PI3K
PI3K inhibitors are compounds that block the activity of Phosphoinositide 3-Kinases (PI3Ks), a family of enzymes involved in a wide range of cellular processes, including growth, proliferation, survival, and metabolism. The PI3K/Akt/mTOR pathway is often dysregulated in cancer, making PI3K a key target for cancer therapy. PI3K inhibitors are critical tools for studying signal transduction, cancer biology, and the development of targeted therapies. At CymitQuimica, we provide a variety of PI3K inhibitors to support your research in cell signaling, oncology, and therapeutic development.
Found 231 products of "PI3K"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
YS-49
CAS:YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).Formula:C20H20BrNO2Purity:99.65%Color and Shape:SolidMolecular weight:386.28Ref: TM-T13376
1mg46.00€2mg58.00€1mL*10mM (DMSO)92.00€5mg95.00€10mg137.00€25mg260.00€50mg386.00€100mg560.00€500mg1,153.00€LY294002
CAS:LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).Formula:C19H17NO3Purity:98% - 99.96%Color and Shape:Pale Yellow SolidMolecular weight:307.34Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Formula:C36H56O13Purity:99.66% - 99.74%Color and Shape:SolidMolecular weight:696.82Ref: TM-T5S1982
1mg35.00€5mg77.00€10mg106.00€1mL*10mM (DMSO)107.00€25mg170.00€50mg253.00€100mg375.00€500mg892.00€TGX-221
CAS:TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.Formula:C21H24N4O2Purity:99.68% - >99.99%Color and Shape:SolidMolecular weight:364.44LX2343
CAS:LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.Formula:C22H19ClN2O6SPurity:99.45%Color and Shape:SolidMolecular weight:474.91Ref: TM-T4398
2mg34.00€5mg50.00€1mL*10mM (DMSO)55.00€10mg79.00€25mg130.00€50mg216.00€100mg323.00€200mg447.00€PI-3065
CAS:PI-3065 is a novel potent and selective PI3K p110δ inhibitor.Formula:C27H31FN6OSPurity:99.84% - ≥95%Color and Shape:SolidMolecular weight:506.64CZC24832
CAS:CZC24832 is a selective inhibitor of PI 3-kinase γ.Formula:C15H17FN6O2SPurity:99.08% - 99.12%Color and Shape:SolidMolecular weight:364.4Ref: TM-T1949
1mg48.00€2mg63.00€5mg92.00€1mL*10mM (DMSO)104.00€10mg138.00€25mg226.00€50mg338.00€100mg497.00€Fimepinostat
CAS:Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.Formula:C23H24N8O4SPurity:98.27% - 99.87%Color and Shape:SolidMolecular weight:508.55Ref: TM-T2078
2mg44.00€5mg66.00€1mL*10mM (DMSO)74.00€10mg92.00€25mg172.00€50mg295.00€100mg485.00€500mg1,035.00€TASP0415914
CAS:TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TFormula:C13H17N5O3SPurity:98.14%Color and Shape:SolidMolecular weight:323.37Ref: TM-T7879
1mg52.00€5mg111.00€1mL*10mM (DMSO)127.00€10mg177.00€25mg299.00€50mg424.00€100mg587.00€200mg792.00€PIK-108
CAS:PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Formula:C22H24N2O3Purity:98.92%Color and Shape:SolidMolecular weight:364.44Ref: TM-T28416
1mg40.00€2mg57.00€5mg97.00€1mL*10mM (DMSO)105.00€10mg156.00€25mg255.00€50mg368.00€100mg510.00€200mg700.00€Flavanomarein
CAS:Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Formula:C21H22O11Purity:98.63% - 99.54%Color and Shape:SolidMolecular weight:450.39Taurolithocholic acid sodium salt
CAS:Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, butFormula:C26H44NNaO5SPurity:99.79% - 99.93%Color and Shape:SolidMolecular weight:505.69ETP-46321
CAS:ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).Formula:C20H27N9O3SPurity:99.8%Color and Shape:SolidMolecular weight:473.55Ref: TM-TQ0229
1mg37.00€5mg82.00€1mL*10mM (DMSO)86.00€10mg116.00€25mg212.00€50mg298.00€100mg408.00€200mg552.00€Autophinib
CAS:Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay andFormula:C14H11ClN6O3Purity:99.25% - 99.41%Color and Shape:SolidMolecular weight:346.73Ref: TM-T4219
2mg39.00€5mg58.00€1mL*10mM (DMSO)66.00€10mg88.00€25mg160.00€50mg215.00€100mg334.00€200mg494.00€Taselisib
CAS:Taselisib (GDC-0032) is an oral PI3K alpha inhibitor with potential cancer-treating properties.Formula:C24H28N8O2Purity:99.62% - 99.79%Color and Shape:SolidMolecular weight:460.53Ref: TM-T1999
2mg43.00€5mg63.00€1mL*10mM (DMSO)63.00€10mg96.00€25mg148.00€50mg187.00€100mg333.00€200mg495.00€500mg797.00€IITZ-01
CAS:IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)Formula:C26H23FN8OPurity:99.31%Color and Shape:SolidMolecular weight:482.51Lupiwighteone
CAS:Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.Formula:C20H18O5Purity:98.92%Color and Shape:SolidMolecular weight:338.35Leniolisib
CAS:Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).Formula:C21H25F3N6O2Purity:99.88%Color and Shape:SolidMolecular weight:450.46Brevianamide F
CAS:Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.
Formula:C16H17N3O2Purity:97.30% - 98.82%Color and Shape:SolidMolecular weight:283.33Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Formula:C19H24O5Purity:96.66% - 99.93%Color and Shape:SolidMolecular weight:332.39BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Formula:C28H25F3N6O2Purity:95.74% - 99.78%Color and Shape:SolidMolecular weight:534.53Ref: TM-T6072L
1mg47.00€2mg62.00€5mg92.00€1mL*10mM (DMSO)107.00€10mg147.00€25mg295.00€50mg485.00€100mg737.00€NIH-12848
CAS:NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.Formula:C20H14F3N3SPurity:99.84% - 99.9%Color and Shape:SolidMolecular weight:385.41Ref: TM-T3556
2mg35.00€5mg51.00€1mL*10mM (DMSO)55.00€10mg75.00€25mg133.00€50mg225.00€100mg323.00€200mg447.00€GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFormula:C17H20N6O2SPurity:98%Color and Shape:SolidMolecular weight:372.44Rigosertib sodium
CAS:Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.Formula:C21H24NNaO8SPurity:98% - 99.37%Color and Shape:SolidMolecular weight:473.47SKI V
CAS:SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM),
Formula:C15H10O4Purity:98.78%Color and Shape:SolidMolecular weight:254.24Erucic acid
CAS:Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ).Formula:C22H42O2Purity:99.64%Color and Shape:Needles From Alcohol Liquid OthersolidMolecular weight:338.57PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Formula:C19H16N4O3Purity:97.79% - 99.3%Color and Shape:SolidMolecular weight:348.36AS-252424
CAS:AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.Formula:C14H8FNO4SPurity:99.06% - 99.09%Color and Shape:SolidMolecular weight:305.28Ref: TM-T6208
1mg37.00€2mg52.00€5mg77.00€1mL*10mM (DMSO)84.00€10mg128.00€25mg205.00€50mg309.00€100mg447.00€500mg973.00€3-Methyladenine
CAS:3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).Formula:C6H7N5Purity:98% - 99.51%Color and Shape:SolidMolecular weight:149.15PF-04691502
CAS:PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Formula:C22H27N5O4Purity:96.27% - ≥95%Color and Shape:SolidMolecular weight:425.48Ref: TM-T6251
1mg34.00€2mg43.00€5mg63.00€1mL*10mM (DMSO)65.00€10mg88.00€25mg117.00€50mg187.00€100mg333.00€Deoxyelephantopin
CAS:Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.Formula:C19H20O6Purity:99.6% - 99.71%Color and Shape:SolidMolecular weight:344.36GDC0084
CAS:GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.
Formula:C18H22N8O2Purity:99.72% - 99.87%Color and Shape:SolidMolecular weight:382.42PIK-294
CAS:PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).Formula:C28H23N7O2Purity:97.22% - >99.99%Color and Shape:SolidMolecular weight:489.53PF-4989216
CAS:PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.Formula:C18H13FN6OSPurity:99.85%Color and Shape:SolidMolecular weight:380.4Ref: TM-T6938
2mg37.00€5mg62.00€1mL*10mM (DMSO)64.00€10mg96.00€25mg177.00€50mg311.00€100mg376.00€200mg535.00€Wortmannin
CAS:Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.Formula:C23H24O8Purity:95.84% - 99.77%Color and Shape:White SolidMolecular weight:428.43Ref: TM-T6283
1mg35.00€2mg50.00€5mg75.00€1mL*10mM (DMSO)84.00€10mg113.00€25mg224.00€50mg385.00€100mg570.00€1-Deoxynojirimycin
CAS:1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.Formula:C6H13NO4Purity:99.65% - 99.98%Color and Shape:White-Beige Solid CrystallineMolecular weight:163.17Ref: TM-T3675
2mg43.00€1mL*10mM (DMSO)57.00€5mg58.00€10mg74.00€25mg140.00€50mg248.00€100mg321.00€500mg773.00€Eganelisib
CAS:Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)Formula:C30H24N8O2Purity:98.92% - 99.28%Color and Shape:SolidMolecular weight:528.56AMG 511
CAS:AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).Formula:C22H28FN9O3SPurity:≥98%Color and Shape:SolidMolecular weight:517.58(E)-Akt inhibitor-IV
CAS:(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.Formula:C31H29IN4SPurity:99.74% - 99.9%Color and Shape:SolidMolecular weight:616.56Ref: TM-T9393
1mg52.00€5mg110.00€1mL*10mM (DMSO)148.00€10mg170.00€25mg319.00€50mg444.00€100mg620.00€200mg875.00€iMDK
CAS:iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.Formula:C21H13FN2O2SPurity:99.99%Color and Shape:SolidMolecular weight:376.4Vps34-PIK-III
CAS:Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.Formula:C17H17N7Purity:98.39% - 98.43%Color and Shape:SolidMolecular weight:319.36Ref: TM-T6945
1mg49.00€2mg67.00€5mg110.00€1mL*10mM (DMSO)110.00€10mg192.00€25mg429.00€50mg628.00€100mg893.00€500mg1,791.00€GNE-477
CAS:GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.Formula:C21H28N8O3S2Purity:98.88% - 99.55%Color and Shape:SolidMolecular weight:504.63Ref: TM-T3692
1mg44.00€2mg57.00€1mL*10mM (DMSO)92.00€5mg93.00€10mg138.00€25mg286.00€50mg447.00€100mg677.00€TG 100713
CAS:TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.
Formula:C12H10N6OPurity:98.17%Color and Shape:SolidMolecular weight:254.25BEBT-908
CAS:BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).Formula:C23H25N9O3SPurity:99.67%Color and Shape:SolidMolecular weight:507.57Ref: TM-T16529
1mg94.00€5mg222.00€1mL*10mM (DMSO)249.00€10mg334.00€25mg562.00€50mg802.00€100mg1,063.00€200mg1,459.00€PI3K-IN-1
CAS:PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.Formula:C31H29N5O6SPurity:97.03% - 98%Color and Shape:SolidMolecular weight:599.661,3-Dicaffeoylquinic acid
CAS:1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.Formula:C25H24O12Purity:98% - 98.81%Color and Shape:SolidMolecular weight:516.45Ref: TM-T5736
1mg37.00€5mg71.00€10mg90.00€1mL*10mM (DMSO)103.00€25mg147.00€50mg208.00€100mg309.00€200mg447.00€Euscaphic acid
CAS:Euscaphic acid has anti-diabetic and anti-inflammatory effects, blocking IKK/MAPKs and NF-κB activation by disrupting TRAF6/IRAK1/TAK1 clustering.Formula:C30H48O5Purity:98.93%Color and Shape:SolidMolecular weight:488.7AS-605240
CAS:AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).Formula:C12H7N3O2SPurity:97% - 99.91%Color and Shape:SolidMolecular weight:257.27GSK1059615
CAS:GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.Formula:C18H11N3O2SPurity:99.3% - ≥95%Color and Shape:SolidMolecular weight:333.36HS-173
CAS:HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).Formula:C21H18N4O4SPurity:99.33% - 99.64%Color and Shape:SolidMolecular weight:422.46Ref: TM-T2308
2mg34.00€5mg52.00€1mL*10mM (DMSO)52.00€10mg77.00€25mg128.00€50mg200.00€100mg296.00€200mg425.00€
