Calcium Channel

<p>Argireline (Acetyl hexapeptide-3) is a peptide that inhibits neurotransmitter release, reducing wrinkles.</p>

<p>Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).</p>

<p>Praeruptorin C/E relaxes arteries, reduces heart contractility, acting like calcium blockers. D/E protect mice from acid lung injury by halting PMNs and IL-6.</p>

<p>SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)</p>

<p>Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.</p>

<p>L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.</p>

<p>Bepridil hydrochloride (CERM 1978) is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels</p>

<p>Azumolene (EU4093 free base)</p>

<p>NFAT Inhibitor-2 is a compound used as a molecular building block.</p>

<p>Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium</p>

<p>Ethacrynic acid (Edecrin) 是谷胱甘肽 S-转移酶抑制剂，也是NF-κB 信号传导途径的有效抑制剂，并且还调节白三烯的形成。它还可抑制 L 型电压依赖性和储存操作的钙通道，从而导致气道平滑肌细胞松弛。它是利尿剂，具有抗炎特性，可减轻类维生素 A 诱导的小鼠耳部水肿。</p>

<p>Gabapentin hydrochloride (Neurontin HCl) is a GABA analogue, used to treat seizures and neuropathic pain.</p>

<p>NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).</p>

<p>Cycleanine has potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities.</p>

<p>Pranidipine (OPC-13340) is a novel, long-acting 1,4-dihydropyridine calcium channel blocker.</p>

<p>Glaucine: antitussive, antioxidative, antiviral, may fight arthritis, boosts IL-10, hinders breast cancer cell spread by inhibiting MMP-9 and NF-κB.</p>

<p>FPL64176 is a L-type calcium channels activator.</p>

<p>Aranidipine (MPC1304) (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects.</p>

<p>TTA-A2: T-type calcium channel blocker; anticonvulsant targeting Cav3.1, Cav3.2; IC50 of 89/92 nM; potential for treating neurological conditions.</p>

<p>Gomisin J is a natural product and have vasodilatory activity.</p>

<p>Fantofarone (SR 33557) is a highly potent antagonist of Calcium Channel.</p>

<p>Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.</p>

<p>Ziconotide Acetate (Prialt, 107452-89-1) is an analgesic for neuropathic pain, acting on N-type calcium channels to block pain signals.</p>

<p>Norfluoxetine Hydrochloride (Norfluoxetine HCl) is an active metabolite of fluoxetine. Fluoxetine is an antidepressant drug.</p>

<p>Lanthanum(III) chloride blocks divalent cation channels, useful for biochemical research.</p>

<p>Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for OX1 and 0.17 nM for OX2.</p>

<p>Barnidipine HCl is a potent dihydropyridine Ca²⁺ blocker with 0.35 nM IC50 in pig coronary artery.</p>

<p>(±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation.</p>

<p>Manidipine (Iperten), a calcium channel blocker, which is dihydropyridine type. It is utilized</p>

<p>ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer.</p>

<p>YM-58483 (BTP2) is a specific and effective inhibitor of CRAC channels and subsequent Ca2+ signals.</p>

<p>Z944 is a T-type calcium channel blocker.</p>

<p>Barnidipine (YM-09730-5(Free base)) is a calcium channel blocker.</p>

<p>Ginsenoside Rf (Panaxoside Rf) is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.</p>

<p>Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.</p>

<p>Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with</p>

<p>Isradipine (PN 200-110), a dihydropyridine, is an antihypertensive calcium channel blocker that dilates arteries and reduces resistance.</p>

<p>Ruthenium Red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria.</p>

<p>Benidipine hydrochloride (Coniel) , a hydrochloride salt form of benidipine, is used as a blocker of dihydropyridine calcium channel.</p>

<p>2-Aminoethyl diphenylborinate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels.</p>

<p>Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite (SM) made by A.</p>

<p>Ned 19 inhibits tumor growth, vascularization, lung metastases in mice, and is a selective NAADP antagonist.</p>

<p>Etripamil is a fast-acting intranasal L-type calcium-channel blocker for Paroxysmal Supraventricular Tachycardia.</p>

<p>Levamlodipine besylate, or S-amlodipine (CAS 103129-82-4), is the active enantiomer of amlodipine, used to treat hypertension and angina.</p>

<p>Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.</p>

<p>Nicardipine (Cardene), a calcium channel blockers belonging to the dihydropyridine class, is a drug used to treat angina and high blood pressure.</p>

<p>CDN1163 is a small molecule activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).</p>

<p>Efonidipine (NZ-105)(NZ-105) is a dihydropyridine calcium channel blocker, blocking both T-type and L-type calcium channels.</p>

<p>Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.</p>

<p>Yangambin: selective PAF antagonist, hypotensive, inhibits Ca2+ influx, induces peripheral vasodilation, affects CNS.</p>

<p>2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.</p>

<p>Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but</p>

<p>DHBP dibromide (1,1'-DI-N-HEPTYL-4,4'-BIPYRIDINIUM DIBRO) is calcium release and a muscle relaxant inhibitor.</p>

<p>Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor.</p>

<p>MDK-4025 is an inhibitor of the high voltage-activated (HVA) Ca2+ current in pyramidal neurons.</p>

<p>Bevantolol hydrochloride (NC-1400 hydrochloride) is a β1-adrenoceptor antagonist that treatment angina pectoris and hypertension.</p>

<p>L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.</p>

<p>"JNJ-26990990: broad-spectrum anticonvulsant, less side effects than topiramate, potential for pain and depression treatment; Phase II in 2007."</p>

<p>Bay K 8644 (SQ 28,873) is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.</p>

<p>SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger.</p>

<p>SN 6 (SN6) is a selective Na+/Ca2+ exchanger (NCX) inhibitor (IC50s of NCX1: 2.9 μM , NCX2: 16 μM ,NCX3: 8.6 μM)</p>

<p>Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Cost-effective and quality-assured.</p>

<p>Pyridaben is a METI acaricide that inhibits mitochondrial electron transport at complex I (METI; Ki = 0.36 nmol/mg protein in rat brain mitochondria).</p>

<p>Equilin (7-Dehydroestrone) is a neurotrophic estrogenic steroid with vasodilatory activity used in the study of hypertension.</p>

<p>Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels</p>

<p>Amlodipine maleate (Amvaz) is an oral dihydropyridine calcium blocker for hypertension and cancer studies.</p>

<p>Apinocaltamide (ACT-709478) is an orally available and selective T-type calcium channel blocker that cross BBB for Cav3.1, Cav3.2, and Cav3.3,epilepsy.</p>

<p>N-Methyl-L-leucine ((S)-4-Methyl-2-(methylamino)pentanoic acid) is a novel calcium channel antagonist used in pain research.</p>

<p>N6-(2-Hydroxyethyl)adenosine is a sedative, Ca2+ antagonist, and anti-inflammatory, affecting brain and heart blood flow.</p>

<p>Diltiazem (CRD 401 free base) is an orally available L-type Ca2+ channel blocker with antihypertensive, antiarrhythmic, and cardioprotective properties that prevent post-reperfusion myocardial injury, angina pectoris, and cardiovascular-related diseases.</p>

<p>Bupivacaine-d9 is a deuterated compound of Bupivacaine. Bupivacaine has a CAS number of 38396-39-3. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.</p>

<p>Gabapentin enacarbil (XP-13512) is a prodrug for the anticonvulsant and analgesic gabapentin, offering sustained dose-proportional exposure and predictable bioavailability.</p>

<p>Applications 4-(2-Chlorophenyl)-2-methyl-5-oxo-4,4a,5,7,8,10-hexahydro-1H-pyrido[2',3':2,3]azeto[2,1-c][1,4]oxazine-3-carboxylic Acid is an intermediate in the synthesis of 3-O-Desethyl-5-O-desmethyl Amlodipine (D291305). 3-O-Desethyl-5-O-desmethyl Amlodipine is an impurity of Amlodipine (A633495), which is a dihydropyridine calcium channel blocker.<br>References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995)<br></p>

<p>Applications 1-tert-Butyl 3-Ethyl 5-methyl 2-((2-((tert-Butoxycarbonyl)amino)ethoxy)methyl)-4-(2-chlorophenyl)-6-methylpyridine-1,3,5(4H)-tricarboxylate is an intermediate in the synthesis of 3-O-Desethyl-5-O-desmethyl Amlodipine (D291305). 3-O-Desethyl-5-O-desmethyl Amlodipine is an impurity of Amlodipine (A633495), which is a dihydropyridine calcium channel blocker.<br>References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995)<br></p>

<p>Amlodipine hydrochloride is a salt of Amlodipine --- a medication used to lower blood pressure and prevent chest pain.</p>

<p>Amlodipine besilate impurity G is a Calcium Channel antagonist with potential application in the study of neurological diseases and is an impurity in the</p>

<p>Cinepazide: a vasodilator targeting adenosine A2 receptors, treats various vascular diseases.</p>

<p>Nifedipine D6 is deuterium labeled nifedipine which is a potent blocker of calcium channel.</p>

<p>Cinnarizine D8 is a deuterium-labeled Cinnarizine which is an antihistamine and a calcium channel blocker.</p>

<p>Topiramate D12 is a deuterium labeled Topiramate. Topiramate is an agent of broad-spectrum antiepileptic. Topiramate is an antagonist of GluR5 receptor.</p>

<p>Maresin 1 is biosynthesized by macrophages (MΦ) and possesses significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice.</p>

<p>ORM-10103 is a novel potent and selective inhibitor of the Na+/Ca2+ exchanger (NCX).ORM-10103 inhibited NCX currents with estimated IC50 values of 55 and 67 nM</p>

<p>R-(-)-Niguldipine HCl: L-type Ca2+ blocker, K+ agonist, α1A antagonist; lowers blood pressure; weaker enantiomer.</p>

<p>Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.</p>

<p>Applications Falipamil is a specific bradycardic agent and a calcium channel blocker.<br>References Boucher, M., et al.: Eur. J. Pharmacol., 306, 93 (1996), Mubagwa, K., et al.: Arch. Int. Pharmacodyn. Ther., 286, 71 (1987), Chaudhry, A., et al.: Development Cardiovascular Medicine, 46, 196 (1985), Ogiwara, Y., et al.: Jpn Heart J., 29, (1988)<br></p>

<p>Stability Light and Temperature Sensitive<br>Applications 3-Desethyl-3-(2-phthalimidoethyl) Phthaloyl Amlodipine is a derivative of Amlodipine (A633495); a dihydropyridine calcium channel blocker where activity mainly resides in the (-)-isomer.<br>References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995)<br></p>

<p>Applications Dihydrocinnamyl Cilnidipine is a metabolite of Cilnidipine (C441375); a dihydropyridine calcium channel blocker.<br>References Ikeda, K., et al.: Oyo Yakuri, 44, 433 (1992); Hosono, M., et al.: J. Pharmacobio-Dyn., 15, 547, (1992); Ishii, M.: Japan Pharmacol. Ther., 21, 59 (1993)<br></p>

<p>Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.</p>

<p>Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.</p>

<p>Ronipamil is an analogue of verapamil that used as a calcium entry blocker.</p>

<p>(S)-Lercanidipine: a dihydropyridine calcium blocker with prolonged antihypertensive and kidney-protective properties.</p>

<p>Riodipine, a calcium channel blocker, is used as cardiovascular drugs.</p>

<p>Hexadecylphosphoserine is a representative growth inhibitor.</p>

<p>β-Amino Acid Imagabalin Hydrochloride is the voltage-dependent calcium channel ligand for the α2δ subunit.</p>

<p>Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.</p>

<p>Dopropidil, a calcium channel antagonist, is used potentially for the treatment of arrhymia and angina pectoris.</p>

<p>Carboxyamidotriazole is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways.</p>