
Proteases/Proteasome
Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.
Subcategories of "Proteases/Proteasome"
- Acetyl-CoA Carboxylase(36 products)
- Cysteine Protease(110 products)
- DPP-4(23 products)
- Glutaminase(45 products)
- HIV Protease(506 products)
- PAI-1(26 products)
- Protease Inhibitors(50 products)
- Protease-activated Receptor(54 products)
- Proteasome(92 products)
- Serine Protease(55 products)
- p97(15 products)
Show 3 more subcategories
Found 1032 products of "Proteases/Proteasome"
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VD2173
CAS:VD2173: a macrocyclic peptide that inhibits HGF serine proteases, matriptase, and hepsin, potentially for lung cancer research.Formula:C31H45N9O6SColor and Shape:SolidMolecular weight:671.815-epi-Arvestonate A
CAS:5-epi-Arvestonate A, a sesquiterpenoid from Seriphidium transiliense, stimulates melanogenesis and suppresses IFN-γ-chemokine in HaCaT cells.
Formula:C16H26O5Color and Shape:SolidMolecular weight:298.37Ichorcumab
CAS:Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.
Color and Shape:LiquidTP0628103
CAS:TP0628103 (compound 18) acts as a selective MMP-7 inhibitor, exhibiting a potent IC 50 value of 0.17 nM, which is crucial in the contexts of cancer and fibrosis [1].Formula:C51H67ClF3N11O11SColor and Shape:SolidMolecular weight:1134.66HCV-IN-7 hydrochloride
CAS:HCV-IN-7 hydrochloride: Oral, potent HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.Formula:C40H50Cl2N8O6SPurity:98%Color and Shape:SolidMolecular weight:841.85FiVe1
CAS:FiVe1 is a vimentin-binding compound that disrupts mitosis in cancer cells, causing cell death, with an IC50 of 234 nM in FOXC2-HMLER.
Formula:C18H16Cl2N4Purity:99.67%Color and Shape:SolidMolecular weight:359.25Sofosbuvir impurity A
CAS:Sofosbuvir impurity A is an diastereoisomer of Sofosbuvir. Sofosbuvir is anHCV RNA replication inhibitor ,with potent anti-hepatitis C virus activity.Formula:C22H29FN3O9PPurity:98%Color and Shape:SolidMolecular weight:529.45SL44
SL44 is an agonist of human caseinolytic protease P (HsClpP) with an EC50 of 1.30 μM. It inhibits LM3 proliferation with an IC50 of 3.1 μM and induces apoptosis in liver cancer cells by degrading respiratory chain complex subunits. In mouse models, SL44 demonstrates antitumor activity without significant toxicity (LD50=400 mg/kg) and exhibits favorable pharmacokinetic properties in rat models.Formula:C22H20ClFN4OMolecular weight:410.13097LM11
LM11 is a transglutaminase 2 (TG2) inhibitor that exhibits activity against glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.
Formula:C26H18Cl2N4O5Molecular weight:536.06543H-Gly-Pro-Hyp-OH
CAS:H-Gly-Pro-Hyp-OH is a potent and oral anti-photoaging collagen peptide and improves the hydration of human skin, elasticity and anti-wrinkle properties.Formula:C12H19N3O5Purity:98.47%Color and Shape:SolidMolecular weight:285.3TAPI1 acetate
TAPI1 acetate (TNF-α processing inhibitor-1) is a TACE (ADAM17) inhibitor that inhibits shedding of TNF-α cytokine receptors; MMP inhibitor .Formula:C28H41N5O7Purity:98.82% - 99.94%Color and Shape:SolidMolecular weight:559.65PPACK II
CAS:PPACK II is an irreversible and specific glandular and plasma kallikreins inhibitor [1] .Formula:C25H33ClN6O3Color and Shape:SolidMolecular weight:501.02PSI-7409
CAS:PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).
Formula:C10H16FN2O14P3Purity:98%Color and Shape:SolidMolecular weight:500.16Dutogliptin tartrate
CAS:Dutogliptin tartrate is an effective and selective oral dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.Formula:C14H26BN3O9Purity:98%Color and Shape:SolidMolecular weight:391.18Linagliptin Methyldimer
CAS:Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.Formula:C50H56N16O4Purity:99.91%Color and Shape:SolidMolecular weight:945.08Phaeosphaone D
CAS:Phaeosphaone D, a thiodiketopiperazine from Phaeosphaeria fuckelii fungus, inhibits mushroom tyrosinase (IC50 = 33.2 μM).Formula:C20H27N3O3S2Color and Shape:SolidMolecular weight:421.58MK-6169
CAS:MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.Formula:C54H62FN9O8SPurity:98%Color and Shape:SolidMolecular weight:1016.2Nostosin G
Nostosin G, a linear peptide with Hpla, Hty, and argininal, inhibits trypsin effectively (IC50 = 0.1 μM).Formula:C25H33N5O6Color and Shape:SolidMolecular weight:499.56PROTAC CG167
PROTAC CG167 is a potent and selective PROTAC degrader of CypA. It degrades CypA in a dose-dependent manner in Jurkat cells, with a DC50 of 123 nM. Additionally, PROTAC CG167 exhibits antiviral activity by inhibiting HIV-1 and HCV. (Pink: CypA Ligand; Black: Linker; Blue: E3LigaseLigand)Formula:C65H79N13O11SColor and Shape:SolidMolecular weight:1250.47Befovacimab
CAS:Befovacimab, a human IgG2 antibody, targets TFPI for hemophilia A/B research.Color and Shape:Liquid

