Stem Cell and Derivatives
Stem cell inhibitors are compounds that specifically target signaling pathways and proteins involved in the maintenance, differentiation, and proliferation of stem cells. These inhibitors are crucial for understanding stem cell biology and for developing strategies to manipulate stem cells for therapeutic purposes, such as regenerative medicine and cancer treatment. By controlling stem cell fate, these inhibitors can help guide stem cell differentiation into specific cell types or prevent unwanted cell growth. At CymitQuimica, we offer a selection of high-quality stem cell inhibitors to support your research in stem cell biology, developmental biology, and regenerative medicine.
Subcategories of "Stem Cell and Derivatives"
- Gamma-secretase(59 products)
- Hedgehog/Smoothened(44 products)
- Hippo pathway(6 products)
- JAK(245 products)
- Porcupine(9 products)
- ROCK(69 products)
- STAT(98 products)
- Stem Cells(484 products)
- TGF-beta/Smad(58 products)
- Wnt/beta-catenin(66 products)
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Found 693 products of "Stem Cell and Derivatives"
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BRD5648
CAS:<p>BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.</p>Formula:C20H23N3OPurity:99.89%Color and Shape:SolidMolecular weight:321.42JAK-IN-26
CAS:<p>JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in</p>Formula:C22H24N6O3Purity:98%Color and Shape:SolidMolecular weight:420.46inS3-54A18
CAS:<p>inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.</p>Formula:C23H16ClNO2Purity:99.68%Color and Shape:SolidMolecular weight:373.83FM-479
CAS:<p>FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.</p>Formula:C25H26N6O2Purity:98%Color and Shape:SolidMolecular weight:442.523Casein kinase 1δ-IN-5
CAS:<p>Casein kinase 1δ-IN-5 is a potent and selective CK-1δ inhibitor, exhibiting an IC50 of 47 nM, and demonstrates neuroprotective and anti-inflammatory effects in</p>Formula:C16H11F3N2OSPurity:98%Color and Shape:SolidMolecular weight:336.33JW 67
CAS:<p>JW 67 is an inhibitor of canonical Wnt pathway signaling.</p>Formula:C21H18N2O6Purity:99.02%Color and Shape:SolidMolecular weight:394.38A 1070722
CAS:<p>A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.</p>Formula:C17H13F3N4O2Purity:99.9%Color and Shape:SolidMolecular weight:362.31JAK-IN-31
CAS:<p>JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,</p>Formula:C21H19N7O2S2Purity:98%Color and Shape:SolidMolecular weight:465.553,7-DMF
CAS:3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Formula:C17H14O4Purity:98%Color and Shape:SolidMolecular weight:282.29ROCK2-IN-2
CAS:<p>ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).</p>Formula:C18H12N6OSPurity:99.65%Color and Shape:SolidMolecular weight:360.39Stafib-2
CAS:<p>Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,</p>Formula:C28H26N2O12P2Purity:98.48%Color and Shape:SolidMolecular weight:644.46JAK-IN-4
CAS:<p>JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.</p>Formula:C18H21N4Na2O6PPurity:98%Color and Shape:SolidMolecular weight:466.341JAK-IN-25
CAS:<p>JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.</p>Formula:C19H17N5O4Purity:98%Color and Shape:SolidMolecular weight:379.37TCS 21311
CAS:<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Formula:C27H25F3N4O4Purity:99.39% - ≥98%Color and Shape:SolidMolecular weight:526.51Lepzacitinib
CAS:<p>Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.</p>Formula:C18H21N5O3Purity:99.85%Color and Shape:SolidMolecular weight:355.39ROCK2-IN-6 hydrochloride
CAS:<p>ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。</p>Formula:C26H22ClF2N7OPurity:98%Color and Shape:SolidMolecular weight:521.95TGFβ-IN-5
CAS:<p>TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.</p>Formula:C20H16N4Purity:99.29% - 99.5%Color and Shape:SolidMolecular weight:312.37ROCK-IN-8
CAS:<p>ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,</p>Formula:C30H25FN4O4SPurity:98%Color and Shape:SolidMolecular weight:556.61Chroman 1
CAS:<p>Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).</p>Formula:C24H28N4O4Purity:99.67% - 99.84%Color and Shape:SolidMolecular weight:436.5JAK-IN-24
CAS:<p>JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.</p>Formula:C20H25N5O2Color and Shape:SolidMolecular weight:367.44Casein kinase 1δ-IN-10
CAS:<p>Casein kinase 1δ-IN-10 is an inhibitor of casein kinase 1δ (CK1δ).</p>Formula:C21H17N3O3Purity:98%Color and Shape:SolidMolecular weight:359.38GSK-3β inhibitor 8
CAS:<p>GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine</p>Formula:C20H20ClN5OSPurity:98.46%Color and Shape:SolidMolecular weight:413.92Upadacitinib tartrate
CAS:<p>Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.</p>Formula:C21H33F3N6O11Purity:98%Color and Shape:SolidMolecular weight:602.521Ginsenoside Rk1
CAS:<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Formula:C42H70O12Purity:98.46% - 99.13%Color and Shape:SolidMolecular weight:767TCJL37
CAS:<p>TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.</p>Formula:C17H11ClF2N4O2Color and Shape:SolidMolecular weight:376.74BMS-983970
CAS:<p>BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.</p>Formula:C26H26F4N4O3Color and Shape:SolidMolecular weight:518.5Tyk2-IN-9
CAS:<p>Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.</p>Formula:C20H17N9Purity:98%Color and Shape:SolidMolecular weight:383.41JAK-IN-17
<p>"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."</p>Formula:C33H38F2N6O8Color and Shape:SolidMolecular weight:684.69BMS-932481
CAS:<p>BMS-932481 is a γ-secretase modulator.</p>Formula:C24H24FN7OColor and Shape:SolidMolecular weight:445.49TP0427736
CAS:<p>TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.</p>Formula:C14H10N4S2Purity:97.26%Color and Shape:SolidMolecular weight:298.39ML115
CAS:<p>ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.</p>Formula:C15H15ClN2O4Purity:99.97%Color and Shape:SolidMolecular weight:322.74BT-GSI
<p>BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma & anti-resorptive for multiple myeloma/bone disease research.</p>Formula:C26H46BrN5O10P2Color and Shape:SolidMolecular weight:730.52GSM-1
CAS:<p>GSM-1 is a modulator of γ-Secretase.</p>Formula:C26H31ClF3NO2Color and Shape:SolidMolecular weight:481.98Itacnosertib (hydrocholide)
CAS:<p>Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].</p>Formula:C26H29ClN8OColor and Shape:SolidMolecular weight:505.01Brepocitinib
CAS:<p>Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).</p>Formula:C18H21F2N7OPurity:99.82%Color and Shape:SolidMolecular weight:389.4JAK-IN-5
CAS:<p>JAK-IN-5 is a JAK inhibitor.</p>Formula:C27H31FN6OPurity:98.1% - 99.37%Color and Shape:SolidMolecular weight:474.57MRK-560
CAS:<p>MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.</p>Formula:C19H17ClF5NO4S2Purity:98.87%Color and Shape:SolidMolecular weight:517.92JAK2-IN-4
CAS:<p>JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.</p>Formula:C23H27N5O4SPurity:98%Color and Shape:SolidMolecular weight:469.56Casein Kinase II Inhibitor IV
CAS:<p>Casein kinase II inhibitor IV is an effective small molecule inducer, which can be used to induce epidermal keratinocyte differentiation.</p>Formula:C24H23N5O3Purity:99.65% - 99.75%Color and Shape:SolidMolecular weight:429.47Nezulcitinib
CAS:<p>Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.</p>Formula:C30H37N7O2Color and Shape:SolidMolecular weight:527.66ABBV-712
CAS:<p>ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases</p>Formula:C24H28N4O5Purity:98%Color and Shape:SolidMolecular weight:452.5SWTX-143
CAS:<p>SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptional</p>Formula:C19H18F3N3OPurity:98%Color and Shape:SolidMolecular weight:361.36DT-6
CAS:<p>DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing</p>Formula:C89H130N20O29S2Purity:98%Color and Shape:SolidMolecular weight:2008.23JAK-IN-1
CAS:<p>JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.</p>Formula:C20H24N6O2Purity:98%Color and Shape:SolidMolecular weight:380.44STAT3-IN-20
CAS:<p>STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear</p>Formula:C30H27F4N7SPurity:98%Color and Shape:SolidMolecular weight:593.64STAT6-IN-2
CAS:<p>STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.</p>Formula:C28H31N5O2Purity:99.67%Color and Shape:SolidMolecular weight:469.58GNE-7883
CAS:<p>GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.</p>Formula:C28H29FN6O2Purity:97.61%Color and Shape:SolidMolecular weight:500.57H-1152 dihydrochloride
CAS:<p>H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.</p>Formula:C16H23Cl2N3O2SPurity:99.85%Color and Shape:SolidMolecular weight:392.34ROCK-IN-1
CAS:<p>ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurological</p>Formula:C20H18FN3OPurity:>99.99%Color and Shape:SolidMolecular weight:335.37Gossypolone
CAS:<p>Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.</p>Formula:C30H26O10Purity:96.66%Color and Shape:SolidMolecular weight:546.52
