
Toxicology
Found 13573 products of "Toxicology"
rac-erythro Methylphenidate Hydrochloride
CAS:Controlled ProductApplications The erythro isomers have been shown to exhibit very little therapeutic effect and contribute mainly to the toxic hypertensive effects of this drug.Controlled substance.
References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., et al.: Anal. Profiles Drug Subs., 10, 473 (1981), Kuczenski, R., et al.: J. Pharmacol. Exp. Ther., 296, 876 (2001), Pelham, W.E., et al.: J. Consult. Clin. Psychol., 61, 506 (1993), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),Formula:C14H19NO2·ClHColor and Shape:NeatMolecular weight:269.77N-Hydroxy Norfloxacin
CAS:Applications A metabolite of Norfloxacin (N681000).
References Uno, T., et al.: J. Med. Chem., 33, 2929 (1990),Formula:C16H18FN3O4Color and Shape:NeatMolecular weight:335.33Cyclosporin A-13C2,d4 Acetate
CAS:Controlled ProductApplications Labelled Cyclosporin A (C988901) derivative. An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005)Formula:C62C2H109D4N11O13Color and Shape:NeatMolecular weight:1250.657-Keto Dehydro Epiandrosterone
CAS:Controlled ProductApplications 7-Keto Dehydro Epiandrosterone is a metabolite of Dehydroepiandrosterone (DHEA) (D229585).
References Majewska, M., et al.: Brain Res., 526, 143 (1990), Charlton, M., et al.: J. Neurochem., 68, 121 (1997), Koob, G., et al.: Biochem. Pharmacol., 68, 1515 (2004);Formula:C19H26O3Color and Shape:WhiteMolecular weight:302.414-Androsten-17α-methyl-d3-17β-ol-3-one
CAS:Controlled ProductApplications Labelled Androgen. It has been used as an androgenic agent. Controlled substance (anabolic steroid).
References Bichet, N., et al.: Toxicol. Appl. Pharmacol., 106, 509 (1990), Gustafson, D., et al.: Toxicol. Sci., 53, 245 (2000), Copple, B., et al.: Toxicol. Sci., 77, 172 (2004), Takashima, K., et al.: Life Sci., 78, 2787 (2006),Formula:C202H3H27O2Color and Shape:Off-WhiteMolecular weight:305.47Aripiprazole-d8
CAS:Controlled ProductApplications Aripiprazole-d8 is a deuterated version of Aripiprazole (A771000), a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity.
References Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998), Oshiro, Y., et al.: J. Med. Chem., 41, 658 (1998),Formula:C232H8H19Cl2N3O2Color and Shape:Off White SolidMolecular weight:456.43N-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-formamide
CAS:Stability Hygroscopic
Applications N-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-formamide is an impurity of miconazole (M342500). Antifungal (topical).
References Godefroi, E.F., et al.: J. Med. Chem., 12, 784 (1969), Brugmans, et al.: Arch. Dermatol., 102, 428 (1970), Heel, R.C., et al.: Drugs, 19, 7 (1980),Formula:C16H13Cl4NO2Color and Shape:NeatMolecular weight:393.09Coproporphyrin lll-d8 (contains up to 5% Coproporphyrin I)
CAS:Controlled ProductFormula:C36H30D8N4O8Color and Shape:Dark Red SolidMolecular weight:662.76Alpidem
CAS:Controlled ProductApplications A peripheral benzodiazepine GABAA receptor ligand, a new anxiolytic.
References Min, D., et al.: Pharmacotherapy, 12, 68 (1992), Rothwell, C., et al.: J. Toxicol. Sci., 27, 35 (2002), Gonzalez-Diaz, H., et al.: Bioorg. Med. Chem. Lett., 15, 1651 (2005), Boelsterli, U., et al.: Curr. Drug Metab., 7, 715 (2006), Rietjens, I., et al.: Chem. Res. Toxicol., 19, 977 (2006),Formula:C21H23Cl2N3OColor and Shape:NeatMolecular weight:404.33N-nitroso-Ritalinic Acid
CAS:Controlled ProductFormula:C13H16N2O3Color and Shape:NeatMolecular weight:248.28Tryptophol-d4
CAS:Controlled ProductFormula:C10D4H7NOColor and Shape:Light BrownMolecular weight:165.225Mycophenolic Acid Phenolic β-D-Glucoside
CAS:Controlled ProductFormula:C23H30O11Color and Shape:White To Off-WhiteMolecular weight:482.48Anastrozole Acid Amide
Applications Anastrozole Acid Amide is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic.
References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)Formula:C17H22N4O3Color and Shape:NeatMolecular weight:330.38rac Talinolol-d5
CAS:Controlled ProductApplications Labelled Talinolol. Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic.
References Assmann, I., et al.: Curr. Med. Res. Opin., 13, 325 (1995), Trausch, B., et al.: Biopharm. Drug Dispos., 16, 403 (1995),Formula:C202H5H28N3O3Color and Shape:Off White CrystallineMolecular weight:368.52Monocarboxyisodecyl Phthalate-d4
CAS:Controlled ProductFormula:C18H20D4O6Color and Shape:Off-WhiteMolecular weight:340.4Foramsulfuron-d6
CAS:Controlled ProductFormula:C17D6H14N6O7SColor and Shape:White To Off-WhiteMolecular weight:458.48Testosterone Oleate
CAS:Controlled ProductFormula:C37H60O3Color and Shape:NeatMolecular weight:552.87Testosterone 17-Valerate
CAS:Controlled ProductApplications Testosterone ester. Testosterone 17-Valerate has been a useful compound in the development of immunochemical techniques for detection of anabolic androgenic steroids in food supplements.
References Ruelle, P., et al.: Int. J. Pharm., 157, 219 (1997), de la Torre, X., et al.: J. Pharm. Biomed. Anal., 24, 645 (2001), Adat, S., et al.: Lett. Drug Des. Discov., 1, 334 (2004), Holubova, B., et al.: Eur. Food Res. Technol., 245, 1011 (2019)Formula:C24H36O3Color and Shape:NeatMolecular weight:372.54Dimethomorph-d8
CAS:Controlled ProductApplications Labelled Dimethomorph (D460530). Agricultural fungicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lu, X., et al.: Phytopathol., 100, 1162 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),Formula:C21D8H14ClNO4Color and Shape:YellowMolecular weight:395.91Melagatran
CAS:Controlled ProductStability Hygroscopic
Applications Synthetic thrombin inhibitor. Thrombin mutant anticoagulant antagonist. Antithrombotic.
References Dewanjee, M., et al.: J. Nucl. Med., 22, 981 (1981), Goodman, S., et al.: J. Biomed. Mater. Res., 45, 240 (1999), Carlsson, S., et al.: Thromb. Res., 115, 9 (2005),Formula:C22H31N5O4Color and Shape:NeatMolecular weight:429.51De(cladinosyl) Clarithromycin
CAS:Controlled ProductImpurity Clarithromycin EP Impurity I
Applications De(cladinosyl) Clarithromycin (Clarithromycin EP Impurity I) is an impurity of Clarithromycin (C559750). De(cladinosyl) Clarithromycin showed significantly potent antibacterial activity against community acquired respiratory pathogens.
References Morimoto, S., et al.: J. Antibiot., 37, 187 (1984), Buxbaum, A., et al.: J. Antimicrob. Chemother., 52, 371 (2003), Westphal, J., et al.: Br. J. Clin. Pharmacol., 50, 285 (2000), Ma, Z., et al.: J. Med. Chem., 44, 4137 (2001),Formula:C30H55NO10Color and Shape:White To Off-WhiteMolecular weight:589.764-Chlorophenylcyanamide
CAS:Controlled ProductStability Hygroscopic
Applications 4-Chlorophenylcyanamide is an intermediate used in synthesis of N-(4-Chlorophenyl)-O-methylisourea Sulfate Salt (~90%) (C378465), which is a cytotoxic agent which displays tumor inhibitory activity.
References Hendry, J. et al.: Brit. J. Pharmacol. Chemother., 6, 201 (1951);Formula:C7H5ClN2Color and Shape:NeatMolecular weight:152.58Deschloro-2-phenylsulfonyl-thiamethoxam
CAS:Controlled ProductApplications Deschloro-2-phenylsulfonyl-thiamethoxam is an impurity of thiamethoxam (T344180), which is a neonicotinoid insecticide. Reports show that when exposed to neonicotinid pesticides honeybees have probelms returnign home after foraging and bumblebee colonies grow poorly and produce fewer queens.
References Oliver, J., et al.: J. Environ. Horticult., 28, 135 (2010), Ghosh, A., et al.: J. Entomol. Res., 34, 35 (2010), Chem. and Eng. News 90: 10 (2012)Formula:C14H15N5O5S2Color and Shape:NeatMolecular weight:397.433-Methyl Adenine-d3
CAS:Controlled ProductApplications 3-Methyl Adenine-d3 is labelled 3-Methyl Adenine (M275904). 3-Methyl Adenine is a selective autophagy and phosphoinositide 3-kinase (PI3K) inhibitor (1,2,3). 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K).
References (1) Munafo, D., et al.: J. Cell Sci., 114, 3619 (2001) (2) Aggarwal, B., et al.: Biochem. Pharmacol., 71, 1397 (2006) (3) Hayat, M., et al.: Oncologist, 12, 20 (2007)Formula:C62H3H4N5Color and Shape:NeatMolecular weight:152.17Ketoconazole-d8
CAS:Controlled ProductApplications Deuterated Ketoconazole, an inhibitor of cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)Formula:C26H20D8Cl2N4O4Color and Shape:White To BeigeMolecular weight:539.484-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluorobenzamide
CAS:Formula:C20H14F4N4O2SColor and Shape:NeatMolecular weight:450.41Desethyl Chloroquine-d4
CAS:Controlled ProductApplications The major product of the stereoselective human metabolism of Chloroquine, used for the therapy and prevention of malaria. It is a COVID19-related research product.
References Essien, E., et al.: J. Pharm. Pharmacol., 38, 543 (1986), Akintonwa, A., et al.: Ther. Drug Monit., 10, 147 (1988), Boelaert, J., et al.: AIDS, 15, 2205 (2001), Basco, L., et al.: Antimicrob. Agents Chemother., 47, 1391 (2003),Formula:C16H18D4ClN3Color and Shape:Light YellowMolecular weight:295.84Candesartan-d5
CAS:Controlled ProductFormula:C242H5H15N6O3Color and Shape:GreyMolecular weight:445.48Lisdexamphetamine Dimesylate
CAS:Controlled ProductApplications Lisdexamphetamine Dimesylate is used as a treatment for adults with attention-deficit/hyperactivity disorder (ADHD). Lisdexamphetamine Dimesylate has been shown to improve executive dysfunction and depressive symptoms in people with mild major depressive disorder (MDD).
References Martin, P.T., et al.: Clin. Drug Invest., 34, 147 (2014); Madhoo, M., et. al.: Neuropsychopharmacol., 39, 1388 (2014);Formula:C15H25N3O·2CH4O3SColor and Shape:NeatMolecular weight:455.591-Methyluric Acid-d3
CAS:Controlled ProductApplications A labelled metabolite of Theophylline.
References Chen, Y., et al.: Clin. Exper. Pharmacol. Physiol., 36, 828 (2009), Yu, C., et al.: J. Bacteriol., 191, 4624 (2009), Jetter, A., et al.: Eur. J. Clin. Pharmacol., 65, 411 (2009),Formula:C62H3H3N4O3Color and Shape:NeatMolecular weight:185.16Abiraterone Ethyl Ether
CAS:Controlled ProductApplications Abiraterone Ethyl Ether is an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)Formula:C26H35NOColor and Shape:NeatMolecular weight:377.56Theobromine-d6
CAS:Controlled ProductStability Hygroscopic
Applications A labelled metabolite of Caffeine.
References Suto, M., et al.: Anticancer Drug Des., 6, 107 (1991), Burkart, V., et al.: Nat. Med., 5, 314 (1999), Hassa, P., et al.: J. Biol. Chem., 278, 45145 2003), Veres, B., et al.: J. Pharmacol. Exp. Ther., 310, 247(2004),Formula:C72H6H2N4O2Color and Shape:WhiteMolecular weight:186.2Pemoline
CAS:Controlled ProductApplications Pemoline is a CNS stimulant. Controlled Substance.
References Connors, C.K., et al.: Psychopharacolgia, 26, 321 (1972), Schafer, E.W., et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972),Formula:C9H8N2O2Color and Shape:White To Off-WhiteMolecular weight:176.17Oseltamivir Glucose Adduct 1(>90%)
Controlled ProductFormula:C22H38N2O9Purity:>90%Color and Shape:White To Dark BrownMolecular weight:474.55(R,R)-Ethambutol Dihydrochloride
CAS:Controlled ProductApplications (R,R)-Ethambutol Dihydrochloride shows antitumor properties when complexed with platinum. Also an isomer of Ethambutol (E889800), an antibacterial (tuberculostatic).
References Coluccia, M. et al.: Anticanc. Res., 11, 281 (1991); Wilkinson, et al.: J. Med. Chem., 5, 835 (1962), Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971), Lee, C.S., et al.: Anal. Profiles Drug Subs., 7, 231 (1978)Formula:C10H26Cl2N2O2Color and Shape:NeatMolecular weight:277.23Oseltamivir citric acid Adduct
Controlled ProductApplications Oseltamivir citric acid is an impurity of Oseltamivir (O701005), an antiviral drug that is an orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. It is a COVID19-related research product.
References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998); Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998); Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999); Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000);Formula:C22H34N2O10Color and Shape:NeatMolecular weight:486.51Didesethyl Chloroquine-d4
CAS:Controlled ProductApplications A labelled metabolite of Chloroquine. It is a COVID19-related research product.
References Ohkuma, S., et al.: J. Cell. Biol., 90, 656 (1981), Araki, N., et al.: J. Biol. Chem., 267, 10211 (1992), Projean, D., et al.: Drug Metab. Dispos., 31, 748 (2003), Traebert, M., et al.: Eur. J. Pharmacol., 484, 41 (2004),Formula:C14H14D4ClN3Color and Shape:NeatMolecular weight:267.79Terbutaline-d9
CAS:Controlled ProductApplications A B-Adrenergic receptor agonist. A Bronchodilator.
References Akhtar, S., et al.: J. Vet. Pharmacol. Ther., 21, 388 (1998), Kasprowicz, D.J., et al.: J. Immunol., 165, 680 (2000)Formula:C12H10D9NO3Color and Shape:NeatMolecular weight:234.34Isosulfamethoxazole
CAS:Applications Isosulfamethoxazole is an impurity of the antibacterial drug Sulfamethoxazole (S699086). It is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.
References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 467 (1973), Wormser, G.P., et al.: Drugs, 24, 459 (1982), Wharton, M., et al.: Ann. Intern. Med., 105, 37 (1986),Formula:C10H11N3O3SColor and Shape:NeatMolecular weight:253.28Profenofos-D3
CAS:Controlled ProductStability Hygroscopic
Applications Profenofos-D3 is the labeled form of Profenofos(P755880). Profenofos is a broad-spectrum organophosphorous pesticide that is used widely in cotton fields for insect control (1). Acetylcholinesterase inhibiting organophosphoric pesticide (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.Formula:C112H3H12BrClO3PSColor and Shape:NeatMolecular weight:376.65Decarboxy Cilastatin
Controlled ProductStability Hygroscopic
Applications Decarboxy Cilastatin is an impurity in the synthesis of Cilastatin (C441100), prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct.
References Finlay, K.R., et al.: Invest. Ophthalmol. Visual Sci., 24, 1147 (1983), Norrby, S.R., et al.: Antimicrob. Agents Chemother., 23, 300 (1983), Washburn, D.E., et al.: J. Antimicrob. Chemother., 12, 39 (1983),Formula:C15H26N2O3SColor and Shape:NeatMolecular weight:314.4432-Desfluoro Fluconazole
CAS:Controlled ProductImpurity Fluconazole EP Impurity D
Applications 2-Desfluoro Fluconazole (Fluconazole EP Impurity D) is an impurity of the antifungal agent Fluconazole (F421000).
References Ramesh, B. et al.: J. Pharm. Res., 4, 1401 (2011); Al-Rimawi, F.: Jor. J. Chem., 4, 357 (2009);Formula:C13H13FN6OColor and Shape:NeatMolecular weight:288.28N-(tert-Butoxycarbonyl) Desethylene Ciprofloxacin
CAS:Controlled ProductApplications A protected metabolite of the fluorinated quinolone antibacterial Ciprofloxacin.
Formula:C20H24FN3O5Color and Shape:Light YellowMolecular weight:405.42Velpatasvir
CAS:Applications Velpatasvir is a NS5A inhibitor in patients with hepatitis C (HCV) infection.
References Gane, E. J., et al.: Gastroenterol., 151, 448 (2016); Feld, J. J., et al.: N. Engl. J. Med. 373, 2599 (2015);Formula:C49H54N8O8Color and Shape:NeatMolecular weight:883.0Ampicillin Sodium Salt
CAS:Applications Sodium Salt of Ampicillin, an orally active, semi-synthetic antibiotic; structurally related to penicillin. Antibacterial.
References Ivashkiv, E., et al.: Anal. Profiles Drug Subs., 2, 1 (1973), Campoli-Richards, D.M., et al.: Drugs, 33, 577 (1987), Sill, M. L., et al.: Antimicrob. Agents Chemother., 52, 1551 (2008),Formula:C16H18N3O4S·NaColor and Shape:Off-WhiteMolecular weight:371.39Sipoglitazar
CAS:Controlled ProductApplications Sipoglitazar is a novel antidiabetic agent. Sipoglitazar displays triple agonistic activities on the human peroxisome proliferator-activated receptors, hPPAR-γ, -α, and -δ.
References Nishihara, M. et al.: Drug Metab. Dispos., 40, 249 (2012);Formula:C25H25N3O4SColor and Shape:White To Off-WhiteMolecular weight:463.55Benzyl Trisulfide
CAS:Controlled ProductApplications Benzyl Trisulfide is a secondary metabolite of Petiveria alliacea, on erythrocyte elasticity, relaxation time and membrane morphol. An antibacterial and antifungal agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mohandas, N., et al.: Semin. Hematol., 20, 225 (1983), De Sousa, J., et al.: Phytochem., 29, 3653 (1990),Formula:C14H14S3Color and Shape:NeatMolecular weight:278.46(2RS,4R,8R)-δ-Tocopherol-d4 (Mixture of Diastereomers)
CAS:Controlled ProductApplications Labelled δ-Tocopherol. One of the naturally occurring forms of Vitamin E. Isolated from soybean oil.
References Emerson, et al.: Science, 83, 421 (1936), Bieri, J.G., et al.: J. Nutr., 104, 850 (1974), Jiang, Q., et al.: Am. J. Clin. Nutr., 74, 714 (2001),Formula:C27H42D4O2Color and Shape:NeatMolecular weight:406.68Triethylamine Trihydrofluoride
CAS:Applications Triethylamine Trihydrofluoride is used in the synthesis of modified siRNA’s in vivo used to inhibit hepatitis B replication (1). Used in RNA synthesis in the removal of t-butyldimethylsilyl protection (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Marimani M. et al.: Bioorg Med Chem. 2013 Oct 15;21(20):6145-55. 2. Westman, E. et al.: Nucleic Acids Res. 1994 Jun 25;22(12):2430-1Formula:C6H18F3NColor and Shape:Colourless To BeigeMolecular weight:161.21Rilpivirine
CAS:Controlled ProductApplications A novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.
References Sun, et al.: J. Med. Chem., 41, 4648 (1998), Kashiwada, et al.: Bioorg. Med. Chem. Lett., 11, 183 (2001),Formula:C22H18N6Color and Shape:YellowMolecular weight:366.42Levofloxacin Ethyl Ester
CAS:Controlled ProductImpurity Levofloxacin USP Related Compound C
Applications Levofloxacin Ethyl Ester (Levofloxacin USP Related Compound C) is an impurity of Levofloxacin (L360000).
References Lalitha Devi, M. et al.: J. Pharrm. Biomed. ANal., 50, 710 (2009); Mehta, J. et al.: Int. J. PharmTech Res., 2, 1932 (2010);Formula:C20H24FN3O4Color and Shape:White To Off-WhiteMolecular weight:389.423-Desmethoxy-3-bromo Trimethoprim
CAS:Controlled ProductApplications An impurity of Trimethoprim (T795615) with inhibitory effects on the enzyme dihydrofolate reductase.
References Kompis, I. et al.: Enzyme Inhib. Proc. Meet., 177 (1980); Hess, S. et al.: J. Pharmac. Biomed. Anal., 25, 531 (2001);Formula:C13H15BrN4O2Color and Shape:NeatMolecular weight:339.19Niclosamide Monohydrate
CAS:Controlled ProductFormula:C13H8Cl2N2O4·H2OColor and Shape:WhiteMolecular weight:345.135Faropenem Sodium Salt Hemipentahydrate
CAS:Controlled ProductFormula:C12H14NO5SNaH2OColor and Shape:NeatMolecular weight:704.67rac Efavirenz
CAS:Applications rac Efavirenz is a mixture of both enantiomers for Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.
References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995); Hadaruga, D. et al.: J. Med Chem., 48, 2432 (2005);Formula:C14H9ClF3NO2Color and Shape:NeatMolecular weight:315.68De-guanidine Peramivir
CAS:Controlled ProductFormula:C14H26N2O4Color and Shape:NeatMolecular weight:286.367Leuco Malachite Green
CAS:Controlled ProductApplications A metabolite of Malachite Green in seafood products. A triphenylmethane dye with fungicidal and limited antiseptic activity. The term Malachine green applies to the oxalate as well as the chloride. Harmful if swallowed. Avoid release to the environment. Dyes and metabolites, Environmental Testing
References Carter, S.G., et al.: J. Biochem. Biophys. Methods, 7, 7 (1982), Saikan, S., et al.: J. Chem. Phys., 79, 4154 (1983), Clemmensen, S., et al.: Arch. Toxicol., 56, 43 (1984),Formula:C23H26N2Color and Shape:White To Light BeigeMolecular weight:330.47(1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol D-Tartrate
CAS:Controlled ProductImpurity Abacavir - In House Impurity
Applications (1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol D-Tartrate (Abacavir - In House Impurity) is an intermediate of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)Formula:C6H11NO·C4H6O6Color and Shape:NeatMolecular weight:263.24N-Formyl Erythromycin A (>85%)
CAS:Controlled ProductApplications N-Formyl Erythromycin A is a derivative of Erythromycin (E649950), an antibiotic medication.
References Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979),Formula:C37H65NO14Purity:>85%Color and Shape:NeatMolecular weight:747.91(R)-(+)-2-Amino-3-benzyloxy-1-propanol
CAS:Controlled ProductApplications (R)-(+)-2-Amino-3-benzyloxy-1-propanol is used as a reagent to synthesize beta-amino alcohols, compounds that are used as therapeutic agents to treat heart disease. (R)-(+)-2-Amino-3-benzyloxy-1-propanol is also used as a reagent to synthesize 15-membered macrolide antibiotics, drugs that are used to treat respiratory tract infections.
References Fisher, G., et al.: J. Org. Chem., 60, 2026 (1995); Metro, T., et al.: J. Org. Chem., 72, 6556 (2007); Sugimoto, T., et al.: Bioorg. Med. Chem., 20, 5787 (2012)Formula:C10H15NO2Color and Shape:NeatMolecular weight:181.23Quinine Sulfate Dihydrate
CAS:Controlled ProductApplications Primary alkaloid of various species of Cinchona (Rubiaceae). Optical isomer of Quinidine. Antimalarial; muscle relaxant (skeletal).
References Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 12, 547 (1983), Kremsner, P.G., et al.: J. Infect. Dis., 169, 467 (1994),Formula:C20H24N2O2·2H2O·H2O4SColor and Shape:White SolidMolecular weight:782.94delta2-Ceftazidime (>80%)
CAS:Controlled ProductImpurity Ceftazidime EP Impurity A
Stability Hygroscopic, Light Sensitive
Applications ∆2-Ceftazidime, 90% (Ceftazidime EP Impurity A) is a Ceftazidime isomer, an impurity of Ceftazidime (C244100).
References Vilanova, B., et al.: Helv. Chim. Acta, 76, 2789 (1993), Zhou, M., et al.: J. Pharm. Sci., 84, 534 (1995), Baertschi, S., et al.: Chemother. 8, 353 (1997), Porra, R., et al.: J. Pharm. Biomed. Anal., 18, 241 (1998),Formula:C22H22N6O7S2Purity:>80%Color and Shape:White To BrownMolecular weight:546.584-Defluoro-4-(1H-1,2,4-triazol-1-yl) Fluconazole
CAS:Controlled ProductImpurity Fluconazole EP Impurity B / Fluconazole USP Related Compound A
Applications 4-Defluoro-4-(1H-1,2,4-triazol-1-yl) Fluconazole (Fluconazole EP Impurity B) is an impurity of the antifungal agent Fluconazole (F421000).
References Ramesh, B. et al.: J. Pharm. Res., 4, 1401 (2011); Al-Rimawi, F.: Jor. J. Chem., 4, 357 (2009);Formula:C15H14FN9OColor and Shape:NeatMolecular weight:355.333-Morpholin-4-ylaniline
CAS:Controlled ProductFormula:C10H14N2OColor and Shape:NeatMolecular weight:178.23Hydroxychloroquine O-Sulfate Sodium Salt
CAS:Controlled ProductApplications Hydroxychloroquine O-Sulfate Sodium Salt is an analogue and potential metabolite of the antimalarial drug Hydroxychloroquine (H916900). Studies suggest that there is increased uptake and retention of Hydroxychloroquine O-Sulfate in blood of rheumatoid arthritis subjects. It is a COVID19-related research product.
References Lucherini, T. et al.: Recenti Prog. Med., 33, 446 (1962); Mueting, D.: Nature, 195, 1003 (1962);Formula:C18H25ClN3NaO4SColor and Shape:White To Light YellowMolecular weight:437.922,2,4-Trimethyl-6(2H)-quinolinone 1-Oxide
CAS:Controlled ProductApplications 2,2,4-Trimethyl-6(2H)-quinolinone 1-Oxide is a derivative of 2,6-Dihydro-2,2,4-trimethyl-6-quinolone (D449900) which is a metabolite of Ethoxyquin (E892800), an oxidation product of the antidegradant.
References Kahl, R., et al.: Toxicology, 28, 229 (1983), Burka, L., et al.: Xenobiotica, 26, 597 (1996), Bammler, T., et al.: Toxicol. Sci., 54, 30 (2000), Hayes, J., et al.: Cancer, 174, 103 (2001),Formula:C12H13NO2Color and Shape:NeatMolecular weight:203.24Atazanavir Bisulfate Salt
CAS:Controlled ProductApplications Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral.
References Palella, F.J. Jr., et al.: N. Engl. J. Med., 338(13), 853 (1998), Nolan, D., et al.: Drugs, 63(23), 2555 (2003), Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),Formula:C38H52N6O7·H2O4SColor and Shape:NeatMolecular weight:802.932',7'-Dichlorodihydrofluorescein Diacetate
CAS:Stability Light Sensitive
Applications 2',7'-Dichlorodihydrofluorescein as a cell-permeable non-fluorescent probe. It is de-esterified intracellularly and turns to highly fluorescent 2′,7′-dichlorofluorescein upon oxidation.
References Lebel, C., et al.: Chem. Res. Toxicol., 5, 227 (1992), Kjaer, M., et al.: Lipids, 43, 813 (2008), Baron, C., et al.: J. Agric. Food Chem., 57, 4185 (2009),Formula:C24H16Cl2O7Color and Shape:ColourlessMolecular weight:487.29Dipotassium Glycyrrhizinate (~80%)
CAS:Controlled ProductStability Hygroscopic
Applications Dipotassium Glycyrrhizinate is used in improving the dissolution property of amphotericin B (AMB) and the bioavailability of the drug incorporated in suppositories.
References Tanaka, M., et. al.: Chem. Pharm. Bull., 40, 1559 (1992);Formula:C42H62K2O16Purity:~80%Color and Shape:NeatMolecular weight:901.13(+)-Costunolide
CAS:Controlled ProductApplications (+)-Costunolide is an inhibitor of osteoclast differentiation, acting as an anti-inflammatory and anti-oxidant agent. It is a sesquiterpene lactone which mediates apoptosis.
References Cheon, Y. et al.: Phytother. Res., 28, 586 (2014); Butturini, E. et al.: Eur. J. Pharm., 730, 107 (2014);Formula:C15H20O2Color and Shape:NeatMolecular weight:232.32Oxociprofloxacin
CAS:Controlled ProductApplications A metabolite of the fluorinated quinolone antibacterial Ciprofloxacin.
Formula:C17H16FN3O4Color and Shape:Beige To BrownMolecular weight:345.325,6-Dihydroyangonin
CAS:Controlled ProductApplications 5,6-Dihydroyangonin is a derivative of Yangonin (Y100550), a lactone isolated from the Kava plant (Piper methysticum). 5,6-Dihydroyangonin was shown to exhibit potential antibacterial and antifungal activities.
References Keledjian, J., et al.: J. Pharm. Sci., 77, 1003 (1988), Clouatre, D., et al.: Toxicol. Lett., 150, 85 (2004), Mathews, J., et al.: Drug Metab. Dispos., 33, 1555 (2005), Clayton, N., et al.: Exp. Toxicol. Pathol., 58, 223 (2007),Formula:C15H16O4Color and Shape:NeatMolecular weight:260.29Piperacillin Sodium
CAS:Controlled ProductStability Hygroscopic
Applications Piperacillin sodium is an antibiotic related to penicillin. Also, it possesses anti-microbial activity against enterobacteria.
References Zhang, Y., et al.: Linchuang Wuzhen Wuzhi, 27, 63-65 (2014)Formula:C23H26N5O7S·NaColor and Shape:White To Off-WhiteMolecular weight:539.543-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl Benzoate
CAS:Controlled ProductApplications 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl Benzoate is used in the preparation of Silodosin (S465000), an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.
References Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995); Murata, S., et al.: J. Urol., 164, 578 (2000)Formula:C22H23N3O4Color and Shape:Light Yellow To YellowMolecular weight:393.44Mometasone Furoate Impurity A
CAS:Impurity Mometasone Furoate EP Impurity A
Applications Mometasone Furoate Impurity A (Mometasone EP Impurity A) is an impurity of Mometasone Furoate, a topical corticosteroid used as an anti-inflammatory.
References Shapiro, E.L., et al.: J. Med. Chem., 30, 1581 (1987); Graft, D., et al.: J. Allergy Clin. Immunol., 98, 724 (1996)Formula:C27H29ClO5Color and Shape:Off WhiteMolecular weight:468.974’-Epi Lamivudine
CAS:Controlled ProductApplications Lamivudine epimer.
References Chang, C., et al.: J. Biol. Chem., 267, 13938 (1992), Jeong, L., et al.: J. Med. Chem., 36, 181 (1993),Formula:C8H11N3O3SColor and Shape:NeatMolecular weight:229.26Valganciclovir Hydrochloride
CAS:Controlled ProductStability Hygroscopic
Applications A pro-drug of Ganciclovir. Used in treatment of retro-virus.
References Acosta, E., et al.: Clin. Pharmacol. Ther., 81, 867 (2007), Nassetta, L., et al.: J. Antimicrob. Chemother., 63, 862 (2009),Formula:C14H22N6O5·ClHColor and Shape:White To Off-WhiteMolecular weight:390.82L-Cycloserine
CAS:Controlled ProductApplications L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase.
Formula:C3H6N2O2Color and Shape:NeatMolecular weight:102.09a-Artemether
CAS:Impurity Artemether USP Related Compound B
Applications Derivative of Artemisinin (A777500). Shows antimalarial and antifungal activity.
References Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011), Galal, A. et al.: J. Nat. Prod. 68, 1274 (2005)Formula:C16H26O5Color and Shape:Off-WhiteMolecular weight:298.372-Toluidine-d7
CAS:Controlled ProductFormula:C7D7H2NColor and Shape:Orange To BrownMolecular weight:114.196Didechloro Vancomycin Hydrochloride (Technical Grade)(Vancomycin Impurity)
CAS:Impurity Vancomycin Impurity
Applications An impurity in Vancomycin.A representative lot was 75% by HPLC with less than 0.1% vancomycin.
References Marshall, F.J., et al.: J. Med. Chem., 8, 18 (1965), Sheldrick, G.M., et al.: Nature, 271, 223 (1987), Dutca-Melan, S., et al.: J. Clin. Microbiol., 33, 24 (1995),Formula:C66H77N9O24•x(HCl)Color and Shape:Off White To Light YellowMolecular weight:1380.4(+)-6-Aminopenicillanic Acid
CAS:Impurity Ampicillin EP Impurity A ; Amoxicillin USP Related Compound A
Applications (+)-6-Aminopenicillanic Acid (Amoxicillin EP Impurity A) is the core structure in penicillins, obtained from the fermentation brew of the Penicillium mold. (+)-6-Aminopenicillanic Acid is used as the main starting block for the preparation of numerous semisynthetic penicillins.
References Zel'tser, I.Z. et al.: Gig. Truda Prof. Zabol., 5, 59 (1983); Hamilton-Miller, J.M.T.: Int. J. Antimicrob. Agents, 31, 189 (2008); Novikova, N.D. et al.: Mikol. Fitopatol., 7, 101 (1973);Formula:C8H12N2O3SColor and Shape:Off-WhiteMolecular weight:216.26Pyrimethanil-d5 (phenyl-d5)
CAS:Controlled ProductApplications Pyrimethanil-d5 (phenyl-d5) (CAS# 2118244-83-8) is a useful isotopically labeled research compound.
Formula:C122H5H8N3Color and Shape:Off White To Light BeigeMolecular weight:204.28Adrenalone
CAS:Applications Adrenalone is a ketone derivative of Epinephrine (E588585) and a potential dopamine β oxidase inhibitor.
References Goldstein, M., et al.: Nature, 192, 1081 (1961)Formula:C9H11NO3Color and Shape:NeatMolecular weight:181.19Naled
CAS:Controlled ProductStability Moisture Sensitive
Applications Naled is a cholinesterase inhibitor. Insecticide; acaricide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),Formula:C4H7Br2Cl2O4PColor and Shape:Colourless To BeigeMolecular weight:380.78Etifoxine Hydrochloride
CAS:Applications Psychotropic agent with anxiolytic and anticonvulsant activity.
References Boissier, J.R., et al.: Therapie, 27, 325 (1972), Bente, D., et al.: Arzneim. Forsch., 25, 944 (1975),Formula:C17H17ClN2O·ClHColor and Shape:Off White SolidMolecular weight:337.24Oxychloroaphine
CAS:Applications Oxychloroaphine is a simple phenazine with weak antifungal activity.
Formula:C13H9N3OColor and Shape:Brown SolidMolecular weight:223.23Pyroxsulam Sulfonic Acid Sodium Salt
Controlled ProductFormula:C7H5F3NNaO4SColor and Shape:NeatMolecular weight:279.169Dichloroprop
CAS:Controlled ProductApplications Dichloroprop is a herbicide used for the post-emergence control of annual and perennial broad-leaved weeds and some brush species.
References Freitas, M.R., et al.: RSC Adv., 5, 7547 (2015); Aizawa, H.: Handbook of Metabolic Pathways of Xenobiotics, 3, 1212 (2014)Formula:C9H8Cl2O3Color and Shape:ColourlessMolecular weight:235.06Misoprostol
CAS:Controlled ProductApplications Misoprostol is a cytoprotective prostaglandin PGE1 analogue.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Graham, Y., et al.: Lancet, 2, 1277 (1988); Graham, D.Y., et al.: Ann. Int. Med., 119, 257 (1993); Fletcher, H., et al.: Obstet. Gynecol., 83, 244 (1994);Formula:C22H38O5Color and Shape:Light Yellow ViscousMolecular weight:382.536β-Hydroxy-3α,5α-cycloandrostan-17-one
CAS:Controlled ProductApplications 6β-Hydroxy-3α,5α-cycloandrostan-17-one is a degredation product of Dehydroepiandrosterone Sodium Sulfate (S673250), an active agent in the preparation of a pharmaceutical for the treatment of asthma or other respiratory diseases.
References Ishihara, T., et al.: Drug. Develop. Indust. Pharmacy., 5, 263 (1979); Sollman, P.B., et al.: J. Org. Chem., 28, 3559 (1963); Van Renterghem, P., et al.: Steroids., 75, 1047 (2010);Formula:C19H28O2Color and Shape:NeatMolecular weight:288.42S-Demethyl (E)-S-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-ethenyl Rosuvastatin Sodium Salt
Controlled ProductFormula:C38H43F2N6NaO8S2Color and Shape:NeatMolecular weight:836.9Azafenidin
CAS:Controlled ProductApplications Azafenidin is a weed controlling herbicide used in various crops.
References Chandran, R.S., et al.: Weed. Technol., 14, 556 (2000); Sharma, S.D., et al.: Bull. Environ. Contamin. Toxiciol., 67, 594 (2001);Formula:C15H13Cl2N3OColor and Shape:NeatMolecular weight:322.19Diquat-d4 Dibromide
CAS:Controlled ProductApplications Contact herbicide used also to produce desiccation and defoliation.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Brian, et al.: Nature, 181, 446 (1958), Gaines, T.B., et al.: Fundam. Appl. Toxicol., 7, 299 (1986),Formula:C12D4H8N2·2BrColor and Shape:Beige To GreyMolecular weight:348.071,2-Dihydro-Betamethasone 17,21-Dipropionate
CAS:Stability Hygroscopic
Applications A degradation product of Betamethasone (B327000).
References Andersson, P., et al.: J. Pharm. Pharmacol., 36, 763 (1984), Wurthwein, G., et al.: Biopharm. Drug Dispos., 11, 381 (1990), Samtani, M., et al.: J. Pharm. Sci., 93, 726 (2004), Samtani, M., et al.: Drug Metab. Dispos., 33, 1124 (2005),Formula:C28H39FO7Color and Shape:NeatMolecular weight:506.6
