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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 985 products of "Proteases/Proteasome"

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  • Acetyl-Calpastatin(184-210)(human), Negative Control


    Acetyl-Calpastatin(184-210)(human), Negative Control is a control scrambled peptide corresponding to Acetyl-Calpastatin(184-210)(human). Acetyl-Calpastatin(184-210)(human) functions as a potent, selective, and reversible calpain inhibitor.
    Formula:C142H230N36O44S
    Molecular weight:3175.65874

    Ref: TM-TP3489

    10mg
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    50mg
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  • Nitidanin


    Nitidanin is a useful organic compound for research related to life sciences and the catalog number is T125599.
    Formula:C21H24O8
    Color and Shape:Solid
    Molecular weight:404.415

    Ref: TM-T125599

    1mg
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    5mg
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  • Cathepsin L-IN-5


    CathepsinL-IN-5 (D6-3) is a potent inhibitor of Cathepsin L (CatL) with an IC50 value of 0.27 nM. It effectively blocks the function of CatL and significantly impedes the entry of SARS-CoV-2 pseudovirus into cells by inhibiting the cleavage of the spike protein. CathepsinL-IN-5 is applicable for research on infections.

    Ref: TM-T200694

    10mg
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    50mg
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  • RJS308


    RJS308 is a PROTAC degrader of cyclosporin A (cyclosporin A) with a DC50 of 284 nM. It exhibits antiviral activity by inhibiting the replication of HIV-1 and HCV. (Pink: ligand for target protein CypA ligand-2; Black: linker; Blue: ligand for E3 ligase VHL (S,R,S)-AHPC-Me)
    Formula:C63H75N13O11S
    Color and Shape:Solid
    Molecular weight:1222.42

    Ref: TM-T205591

    10mg
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    50mg
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  • N-CBZ-Phe-Arg-AMC TFA


    N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.
    Formula:C35H37F3N6O8
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:726.7

    Ref: TM-T76010

    1mg
    52.00€
    5mg
    109.00€
    10mg
    160.00€
    25mg
    314.00€
    50mg
    498.00€
  • Leptosphaerodione

    CAS:
    Leptosphaerodione from Remotididymella sp.: a potent UPS inhibitor with 3.2 μM IC50 in HeLa cells; anti-tumor.
    Formula:C21H22O5
    Color and Shape:Solid
    Molecular weight:354.4

    Ref: TM-T75488

    5mg
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    50mg
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  • HCVP-IN-1

    CAS:
    HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.
    Formula:C30H34FN5O3
    Color and Shape:Solid
    Molecular weight:531.632

    Ref: TM-T41002

    5mg
    873.00€
  • Paritaprevir dihydrate

    CAS:
    Paritaprevir dihydrate: potent oral HCV NS3/4A inhibitor (EC50: 0.21-1 nM), SARS-CoV-3CL blocker (IC50: 1.31 μM), metabolized by CYP3A, boosted by Ritonavir.
    Formula:C40H47N7O9S
    Color and Shape:Solid
    Molecular weight:801.91

    Ref: TM-T73898

    5mg
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    50mg
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  • Dansyl-Glu-Gly-Arg-Chloromethylketone

    CAS:
    Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically impedes serine/threonine proteases and has been shown to inhibit activated
    Formula:C26H36ClN7O7S
    Color and Shape:Solid
    Molecular weight:626.12

    Ref: TM-T80094

    5mg
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    50mg
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  • L 659286

    CAS:
    L 659286 is one kind of cephalosporin derivative.
    Formula:C17H21N5O7S2
    Color and Shape:Solid
    Molecular weight:471.51

    Ref: TM-T32460

    25mg
    1,369.00€
  • TP0628103 TFA

    CAS:
    TP0628103 (Compound 18) TFA is a selective MMP-7 inhibitor with an IC50 value of 0.17 nM, playing a significant role in cancer and fibrosis.
    Formula:C53H68ClF6N11O13S
    Color and Shape:Solid
    Molecular weight:1248.68

    Ref: TM-T210971

    10mg
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  • Sulodexide

    CAS:
    Sulodexide is an orally administered combination of glycosaminoglycans, consisting of low molecular weight heparin (80%) and dermatan sulfate (20%). It demonstrates antithrombotic properties by interacting with antithrombin III (AT III) and heparin cofactor II (HC II), and by inhibiting thrombin formation. Additionally, sulodexide enhances profibrinolytic activity by releasing tissue plasminogen activator (tPA). It also offers endothelial protection, possesses anti-inflammatory effects, and alleviates chronic venous disease.
    Color and Shape:Solid

    Ref: TM-T88323

    10mg
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    50mg
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  • Ellipyrone A


    Ellipyrone A: γ-pyrone macrocycle, inhibits DPP-4 (IC50=0.35mM), α-glucosidase (IC50=0.74mM), α-amylase (IC50=0.59mM).
    Formula:C25H34O8
    Color and Shape:Solid
    Molecular weight:462.53

    Ref: TM-T75492

    5mg
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    50mg
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  • Leptosin D

    CAS:
    Leptosin D, a thiodiketopiperazine alkaloid derived from mushrooms, effectively inhibits tyrosinase activity, demonstrating an inhibition concentration (IC50)
    Formula:C25H24N4O3S2
    Color and Shape:Solid
    Molecular weight:492.61

    Ref: TM-T75472

    5mg
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    50mg
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  • Pseudostellarin G

    CAS:
    Pseudostellarin G, a naturally occurring cyclo-octapeptide, exhibits inhibitory activity against tyrosinase and suppresses melanin production.
    Formula:C42H56N8O9
    Color and Shape:Solid
    Molecular weight:816.94

    Ref: TM-TP2861

    10mg
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    50mg
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  • CTTHWGFTLC, CYCLIC

    CAS:
    CTT Gelatinase Inhibitor peptide blocks MMP-2/9, hindering cancer by stopping tumor growth.
    Formula:C52H71N13O14S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1166.33

    Ref: TM-TP1501

    100mg
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    500mg
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  • Z-Leu-Tyr-Chloromethylketone

    CAS:
    Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].
    Formula:C24H29ClN2O5
    Color and Shape:Solid
    Molecular weight:460.95

    Ref: TM-T80103

    5mg
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    50mg
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  • Histatin 5 TFA


    Histatin 5 TFA effectively inhibits host matrix metalloproteinases (MMP-2) and (MMP-9), demonstrating inhibition concentrations (IC 50s) of 0.57 μM and 0.25 μM
    Formula:C135H196N51F3O35
    Color and Shape:Solid
    Molecular weight:3150.31

    Ref: TM-T75755

    5mg
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    50mg
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  • FXIIa-IN-1

    CAS:
    XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor with an apparent inhibition constant (K i app) of 97.8 nM, utilized in the study of thrombosis [1].
    Formula:C21H16N2O6
    Color and Shape:Soild
    Molecular weight:392.36

    Ref: TM-T82361

    5mg
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    50mg
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  • Phosphorylase Kinase β-Subunit Fragment (420-436)

    CAS:
    Phosphorylase Kinase β-Subunit Fragment (420-436) is a peptide fragment (430-436) derived from the β-Subunit of phosphorylase kinase.
    Formula:C79H131N31O25S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1947.14

    Ref: TM-TP1056

    100mg
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    500mg
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  • GSK2818713

    CAS:
    GSK2818713 is a novel Hepatitis C NS5A replication complex inhibitor.
    Formula:C46H56N8O8
    Color and Shape:Solid
    Molecular weight:849.002

    Ref: TM-T38858

    5mg
    922.00€
  • CRA-2059 hydrochloride


    CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].
    Color and Shape:Solid

    Ref: TM-T38051

    5mg
    315.00€
    10mg
    492.00€
    25mg
    960.00€
  • Ecallantide TFA


    Ecallantide (DX-88) TFA, a specific recombinant plasma kallikrein inhibitor, directly inhibits bradykinin production and is indicated for the prevention of
    Color and Shape:Odour Solid

    Ref: TM-T82510

    5mg
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    50mg
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  • Sitagliptin fenilalanil hydrochloride

    CAS:
    Sitagliptin phenylalanine hydrochloride, a dipeptidyl peptidase-4 (DPP-4) inhibitor [1], is a chemical compound utilized in medical applications.
    Formula:C25H25ClF6N6O2
    Color and Shape:Solid
    Molecular weight:590.95

    Ref: TM-T74592

    2mg
    85.00€
  • AR-H067637

    CAS:
    AR-H067637 is a fast-acting, reversible thrombin inhibitor with K(i) 2-4 nM; it also reduces clot-bound thrombin and platelet activation/aggregation.
    Formula:C21H21ClF2N4O4
    Color and Shape:Solid
    Molecular weight:466.87

    Ref: TM-T26657

    25mg
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  • Zetomipzomib maleate

    CAS:
    Zetomipzomib maleate (KZR-616) selectively targets LMP7/2 in immunoproteasomes, potential for autoimmune research.
    Formula:C34H46N4O12
    Color and Shape:Solid
    Molecular weight:702.758

    Ref: TM-T39653

    5mg
    1,341.00€
  • Platelet aggregation-IN-1


    Platelet aggregation-IN-1 (Compound 10e) acts as an inhibitor of platelet aggregation and can achieve complete (100%) inhibition of thrombin-induced platelet aggregation at a concentration of 50 μM.
    Formula:C18H13N3O4
    Molecular weight:335.09061

    Ref: TM-T210149

    10mg
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    50mg
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  • CRA-2059 TFA


    CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].
    Color and Shape:Solid

    Ref: TM-T38052

    5mg
    1,295.00€
  • DPP8/9-IN-1


    DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.
    Color and Shape:Odour Solid

    Ref: TM-T206718

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  • Ac-Phe-Gly-pNA

    CAS:
    Ac-Phe-Gly-pNA is the chymotrypsin specific substrate [1] .
    Formula:C19H20N4O5
    Color and Shape:Solid
    Molecular weight:384.39

    Ref: TM-T74692

    5mg
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    50mg
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  • Histatin 5

    CAS:
    Histatin 5, a human saliva peptide, blocks MMP-2 and MMP-9 at IC50s of 0.57/0.25 μM and kills fungi.
    Formula:C133H195N51O33
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3036.29

    Ref: TM-TP1741

    1mg
    163.00€
    5mg
    562.00€
    10mg
    892.00€
  • PSI-7409

    CAS:

    PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).

    Formula:C10H16FN2O14P3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:500.16

    Ref: TM-T12572

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  • SL44


    SL44 is an agonist of human caseinolytic protease P (HsClpP) with an EC50 of 1.30 μM. It inhibits LM3 proliferation with an IC50 of 3.1 μM and induces apoptosis in liver cancer cells by degrading respiratory chain complex subunits. In mouse models, SL44 demonstrates antitumor activity without significant toxicity (LD50=400 mg/kg) and exhibits favorable pharmacokinetic properties in rat models.
    Formula:C22H20ClFN4O
    Molecular weight:410.13097

    Ref: TM-T210251

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  • Tyrosinase/elastase-IN-1


    Tyrosinase/elastase-IN-1, a triterpenoid extracted from the leaves of Rubus fraxinifolius, exhibits inhibitory activities against both tyrosinase and elastase
    Formula:C33H52O5
    Color and Shape:Solid
    Molecular weight:528.76

    Ref: TM-T74243

    5mg
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    50mg
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  • MK-6169

    CAS:
    MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.
    Formula:C54H62FN9O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1016.2

    Ref: TM-T24476

    25mg
    1,369.00€
  • Fotagliptin benzoate

    CAS:
    Fotagliptin benzoate, a DPP-4 inhibitor (IC50=2.27 nM), is safe in rats/dogs, useful for Type 2 diabetes research.
    Formula:C24H25FN6O3
    Color and Shape:Solid
    Molecular weight:464.49

    Ref: TM-T73875

    5mg
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    50mg
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  • Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2

    CAS:
    Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic probe for MMP-1 and MMP-9 detection, releasing fluorescent Nma upon cleavage (Ex/Em: 340/440 nm).
    Formula:C49H68N14O12S
    Color and Shape:Solid
    Molecular weight:1077.22

    Ref: TM-T36360

    1mg
    384.00€
  • FiVe1

    CAS:
    FiVe1 is a vimentin-binding compound that disrupts mitosis in cancer cells, causing cell death, with an IC50 of 234 nM in FOXC2-HMLER.
    Formula:C18H16Cl2N4
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:359.25

    Ref: TM-T9657

    1mg
    86.00€
    5mg
    182.00€
    10mg
    274.00€
    25mg
    495.00€
    50mg
    745.00€
    100mg
    1,108.00€
    1mL*10mM (DMSO)
    To inquire
  • Rivulariapeptolides 1185


    Rivulariapeptolides 1185 inhibits serine proteases; IC50: chymotrypsin 13.17 nM, elastase 23.59 nM, proteinase K 55.26 nM.
    Formula:C61H87N9O15
    Color and Shape:Solid
    Molecular weight:1186.39

    Ref: TM-T75649

    5mg
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    50mg
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  • MMP-12 Inhibitor

    CAS:

    MMP-12 Inhibitor is a selective inhibitor of MMP-12 with IC50s of 2, 160, 320, and 22.3 nM for human, mouse, rat, and sheep MMP-12.

    Formula:C19H20N2O7S
    Purity:97.51% - 99.96%
    Color and Shape:Soild
    Molecular weight:420.44

    Ref: TM-T60083

    1mg
    185.00€
    5mg
    425.00€
    10mg
    642.00€
    25mg
    1,096.00€
    50mg
    1,643.00€
    100mg
    2,465.00€
  • Trivalent hydroxyarsinothricn


    Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.
    Formula:C4H10AsNO4
    Molecular weight:210.98258

    Ref: TM-T210094

    10mg
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  • Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2

    CAS:
    Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effect
    Formula:C47H64N14O10
    Color and Shape:Solid
    Molecular weight:985.1

    Ref: TM-T76347

    5mg
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    50mg
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  • Acetyl-Hirudin (54-65) (sulfated)

    CAS:
    Acetyl-Hirudin (54-65) (sulfated) binds thrombin-rHCII(L444R), blocking rHCII's N-terminal/thrombin exosite I interaction, stabilizing the complex.
    Formula:C68H95N13O29S
    Color and Shape:Solid
    Molecular weight:1590.63

    Ref: TM-T38645

    100mg
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    500mg
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  • Elastatinal

    CAS:
    Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.
    Formula:C21H36N8O7
    Color and Shape:Yellowish Solid
    Molecular weight:512.56

    Ref: TM-T20130

    5mg
    304.00€
    10mg
    575.00€
    25mg
    1,251.00€
  • Sofosbuvir impurity J

    CAS:
    Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
    Formula:C22H30FN4O8P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:528.47

    Ref: TM-T12965

    25mg
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  • Dutogliptin tartrate

    CAS:
    Dutogliptin tartrate is an effective and selective oral dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
    Formula:C14H26BN3O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:391.18

    Ref: TM-T11127

    25mg
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    50mg
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    100mg
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  • Sadopeptins B


    Sadopeptins B, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].
    Formula:C48H69N9O13S
    Color and Shape:Solid
    Molecular weight:1012.18

    Ref: TM-T75624

    5mg
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    50mg
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  • Nostosin G


    Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).
    Formula:C25H33N5O6
    Color and Shape:Solid
    Molecular weight:499.56

    Ref: TM-T75647

    5mg
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    50mg
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  • L-Methionine-DL-sulfoximine

    CAS:
    MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.
    Formula:C5H12N2O3S
    Purity:99.56% - ≥98%
    Color and Shape:White Crystalline Powder
    Molecular weight:180.23

    Ref: TM-T41299

    50mg
    39.00€
    100mg
    52.00€
  • Atecegatran TFA

    CAS:
    Atecegatran TFA is often used as an anticoagulant and can be used to treat cardiovascular disease.
    Formula:C23H22ClF5N4O6
    Purity:97.47% - 99.77%
    Color and Shape:Solid
    Molecular weight:580.89

    Ref: TM-T30191L

    1mg
    185.00€
    5mg
    459.00€
    50mg
    1,415.00€
    100mg
    1,872.00€