AMPK

GSK621 is a specific and potent AMPK activator.

Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced …

Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin …

Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as …

HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).

YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid …

Cimiracemoside C is an active component of Cimicifuga racemosa. It activates AMPK and has the …

MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 …

Chikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from TC3 cells via …

Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.

ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.

Dorsomorphin is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not …

Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation …

Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute …

Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also …

XMD-17-51 Trifluoroacetate is a potent and highly selective NUAK1 inhibitor.

HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 …

ML753286 has high permeability and low to medium clearance in rodent and human liver S9 …

Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.

N,N'-Diacetyl-L-cystine is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects …

MK8722 is an effective and systemic activator of pan-AMPK.

Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can …

HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 …

3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular …

Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver …

7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).

O-304 is a pan-activator of AMP-activated protein kinase (AMPK).

Metformin HCl, a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. …

Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement …

Ampkinone is an indirect AMPK activator.

Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.

1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. …

EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and …

3-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator …

Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates …

XMD-17-51 is a potent and highly selective NUAK1 inhibitor.

MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).

Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation …

AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates …

PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, …

N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor (Ki: 29 nM for Rat ecto-5-Nucleotidase).

Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to …

Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.

Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value …

Chitosan oligosaccharide, an oligomer of -(14)-linked D-glucosamine, activates AMPK and inhibits inflammatory signaling pathways.

Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and …

Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 …

A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).

Sesamol could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory …

Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.

Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and …

WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 …

4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.

Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent …

Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNF± expression/production in human macrophage cells (THP-1 …

Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell …

Buformin hydrochloride is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin …