
Proteases/Proteasome
Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.
Subcategories of "Proteases/Proteasome"
- Acetyl-CoA Carboxylase(34 products)
- Cysteine Protease(96 products)
- DPP-4(20 products)
- Glutaminase(40 products)
- HIV Protease(447 products)
- PAI-1(25 products)
- Protease Inhibitors(50 products)
- Protease-activated Receptor(54 products)
- Proteasome(94 products)
- Serine Protease(50 products)
- p97(14 products)
Show 3 more subcategories
Found 1045 products of "Proteases/Proteasome"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Tyrosinase-IN-33
CAS:<p>Tyrosinase-IN-33 (compound 5), a pyridine-based compound, acts as an effective inhibitor of diphenolase activity in mushroom tyrosinase. It significantly reduces enzyme activity with an IC50 of 9.0 μM.</p>Formula:C19H17NS2Color and Shape:SolidMolecular weight:323.48BAY-7598
CAS:<p>BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).</p>Formula:C28H31N3O6Purity:98%Color and Shape:SolidMolecular weight:505.56GW311616 hydrochloride
CAS:<p>GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).</p>Formula:C19H32ClN3O4SPurity:98%Color and Shape:SolidMolecular weight:433.99Tyrosinase-IN-35
CAS:<p>Tyrosinase-IN-35 (compound 6g), exhibiting a IC 50 value of 2.09 μM, serves as a more effective inhibitor of human tyrosinase compared to Kojic Acid (IC 50: 16.38 μM). At concentrations of 4 μM and 8 μM, this compound effectively lowers melanin levels in melanoma B16F10 cells in vitro.</p>Formula:C17H15N5OSColor and Shape:SolidMolecular weight:337.40Tyrosinase-IN-29
CAS:<p>Tyrosinase-IN-29 (compound 5c) is an effective inhibitor of abTYR tyrosinase, demonstrating an IC50 value of 6.11 μM. It is suitable for further research into the inhibition of excessive skin pigmentation.</p>Formula:C10H9NO2Color and Shape:SolidMolecular weight:175.18SD-7300
CAS:<p>SD-7300 (SC-81490) functions as an orally active inhibitor targeting MMP-2, MMP-9, and MMP-13, exhibiting potent inhibition with K_i values of 0.03, 0.01, and 0.03 nM, respectively. By inhibiting these metalloproteinases, SD-7300 effectively reduces extracellular matrix degradation by tumor cells, thereby curbing their invasion and metastasis. Additionally, this compound acts as a dose-dependent inhibitor of mouse corneal angiogenesis and prevents interleukin-1-induced degradation of bovine cartilage. SD-7300 is applicable in the study of breast cancer.</p>Formula:C21H30F3N3O7SColor and Shape:SolidMolecular weight:525.54Tyrosinase-IN-20
CAS:<p>Tyrosinase-IN-20 (compound 6a) acts as a potent Tyrosinase inhibitor, demonstrating an IC 50 value of 28.50 μM [1].</p>Formula:C17H18N2O2SColor and Shape:SolidMolecular weight:314.4RJF02215
CAS:<p>RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.</p>Formula:C17H12ClN3OS3Color and Shape:SolidMolecular weight:405.95AMG-222 tosylate
CAS:<p>AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.</p>Formula:C39H47N9O6SColor and Shape:SolidMolecular weight:769.91Narlaprevir
CAS:<p>Narlaprevir (SCH 900518) is an HCV NS3 inhibitor with anti-HCV activity, inhibiting SARS-CoV-2, and useful in virus infection research.</p>Formula:C36H61N5O7SPurity:98%Color and Shape:SolidMolecular weight:707.96Vaniprevir
CAS:<p>Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.</p>Formula:C38H55N5O9SPurity:97.41%Color and Shape:SolidMolecular weight:757.94IDX184
CAS:<p>IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3</p>Formula:C25H35N6O9PSPurity:97.15%Color and Shape:SolidMolecular weight:626.62JTK-109
CAS:<p>JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.</p>Formula:C37H33ClFN3O4Purity:98.48% - 99.68%Color and Shape:SolidMolecular weight:638.13MIV-247
CAS:<p>MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.</p>Formula:C17H24F3N3O4Purity:99.27%Color and Shape:SolidMolecular weight:391.39PD 151746
CAS:<p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>Formula:C11H8FNO2SPurity:98.63% - ≥95%Color and Shape:SolidMolecular weight:237.25Sebetralstat
CAS:<p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>Formula:C26H26FN5O4Purity:99.85%Color and Shape:SolidMolecular weight:491.512,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
CAS:Formula:C37H48N6O5S2Purity:≥98%Color and Shape:SolidMolecular weight:720.9442ALLM
CAS:<p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>Formula:C19H35N3O4SPurity:98%Color and Shape:White PowderMolecular weight:401.56ABT-072 potassium trihydrate
CAS:<p>ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).</p>Formula:C24H32KN3O8SColor and Shape:SolidMolecular weight:561.69IPN60090 dihydrochloride
CAS:<p>IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.</p>Formula:C24H29Cl2F3N8O3Color and Shape:SolidMolecular weight:605.44

