Biochemicals and Reagents

<p>Febuxostat is a non-peptide inhibitor of xanthine oxidase (XO), an enzyme that catalyzes the conversion of xanthine and hypoxanthine to uric acid. Febuxostat is used as a treatment for chronic gout in adults who are not adequately controlled on allopurinol alone or who cannot tolerate allopurinol. Febuxostat has been shown to be effective in inhibiting the activity of human recombinant XO, both in vitro and in vivo. The compound is a competitive inhibitor of L-histidine with an IC50 of 0.3 microM at pH 7.4 and 0.1 microM at pH 6.0, which is more potent than other peptidomimetics such as febuprofen and fexofenadine, but less potent than CGP57148B and CGP37849A.<br>Febuxostat has also been shown to have</p>

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<p>Positive allosteric modulator of mGlu5 receptors</p>

<p>DPM-1001 is a bioactive synthetic compound, classified as a small molecule inhibitor, which is derived from targeted chemical synthesis and optimization processes. It functions through the inhibition of specific enzymatic pathways that are critical in cellular signaling cascades. The mode of action involves binding to the active site of the target enzyme, thereby preventing its normal substrate interaction and subsequent downstream signaling. This mechanism allows for the modulation of specific biochemical pathways, making it a powerful tool in cellular research.</p>

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<p>γ-Glu-Ser is a peptide that belongs to the group of activators. It is an inhibitor of ion channels and receptors, which are proteins that bind to ligands or drugs. γ-Glu-Ser has been shown to inhibit the activity of the NMDA receptor in rat brain synaptosomes. The binding site for γ-Glu-Ser was identified as a region on the NR2B subunit. This inhibition may be due to the inhibition of calcium influx through NMDA receptor channels.</p>

<p>BMS-986235 is a research tool that has been shown to inhibit the function of ion channels. This inhibitor binds to the ligand-binding site of the receptor and blocks ATP binding, preventing activation and increasing the duration of inactivation. The high purity of BMS-986235 allows for use in pharmacological studies. BMS-986235 also inhibits peptide binding to receptors and prevents protein interactions, making it an activator as well as an inhibitor.</p>

<p>Dg 041 is a synthetic peptide that has been shown to inhibit the activity of myosin phosphatase in the tibialis anterior muscle of wild-type mice. This inhibition was associated with an increase in intracellular calcium concentration, which may be due to receptor binding. Dg 041 has also been shown to have a protective effect on bladder tissue and β-cells against oxidative stress induced by pentobarbital sodium, as well as insulin resistance in liver cells. Dg 041 may also be used as an antiplatelet agent and as an inhibitor of cancer cell growth.</p>

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<p>(4R)-2-Undecyl-4-thiazolidinecarboxylic acid is a synthetic compound, which is often used as a chemical reagent. Derived from thiazolidine, it is formed through the cyclization of an aldose or ketose with cysteamine. Its mode of action involves the scavenging of free radicals; this thiol-containing compound can neutralize reactive oxygen species, thereby preventing cellular damage.</p>

<p>This drug is an antagonist of melanin production. It is a carboxamide derivative that acts as a competitive inhibitor of the enzyme tyrosinase, which is involved in the synthesis of melanin. This drug has been shown to have pharmacological effects on the body, including toxicology and clinical trials. The physicochemical properties of this drug are not well-known due to lack of data.</p>

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<p>(E)-Metaflumizone is an anticancer drug that induces apoptosis in human tumor cells. It is a potent inhibitor of protein kinases, including Chinese hamster ovary cell kinase and geniposide analogs. (E)-Metaflumizone has been shown to inhibit the growth of cancer cells by blocking the activity of key enzymes involved in cell division and proliferation. This drug also inhibits the activity of protein kinases, which play a crucial role in cancer development and progression. In addition, (E)-Metaflumizone has been found to be effective against a wide range of cancer types, making it a promising candidate for further clinical development.</p>

<p>4-Pentadecylbenzylphosphonic acid is a cell permeant inhibitor of the antibody response, which can be used as a research tool for studying the function of antibodies. It can also be used to study the effects of peptides on receptor-mediated signal transduction pathways. 4-Pentadecylbenzylphosphonic acid binds to anionic phospholipids and blocks calcium ion channels by binding to their ligand binding site. This inhibits the release of neurotransmitters and slows down nerve impulses, which may help in treating pain and epilepsy.</p>

<p>Briciclib disodium is a prodrug that is administered in the form of a tablet. It is used as an antineoplastic agent to treat cancer. Briciclib disodium is an analog of benzyl bromide, which is a diagnostic agent and has been used in the past to study translation and profiles. This drug can be detected in body fluids such as urine, serum, or plasma. Briciclib disodium has been shown to have potential anti-neoplastic properties and can be used for the treatment of cavity or cancer.</p>

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<p>Nutlin-3b is a small molecule that inhibits the activity of the tumor suppressor protein Mcl-1. Nutlin-3b binds to Mcl-1 and prevents its interaction with other proteins, resulting in decreased levels of Mcl-1 and increased apoptosis. It has been shown to be active in vitro against a variety of human cancer cell lines, including HL60 cells. In addition, Nutlin-3b has minimal toxicity in animal models and significant cytotoxicity against malignant cells. This compound is also effective against Mcl-deficient cell lines, suggesting that it may have potential as an anticancer drug for patients with acquired resistance to other chemotherapeutic agents.</p>

<p>PCNA, His tagged human, is a recombinant protein that plays a critical role in DNA replication and repair, serving as a pivotal component of the DNA replication machinery. It is derived from a human source and is produced using recombinant DNA technology, with a His-tag for purification and detection purposes. The His-tag is a polyhistidine sequence that facilitates purification through affinity chromatography, allowing for high purity and specificity in experimental applications.</p>

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<p>CBL0137 hydrochloride is a small molecule anti-cancer agent, which is a synthetic compound derived from curaxins. It acts as an inhibitor of chromatin remodeling. The source of this compound consists of artificial synthesis designed to target molecular pathways involved in cancer cell survival.</p>

<p>Peptide H-GLIQLVEGV-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>CDKI-73 is a selective cyclin-dependent kinase (CDK) inhibitor, which originates from targeted medicinal chemistry efforts aimed at modulating cell cycle progression. This compound operates through the inhibition of specific CDK enzymes, crucial regulators of the cell cycle, and transcriptional processes. By selectively targeting these kinases, CDKI-73 disrupts the phosphorylation events necessary for cell cycle progression, thereby inducing cell cycle arrest and promoting apoptosis in cancer cells.</p>

<p>Melatonin receptor antagonist</p>

<p>(S)-5-((1,1'-Biphenyl)-4-ylmethyl)pyrrolidin-2-one is a ligand of the beta2 adrenergic receptor. It is an inhibitor of ion channels and has been shown to be an excellent research tool for studying cell biology and receptor binding. (S)-5-((1,1'-Biphenyl)-4-ylmethyl)pyrrolidin-2-one can be used in the study of peptides or antibodies that interact with the beta2 adrenergic receptor.</p>

<p>Lupan-3-one is an analog of lupeol, a natural compound found in Chinese medicinal herbs. It has been shown to have potent anticancer properties and acts as an inhibitor of human tumor protein kinase. Lupan-3-one has been studied extensively for its ability to inhibit cancer cell growth and induce apoptosis, or programmed cell death. This compound has also been shown to block the cell cycle in cancer cells, preventing them from dividing and multiplying. Lupan-3-one is excreted in urine and may have potential as a biomarker for cancer diagnosis or treatment monitoring. Its potent anticancer effects make it a promising candidate for future cancer therapies.</p>

<p>Suc-Ala-Phe-Lys-amc trifluoroacetate salt is an analog inhibitor of protein kinases that has been shown to have potential anticancer properties. It inhibits tumor cell cycle progression and induces apoptosis in cancer cells. This medicinal compound has been extensively studied for its ability to inhibit the activity of various kinases, including those involved in cancer cell proliferation and survival. Suc-Ala-Phe-Lys-amc trifluoroacetate salt has been found to be effective against various types of human cancers, including breast, prostate, and lung cancer. It is a promising candidate for the development of novel anticancer drugs due to its potent inhibitory activity against protein kinases involved in tumor growth and survival.</p>

<p>Please enquire for more information about Cis-asenapine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Activator of NAMPT transferase</p>

<p>S-Acebutolol-d7 is a medicinal compound that has shown promising results in the treatment of cancer. It is an analog of Acebutolol, a beta-blocker that is commonly used to treat hypertension and arrhythmias. S-Acebutolol-d7 has been found to be an effective inhibitor of protein kinases, which are enzymes that play a key role in the regulation of cell growth and division. This compound induces apoptosis (programmed cell death) in cancer cells and has been shown to inhibit tumor growth in human cancer cell lines. Additionally, S-Acebutolol-d7 has demonstrated anticancer activity by blocking the cell cycle progression and suppressing the activity of inhibitors such as Chinese hamster ovary cells. This compound can be detected in urine samples and may have potential as a novel therapeutic agent for cancer treatment.</p>

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<p>Leukotriene D4 is an inhibitor analog that has been found in human urine. It has been studied for its potential as an anticancer agent due to its ability to induce apoptosis in cancer cells. Leukotriene D4 also inhibits protein kinases, which are enzymes involved in cell growth and division. Medicinal research has shown that this compound may have potential as a therapeutic agent for the treatment of cancer and other diseases. In Chinese medicine, Leukotriene D4 is used as an inhibitor of tumor growth and proliferation. Researchers are continuing to study the effects of this compound on various types of cancer cells to determine its full potential as a medicinal agent.</p>

<p>Tauroursodeoxycholate dihydrate is a monoclonal antibody that binds to the bile acid receptor TGR5, which is expressed in the intestines. The antibody can be activated by acetylation of its phenylalanine side chains and then bind to cancer cells in culture. Activated tauroursodeoxycholate can have anti-cancer effects, such as inhibition of cell proliferation and induction of apoptosis. Bile acids are also known to inhibit tumor growth and induce apoptosis in animal models of cancer.</p>

<p>N-Methoxysuccinyl-Ala-Ala-Pro-Met p-nitroanilide is a synthetic chromogenic substrate, which is typically utilized in biochemical assays to assess protease activity, particularly that of elastase-like enzymes. The product is derived from chemical synthesis in the laboratory, featuring a specific peptide sequence conjugated to the p-nitroanilide group.</p>

<p>Rasagiline is a research tool that belongs to the class of ligands. It has been shown to activate receptors, such as ion channels and cell biology. Rasagiline has been shown to inhibit ion channels in the brain and thereby reduce the effects of Parkinson's disease. Rasagiline has also been used as an inhibitor for high purity peptides, proteins and antibodies.</p>

<p>Apilimod mesylate is a small molecule that inhibits viral replication by selective inhibition of the toll-like receptor (TLR) signaling pathway. Apilimod mesylate has been shown to have significant cytotoxicity in vitro and in vivo. It also has the ability to inhibit both TLR-3 and TLR-4, which are receptors for the recognition of lipopolysaccharide, an inflammatory molecule produced by Gram-negative bacteria. Apilimod mesylate has been shown to be effective in treating bowel disease and eye disorders such as dry eye. Apilimod mesylate has a long half-life and provides significant efficacy following long term treatment with no observed toxicity.</p>

<p>BTK inhibitor 1 (Compound 27) is a potent and selective inhibitor of B-cell receptor kinase, which has been shown to inhibit the formation of tubulogenesis in vitro. It is a small molecule that binds to the apical membrane of cells that line blood vessels, including endothelial cells, and regulates cell proliferation. Compound 27 inhibits the activation of GTPases such as cdc42 and RhoA and inhibits tubulogenesis by regulating the expression of caveolin-1.</p>

<p>M8-B hydrochloride is a monoclonal antibody that binds to the extracellular domain of the cation channel (TRPA1) and inhibits its activity. It has been shown to inhibit spontaneous pain in mice with neuropathic pain and inflammatory pain. M8-B hydrochloride also blocks TRPA1 activity in prostate cancer cells, which are used as an experimental model for prostate cancer.</p>

<p>Please enquire for more information about Etymemazine-d6 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>BF 544 is a peptide that is used as a research tool. It has been shown to activate the ion channels in cells, which leads to changes in the membrane potential. BF 544 also interacts with antibodies and receptors, causing changes in ligand binding and protein interactions. This peptide can be used as an inhibitor for pharmacological studies of ion channels and membrane proteins.</p>

<p>Ki16198 is a small molecule that inhibits the growth of cancer cells by blocking the activity of the growth factor-β1. Ki16198 has been shown to inhibit tumorigenesis in a number of cell and animal models. Ki16198 also inhibits the production and secretion of matrix metalloproteinases, which are enzymes involved in tissue remodeling. Ki16198 has shown an inhibitory effect on tumor growth, with no detectable toxicity when administered orally in mice.</p>

<p>CY5.5-NHS-ester is a bright and photostable near-IR dye.  CY5.5-NHS-ester is completely water-soluble and often a reagent of choice for labeling antibodies, peptides, and proteins that are sensitive toward organic co-solvents. Cy5.5 conjugates are pH insensitive from pH 4 to pH 10 and produce minimal auto-fluorescence of biological specimens in this region of the spectrum.</p>

<p>U91356 is an agonist of the nicotinic acetylcholine receptor. It is a potent inhibitor of ACh-activated currents in rat sympathetic neurons, and also inhibits potassium-evoked currents in rat hippocampal neurons. U91356 is a competitive antagonist at the alpha3beta4 nicotinic acetylcholine receptor, but does not inhibit responses to ACh or nicotine in mice with alpha7 nicotinic acetylcholine receptor deficiency.</p>

<p>Pirprofen is a nonsteroidal anti-inflammatory drug that inhibits prostaglandin synthesis. It has been shown to reduce the levels of serum aminotransferases, which are enzymes that catalyze the conversion of amino acids to amines and can be used as a marker for liver damage. Pirprofen is used in clinical settings to treat patients with chronic arthritis, hepatitis, or other infectious diseases. The pharmacokinetic properties of pirprofen are similar to those of other NSAIDs. However, pirprofen has a statistically higher incidence of gastrointestinal side effects than does ibuprofen or naproxen. Pirprofen should not be administered in patients who have hepatic impairment (elevated serum aminotransferase levels) because it may lead to an increase in these enzyme levels.</p>

<p>BLZ 945 is a novel small molecule that inhibits the activation of microglia, which are immune cells in the brain. It has been shown to inhibit tumor growth and radiation-induced tissue damage in cancer research. BLZ 945 also reduces the severity of autoimmune diseases by inhibiting the production of pro-inflammatory cytokines such as csf-1r and toll-like receptor 4. In addition, it has anti-inflammatory properties due to its inhibition of macrophage migration and adhesion. The drug has been shown to reduce the size of solid tumours in mice by reducing tumor angiogenesis and inhibiting cell proliferation.</p>

<p>Inhibitor of c-MET receptor tyrosine kinase; antineoplastic</p>

<p>PJ34 is a chemical compound that induces apoptosis in cancer cells. It has been shown to induce caspase-independent cell death in myeloma cells and HL-60 leukemia cells, but not in normal cells. PJ34 is a selective inhibitor of PARP-1, an enzyme that regulates the balance between DNA repair and apoptosis. This drug also induces neuronal death by inhibiting basic proteins without inducing necrosis.</p>

<p>MSX-130 is a photochemically active compound that has been shown to be solvated in organic solvents. This compound has a halochromic property, which causes it to change color depending on the solvent used. The crystal structure of MSX-130 was determined by x-ray diffraction and the thermochromic properties were observed using infrared spectroscopy. A strong bond between this molecule and imidazole derivatives was observed. It is also capable of absorbing light in the visible spectrum and converting it into thermal energy.<br>MSX-130 is a crystalline solid at room temperature but becomes a liquid when heated to 60°C.</p>

<p>CE 3F4 is a proarrhythmic agent that activates the mitochondria and increases the levels of ATP. It has been shown to inhibit autophagy, which is the process by which cells degrade their own components. CE 3F4 also has potential as a drug target for cardiac arrhythmias. In animal models, CE 3F4 prevents atrial fibrillation and restores normal myocardial function after a myocardial infarct. CE 3F4 may have anticancer properties due to its ability to induce apoptosis in some types of cancer cells. The drug was also found to be highly effective against human leukemia cell lines when tested in vitro.</p>

<p>Asp 2535 is a sodium hypochlorite-based compound, which is a chlorine-releasing agent with potent antimicrobial properties. It originates from the oxidation of sodium chloride and displays its efficacy through the release of hypochlorous acid upon dissolution in water. This mode of action involves the disruption of essential cellular processes in microorganisms, including protein synthesis and nucleic acid structure, ultimately leading to cell death.</p>

<p>MV1 is a protein that belongs to the group of calcium binding proteins. It has been shown to be an important biomarker for active antiretroviral therapy in HIV-infected patients. MV1 is also expressed at high levels in primary cells, such as T lymphocytes and macrophages, and can be used as a marker for cell lysis in model organisms, such as mice. The protein has been shown to have potential therapeutic applications in the treatment of obesity-related disorders by regulating body mass index (BMI). MV1 has also been shown to bind bacterial strains and viruses, which makes it a potential diagnostic tool. This protein can also act as a vector for experimental models.</p>

<p>YHO-13177 is a novel chemotherapeutic drug that is being investigated for its effectiveness against cancer. YHO-13177 has been shown to inhibit the ATP binding cassette transporter, which prevents the export of nucleotides from cells and inhibits DNA synthesis. It also inhibits cancer cell proliferation in a dose-dependent manner and has been shown to be effective against murine leukemia. YHO-13177 has been shown to bind to human cervical carcinoma cells, but not to healthy cells, suggesting that it may have potential as a treatment for cervical cancer.</p>

<p>Aklavine is a peptide that functions as an ion channel inhibitor. Aklavine is a ligand that binds to the receptor site of the ion channel, preventing flow of ions. This inhibition prevents the release of neurotransmitters from presynaptic neurons and blocks action potentials in postsynaptic neurons. Aklavine has been shown to inhibit potassium channels, calcium channels, and sodium channels. It also has been shown to activate glutamate receptors and acetylcholine receptors. Aklavine is used as a research tool for studying ion channel activity and protein interactions. It is also used as an antibody labeling agent for immunohistochemical or immunocytochemical experiments on cultured cells.</p>

<p>Velagliflozin is an investigational pharmaceutical compound, which is a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor. It is derived from synthetic chemical sources, specifically designed for the modulation of glucose levels in the bloodstream. Velagliflozin functions by inhibiting the SGLT2 protein in the proximal renal tubules, thereby preventing glucose reabsorption in the kidney and promoting its excretion through urine. This mechanism of action effectively lowers blood glucose levels and provides an adjunct therapeutic approach in the management of type 2 diabetes mellitus.</p>

<p>SKI 5C is a small-molecule inhibitor, which is synthetically derived with a unique mechanism that targets specific signaling pathways involved in cancer cell proliferation. The source of SKI 5C lies in its synthetic chemistry, designed to interact precisely with cellular components that regulate growth signals within cancerous cells. Its mode of action includes the inhibition of key enzymes and receptors involved in these pathways, effectively disrupting the processes that lead to uncontrolled cell division.<br><br>In research and clinical applications, SKI 5C is primarily used to study and potentially treat malignancies characterized by aberrant signaling activities. By selectively targeting cancer cells while sparing normal cells, SKI 5C provides a valuable model for understanding the molecular dynamics of cancer growth and resistance. Its precise intervention in cellular signaling cascades makes it an important tool for experimental therapeutics and biomarker discovery, offering insights into new avenues for targeted oncological therapies. Through its application, SKI 5C contributes to the broader research goals of improving the specificity and efficacy of cancer treatments.</p>

<p>(±)-ADX 71743 is a metabotropic glutamate receptor (mGluR) allosteric modulator that increases the activity of the receptor by binding to it. This modulates neurotransmission and reduces pain signals in the central nervous system. (±)-ADX 71743 has been shown to be effective in animal models of nerve injury, sciatic nerve injury, and neuropathic pain. In these models, (±)-ADX 71743 was found to reduce both spontaneous pain and evoked pain responses. It also reduced neuronal hyperexcitability in the dorsal horn of the spinal cord, which is involved in processing nociceptive signals from peripheral tissues. The drug binds to mGluR7 with high affinity, but does not bind to mGluR1 or other subtypes of mGluRs.</p>

<p>SB-415286 is a small molecule inhibitor of GSK-3β. It prevents phosphorylation of the substrate by GSK-3β, thereby preventing the inhibition of downstream signaling pathways, such as those that regulate energy metabolism and neuronal death. SB-415286 has been shown to inhibit 3t3-l1 preadipocytes differentiation into adipocytes, although it does not inhibit proliferation or stimulate apoptosis. This agent also inhibits neuronal death in axons and axon regeneration in t-cell lymphomas, suggesting that this drug may be useful for treating diseases like Alzheimer's disease or stroke.</p>

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<p>Balicatib is a small molecule that binds to the receptor on the surface of cancer cells and inhibits the activity of cathepsin. It has been shown to have an inhibitory effect on tumor growth in preclinical models by inhibiting tumor angiogenesis, preventing tumor cells from migrating, and inducing cell death. Balicatib has also been shown to be effective in reducing pain caused by diabetic neuropathy and cancer-related bone pain. Furthermore, balicatib is not metabolized by the liver and does not affect platelet aggregation.</p>

<p>Sulfo-SPDB is a lysine analog that has potent antitumor activity and is being evaluated as a potential cancer therapeutic agent. It inhibits tumor growth in vitro by inhibiting the expression of proteins important for cell division and survival. Sulfo-SPDB binds to the lysine residues on the surface of cells, including erythrocytes, lymphocytes, and tumor cells. This binding prevents protein synthesis and cell division. In vivo studies have shown that sulfo-SPDB is effective against human liver cancer xenografts in mice, cervical cancer xenografts in mice, and t-cell lymphoma xenografts in mice. Clinical studies are underway to determine if it is safe for use in humans.</p>

<p>5-Fluorouracil-15N2 is an anticancer drug that acts as a potent inhibitor of kinases involved in cell division and proliferation. It is used to treat various types of cancer, including breast, colon, and prostate cancer. This drug works by interfering with the synthesis of DNA and RNA, leading to the inhibition of protein synthesis and ultimately inducing apoptosis in cancer cells. 5-Fluorouracil-15N2 has been shown to be effective against human cancer cell lines in vitro as well as in vivo tumor models. This medicinal analog can be detected in urine samples after administration and has been studied for its potential use as a biomarker for monitoring cancer therapy. Additionally, recent studies have shown that 5-Fluorouracil-15N2 may have anti-tumor effects in Chinese hamster ovary cells by inhibiting protein kinase C activity.</p>

<p>PYR-5084 is a peptide that is used for research purposes. It is an activator of the alpha subunit of the G protein, which increases the production of cAMP and inhibits the production of cGMP. PYR-5084 has been shown to bind to the beta2-adrenergic receptor and activate it in a similar manner as epinephrine. PYR-5084 also binds to a variety of other receptors including muscarinic acetylcholine receptors, serotonin receptors, dopamine receptors, and nicotinic acetylcholine receptors.</p>

<p>SB 204741 is a drug that blocks the action of serotonin receptors. It is used in the treatment of autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus. SB 204741 has been shown to reduce levels of cytosolic calcium, which may be due to its inhibition of phospholipase C. This drug also inhibits the polymerase chain reaction and slows cardiac muscle cell growth. In addition, it inhibits the release of growth factor-β1 from platelets and 5-hydroxytryptamine (5-HT) from synaptosomes in rat brain cells. SB 204741 also has a synergistic effect with detrusor muscle relaxants and potentiates the effects of selective 5-HT2C receptor antagonists on 5-HT2B receptors.</p>

<p>SB 699551 Dihydrochloride is a selective 5-HT2 receptor antagonist that has been shown to be effective in the treatment of depression and pain. In animal studies, SB 699551 Dihydrochloride has been shown to reduce depression-like behaviors and pain responses. The drug also exhibits high affinity for 5-HT7 receptors with low efficacy. SB 699551 Dihydrochloride is not active against 5-HT1A or 5-HT7 receptors, which are involved in the regulation of serotonin release. This drug may be helpful in the treatment of depression and pain by blocking serotonergic activity at the 5-HT2 receptor.</p>

<p>MSOP is a drug that is used to treat depression. It is an intravitreal injection that has been shown to be effective in treating orthopaedic reactions, such as pain and inflammation, caused by reaction products. MSOP also has clinical pathology benefits for the treatment of n-methyl-d-aspartic acid glutamate receptor activity. This drug has been shown to increase locomotor activity and reduce intestinal parasites in women with high blood pressure. MSOP may also have a beneficial effect on depression due to its ability to modulate the neurotransmitter systems in the brain, including serotonergic, noradrenergic, dopaminergic, and glutamatergic systems.</p>

<p>Big endothelin-1 is a peptide that belongs to the class of endothelin family. It is used as a research tool in cell biology and pharmacology, because it binds to the ET-A receptor, which is a ligand-gated ion channel. Big endothelin-1 has been shown to activate this receptor, leading to an increase in intracellular calcium levels and vasoconstriction. It also inhibits the production of nitric oxide by endothelial cells and inhibits the activity of phospholipase A2. Big endothelin-1 has been shown to be an inhibitor of angiotensin converting enzyme (ACE).</p>

<p>Milfasartan is an angiotensin II receptor blocker (ARB), which is synthetically derived. Its mode of action involves selectively blocking the binding of angiotensin II to the angiotensin I receptor, a crucial aspect in the regulation of blood pressure. This inhibition results in vasodilation, thereby reducing blood pressure and decreasing the workload on the heart.</p>

<p>Portion of EBV BZLF-1</p>

<p>ML337 is a functional ligand that binds to the metabotropic glutamate receptor subtype 2 (mGlu2). It has been shown to be an allosteric modulator of mGlu2, where it acts as an agonist at low concentrations and as a negative allosteric modulator at high concentrations. ML337 has been shown to inhibit calcium-sensing receptor function in renal cells and may have potential for the treatment of chronic kidney diseases.</p>

<p>FR194921 is a selective, high-affinity antagonist of the adenosine A1 receptor. It has been shown to selectively bind to the adenosine A1 receptor and block its binding site. FR194921 is orally active and has shown potential in the treatment of Parkinson's disease, Alzheimer's disease, and schizophrenia. The molecular structure of FR194921 is similar to that of caffeine with a fluorine atom replacing one hydrogen atom on the methyl group. This chemical property may account for some of its pharmacological properties.<br>FR194921 binds to the adenosine A1 receptor at a different site than caffeine, which may explain why FR194921 does not have any stimulant effects.</p>

<p>Angiotensin receptor AT2 antagonist</p>

<p>K 114 is a selective herbicide, which is a synthetic chemical intervention designed to target and manage unwanted plant species in agricultural settings. Derived from advanced chemical synthesis processes, it ensures high purity and efficacy in real-world applications. The mode of action involves the inhibition of key enzymatic pathways crucial for the survival and growth of broadleaf and grassy weeds, thereby effectively hindering their development without affecting the desired crops.</p>

<p>3,29-O-Dibenzoyloxykarounidiol is a saponin that can be found in the roots of the karoung plant. It has been shown to have anticarcinogenic properties and is used in traditional medicine for the treatment of skin tumors. 3,29-O-Dibenzoyloxykarounidiol has been shown to inhibit tumor growth in mice by inhibiting fatty acid biosynthesis. This compound also has a protective effect on the liver and exhibits hepatoprotective effects. 3,29-O-Dibenzoyloxykarounidiol is also believed to have anti-inflammatory properties due to its inhibition of prostaglandin synthesis.</p>

<p>Please enquire for more information about UC-514321 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>ONC212 is a potent anti-cancer agent with transcriptional regulatory activity. ONC212 has been shown to have potent antitumor activity against skin cancer in vivo. The compound also showed synergistic effects in vitro when combined with other chemotherapeutic drugs, such as dopamine or 5-fluorouracil. It has been shown that ONC212 interacts with the cell membrane, which may be due to its ability to inhibit energy metabolism and induce apoptosis in malignant brain cells. Furthermore, ONC212 was found to be a potent inducer of cell death in cancer cells and shows biological properties that are relevant for the treatment of cancer.</p>

<p>Isoagarotetrol is a chemical compound that belongs to the group of volatile oils. It has been shown to inhibit the production of reactive oxygen species, which causes cell damage and inflammation in tissues. Isoagarotetrol also prevents lipid peroxidation and reduces the production of nitric oxide, both of which are involved in the inflammatory process. Isoagarotetrol has been shown to have neuroprotective effects through its inhibition of oxidative stress-induced neuronal death. Isoagarotetrol exhibits pharmacokinetic properties that are dependent on the concentration used and is active against PC12 cells when administered at high concentrations.</p>

<p>Pt-TTPY is a telomerase inhibitor that binds to the protein subunit of telomerase and prevents the elongation of telomeres. Pt-TTPY has been shown to inhibit cancer cells in vitro, which may be due to its ability to inhibit the synthesis of DNA. The compound also inhibits the proliferation of cancer cells and tumor growth in vivo. Pt-TTPY has been tested in clinical trials for use with cisplatin as a cancer therapy. Pt-TTPY binds to DNA in a sequence-dependent manner and is concomitantly detected by mass spectrometry and fluorescence resonance energy transfer (FRET) measurements. This compound can be used for the detection of telomerase activity or for the measurement of telomere length.</p>

<p>Please enquire for more information about Zolmitriptan-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Mouse anti-rat kappa 1 light chain (HRP) was raised in mouse using rat kappa-L chain as the immunogen.</p>

<p>Inhibitor of calpain and cathepsin B</p>

<p>ABP 688 is a radiolabeled ligand, which is a synthetic compound used primarily in positron emission tomography (PET) to visualize metabotropic glutamate receptor subtype 5 (mGluR5) in vivo. Developed from chemical synthesis, ABP 688 acts by selectively binding to the allosteric site of the mGluR5 receptor with high affinity and specificity. When labeled with a positron-emitting isotope such as Carbon-11 or Fluorine-18, it allows for the non-invasive imaging and quantification of mGluR5 distribution and density in the brain.</p>

<p>PFI-4 is a small molecule that has been shown to inhibit cancer cell growth and proliferation. It is a hydroxyl group analog that binds to the bromodomain of proteins in the cellular nucleus and blocks the interaction between acetylated histones and transcription factors. PFI-4 also inhibits virus replication, specifically influenza virus, by binding to the stem cell-like antigen. This drug is an optical imaging agent that can be used for optical imaging of cells with stem cell-like phenotypes. PFI-4 also inhibits tumor growth by disrupting the disulfide bond in water molecules.</p>

<p>Please enquire for more information about GSK 591 dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 2-cyano-2-ethoxyacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>BMS-1001 hydrochloride is a peptide that is an activator of ion channels. It has been shown to inhibit the activation of potassium channels and calcium channels in rat brain slices. BMS-1001 hydrochloride also binds to the receptor site of human calcitonin gene-related peptide (CGRP) and blocks its binding to CGRP receptor sites on mast cells. This prevents the release of histamine, which is responsible for allergic reactions such as hay fever, asthma, and chronic urticaria.<br>BMS-1001 hydrochloride has been shown to be a potent inhibitor of protein interactions with ligands and receptors. It inhibits the interaction between human erythropoietin (EPO) and its receptor by competing with endogenous EPO for binding sites on the surface of erythrocytes.</p>

<p>Inhibitor of pan-AKT</p>

<p>I-SAP is a h2 receptor antagonist that is used in the diagnosis of cardiac diseases. It can be used to measure the uptake of I-SAP by the circulatory system and diagnose disorders such as transthyretin amyloidosis, which is a familial disorder affecting the heart, circulatory system, and other organs. I-SAP can also be used to measure the uptake of I-SAP by the pancreas, which is useful for diagnosing pancreatic cancer.<br>I-SAP is not currently FDA approved for use in humans.</p>

<p>GMC 2-29 is a broad-spectrum fungicide, which is derived from chemical synthesis with systemic properties. As a product of chemico-biological research, it is engineered to inhibit fungal growth by interfering with essential cellular processes within target pathogens. Its active ingredients penetrate plant tissues, providing efficient internal protection against a range of fungal diseases.</p>

<p>Inhibitor of PI3KΎ and PI3Kγ kinases</p>

<p>Please enquire for more information about rac Styrene-d5 oxide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>BYK 49187 is an experimental drug that has been shown to have the ability to inhibit cancer cell growth in vitro. The compound was found to be effective against a number of different types of cancer cells, including kidney, colorectal, prostate and breast cancers. BYK 49187 binds to adenosine diphosphate-ribose (ADPR) and inhibits the synthesis of DNA and RNA by blocking the enzyme ribonucleotide reductase. This process prevents cancer cells from dividing or repairing DNA damage. In addition, the drug has been shown to suppress cardiac hypertrophy and heart failure in anesthetized rats.<br>BYK 49187 is not yet approved for use in humans.</p>

<p>15(S)-HETRE is an analog that acts as a kinase inhibitor with potential anti-cancer properties. It has been shown to inhibit the activity of several kinases, including those involved in cancer cell growth and proliferation. Studies have demonstrated its ability to induce apoptosis in Chinese hamster ovary cells and human tumor cells, making it a promising candidate for medicinal use as an anticancer agent. Additionally, 15(S)-HETRE has been found in urine samples of cancer patients, further supporting its potential as a therapeutic protein for cancer treatment.</p>

<p>D-3263 hydrochloride is a novel drug that has been shown to be effective against chronic kidney disease. This drug is an orally active small molecule that was identified by the use of a multivariable approach in the chemical biology field. D-3263 hydrochloride has been shown to bind to specific targets (e.g., markers) and inhibit cancer cell proliferation and growth, as well as induce cancer cell death. It also inhibits angiogenesis, which is the formation of new blood vessels from pre-existing ones, and can be used for cancer therapy. The mechanism of action of this drug is unknown but may involve redox signaling pathways and gaseous molecules.</p>

<p>AMG 853 is a molecule that inhibits the activity of the enzyme Crth2, which plays a key role in calcium binding and release. AMG 853 has been shown to be safe and effective in the treatment of allergic and inflammatory diseases. The drug's mechanism of action is not fully understood, but it may work by preventing calcium from being released from cells. This would prevent the release of pro-inflammatory substances such as histamine, which are released by mast cells when they bind to IgE antibodies on their surface. AMG 853 has been shown to significantly reduce symptoms in patients with chronic urticaria (hives) over a four-week period without any side effects.</p>