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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 992 products of "Proteases/Proteasome"

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  • 3-Aminobenzene-1,2-diol

    CAS:
    3-Aminobenzene-1,2-diol (compound C8) is an inhibitor of matrix metalloproteinases (MMP), with IC50 values of 20, 26, 16, and 16.3 μM against MMP-2, MMP-8, MMP-9, and MMP-14, respectively.
    Formula:C6H7NO2
    Color and Shape:Solid
    Molecular weight:125.13

    Ref: TM-T201595

    10mg
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    50mg
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  • HCV NS5B polymerase-IN-2

    CAS:
    HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.
    Formula:C26H24N2O4
    Color and Shape:Solid
    Molecular weight:428.48

    Ref: TM-T204671

    10mg
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    50mg
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  • HCV-IN-40

    CAS:
    HCV-IN-39 is a potent oral drug inhibiting HCV, effective on GT1a (EC50: 0.259μM), GT1b (EC50: 0.434μM), GT1b CES1 (EC50: 0.069μM) replicons.
    Formula:C21H26BrFN3O9P
    Color and Shape:Solid
    Molecular weight:594.32

    Ref: TM-T64202

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • GSK5852


    GSK5852, an HCV NS5B inhibitor, has IC50 of 50 nM; potently fights HCV with EC50 of 3.0 nM for GT1a and 1.7 nM for GT1b.
    Formula:C27H27BF2N2O6S
    Color and Shape:Solid
    Molecular weight:556.39

    Ref: TM-T63936

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • UK 356618

    CAS:

    UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).

    Formula:C34H43N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:557.72

    Ref: TM-T17201

    5mg
    408.00€
    10mg
    710.00€
    25mg
    1,444.00€
  • SMCypI C31


    SMCypIC31, a non-peptide cyclophilin inhibitor, blocks PPIase at 0.1 μM IC50 and fights various HCV genotypes (EC50: 1.20-7.76 μM).
    Formula:C27H30N4O2S
    Color and Shape:Solid
    Molecular weight:474.62

    Ref: TM-T63090

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • Dup-714

    CAS:
    Dup-714 is a thrombin inhibitor.
    Formula:C21H33BN6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:460.33

    Ref: TM-T27220

    25mg
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    50mg
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    100mg
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  • RJF02215

    CAS:
    RJF02215, an MMP-9 inhibitor, exhibits growth inhibitory activity against the ovarian cancer cell line SKOV3. It is utilized in tumor research.
    Formula:C17H12ClN3OS3
    Color and Shape:Solid
    Molecular weight:405.95

    Ref: TM-T89894

    10mg
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    50mg
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  • (1R,3S)-THCCA-Asn


    (1R,3S)-THCCA-Asn (4j) is a selective inhibitor of thrombin (IC50: 0.07-0.14 μM) with anti-thrombotic effects.
    Formula:C24H24N4O6
    Color and Shape:Solid
    Molecular weight:464.47

    Ref: TM-T62949

    25mg
    1,369.00€
    50mg
    1,783.00€
    100mg
    2,250.00€
  • RBx-0597

    CAS:
    RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.
    Formula:C19H20F2N4O2
    Color and Shape:Solid
    Molecular weight:374.384

    Ref: TM-T206740

    10mg
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    50mg
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  • Tilpisertib fosmecarbil

    CAS:
    Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.
    Formula:C35H36ClN8O7P
    Color and Shape:Solid
    Molecular weight:747.14

    Ref: TM-T72292

    25mg
    3,012.00€
    50mg
    3,971.00€
    100mg
    5,510.00€
  • RO5461111

    CAS:
    RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.
    Formula:C27H24F6N4O4S
    Color and Shape:Solid
    Molecular weight:614.56

    Ref: TM-T73220

    25mg
    2,942.00€
    50mg
    4,319.00€
    100mg
    To inquire
  • UK-370106

    CAS:
    UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-
    Formula:C35H44N2O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:572.73

    Ref: TM-T13249

    10mg
    1,009.00€
  • TG-2-IN-4

    CAS:
    TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].
    Formula:C34H40N6O5
    Color and Shape:Solid
    Molecular weight:612.72

    Ref: TM-T87508

    10mg
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    50mg
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  • SAR107375

    CAS:
    SAR107375 is a potent, orally active dual inhibitor of thrombin and factor Xa, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively [1].
    Formula:C24H30ClN5O5S2
    Color and Shape:Solid
    Molecular weight:568.11

    Ref: TM-T87355

    10mg
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    50mg
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  • Marizomib

    CAS:
    Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.
    Formula:C15H20ClNO4
    Purity:98.03% - 99.41%
    Color and Shape:Solid
    Molecular weight:313.78

    Ref: TM-T16012

    1mg
    525.00€
    5mg
    1,121.00€
    100µg
    120.00€
    500µg
    321.00€
  • RDN2150

    CAS:
    RDN2150 (Compound 25), a ZAP-70 inhibitor with an IC50 of 14.6 nM, covalently binds to the C346 residue of ZAP-70, suppressing the expression of CD25 and CD69
    Formula:C28H29ClN8O4
    Color and Shape:Solid
    Molecular weight:577.03

    Ref: TM-T81308

    1mg
    260.00€
    5mg
    580.00€
    10mg
    888.00€
    25mg
    1,783.00€
    50mg
    2,943.00€
    100mg
    3,979.00€
  • SD-7300

    CAS:
    SD-7300 (SC-81490) functions as an orally active inhibitor targeting MMP-2, MMP-9, and MMP-13, exhibiting potent inhibition with K_i values of 0.03, 0.01, and 0.03 nM, respectively. By inhibiting these metalloproteinases, SD-7300 effectively reduces extracellular matrix degradation by tumor cells, thereby curbing their invasion and metastasis. Additionally, this compound acts as a dose-dependent inhibitor of mouse corneal angiogenesis and prevents interleukin-1-induced degradation of bovine cartilage. SD-7300 is applicable in the study of breast cancer.
    Formula:C21H30F3N3O7S
    Color and Shape:Solid
    Molecular weight:525.54

    Ref: TM-T200306

    25mg
    1,639.00€
    50mg
    2,142.00€
    100mg
    2,790.00€
  • IDX184

    CAS:
    IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3
    Formula:C25H35N6O9PS
    Purity:97.15%
    Color and Shape:Solid
    Molecular weight:626.62

    Ref: TM-T27586

    1mg
    172.00€
    5mg
    432.00€
    10mg
    618.00€
    25mg
    973.00€
    50mg
    1,333.00€
  • Vaniprevir

    CAS:
    Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.
    Formula:C38H55N5O9S
    Purity:97.41%
    Color and Shape:Solid
    Molecular weight:757.94

    Ref: TM-T8675

    1mg
    792.00€
    5mg
    1,611.00€
    10mg
    2,178.00€
    25mg
    3,240.00€
    50mg
    4,365.00€