ClN2O4SPurity:98%Color and Shape:SolidMolecular weight:541.1NaPi2b-IN-2
CAS:<p>NaPi2b-IN-2 (compound 5) serves as a potent inhibitor of the sodium-dependent transport protein 2b (SLC34A2, NaPi2b), exhibiting an IC50 of 38 nM against human</p>Formula:C41H47ClF3N5O5SPurity:98%Color and Shape:SolidMolecular weight:814.36Linaprazan
CAS:<p>Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.</p>Formula:C21H26N4O2Purity:99.54%Color and Shape:SolidMolecular weight:366.46Cavα2δ1&NET-IN-3
CAS:<p>Cavα2δ1&NET-IN-3 (example 216) is an inhibitor targeting both the α2δ subunit of voltage-gated calcium channels (VGCC) and the noradrenaline transporter (NET).</p>Formula:C24H30N6O2SColor and Shape:SolidMolecular weight:466.6APS3
CAS:<p>APS3 is an inhibitor of GABA and nACh receptors, exhibiting an LC50 value of 7.2423 μg/mL against Plutella xylostella [1].</p>Formula:C18H7Cl2F6N5O5S2Color and Shape:SolidMolecular weight:622.31mGAT-IN-1
CAS:<p>mGAT-IN-1 is a potent, non-selective GAT inhibitor that inhibits mGAT3 activity well (IC50: 2.5 μM, pIC50: 5.61).</p>Formula:C28H34ClN3O2S2Color and Shape:SolidMolecular weight:544.17p-fin4
CAS:p-fin4, a peptide, inhibits STEP-GluA2 interaction, Ki 0.4 μM; may enhance cognition, has anxiolytic and antidepressant effects.Formula:C39H53N8O18PColor and Shape:SolidMolecular weight:952.85AMPA-IN-1
CAS:<p>AMPA-IN-1: Potent AMPA receptor inhibitor; key in regulating brain excitatory transmission and plasticity.</p>Formula:C23H12F2N4O2Color and Shape:SolidMolecular weight:414.36Dibutyryl-cGMP sodium
CAS:<p>Bt2cGMP sodium is a cGMP analog, activates PKG, inhibits platelet [3H]-arachidonate, and induces analgesia via K+ channels.</p>Formula:C18H24N5NaO9PPurity:98%Color and Shape:SolidMolecular weight:508.38TRPV2-selective blocker 1
CAS:<p>TRPV2-selective blocker 1 (compound IV2-1) is a selective inhibitor of the TRPV2 channel, exhibiting an IC50 value of 6.3 μM.</p>Formula:C15H18OS2Color and Shape:SolidMolecular weight:278.43Risevistinel
CAS:<p>Risevistinel (NYX-783), a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, may mitigate cognitive deficits in neurodegenerative</p>Formula:C14H23N3O4Purity:98%Color and Shape:SolidMolecular weight:297.35BMS-199264 hydrochloride
CAS:<p>BMS-199264 hydrochloride is selective inhibitor of mitochondrial F1F0 ATP hydrolase,inhibit decline of ATP and myocardial necrosis during myocardial ischemia.</p>Formula:C26H32Cl2N4O4SPurity:99.86%Color and Shape:SolidMolecular weight:567.53Dimethylamiloride
CAS:<p>Dimethylamiloride is a specific inhibitor of antiporters [1].</p>Formula:C8H12ClN7OPurity:98%Color and Shape:SolidMolecular weight:257.68(-)-Bicuculline methochloride
CAS:<p>(-)-Bicuculline methochloride is a potent antagonist of GABAA receptor.</p>Formula:C21H20ClNO6Purity:98%Color and Shape:SolidMolecular weight:417.84Co 102862
CAS:<p>Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.</p>Formula:C14H12FN3O2Purity:99.82%Color and Shape:SolidMolecular weight:273.26Sodium Channel inhibitor 4
CAS:<p>Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].</p>Formula:C19H18ClN3O4S2Purity:98%Color and Shape:SolidMolecular weight:451.95P2X3 antagonist 34
CAS:<p>Potent P2X3 antagonist 34, oral, selective for human, rat, guinea pig receptors; IC50s: 25/92/126 nM; strong anti-tussive, no taste change.</p>Formula:C24H26F2N4O3Purity:98%Color and Shape:SolidMolecular weight:456.48ML-252 hydrochloride
CAS:<p>ML-252 is a potent, selective inhibitor of the Kv7.2 voltage-gated potassium channel, demonstrating an IC50 value of 69 nM in patch clamp assays. It exists as the (S)-enantiomer, which is significantly more effective than both its (R)-enantiomer counterpart and the racemic mixture, with respective IC50 values of 944 nM and 160 nM. ML-252 exhibits high selectivity for Kv7.2 over other potassium channel subtypes and shows minimal activity against more than 68 G protein-coupled receptors, various transporters, L- and N-type calcium channels, K_ATP, and hERG potassium channels. However, it does inhibit the melatonin MT1 receptor by 61% at a 10 µM concentration.</p>Formula:C20H24N2OHClColor and Shape:SolidMolecular weight:344.9PF-05105679
CAS:<p>PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.</p>Formula:C26H21FN2O3Purity:99.84%Color and Shape:SolidMolecular weight:428.45SCS
CAS:<p>SCS is a GABAA receptor antagonist.</p>Formula:C14H12N2O3Purity:99.73%Color and Shape:SolidMolecular weight:256.26P-1075
CAS:<p>P-1075 activates SUR2-KIR6 channels at 45 nM; may open mitoKATP channels and protect the heart.</p>Formula:C12H17N5Purity:99.85%Color and Shape:SolidMolecular weight:231.3Mesendogen
CAS:<p>Mesendogen is an inhibitor of transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) and acts by inhibiting TRPM6/TRPM7</p>Formula:C18H16ClF3N2OSPurity:99.66%Color and Shape:SolidMolecular weight:400.85LOE 908 hydrochloride
CAS:<p>Broad spectrum cation channel blocker</p>Formula:C41H49ClN2O9Purity:98%Color and Shape:SolidMolecular weight:749.293′-Acetate-ATP
CAS:<p>3’-Acetate-ATP, an analogue of ATP and its acetylation product, exhibits maximum ultraviolet absorption at 259 nm in neutral aqueous solutions.</p>Formula:C12H18N5O14P3Color and Shape:SolidMolecular weight:549.22KCa1.1 channel activator-1
<p>A selective vascular KCa1.1 channel stimulator with CaV1.2 blocking ability and mild myorelaxant effects.</p>Formula:C25H16O10Color and Shape:SolidMolecular weight:476.39NCS-382 sodium
CAS:<p>NCS-382 (sodium) is a potent antagonist of the GABA receptor, exhibiting anti-sedative and anti-hypnotic properties, with applications in neurological disease</p>Formula:C13H13NaO3Purity:98%Color and Shape:SolidMolecular weight:240.23Pumaprazole
CAS:<p>Pumaprazole (BY-841) is an antagonist of a reversible proton pump.</p>Formula:C19H22N4O2Purity:99.91%Color and Shape:SolidMolecular weight:338.4CLP257
CAS:<p>CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.</p>Formula:C14H14FN3O2SPurity:99.5%Color and Shape:SolidMolecular weight:307.34Y-27152
CAS:<p>Y-27152 is a prodrug of the KATP (Kir6) channel opener Y-26763 and is a long-acting K+ channel opener.</p>Formula:C21H22N2O4Purity:98%Color and Shape:SolidMolecular weight:366.41S-Pantoprazole sodium trihydrate
CAS:<p>S-Pantoprazole (sodium trihydrate), a variant of Pantoprazole, is pivotal in managing diseases associated with gastric acid secretion disorders, serving as a</p>Formula:C16H20F2N3NaO7SPurity:98%Color and Shape:SolidMolecular weight:459.4Caroverine
CAS:Caroverine is a potential chemotherapeutical agent in HNSCC cell lines.Formula:C22H27N3O2Color and Shape:SolidMolecular weight:365.47BPO-27 racemate
CAS:<p>BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.</p>Formula:C26H18BrN3O6Purity:97.67% - 98.86%Color and Shape:SolidMolecular weight:548.34Iganidipine HCl
CAS:NKY-722 (HCl), also known as Iganidipine, is a calcium channel blocker potentially for the treatment of glaucoma.Formula:C28H40Cl2N4O6Color and Shape:SolidMolecular weight:599.55GSK3395879
CAS:<p>GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).</p>Formula:C20H15F4N3O5SPurity:98%Color and Shape:SolidMolecular weight:485.41CGP 54626 hydrochloride
CAS:<p>CGP 54626 hydrochloride is a GABAB receptor antagonist.</p>Formula:C18H29Cl3NO3PPurity:98%Color and Shape:SolidMolecular weight:444.76Aneratrigine
CAS:<p>Aneratrigine is a blocker of the sodium channel protein type 9 subunit alpha, utilized in research on neuropathic pain diseases [1].</p>Formula:C19H20ClF2N5O2S2Purity:98%Color and Shape:SolidMolecular weight:487.97Biricodar
CAS:<p>Biricodar is a P-glycoprotein and MRP-1 modulator.</p>Formula:C34H41N3O7Purity:98%Color and Shape:SolidMolecular weight:603.71Budiodarone
CAS:<p>Budiodarone (ATI-2042) resembles amiodarone, potentially preventing atrial fibrillation.</p>Formula:C27H31I2NO5Color and Shape:SolidMolecular weight:703.35(R)-Elexacaftor
CAS:<p>(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.</p>Formula:C26H34F3N7O4SPurity:98.991%Color and Shape:SolidMolecular weight:597.65Adipiplon
CAS:<p>Adipiplon(NG2-73, NG273) is a novel selective gamma-aminobutyric acid (GABA) partial agonist.</p>Formula:C18H18FN7Color and Shape:SolidMolecular weight:351.38Piperidine-4-sulfonic acid
CAS:<p>Piperidine-4-sulfonic acid is a potent GABA agonist, demonstrating an IC50 value of 0.034 μM for the inhibition of H-GABA binding [1].</p>Formula:C5H11NO3SPurity:98%Color and Shape:SolidMolecular weight:165.21NPEC-caged-(S)-AMPA
CAS:<p>AMPA receptor agonist</p>Formula:C16H17N3O8Purity:98%Color and Shape:SolidMolecular weight:379.32LG 83-6-05
CAS:<p>LG 83-6-05 is a novel kind of sodium channel blocking agent.</p>Formula:C21H30ClNO3SColor and Shape:SolidMolecular weight:411.99VU0463271
CAS:<p>VU0463271: KCC2 antagonist, IC50 61 nM, >100x selective over NKCC1, inactive on other GPCRs, channels, transporters.</p>Formula:C19H18N4OS2Purity:97.84% - 99.55%Color and Shape:SolidMolecular weight:382.5Aneratrigine hydrochloride
CAS:<p>Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.</p>Formula:C19H21Cl2F2N5O2S2Purity:98.37% - 99.16%Color and Shape:SolidMolecular weight:524.43MCT1-IN-3
CAS:<p>MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor.</p>Formula:C22H19N3O4Purity:99.35%Color and Shape:SoildMolecular weight:389.4AMG-0347
CAS:<p>AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.</p>Formula:C24H26F3N3O2Purity:99.93%Color and Shape:SolidMolecular weight:445.48Maralixibat Chloride
CAS:<p>Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.</p>Formula:C40H56ClN3O4SPurity:99.19% - 99.65%Color and Shape:SolidMolecular weight:710.41Bupivacaine hydrochloride monohydrate
CAS:<p>Bupivacaine hydrochloride monohydrate is an NMDA receptor inhibitor that inhibits SCN5A channels and is commonly used in the study of chronic pain.</p>Formula:C18H31ClN2O2Purity:99.91%Color and Shape:SolidMolecular weight:342.9Kv3 modulator 1
CAS:<p>Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.</p>Formula:C20H20N4O4Purity:99.41%Color and Shape:SolidMolecular weight:380.4L-DABA hydrobromide
CAS:<p>L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) , GABA transaminase inhibitor with antitumor and anticonvulsant activity.</p>Formula:C4H11BrN2O2Purity:99.11%Color and Shape:SolidMolecular weight:199.05Reldesemtiv
CAS:<p>Reldesemtiv (CK-2127107) boosts exercise capacity, targeting fast muscle troponin, EC50 3.4 μM.</p>Formula:C19H18F2N6OPurity:97.27%Color and Shape:SolidMolecular weight:384.38CE-224535
CAS:<p>CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.</p>Formula:C22H29ClN4O6Purity:99.68%Color and Shape:SolidMolecular weight:480.94C 101248
CAS:<p>C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.</p>Formula:C15H12N6OPurity:99.14% - 99.31%Color and Shape:SolidMolecular weight:292.3EMD57033
CAS:<p>EMD57033 activates cardiac troponin C, enhances Ca2+ sensitivity to boost heart contraction.</p>Formula:C22H23N3O4SPurity:99.72% - >99.99%Color and Shape:SolidMolecular weight:425.5Funapide
CAS:<p>Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.</p>Formula:C22H14F3NO5Purity:99.91%Color and Shape:SolidMolecular weight:429.35Soraprazan
CAS:<p>BS3 Crosslinker (Bis(sulfosuccinimidyl)suberate) is an ADC linker that can be used to synthesize antibody-coupled active molecules.</p>Formula:C21H25N3O3Purity:97.69% - 99.84%Color and Shape:SolidMolecular weight:367.44VGSCs-IN-1
CAS:<p>VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.</p>Formula:C12H12F3N3OSPurity:99.88%Color and Shape:SolidMolecular weight:303.3CFTR corrector 4
CAS:<p>Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.</p>Formula:C29H27F2NO7Purity:99.32%Color and Shape:SolidMolecular weight:539.52LE135
CAS:<p>LE135: RARα/RARβ antagonist (Ki: 1.4 μM/220 nM), favors RARβ, selective vs RARγ/RXRs; also activates TRPV1/TRPA1 (EC50s: 2.5/20 μM).</p>Formula:C29H30N2O2Purity:97.94%Color and Shape:SolidMolecular weight:438.56AMG2850
CAS:<p>AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).</p>Formula:C19H17F6N3OPurity:99.84%Color and Shape:SolidMolecular weight:417.35GABAA receptor agonist 1
<p>Compound 3e, a potent GABAA agonist, targets GABA sites and has potential anti-depressive effects in mice.</p>Formula:C20H30O3Color and Shape:SolidMolecular weight:318.45AP-6
CAS:AP-6, a selective TMEM175 inhibitor, enhances lysosomal macromolecular catabolism by acutely inhibiting TMEM175, thus speeding up macrophage and other digestive activities. This compound holds potential for use in Parkinson's disease research due to its role in modulating lysosomal function.Formula:C16H14N4Color and Shape:SolidMolecular weight:262.31BMS-986163
CAS:<p>BMS-986163, a prodrug, quickly becomes BMS-986169, a GluN2B inhibitor (Ki=4 nM, IC50=24 nM).</p>Formula:C23H28FN2O5PPurity:98%Color and Shape:SolidMolecular weight:462.45IAB15
CAS:<p>IAB15 is a potent inhibitor of T-type calcium channel that can be used in the research of epilepsy [1].</p>Formula:C15H14F3NO2Color and Shape:SolidMolecular weight:297.27T-Type calcium channel inhibitor 2
<p>Compound 6g inhibits T-type Ca channels (IC50: Cav3.1-31μM, Cav3.2-83μM), cytotoxic to A549 (IC50: 5μM) & HCT-116 cells (IC50: 6.4μM).</p>Formula:C36H39FN4OSColor and Shape:SolidMolecular weight:594.78CAD204520
CAS:<p>CAD204520 functions as an inhibitor of SERCA (IC50 = 0.34 μM), specifically targeting mutations in the wild-type NOTCH1 protein associated with T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL).</p>Formula:C23H32F3N3O2Color and Shape:SolidMolecular weight:439.51PF-06462894
CAS:PF-06462894: morpholinopyrimidone, mGlu5 antagonist (Ki=6nM), no immune activation in mouse model.Formula:C18H23N3O3Purity:98%Color and Shape:SolidMolecular weight:329.39Caged MK801
CAS:<p>Caged MK801 (cMK801) is a selective, noncompetitive, and irreversible blocker of the NMDA receptor open channel. The NVOC cage is compatible in neuropharmacology and does not alter the intrinsic activity of the molecule.</p>Formula:C26H24N2O6Color and Shape:SolidMolecular weight:460.48P-gp modulator 2
<p>P-gp modulator 2 (Compound 27) is a potent competitive and metabotropic P-glycoprotein (P-gp) modulator.</p>Formula:C22H20BrN3O4Color and Shape:SolidMolecular weight:470.32ZK 93426 hydrochloride
CAS:<p>benzodiazepine receptor antagonist,competitive</p>Formula:C18H21ClN2O3Purity:98%Color and Shape:SolidMolecular weight:348.82LY3130481
CAS:<p>LY3130481: TARP γ-8 dependent AMPA receptor blocker; selectively targets AMPA/TARP γ-8 with 65 nM IC50.</p>Formula:C19H18N4O3SColor and Shape:SolidMolecular weight:382.44Crinecerfont tosylate
CAS:<p>Crinecerfont tosylate is an effective oral CRF1 receptor antagonist. It is applicable to studies involving congenital adrenal hyperplasia (CAH).</p>Formula:C34H36ClFN2O4S2Color and Shape:SolidMolecular weight:655.242Kv7.2/Kv7.3 agonist 1
CAS:<p>Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.</p>Formula:C14H14FN3O2Color and Shape:SolidMolecular weight:275.28O4I4
CAS:<p>O4I4 is an OCT4-inducing compound capable of activating endogenous OCT4 and its associated signaling pathways, shown anti-aging effects.</p>Formula:C15H20N2SPurity:99.74%Color and Shape:SolidMolecular weight:260.43-Methoxy PCE hydrochloride
CAS:<p>3-Methoxy PCE (3-MEO PCE) hydrochloride is an arylcyclohexylamine compound that functions as an NMDA receptor antagonist with a pKi value of 7.22.</p>Formula:C15H24ClNOColor and Shape:SolidMolecular weight:269.81WS-898
<p>WS-898 boosts paclitaxel efficacy in resistant cells by inhibiting ABCB1; IC50: SW620/Ad300 - 5.0 nM, KB-C2 - 3.67 nM, HEK293/ABCB1 - 3.68 nM.</p>Formula:C33H25N7OSColor and Shape:SolidMolecular weight:567.66LY 235959
CAS:<p>LY 235959 is a NMDA receptor antagonist.</p>Formula:C11H20NO5PPurity:98%Color and Shape:SolidMolecular weight:277.25Vormatrigine
CAS:<p>Vormatrigine effectively inhibits sodium channels (sodium channel).</p>Formula:C16H12F6N4O2Color and Shape:SolidMolecular weight:406.28H052
CAS:<p>H052 is a selective inhibitor of Staphylococcus aureus α-hemolysin (Hla). It binds to the Hla monomer, disrupting its interaction with the host cell membrane, thereby blocking pore formation and inhibiting calcium influx, cytotoxicity, and inflammatory response. H052 exhibits inhibitory activity against Hla-induced calcium influx (EC50 = 30 nM in U937 cells) and holds potential for research into lung infections caused by S. aureus.</p>Formula:C21H15ClFN3O4SColor and Shape:SolidMolecular weight:459.88CFTR corrector 15
CAS:<p>CFTR Corrector 15 (Compound 4172) serves as a corrector for cystic fibrosis transmembrane conductance regulator (CFTR). When used in combination with VX-809, it addresses the folding defects of F508del-CFTR. CFTR Corrector 15 is also applicable in the research of cystic fibrosis.</p>Formula:C24H22ClN5O2SColor and Shape:SolidMolecular weight:479.988-Prenylchrysin
CAS:<p>8-Prenylchrysin is a C8-isopentenyl flavonoid compound. It acts as an inhibitor of P-glycoprotein (P-gp) and can be utilized in cancer research.</p>Formula:C20H18O4Color and Shape:SolidMolecular weight:322.354MSK-195
CAS:<p>MSK-195 is an effective TRPV1 agonist.</p>Formula:C28H40N2O5Purity:98%Color and Shape:SolidMolecular weight:484.63Perfluoroheptanesulfonic acid
CAS:<p>Perfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid) is a perfluoroalkyl substance (PFAS). This compound has been detected in landfill leachate and has been shown to induce deformities in zebrafish larvae (EC50=168.1 μM). Exposure to PFHpS in fetuses can lead to reduced birth weight.</p>Formula:C7HF15O3SColor and Shape:SolidMolecular weight:450.12NMDA receptor antagonist-3
<p>NMDA antagonist-3: recovery rate 40% at 100 μM, low toxicity in SH-SY5Y, human stem cells.</p>Formula:C13H19N3O6Color and Shape:SolidMolecular weight:313.31(R)-Duloxetine
CAS:<p>(R)-Duloxetine, an isomer of Duloxetine, induces tonic and use-dependent blockade of neuronal Na+ channels. This compound is utilized in pain research.</p>Formula:C18H19NOSColor and Shape:SolidMolecular weight:297.42Tuclazepam
CAS:<p>Tuclazepam (KC 1956) is a derivative of the benzodiazepine class of drugs, exhibiting anti-anxiety and sedative properties.</p>Formula:C17H16Cl2N2OColor and Shape:SolidMolecular weight:335.23Antimalarial agent 7
<p>Antimalarial agent 7 is a potent and effective inhibitor of PfATP4. Antimalarial agent 7 has potential for the study of the human plasmodium falciparum.</p>Formula:C23H22F2N4O3Color and Shape:SolidMolecular weight:440.44EU 1622-240
CAS:<p>EU 1622-240 is an allosteric modulator with a preference for GluN2B, GluN2C, and GluN2D, exhibiting EC50 values of 0.57, 0.82, and 1.1 μM, respectively. It possesses favorable physicochemical properties, along with in vitro stability and permeability.</p>Formula:C20H14BrF2N3O2SColor and Shape:SolidMolecular weight:478.31Cyproflanilide
CAS:<p>Cyproflanilide is a GABAR antagonist that exhibits high activity against a variety of pests, including those from the Lepidoptera, Coleoptera, and Thysanoptera orders.</p>Formula:C28H17BrF12N2O2Color and Shape:SolidMolecular weight:721.33CRM1 degrader 1
<p>CRM1 degrader 1 (1l) is a low-toxic CRM1 degrader that induces apoptosis in gastric carcinoma and selectively inhibits the proliferation of gastric cancer[1].</p>Formula:C16H20O3Color and Shape:SolidMolecular weight:260.33KCC2 Modulator-2
CAS:<p>KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.</p>Formula:C35H45N5O3Color and Shape:SolidMolecular weight:583.76TRPC4/5-IN-1
<p>TRPC4/5-IN-1, a TRPC5/4 inhibitor with IC50s 0.54 μM/2.06 μM, targets skin inflammation and proteinuric kidney diseases.</p>Formula:C21H21N3OColor and Shape:SolidMolecular weight:331.41N-Depropylpropafenone
CAS:<p>N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.</p>Formula:C18H21NO3Color and Shape:SolidMolecular weight:299.36P2X4-IN-1
CAS:<p>P2X4-IN-1 is an orally active P2X4 inhibitor. P2X4-IN-1 is applicable in research focused on disease prevention.</p>Formula:C18H14ClN5O3SColor and Shape:SolidMolecular weight:415.85Desmethylflunitrazepam
CAS:<p>Desmethylflunitrazepam (Norflunitrazepam) is a benzodiazepine derivative and an active metabolite of Flunitrazepam.</p>Formula:C15H10FN3O3Color and Shape:SolidMolecular weight:299.26Tizolemide
CAS:<p>Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.</p>Formula:C11H14ClN3O3S2Color and Shape:SolidMolecular weight:335.83IAA65
CAS:<p>IAA65 is a potent inhibitor of T-type calcium channels, exhibiting an IC50 value of 18.9 μM, and holds potential for use in epilepsy research [1].</p>Formula:C16H13F6NO2Color and Shape:SolidMolecular weight:365.27TRPV1 antagonist 3
<p>TRPV1 antagonist 3 (7q) strongly blocks TRPV1 at 2.66 nM IC50, is selective, 60% bioavailable, and crosses the blood-brain barrier.</p>Formula:C23H25N3OSColor and Shape:SolidMolecular weight:391.53S 0960
CAS:<p>S 0960 is a dimeric bile acid analogue, a specific inhibitor of the sodium-dependent bile salt transporter in the ileum, used in metabolic disease research.</p>Formula:C48H79NO8Purity:99.32% - >99.99%Color and Shape:SolidMolecular weight:798.14Unoprostone isopropyl
CAS:<p>Unoprostone isopropyl, a prostanoid and synthetic docosanoid, is approved for the treatment of ocular hypertension and open-angle glaucoma.</p>Formula:C25H44O5Purity:98%Color and Shape:SolidMolecular weight:424.61ATP synthase inhibitor 2
CAS:<p>ATP synthase inhibitor 2 blocks P. aeruginosa ATP synthase; IC50=10 μg/mL, fully inhibits at 128 μg/mL.</p>Formula:C21H22N2O3SColor and Shape:SolidMolecular weight:382.48KV1.3-IN-2
CAS:<p>KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.</p>Formula:C16H23ClN2O4Color and Shape:SolidMolecular weight:342.818pan-HCN-IN-1
CAS:<p>Pan-HCN-IN-1 (Compound J&J12e) is an inhibitor of the hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with an IC50 of 58 nM. Pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rat brain slices [1].</p>Formula:C23H37N3O2Color and Shape:SolidMolecular weight:387.56Valbenazine tosylate
CAS:<p>Valbenazine tosylate, the tosylate salt of valbenazine, is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying no</p>Formula:C38H54N2O10S2Purity:98%Color and Shape:SolidMolecular weight:762.97GNE-616
CAS:<p>GNE-616: a potent, stable, oral Nav1.7 inhibitor; Ki: 0.79 nM, Kd: 0.38 nM; for chronic pain.</p>Formula:C24H23F4N5O3SPurity:98%Color and Shape:SolidMolecular weight:537.53PF-05661014
CAS:<p>PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.</p>Formula:C17H16N4O3S2Color and Shape:SolidMolecular weight:388.46TP003
CAS:<p>TP003 is a novel non-selective GABAA receptor benzodiazepine site agonist with affinity for α1β2gam2, α2β3gam2, α3β3gam2, α5β2gam2, EC50 of 20.3, 10.6, 3.24, 5.</p>Formula:C23H16F3N3OPurity:99.17%Color and Shape:SolidMolecular weight:407.39Cav 3.2 inhibitor 3
<p>Cav 3.2 inhibitor 3 is a potent inhibitor of the Cav3.2 T-type Ca2+channel (IC50: 0.1534 μM) and has a low binding affinity for D2 receptors.</p>Formula:C32H37N3O2Color and Shape:SolidMolecular weight:495.66ErSO-TFPy
CAS:<p>ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.</p>Formula:C19H13F7N2O2Color and Shape:SolidMolecular weight:434.307Fletazepam
CAS:<p>Fletazepam, a benzodiazepine derivative, exhibits sedative, anti-anxiety, and muscle-relaxant properties. It is utilized in neurological research.</p>Formula:C17H13ClF4N2Color and Shape:SolidMolecular weight:356.74ABCA1 inducer 2
CAS:<p>ABCA1 inducer 2 is a non-lipogenic inducer of ABCA1. It increases the expression of ABCA1 by targeting the LXR pathway, thereby reducing lipid accumulation induced by ox-LDL and inhibiting foam cell formation. ABCA1 inducer 2 holds potential as an anti-atherosclerotic agent.</p>Formula:C16H11BrN2OColor and Shape:SolidMolecular weight:327.175KPH2f
CAS:<p>KPH2f: dual URAT1/GLUT9 inhibitor, orally active, IC50: 0.24μM (URAT1), 9.37μM (GLUT9), minimal OAT1/ABCG2 impact.</p>Formula:C24H16N3NaO2SColor and Shape:SolidMolecular weight:433.46Mibefradil dihydrochloride hydrate
CAS:<p>Mibefradil dihydrochloride hydrate is a long-acting antihypertensive blocking high-voltage L calcium channels.</p>Formula:C29H42Cl2FN3O4Color and Shape:SolidMolecular weight:586.57AN-988
CAS:<p>AN-988 (compound 6) is a covalent CRM1 inhibitor.</p>Formula:C22H22N2O4SColor and Shape:SolidMolecular weight:410.49Detajmium
CAS:<p>Detajmium is an anti-arrhythmia compound. It is an Na(+)-channel-blocking drug with an extremely long recovery from use-dependent sodium channel block.</p>Formula:C27H42N3O3Purity:98%Color and Shape:SolidMolecular weight:456.64P2X receptor-1
<p>P2X receptor-1 is a potential inhibitor of P2X receptor for the treatment of pain and inflammation.</p>Formula:C14H14ClN3O3S2Color and Shape:SolidMolecular weight:371.86Kv7.2/Kv7.3 modulator-1
CAS:<p>Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.</p>Formula:C20H21F4N3O3Color and Shape:SolidMolecular weight:427.393DS88790512
CAS:<p>DS88790512, IC50 at 11 nM, is an effective, selective, oral bioeffective TRPC6 inhibitor.</p>Formula:C22H29N3O2Purity:98%Color and Shape:SolidMolecular weight:367.48SP100030 analogue 1
CAS:SP100030 analogue 1 (compound 11) is a selective transcription activation (SITA) inhibitor within the SP100030 class, capable of inhibiting XPO1-dependent upregulation of IL2 in a Jurkat-based IL2-Luc reporter assay, with an EC50 of 137 nM.Formula:C13H5ClF7N3OColor and Shape:SolidMolecular weight:387.64PF-06305591 dihydrate
<p>PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker (IC 50 = 15 nM) with an excellent preclinical in vitro ADME</p>Formula:C15H26N4O3Color and Shape:SolidMolecular weight:310.39INCB-056868
CAS:<p>INCB-056868 is the metabolite M11 of Epacadostat. It serves as a substrate for BCRP and holds potential for use in the study of metabolic diseases.</p>Formula:C11H13BrFN7O3SColor and Shape:SolidMolecular weight:422.23P-gp modulator 1
CAS:<p>P-gp modulator 1 is a high affinity and orally available P-glycoprotein (Pgp) modulator</p>Formula:C41H72N2O6Purity:98%Color and Shape:SolidMolecular weight:689.02(R)-KMH-233
CAS:<p>(R)-KMH-233 is an isomer of KMH-233, which can serve as a reference compound in experiments. KMH-233 functions as a potent, reversible, and selective inhibitor of L-type amino acid transporter 1 (LAT1), effectively hindering the uptake of LAT1 substrate, l-leucine (IC50=18 μM), and also inhibiting cell growth. Even at a low concentration of 25 μM, KMH-233 significantly enhances the efficacy of Bestatin and cisplatin.</p>Formula:C32H25N7O5Molecular weight:587.58Gabaculine HCl
CAS:<p>Gabaculine, an irreversible GABA-T inhibitor (Ki: 2.9 μM), impacts plastid development and affects DPOR/GluTR levels.</p>Formula:C7H10ClNO2Color and Shape:SolidMolecular weight:175.61SGC-CAMKK2-1
CAS:<p>SGC-CAMKK2-1 is a selective inhibitor of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC50 of 30 nM. It effectively inhibits AMPK phosphorylation in C4-2 cells, exhibiting an IC50 value of 1.6 µM.</p>Formula:C26H23NO3Color and Shape:SolidMolecular weight:397.466DFBTA
<p>DFBTA inhibits ANO1 with IC50 of 24 nM, effectively treating inflammatory pain orally.</p>Formula:C18H10ClF2NO3SColor and Shape:SolidMolecular weight:393.795-O-Desmethyl donepezil
CAS:<p>5-O-Desmethyl donepezil is a metabolite of Donepezil that acts as an inhibitor of hERG channels, with an IC50 of 1.5 μM.</p>Formula:C23H27NO3Color and Shape:SolidMolecular weight:365.465(3S,6R)-NML
CAS:<p>(3S,6R)-NML is an NMDA receptor antagonist with pIC50 values of 4.8 [GluN1-GluN2A], 4.6 [GluN1-GluN2B], 5.0 [GluN1-GluN2C], and 5.0 [GluN1-GluN2D]. It is applicable in the study of depression.</p>Formula:C20H27NOColor and Shape:SolidMolecular weight:297.435(RS)-AMPA
CAS:<p>(RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA is an agonist of effective and selective excitatory neurotransmitter L-glutamic acid.</p>Formula:C7H10N2O4Purity:98%Color and Shape:SolidMolecular weight:186.17TRPC5-IN-4
CAS:<p>TRPC5-IN-4: Potent, safe inhibitor; IC50 14.07 nM (TRPC5), 65 nM (TRPC4); non-toxic to liver/kidney cells; for CKD research.</p>Formula:C18H11ClF4N4O3Color and Shape:SolidMolecular weight:442.75TTA-P1
CAS:<p>TTA-P1: potent T-type calcium channel inhibitor; impacts neuron firing, hormone secretion, cell growth; potential in absence epilepsy research.</p>Formula:C19H27Cl2FN2OColor and Shape:SolidMolecular weight:389.33Lu AF90103
CAS:<p>Lu AF90103 (Compound 42e) is the methyl ester prodrug of compound 42d, capable of crossing the blood-brain barrier. Compound 42d acts as a partial agonist of the GluN1/GluN2B complex, with an efficacy of 24% and an EC50 value of 78 nM. Lu AF90103 plays a significant role in neuropsychiatric disorder research.</p>Formula:C13H15N3O3SColor and Shape:SolidMolecular weight:293.3422-PPA
CAS:2-PPA serves as a selective TMEM175 inhibitor (IC 50 =32 μM), primarily influencing lysosomal activity. Through acute inhibition of TMEM175, 2-PPA enhances lysosomal macromolecular catabolism, which in turn boosts macrophage activity and other digestive processes. This compound holds significance in Parkinson's disease research.Formula:C11H10N2Color and Shape:SolidMolecular weight:170.21Antidepressant agent 8
CAS:<p>Antidepressant agent 8 (Compound 1f) acts as a selective antagonist for the NMDA receptor GluN1/2A (NMDA receptorGluN1/2A), with an IC50 of 2.94 μmol/L. In a hydrocortisone-induced zebrafish depression model, it demonstrates antidepressant-like effects and shows good blood-brain barrier penetration.</p>Formula:C18H23FN4OS2Color and Shape:SolidMolecular weight:394.53Cav 2.2/3.2 blocker 1
<p>Compound 9e is a Cav 2.2/3.2 blocker; IC50: 1.22 μM & 80 μM, respectively; penetrates CNS.</p>Formula:C28H30N2O3Color and Shape:SolidMolecular weight:442.55NSC73306
CAS:<p>NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.</p>Formula:C16H14N4O2SColor and Shape:SolidMolecular weight:326.373Sesamodil
CAS:<p>Sesamodil (SD 3211) is a novel calcium antagonist that can be used to study hypertension.</p>Formula:C29H32N2O6SPurity:98.58% - 99.01%Color and Shape:SolidMolecular weight:536.64PD-217014
CAS:<p>PD-217014 is an α2δ ligand that exhibits visceral analgesic activity and can suppress visceral hypersensitivity. Its antihyperalgesic effects are dose-dependent.</p>Formula:C10H17NO2Color and Shape:SolidMolecular weight:183.25Lorajmine
CAS:Lorajmine, a monochloroacetyl derivative of ajmaline, is a class Ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases.Formula:C22H27ClN2O3Purity:98%Color and Shape:SolidMolecular weight:402.91URAT1 inhibitor 2
<p>URAT1 inhibitor 2: oral URAT1/CYP blocker, IC50 of 1.36μM (URAT1), 16.97μM (CYP1A2), 5.22μM (CYP2C9); potential gout treatment.</p>Formula:C21H18BrN3O2SColor and Shape:SolidMolecular weight:456.36Onfasprodil
CAS:<p>Onfasprodil, NR2B inhibitor & GABA regulator, potential for Alzheimer's research. (Patent CN111481543A)</p>Formula:C20H23FN2O3Color and Shape:SolidMolecular weight:358.41LY 215490
CAS:<p>LY 215490 is a selective AMPA receptor antagonist with neuroprotective properties in rat ischemia.</p>Formula:C13H21N5O2Purity:98%Color and Shape:SolidMolecular weight:279.34SOAT-IN-1
CAS:<p>SOAT-IN-1 (compound 40) is a potent and selective inhibitor targeting the sodium-dependent organic anion transporter (SOAT), exhibiting IC50 values of 1.6 µM for SOAT and 14.3 µM for NTCP.</p>Formula:C20H16ClN3O6SColor and Shape:SolidMolecular weight:461.88Coleon-U-quinone
CAS:<p>Coleon-U-quinone, a P-gp inhibitor, reduces cancer cell viability and enhances Doxorubicin sensitivity in resistant cells.</p>Formula:C20H24O5Color and Shape:SolidMolecular weight:344.4TRPV1 antagonist 10
CAS:<p>TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.</p>Formula:C16H14N2O5Color and Shape:SolidMolecular weight:314.293CFTR corrector 16
CAS:<p>CFTRcorrector 16 (Compound 39) is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), utilized in the research of cystic fibrosis disease.</p>Formula:C27H26ClN5O2SColor and Shape:SolidMolecular weight:520.05Ro-51
CAS:<p>dual P2X3 and P2X2/3 antagonist</p>Formula:C17H23IN4O4Purity:98%Color and Shape:SolidMolecular weight:474.29Quinacainol dihydrochloride
CAS:<p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>Formula:C21H32Cl2N2OColor and Shape:SolidMolecular weight:399.398Butein tetramethyl ether
CAS:<p>Butein tetramethyl ether (Compound 20) is a potent and selective inhibitor of breast cancer resistance protein / ATP-binding cassette sub-family G member 2 (BCRP/ABCG2). It inhibits MCF-7 MX and MDCKBCRP cells with IC50 values of 2.2 μM and 1.03 μM, respectively. Butein tetramethyl ether holds potential for cancer research.</p>Formula:C19H20O5Color and Shape:SolidMolecular weight:328.359Olisutrigine bromide
CAS:<p>Olisutrigine bromide is a sodium channel blocker used as an analgesic.</p>Formula:C25H35BrN2Color and Shape:SolidMolecular weight:443.463DAD dichloride
<p>DAD dichloride is a 3rd-gen photoelectric switch, blocks K+ channels, and helps in visual function research.</p>Formula:C26H42Cl2N6OColor and Shape:SolidMolecular weight:525.56P-gp inhibitor 2
CAS:<p>Potent P-gp inhibitor 2 reverses Doxorubicin resistance in colorectal carcinoma cells with IC50 of 0.22 µM.</p>Formula:C29H26N2O6Color and Shape:SolidMolecular weight:498.53ICA-105665
CAS:<p>ICA-105665 is an orally active Kv7.2/7.3/7.5 channel opener, CNS-penetrant with antiseizure effects, and low hepatocyte cytotoxicity.</p>Formula:C19H15F2N3O2Purity:98%Color and Shape:SolidMolecular weight:355.34DAD
<p>DAD is an ion channel blocker (blocks voltage-gated potassium channels) and is a third generation photoelectric switch that responds to visible light.</p>Formula:C26H40N6OColor and Shape:SolidMolecular weight:452.64TRPA1 Antagonist 1
CAS:<p>TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.</p>Formula:C24H20F6N5Na2O7PSPurity:98%Color and Shape:SolidMolecular weight:713.45(RS)-AMPA hydrobromide
CAS:AMPAR agonistFormula:C7H11BrN2O4Purity:98%Color and Shape:SolidMolecular weight:267.08SR 33805 oxalate
CAS:<p>Ca2+ channel antagonist</p>Formula:C34H42N2O9SPurity:98%Color and Shape:SolidMolecular weight:654.77cis-KV1.3-IN-1
CAS:<p>cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.</p>Formula:C23H30N2O4SColor and Shape:SolidMolecular weight:430.56Dehydroindapamide
CAS:<p>Dehydroindapamide, an indole form of Indapamide, is utilized to quantify the turnover rate of Indapamide in CYP3A4, which is approximately 10 times higher than that of Indoline, with slightly enhanced affinity for CYP3A4.</p>Formula:C16H14ClN3O3SColor and Shape:SolidMolecular weight:363.82Cyazofamid
CAS:<p>Cyazofamid functions as a fungicide by impairing the production of ATP. It inhibits Organic Cation Transporter 3 (OCT3) and OAT1 with IC50 values of 1.54 and 17.3 μM, respectively.</p>Formula:C13H13ClN4O2SColor and Shape:SolidMolecular weight:324.79CFTR corrector 18
CAS:<p>CFTRcorrector 18 (Compound I-99) acts as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It enhances the processing and trafficking of CFTR, thereby increasing the amount of CFTR present on the cell surface. CFTRcorrector 18 holds potential for research in cystic fibrosis (CF).</p>Formula:C38H40N6O5SColor and Shape:SolidMolecular weight:692.826S9-A13
CAS:<p>S9-A13 is a potent and selective inhibitor of SLC26A9, exhibiting an IC50 of 90.9 nM without inhibiting other members of the SLC26 family, such as SLC26A3, SLC26A4, and SLC26A6. It also inhibits the SLC26A9 Cl- current in cells lacking CFTR expression.</p>Formula:C20H18ClN3O2SColor and Shape:SolidMolecular weight:399.89BGT1-IN-1
CAS:<p>BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.</p>Formula:C6H9NO2Color and Shape:SolidMolecular weight:127.14Caramboxin
CAS:<p>Caramboxin, a neurotoxin, can induce acute kidney injury.</p>Formula:C11H13NO6Color and Shape:SolidMolecular weight:255.22RO-275
CAS:<p>RO-275 is an HCN1 inhibitor that also inhibits HCN2, HCN3, and HCN4, improving working memory deficits and being used in research on cognitive disorders.</p>Formula:C18H14ClN5OPurity:98.12% - 98.3%Color and Shape:SolidMolecular weight:351.79CFTR corrector 17
CAS:<p>CFTRcorrector 17 (example 17) is a regulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It is utilized in the study of diseases mediated by CFTR.</p>Formula:C18H15FN2O2Color and Shape:SolidMolecular weight:310.32LY503430
CAS:<p>LY503430: Oral AMPA enhancer with nootropic, neuroprotective properties, mitigates 6-OHDA/MPTP brain damage.</p>Formula:C20H25FN2O3SPurity:98%Color and Shape:SolidMolecular weight:392.494α-PDD
CAS:<p>4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through PKC.</p>Formula:C40H64O8Color and Shape:SolidMolecular weight:672.93Kv7.2/Kv7.3 activator-1
CAS:<p>Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.</p>Formula:C19H22F2N4OColor and Shape:SolidMolecular weight:360.40SGE-516
CAS:<p>SGE516: neuroactive steroid, enhances GABAA, lowers neuronal activity, protects from seizures.</p>Formula:C23H35N3O2Purity:98%Color and Shape:SolidMolecular weight:385.54MRS4738
<p>MRS4738 is a potent antagonist with high affinity for the P2Y14R receptor. It demonstrates in vivo anti-hyperallodynic and antiasthmatic activity [1].</p>Formula:C30H24F3NO2Color and Shape:SolidMolecular weight:487.51VU0463271 quarterhydrate
<p>VU0463271 quarterhydrate is a potent KCC2 antagonist, with an IC 50 of 61 nM [1].</p>Formula:C19H20N4O2S2Color and Shape:SolidMolecular weight:387(RS)-AMPA monohydrate
CAS:<p>(RS)-AMPA monohydrate, potent glutamate analogue, selectively activates L-glutamic acid without affecting kainic acid or NMDA receptors.</p>Formula:C7H12N2O5Color and Shape:SolidMolecular weight:204.182Moxetomidate
CAS:<p>Moxetomidate is a GABAA receptor (GABAA receptor) agonist with hypnotic properties.</p>Formula:C15H18N2O3Color and Shape:SolidMolecular weight:274.315hURAT1 inhibitor 2
CAS:<p>hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. It also exhibits some inhibitory activity against OATP1B1, with an IC50 of 0.73 μM. hURAT1 inhibitor 2 can be used in research related to hyperuricemia, gout, and other diseases associated with abnormal uric acid metabolism.</p>Formula:C17H11Br2FO3Color and Shape:SolidMolecular weight:442.074Lubeluzole dihydrochloride
CAS:<p>Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.</p>Formula:C22H27Cl2F2N3O2SColor and Shape:SolidMolecular weight:506.44PDE2 inhibitor 6
CAS:<p>PDE2 inhibitor6 (Compound 1) is an orally active phosphodiesterase (PDE) inhibitor, effectively inhibiting PDE2A, PDE3B, and PDE10A2 with IC50 values of 0.95 nM, 6.17 μM (pIC50=5.21), and 87.1 nM (pIC50=7.06), respectively. It modulates AMPA receptor activity, enhances synaptic plasticity, and improves learning and memory in rat models. Furthermore, PDE2 inhibitor6 possesses blood-brain barrier permeability.</p>Formula:C20H22F2N6OColor and Shape:SolidMolecular weight:400.425Ro 0437626
CAS:<p>P2X1 purinergic receptor antagonist</p>Formula:C27H35N5O4SPurity:98%Color and Shape:SolidMolecular weight:525.66Probenecid sodium
CAS:<p>Probenecid sodium is the sodium salt of Probenecid, a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Additionally, Probenecid acts as an inhibitor of pannexin 1 channels.</p>Formula:C13H18NNaO4SColor and Shape:SolidMolecular weight:307.341Metaphit methylsulfate
CAS:<p>Metaphit methylsulfate is a specific PCP antagonist and an acylating agent for the [3H] phencyclidine binding site in rat brain homogenate. It inhibits PCP-induced motor activity through a presynaptic mechanism.</p>Formula:C19H28N2O3S2Color and Shape:SolidMolecular weight:396.567EMD-95885
CAS:<p>EMD-95885 is a selective antagonist of NMDA receptors containing NR2B subunits, with an IC50 of 3.9 nM. It does not interact with other sites on the NMDA receptor.</p>Formula:C22H23FN2O3Color and Shape:SolidMolecular weight:382.428
