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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 1045 products of "Proteases/Proteasome"

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  • Sofosbuvir impurity K

    CAS:
    <p>Sofosbuvir impurity K is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.</p>
    Formula:C22H29ClN3O9P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:545.91
  • GSK2818713

    CAS:
    <p>GSK2818713 is a novel Hepatitis C NS5A replication complex inhibitor.</p>
    Formula:C46H56N8O8
    Color and Shape:Solid
    Molecular weight:849.002
  • GLS1 Inhibitor-7


    <p>GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, and</p>
    Formula:C20H17F3N4O3S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:482.5
  • 7-Methoxy obtusifolin

    CAS:
    <p>7-Methoxy obtusifolin (Compound 4) is a chemical compound that acts as a competitive inhibitor of the enzyme tyrosinase, displaying an inhibitory concentration</p>
    Formula:C17H14O6
    Color and Shape:Solid
    Molecular weight:314.29
  • Ellipyrone B


    <p>Ellipyrone B, a γ-pyrone-based macrocyclic polyketide with antihyperglycemic properties, demonstrates inhibitory activity against dipeptidyl peptidase-4 (IC 50</p>
    Formula:C25H38O7
    Color and Shape:Solid
    Molecular weight:450.57
  • Rivulariapeptolides 1155


    <p>Rivulariapeptolides 1155 inhibits chymotrypsin (41.84 nM), elastase (4.94 nM), and proteinase K (56.54 nM).</p>
    Formula:C59H81N9O15
    Color and Shape:Solid
    Molecular weight:1156.33
  • PSI-353661

    CAS:
    <p>PSI-353661 (GS-558093), inhibits HCV's NS5B polymerase; EC90: 8nM (wild-type), 11nM (S282T); active in human hepatocytes.</p>
    Formula:C24H32FN6O8P
    Color and Shape:Solid
    Molecular weight:582.52
  • HCVP-IN-1

    CAS:
    <p>HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.</p>
    Formula:C30H34FN5O3
    Color and Shape:Solid
    Molecular weight:531.632
  • Carboxypeptidase C

    CAS:
    <p>Carboxypeptidase C removes COOH-terminal amino acids and others in peptides for biochemical studies.</p>
    Color and Shape:Solid
  • Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2

    CAS:
    <p>Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effect</p>
    Formula:C47H64N14O10
    Color and Shape:Solid
    Molecular weight:985.1
  • ADAM8-IN-1

    CAS:
    <p>ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC 50 value of 73 nM.</p>
    Formula:C44H44Br4N6O12S2
    Color and Shape:Solid
    Molecular weight:1232.6
  • PS 915

    CAS:
    <p>PS 915 is a substrate for colorimetric assay. It was used for plasma antithrombin.</p>
    Formula:C27H36ClN7O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:590.08
  • Ichorcumab

    CAS:
    <p>Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.</p>
    Color and Shape:Liquid
  • KKI-5

    CAS:
    <p>KKI 5: Serine protease inhibitor, blocks kallikrein &amp; plasmin, potential for cancer therapy &amp; angioedema treatment.</p>
    Formula:C35H55N11O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:773.88
  • Histargin

    CAS:
    <p>Histargin is an enzyme inhibitor separated from Streptomyces roseoviridis.</p>
    Formula:C14H25N7O4
    Color and Shape:Solid
    Molecular weight:355.39
  • Relacatib

    CAS:
    <p>Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.</p>
    Formula:C27H32N4O6S
    Color and Shape:Solid
    Molecular weight:540.64
  • AL-611

    CAS:
    <p>AL-611 is an HCV NS5B polymerase inhibitor ( EC 50 = 5 nM).</p>
    Formula:C25H33F2N6O8P
    Color and Shape:Solid
    Molecular weight:614.544
  • Chymotrypsinogen

    CAS:
    <p>Chymotrypsinogen is an inactive precursor of Chymotrypsin . Chymotrypsin is a serine protease produced by the pancreas [1] [2] .</p>
    Color and Shape:Solid
  • BMS 180742

    CAS:
    <p>BMS 180742 is an exosite inhibitor of thrombin.</p>
    Formula:C67H93N11O22
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1404.52
  • NS5A-IN-1


    <p>NS5A-IN-1 is a proagent of the HCV NS5A inhibitor Pibrentasvir (ABT-530).</p>
    Formula:C72H86F5N10O14P
    Color and Shape:Solid
    Molecular weight:1441.48
  • Procizumab


    <p>Procizumab is a humanized IgG1 antibody that targets dipeptidyl peptidase 3 (DPP3). It shows potential for investigating sepsis. For the isotype control, refer to HumanIgG1kappa, Isotype Control.</p>
    Color and Shape:Odour Liquid
  • Hepcidin-1 (mouse)

    CAS:
    <p>Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion.</p>
    Formula:C111H169N31O35S8
    Color and Shape:Solid
    Molecular weight:2754.24
  • Benzamidine

    CAS:
    <p>Benzamidine is a reversible competitive inhibitor of trypsin with a Ki of 19 μM. It also exhibits inhibitory activity on an enzyme in homogenized porcine sperm acrosome, with a Ki of 4 μM.</p>
    Formula:C7H8N2
    Color and Shape:Solid
    Molecular weight:120.15
  • (-)-Sitagliptin Carbamoyl Glucuronide

    CAS:
    <p>Minor phase II metabolite of DPP-4 inhibitor sitagliptin, found in rat and dog plasma.</p>
    Formula:C23H23F6N5O9
    Color and Shape:Solid
    Molecular weight:627.453
  • GCPII-IN-1

    CAS:
    <p>GCPII-IN-1, a potent PSMA inhibitor, binds with 44.3 nM affinity.</p>
    Formula:C12H21N3O7
    Color and Shape:Solid
    Molecular weight:319.314
  • Tyrosinase-IN-40


    <p>Tyrosinase-IN-40 (Compound 9r) is a competitive inhibitor of tyrosinase, boasting an IC50 value of 17.02 µM and a Ki value of 14.87 µM. This compound also exhibits antioxidant activity and can be utilized in studies related to melanin.</p>
    Formula:C34H29N9O10
    Color and Shape:Solid
    Molecular weight:723.648
  • Thrombin (MW 37kDa)

    CAS:
    <p>Thrombin (MW 37kDa) is a trypsin-like allosteric serine protease.</p>
    Purity:98%
    Color and Shape:Solid
    Molecular weight:37kDa
  • Rivulariapeptolides 1121


    <p>Rivulariapeptolides 1121 inhibits serine proteases: chymotrypsin (IC50=35.52 nM), elastase (13.24 nM), proteinase K (48.05 nM).</p>
    Formula:C56H83N9O15
    Color and Shape:Solid
    Molecular weight:1122.31
  • α 1 Antichymotrypsin, Human Plasma

    CAS:
    <p>Alpha 1 Antichymotrypsin, Human Plasma is an inhibitor of serine proteases. This compound is present in amyloid lesions associated with Alzheimer's disease and can be utilized in Alzheimer's research.</p>
    Color and Shape:Solid
  • MMP-9-IN-6

    CAS:
    <p>MMP-9-IN-6: MMP-9 inhibitor, IC50 of 50 µM, anti-ulcer, potential anti-tumor, for tissue repair studies.</p>
    Formula:C25H19NO2
    Purity:99.75%
    Color and Shape:Soild
    Molecular weight:365.42
  • Ecallantide TFA


    <p>Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention of</p>
    Color and Shape:Odour Solid
  • Clathrin-IN-1

    CAS:
    <p>Pitstop 2 inhibits clathrin-mediated endocytosis, targeting clathrin's terminal domain, with potential in cancer research.</p>
    Formula:C20H13BrN2O3S2
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:473.36
  • PPACK II

    CAS:
    <p>PPACK II is an irreversible and specific glandular and plasma kallikreins inhibitor [1] .</p>
    Formula:C25H33ClN6O3
    Color and Shape:Solid
    Molecular weight:501.02
  • Fotagliptin

    CAS:
    <p>Fotagliptin is a dipeptidyl peptidase IV inhibitor.</p>
    Formula:C17H19FN6O
    Color and Shape:Solid
    Molecular weight:342.37
  • Gly-Pro-pNA hydrochloride

    CAS:
    <p>Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase</p>
    Formula:C13H17ClN4O4
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:328.75
  • Cepeginterferon alfa-2b

    CAS:
    <p>Cepeginterferon alfa-2b: pegylated interferon with 20 kDa PEG for HCV, PV, ET research.</p>
    Color and Shape:Liquid
  • Anticancer agent 114


    <p>Anticancer agent 114: oral dipeptide boronic acid, proteasome inhibitor, IC 50 = 2.2 nM, halts RPMI-8226 cell growth, for multiple myeloma research.</p>
    Formula:C28H33BF6N2O7
    Color and Shape:Solid
    Molecular weight:634.37
  • Cathepsin D and E FRET Substrate

    CAS:
    <p>Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.</p>
    Formula:C85H122N22O19
    Color and Shape:Solid
    Molecular weight:1756.046
  • Ac-VDQQD-pNA

    CAS:
    <p>Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).</p>
    Formula:C31H43N9O14
    Color and Shape:Solid
    Molecular weight:765.73
  • H-Gly-Pro-Hyp-OH

    CAS:
    <p>H-Gly-Pro-Hyp-OH is a potent and oral anti-photoaging collagen peptide and improves the hydration of human skin, elasticity and anti-wrinkle properties.</p>
    Formula:C12H19N3O5
    Purity:98.47%
    Color and Shape:Solid
    Molecular weight:285.3
  • Cerpegin

    CAS:
    <p>Cerpegin, a pyridine ketone fused c-lactone, acts as an inhibitor of the 20S proteasome. It possesses pharmacological properties as a neuropsychiatric sedative, anti-inflammatory, analgesic, and exhibits anti-ulcer activity.</p>
    Formula:C10H11NO3
    Color and Shape:Solid
    Molecular weight:193.2
  • MMP Inhibitor 4


    <p>MMP Inhibitor4 (compound 4 B) is an effective MMP inhibitor with anti-proliferative properties. It induces cell cycle arrest at the subG1 phase and reduces the mRNA expression of MMP2, MMP9, and VEGFA.</p>
    Formula:C16H18BrClN2O5
    Color and Shape:Solid
    Molecular weight:433.68
  • Apovincamine

    CAS:
    <p>Apovincamine is a vinca alkaloid and a chemical precursor of Vinpocetine, which is a derivative of Vincamine with vasodilating activity.</p>
    Formula:C21H24N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:336.44
  • Talabostat isomer mesylate


    <p>Talabostat isomer mesylate, a PT100/Val-boroPro variant, is a potent oral DPP-IV inhibitor (Ki: 0.18 nM).</p>
    Formula:C10H23BN2O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:310.18
  • BMS-767778

    CAS:
    <p>BMS-767778, a DPP-4 inhibitor, is used potentially for the treatment of type 2 diabetes.</p>
    Formula:C19H20Cl2N4O2
    Color and Shape:Solid
    Molecular weight:407.29
  • Tiprelestat

    CAS:
    <p>Tiprelestat: strong inhibitor of human neutrophil elastase, anti-inflammatory, antimicrobial, used in inflammation/immune research.</p>
    Formula:C254H416N72O75S10
    Color and Shape:Solid
    Molecular weight:5999.09
  • Nitidanin


    <p>Nitidanin is a useful organic compound for research related to life sciences and the catalog number is T125599.</p>
    Formula:C21H24O8
    Color and Shape:Solid
    Molecular weight:404.415
  • NVP-DPP728 dihydrochloride

    CAS:
    <p>NVP-DPP728 dihydrochloride is a potent, selective DPP-IV inhibitor with a Ki of 11 nM, useful in diabetes research.</p>
    Formula:C15H20Cl2N6O
    Color and Shape:Solid
    Molecular weight:371.27
  • RJS308


    <p>RJS308 is a PROTAC degrader of cyclosporin A (cyclosporin A) with a DC50 of 284 nM. It exhibits antiviral activity by inhibiting the replication of HIV-1 and HCV. (Pink: ligand for target protein CypA ligand-2; Black: linker; Blue: ligand for E3 ligase VHL (S,R,S)-AHPC-Me)</p>
    Formula:C63H75N13O11S
    Color and Shape:Solid
    Molecular weight:1222.42
  • α 1(I) Collagen (614-639), human

    CAS:
    <p>This is a peptide inhibitor of collagen fibrillar matrix assembly.</p>
    Formula:C134H189N37O39
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2942.16