PI3K
PI3K inhibitors are compounds that block the activity of Phosphoinositide 3-Kinases (PI3Ks), a family of enzymes involved in a wide range of cellular processes, including growth, proliferation, survival, and metabolism. The PI3K/Akt/mTOR pathway is often dysregulated in cancer, making PI3K a key target for cancer therapy. PI3K inhibitors are critical tools for studying signal transduction, cancer biology, and the development of targeted therapies. At CymitQuimica, we provide a variety of PI3K inhibitors to support your research in cell signaling, oncology, and therapeutic development.
Found 231 products for "PI3K".
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IITZ-01
CAS:IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)Formula:C26H23FN8OPurity:99.31%Color and Shape:SolidMolecular weight:482.51Lupiwighteone
CAS:Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.Formula:C20H18O5Purity:98.92%Color and Shape:SolidMolecular weight:338.35Leniolisib
CAS:Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).Formula:C21H25F3N6O2Purity:99.88%Color and Shape:SolidMolecular weight:450.46Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Formula:C19H24O5Purity:96.66% - 99.93%Color and Shape:SolidMolecular weight:332.39BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Formula:C28H25F3N6O2Purity:95.74% - 99.78%Color and Shape:White SolidMolecular weight:534.53Ref: TM-T6072L
1mg47.00€2mg62.00€5mg92.00€1mL*10mM (DMSO)107.00€10mg147.00€25mg295.00€50mg485.00€100mg737.00€NIH-12848
CAS:NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.Formula:C20H14F3N3SPurity:99.87% - 99.9%Color and Shape:SolidMolecular weight:385.41Ref: TM-T3556
2mg35.00€5mg51.00€1mL*10mM (DMSO)55.00€10mg75.00€25mg133.00€50mg225.00€100mg323.00€200mg447.00€GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFormula:C17H20N6O2SPurity:98%Color and Shape:SolidMolecular weight:372.44Rigosertib sodium
CAS:Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.Formula:C21H24NNaO8SPurity:98% - 99.37%Color and Shape:SolidMolecular weight:473.47Heterophyllin B
CAS:Heterophyllin B hinders esophageal cancer cell adhesion/invasion via PI3K/AKT/β-catenin and gene regulation.Formula:C40H58N8O8Purity:98.77% - 99.85%Color and Shape:White SolidMolecular weight:778.94AMG319
CAS:AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.Formula:C21H16FN7Purity:98.9% - 99.24%Color and Shape:Crystalline SolidMolecular weight:385.4P7C3-A20
CAS:P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.Formula:C22H19Br2FN2OPurity:96.83% - ≥98%Color and Shape:White SolidMolecular weight:506.21Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Formula:C13H14N6OPurity:98.21% - 99.69%Color and Shape:SolidMolecular weight:270.29Ref: TM-T7014
1mg35.00€2mg50.00€5mg74.00€1mL*10mM (DMSO)74.00€10mg117.00€25mg226.00€50mg364.00€100mg532.00€Umbralisib
CAS:Umbralisib (TGR 1202) is a PI3Kδ inhibitor.Formula:C31H24F3N5O3Purity:99.56% - 99.56%Color and Shape:White SolidMolecular weight:571.55Ref: TM-T4976
1mg46.00€2mg62.00€5mg90.00€1mL*10mM (DMSO)114.00€10mg166.00€25mg324.00€50mg425.00€100mg623.00€AZD-8835
CAS:AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).Formula:C22H31N9O3Purity:98.22% - 99.88%Color and Shape:SolidMolecular weight:469.54AS-604850
CAS:AS-604850: ATP-competitive PI3Kγ inhibitor, IC50 250 nM, 18x > PI3Kα, 80x > PI3Kδ/β.Formula:C11H5F2NO4SPurity:99.65%Color and Shape:SolidMolecular weight:285.22PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Formula:C14H16ClN3O4S2Purity:97.72%Color and Shape:SolidMolecular weight:389.88Ref: TM-T2616
1mg42.00€5mg85.00€1mL*10mM (DMSO)94.00€10mg105.00€25mg200.00€50mg305.00€100mg427.00€200mg613.00€CH5132799
CAS:CH5132799 has been used in trials studying the treatment of Solid Tumors.Formula:C15H19N7O3SPurity:99.41% - 99.87%Color and Shape:SolidMolecular weight:377.42Ref: TM-T2619
1mg60.00€2mg92.00€5mg137.00€10mg215.00€25mg399.00€50mg590.00€100mg838.00€500mg1,693.00€Seletalisib
CAS:Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).Formula:C23H14ClF3N6OPurity:99.81%Color and Shape:SolidMolecular weight:482.85Ref: TM-TQ0044
1mg54.00€2mg77.00€5mg114.00€1mL*10mM (DMSO)119.00€10mg178.00€25mg313.00€50mg447.00€100mg625.00€α-Linolenic acid
CAS:α-Linolenic Acid (ALA) is an essential fatty acid. α-Linolenic acid improves memory, inhibits thrombosis, and lowers blood lipids. Cost-effective and quality-assured.Formula:C18H30O2Purity:97.05% - 99.81%Color and Shape:Transparent LiquidMolecular weight:278.43GSK2636771
CAS:GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, andFormula:C22H22F3N3O3Purity:98.58% - ≥95%Color and Shape:SolidMolecular weight:433.42Ref: TM-T2073
1mg40.00€2mg54.00€5mg84.00€1mL*10mM (DMSO)84.00€10mg142.00€25mg240.00€50mg340.00€100mg518.00€Vps34-IN-1
CAS:Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.Formula:C21H24ClN7OPurity:97.04%Color and Shape:SolidMolecular weight:425.91Ref: TM-T7015
1mg43.00€2mg56.00€5mg88.00€1mL*10mM (DMSO)96.00€10mg124.00€25mg207.00€50mg333.00€100mg477.00€SAR405
CAS:SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.Formula:C19H21ClF3N5O2Purity:99.42% - 99.99%Color and Shape:SolidMolecular weight:443.85PIK-90
CAS:PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .Formula:C18H17N5O3Purity:98.25% - ≥95%Color and Shape:SolidMolecular weight:351.36A66
CAS:A66 is a specific and effective p110α inhibitor(IC50=32 nM).Formula:C17H23N5O2S2Purity:99.51% - ≥95%Color and Shape:SolidMolecular weight:393.53Ref: TM-T2418
2mg34.00€5mg52.00€1mL*10mM (DMSO)52.00€10mg79.00€25mg137.00€50mg234.00€100mg344.00€200mg485.00€Linperlisib
CAS:Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3KδFormula:C28H37FN6O5SPurity:99.01%Color and Shape:SolidMolecular weight:588.69Ref: TM-T6330
1mg34.00€2mg46.00€5mg66.00€1mL*10mM (DMSO)87.00€10mg90.00€25mg192.00€50mg295.00€100mg462.00€Vps34-IN-4
CAS:VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)Formula:C21H25N7OPurity:98.6%Color and Shape:SolidMolecular weight:391.47Ref: TM-T7944
1mg63.00€5mg137.00€1mL*10mM (DMSO)150.00€10mg215.00€25mg378.00€50mg537.00€100mg713.00€200mg982.00€CAY10505
CAS:CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).Formula:C14H8FNO3SPurity:99.69% - 99.74%Color and Shape:SolidMolecular weight:289.28Ref: TM-T6433
10mg34.00€1mL*10mM (DMSO)38.00€25mg52.00€50mg96.00€100mg144.00€200mg205.00€500mg350.00€GDC-0326
CAS:GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).Formula:C19H22N6O3Purity:99.35% - >99.99%Color and Shape:SolidMolecular weight:382.42Ref: TM-T3985
1mg34.00€2mg50.00€1mL*10mM (DMSO)88.00€5mg90.00€10mg146.00€25mg241.00€50mg385.00€100mg560.00€AZD8186
CAS:AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).Formula:C24H25F2N3O4Purity:99.89% - 99.91%Color and Shape:SolidMolecular weight:457.47Ref: TM-T6773
2mg43.00€5mg63.00€1mL*10mM (DMSO)69.00€10mg94.00€25mg165.00€50mg289.00€100mg477.00€500mg1,063.00€Selective PI3Kδ Inhibitor 1
CAS:Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).Formula:C23H20FN7OPurity:97.96%Color and Shape:SolidMolecular weight:429.45Pilaralisib analogue
CAS:Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.Formula:C21H16N6O2S2Purity:99.3% - 99.72%Color and Shape:SolidMolecular weight:448.52Ref: TM-T2377
2mg35.00€5mg52.00€1mL*10mM (DMSO)58.00€10mg84.00€25mg132.00€50mg205.00€100mg354.00€200mg460.00€AZD 6482
CAS:AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.Formula:C22H24N4O4Purity:99.87% - 99.95%Color and Shape:SolidMolecular weight:408.45PIK-293
CAS:PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.Formula:C22H19N7OPurity:99.65%Color and Shape:SolidMolecular weight:397.43Ref: TM-T3348
1mg46.00€2mg62.00€5mg90.00€1mL*10mM (DMSO)100.00€10mg144.00€25mg260.00€50mg394.00€100mg572.00€ETP-45658
CAS:ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).Formula:C16H17N5O2Purity:99.14%Color and Shape:White SolidMolecular weight:311.34Ref: TM-T25399
1mg50.00€5mg105.00€1mL*10mM (DMSO)117.00€10mg172.00€25mg299.00€50mg485.00€100mg708.00€Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Formula:C30H23N5OPurity:97.64% - 99.85%Color and Shape:SolidMolecular weight:469.54Pectolinarin
CAS:Pectolinarin is a Cirsium isolate with anti-inflammatory activity.Formula:C29H34O15Purity:98% - 99.79%Color and Shape:SolidMolecular weight:622.57MTX-211
CAS:MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.Formula:C20H14Cl2FN5O2SPurity:97.81% - >99.99%Color and Shape:SolidMolecular weight:478.33Ref: TM-T4296
1mg60.00€2mg89.00€5mg167.00€1mL*10mM (DMSO)170.00€10mg260.00€25mg439.00€50mg605.00€100mg802.00€200mg1,099.00€Pictilisib
CAS:Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).Formula:C23H27N7O3S2Purity:98.69% - 99.97%Color and Shape:White SolidMolecular weight:513.64Sincalide
CAS:Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.Formula:C49H62N10O16S3Purity:98.32%Color and Shape:White ViscousMolecular weight:1143.27IC-87114
CAS:IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).Formula:C22H19N7OPurity:99.30% - >99.99%Color and Shape:SolidMolecular weight:397.43Orobol
CAS:Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover.Formula:C15H10O6Purity:98% - 98%Color and Shape:SolidMolecular weight:286.24Musk ketone
CAS:Musk ketone may suppress cancer cell growth, induce apoptosis, and boost glutathione S-transferase, potentially aiding cancer protection.Formula:C14H18N2O5Purity:99.85%Color and Shape:SolidMolecular weight:294.30AS-041164
CAS:AS-041164: Oral PI3Kγ inhibitor, IC50 70 nM; weaker on PI3Kα/β/δ; anti-inflammatory.Formula:C11H7NO4SPurity:99.45%Color and Shape:SolidMolecular weight:249.24PQR530
CAS:PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.Formula:C18H23F2N7O2Purity:99.5%Color and Shape:White SolidMolecular weight:407.42YM-201636
CAS:YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.Formula:C25H21N7O3Purity:93.28% - 98.3%Color and Shape:SolidMolecular weight:467.48Ref: TM-T6110
1mg46.00€2mg60.00€5mg90.00€1mL*10mM (DMSO)92.00€10mg170.00€25mg340.00€50mg532.00€100mg760.00€500mg1,558.00€Polygalasaponin F
CAS:Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.Formula:C53H86O23Purity:98% - 99.83%Color and Shape:White SolidMolecular weight:1091.24Isorhamnetin
CAS:Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.Formula:C16H12O7Purity:99.20% - >99.99%Color and Shape:Yellow SolidMolecular weight:316.26Ref: TM-T2836
1mg38.00€2mg49.00€5mg78.00€1mL*10mM (DMSO)81.00€10mg113.00€25mg222.00€50mg371.00€100mg532.00€Pilaralisib
CAS:Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K).Formula:C25H25ClN6O4SPurity:98.51% - 99.61%Color and Shape:Yellow SolidMolecular weight:541.02SF2523
CAS:SF2523 is a highly selective and potent inhibitor.Formula:C19H17NO5SPurity:99.1% - 99.51%Color and Shape:SolidMolecular weight:371.41Ref: TM-T3986
1mg34.00€5mg74.00€1mL*10mM (DMSO)82.00€10mg113.00€25mg260.00€50mg409.00€100mg605.00€500mg1,288.00€LY-294002 hydrochloride
CAS:LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.Formula:C19H17NO3·HClPurity:99.95% - 99.98%Color and Shape:Purple LiquidMolecular weight:343.81
