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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 1045 products of "Proteases/Proteasome"

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  • Tyrosinase-IN-33

    CAS:
    <p>Tyrosinase-IN-33 (compound 5), a pyridine-based compound, acts as an effective inhibitor of diphenolase activity in mushroom tyrosinase. It significantly reduces enzyme activity with an IC50 of 9.0 μM.</p>
    Formula:C19H17NS2
    Color and Shape:Solid
    Molecular weight:323.48
  • BAY-7598

    CAS:
    <p>BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).</p>
    Formula:C28H31N3O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:505.56
  • GW311616 hydrochloride

    CAS:
    <p>GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).</p>
    Formula:C19H32ClN3O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:433.99
  • Tyrosinase-IN-35

    CAS:
    <p>Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.</p>
    Formula:C17H15N5OS
    Color and Shape:Solid
    Molecular weight:337.40
  • Tyrosinase-IN-29

    CAS:
    <p>Tyrosinase-IN-29 (compound 5c) is an effective inhibitor of abTYR tyrosinase, demonstrating an IC50 value of 6.11 μM. It is suitable for further research into the inhibition of excessive skin pigmentation.</p>
    Formula:C10H9NO2
    Color and Shape:Solid
    Molecular weight:175.18
  • SD-7300

    CAS:
    <p>SD-7300 (SC-81490) functions as an orally active inhibitor targeting MMP-2, MMP-9, and MMP-13, exhibiting potent inhibition with K_i values of 0.03, 0.01, and 0.03 nM, respectively. By inhibiting these metalloproteinases, SD-7300 effectively reduces extracellular matrix degradation by tumor cells, thereby curbing their invasion and metastasis. Additionally, this compound acts as a dose-dependent inhibitor of mouse corneal angiogenesis and prevents interleukin-1-induced degradation of bovine cartilage. SD-7300 is applicable in the study of breast cancer.</p>
    Formula:C21H30F3N3O7S
    Color and Shape:Solid
    Molecular weight:525.54
  • Tyrosinase-IN-20

    CAS:
    <p>Tyrosinase-IN-20 (compound 6a) acts as a potent Tyrosinase inhibitor, demonstrating an IC 50 value of 28.50 μM [1].</p>
    Formula:C17H18N2O2S
    Color and Shape:Solid
    Molecular weight:314.4
  • RJF02215

    CAS:
    <p>RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.</p>
    Formula:C17H12ClN3OS3
    Color and Shape:Solid
    Molecular weight:405.95
  • AMG-222 tosylate

    CAS:
    <p>AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.</p>
    Formula:C39H47N9O6S
    Color and Shape:Solid
    Molecular weight:769.91
  • Narlaprevir

    CAS:
    <p>Narlaprevir (SCH 900518) is an HCV NS3 inhibitor with anti-HCV activity, inhibiting SARS-CoV-2, and useful in virus infection research.</p>
    Formula:C36H61N5O7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:707.96
  • Vaniprevir

    CAS:
    <p>Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.</p>
    Formula:C38H55N5O9S
    Purity:97.41%
    Color and Shape:Solid
    Molecular weight:757.94
  • IDX184

    CAS:
    <p>IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3</p>
    Formula:C25H35N6O9PS
    Purity:97.15%
    Color and Shape:Solid
    Molecular weight:626.62
  • JTK-109

    CAS:
    <p>JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.</p>
    Formula:C37H33ClFN3O4
    Purity:98.48% - 99.68%
    Color and Shape:Solid
    Molecular weight:638.13
  • MIV-247

    CAS:
    <p>MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.</p>
    Formula:C17H24F3N3O4
    Purity:99.27%
    Color and Shape:Solid
    Molecular weight:391.39
  • PD 151746

    CAS:
    <p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>
    Formula:C11H8FNO2S
    Purity:98.63% - ≥95%
    Color and Shape:Solid
    Molecular weight:237.25
  • Sebetralstat

    CAS:
    <p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>
    Formula:C26H26FN5O4
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:491.51
  • ALLM

    CAS:
    <p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>
    Formula:C19H35N3O4S
    Purity:98%
    Color and Shape:White Powder
    Molecular weight:401.56

    Ref: TM-T14187

    50mg
    Discontinued
    100mg
    Discontinued
    Discontinued product
  • ABT-072 potassium trihydrate

    CAS:
    <p>ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).</p>
    Formula:C24H32KN3O8S
    Color and Shape:Solid
    Molecular weight:561.69

    Ref: TM-T38510

    ne
    Discontinued
    Discontinued product
  • IPN60090 dihydrochloride

    CAS:
    <p>IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.</p>
    Formula:C24H29Cl2F3N8O3
    Color and Shape:Solid
    Molecular weight:605.44

    Ref: TM-T39544

    ne
    Discontinued
    Discontinued product