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Proteases/Proteasome

Proteases/Proteasome

Protease and proteasome inhibitors are compounds that block the activity of proteases and the proteasome, which are involved in protein degradation and turnover. These inhibitors are vital for studying the regulation of protein homeostasis, cell cycle control, and apoptosis. Protease and proteasome inhibitors are also used in the treatment of diseases such as cancer, where abnormal protein degradation plays a role in disease progression. By inhibiting proteases or the proteasome, these compounds can induce cell death in cancer cells and are critical tools in both basic research and therapeutic development. At CymitQuimica, we provide a wide range of high-quality protease and proteasome inhibitors to support your research in biochemistry, cell biology, and drug development.

Subcategories of "Proteases/Proteasome"

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Found 993 products of "Proteases/Proteasome"

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  • IDX184

    CAS:
    IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3
    Formula:C25H35N6O9PS
    Purity:97.15%
    Color and Shape:Solid
    Molecular weight:626.62

    Ref: TM-T27586

    1mg
    172.00€
    5mg
    432.00€
    10mg
    618.00€
    25mg
    973.00€
    50mg
    1,333.00€
  • Vaniprevir

    CAS:
    Vaniprevir is a competitive HCV NS3/4A protease inhibitor, an antiviral(hepatitis C virus) drug that acts directly and blocks the viral replication process.
    Formula:C38H55N5O9S
    Purity:97.41%
    Color and Shape:Solid
    Molecular weight:757.94

    Ref: TM-T8675

    1mg
    792.00€
    5mg
    1,611.00€
    10mg
    2,178.00€
    25mg
    3,240.00€
    50mg
    4,365.00€
  • MIV-247

    CAS:
    MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.
    Formula:C17H24F3N3O4
    Purity:99.27%
    Color and Shape:Solid
    Molecular weight:391.39

    Ref: TM-T12051

    1mg
    1,234.00€
    2mg
    1,665.00€
    5mg
    2,475.00€
    10mg
    3,312.00€
    25mg
    4,941.00€
    50mg
    6,688.00€
  • PD 151746

    CAS:
    PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.
    Formula:C11H8FNO2S
    Purity:98.63% - ≥95%
    Color and Shape:Solid
    Molecular weight:237.25

    Ref: TM-T2493

    5mg
    39.00€
    10mg
    62.00€
    25mg
    111.00€
    50mg
    172.00€
    1mL*10mM (DMSO)
    46.00€
  • Sebetralstat

    CAS:

    Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.

    Formula:C26H26FN5O4
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:491.51

    Ref: TM-T39350

    1mg
    35.00€
    5mg
    74.00€
    10mg
    105.00€
    25mg
    187.00€
    50mg
    279.00€
    100mg
    414.00€
  • ABT-072 potassium trihydrate

    CAS:
    ABT-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the HCV NS5B polymerase, administered orally. This compound exhibits potent activity against HCV GT1a (with an EC50 of 1 nM) and HCV GT1b (with an EC50 of 0.3 nM).
    Formula:C24H32KN3O8S
    Color and Shape:Solid
    Molecular weight:561.69

    Ref: TM-T38510

    ne
    Discontinued
    Discontinued product
  • IPN60090 dihydrochloride

    CAS:
    IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.
    Formula:C24H29Cl2F3N8O3
    Color and Shape:Solid
    Molecular weight:605.44

    Ref: TM-T39544

    ne
    Discontinued
    Discontinued product
  • MMP13-IN-2

    CAS:
    MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.
    Formula:C24H19FN6O4S
    Color and Shape:Solid
    Molecular weight:506.51

    Ref: TM-T41079

    ne
    Discontinued
    Discontinued product
  • ALLM

    CAS:
    ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].
    Formula:C19H35N3O4S
    Purity:98%
    Color and Shape:White Powder
    Molecular weight:401.56

    Ref: TM-T14187

    50mg
    Discontinued
    100mg
    Discontinued
    Discontinued product
  • Oxindole

    CAS:

    Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.

    Formula:C8H7NO
    Purity:99.34%
    Color and Shape:Off-White Crystalline Powder
    Molecular weight:133.15

    Ref: TM-FR16741

    1g
    Discontinued
    5g
    Discontinued
    10g
    Discontinued
    Discontinued product
  • Butabindide oxalate

    CAS:
    CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor
    Formula:C19H27N3O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:393.43

    Ref: TM-T22619

    50mg
    Discontinued
    100mg
    Discontinued
    Discontinued product
  • Davelizomib

    CAS:

    Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].

    Formula:C21H26BF2N3O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:481.25

    Ref: TM-T79842

    ne
    Discontinued
    5mg
    Discontinued
    50mg
    Discontinued
    Discontinued product